WO2012007777A1 - Novel proteins, process for preparation thereof, and use thereof - Google Patents

Novel proteins, process for preparation thereof, and use thereof Download PDF

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Publication number
WO2012007777A1
WO2012007777A1 PCT/HU2011/000066 HU2011000066W WO2012007777A1 WO 2012007777 A1 WO2012007777 A1 WO 2012007777A1 HU 2011000066 W HU2011000066 W HU 2011000066W WO 2012007777 A1 WO2012007777 A1 WO 2012007777A1
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masp
seq
protein
proteins
enzyme
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PCT/HU2011/000066
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English (en)
French (fr)
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Péter GÁL
Gábor PÁL
Dávid HÉJA
Péter ZÁVODSKY
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Eötvös Loránd Tudományegyetem
Magyar Tudományos Akadémia Szegedi Biológiai Központ Enzimológiai Intézete
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Publication of WO2012007777A1 publication Critical patent/WO2012007777A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433Serine endopeptidases (3.4.21)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
PCT/HU2011/000066 2010-07-13 2011-07-13 Novel proteins, process for preparation thereof, and use thereof WO2012007777A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1000366 2010-07-13
HU1000366A HUP1000366A2 (en) 2010-07-13 2010-07-13 Novel proteins, their production process and use tereof

Publications (1)

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WO2012007777A1 true WO2012007777A1 (en) 2012-01-19

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HU (1) HUP1000366A2 (hu)
WO (1) WO2012007777A1 (hu)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103014013A (zh) * 2012-11-28 2013-04-03 中国科学院海洋研究所 三疣梭子蟹Pacifastin型丝氨酸蛋白酶抑制剂PtPLC基因及其编码蛋白和应用
WO2014144542A3 (en) * 2013-03-15 2014-12-31 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
WO2018127719A2 (en) 2017-01-06 2018-07-12 Evolveritas Kft. Novel proteins and use thereof
US11045544B2 (en) 2013-03-15 2021-06-29 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
JP2021525728A (ja) * 2018-05-29 2021-09-27 オメロス コーポレーション Masp−2阻害剤および使用方法
US11807641B2 (en) 2019-12-04 2023-11-07 Omeros Corporation MASP-2 inhibitors and methods of use
WO2024069200A2 (en) 2022-09-29 2024-04-04 Evolveritas Biotechnológiai Korlátolt Felelősségű Társaság A modified protein scaffold and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032157A1 (en) * 2002-08-08 2005-02-10 Peter Gal Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
US20070172483A1 (en) * 2004-06-10 2007-07-26 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
WO2007095154A2 (en) * 2006-02-10 2007-08-23 The Brigham And Women's Hospital, Inc. Lectin complement pathway assays and related compositions and methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032157A1 (en) * 2002-08-08 2005-02-10 Peter Gal Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
US20070172483A1 (en) * 2004-06-10 2007-07-26 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
WO2007095154A2 (en) * 2006-02-10 2007-08-23 The Brigham And Women's Hospital, Inc. Lectin complement pathway assays and related compositions and methods

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103014013A (zh) * 2012-11-28 2013-04-03 中国科学院海洋研究所 三疣梭子蟹Pacifastin型丝氨酸蛋白酶抑制剂PtPLC基因及其编码蛋白和应用
WO2014144542A3 (en) * 2013-03-15 2014-12-31 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
JP2016514456A (ja) * 2013-03-15 2016-05-23 オメロス コーポレーション 生物活性ペプチド担持抗体を生成する方法およびそれを含む組成物
EP2968546A4 (en) * 2013-03-15 2016-11-02 Omeros Corp METHODS OF GENERATING BIOACTIVE PEPTIDE CARRIER ANTIBODIES AND COMPOSITIONS COMPRISING THE SAME
AU2014229020B2 (en) * 2013-03-15 2017-09-28 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
US11045544B2 (en) 2013-03-15 2021-06-29 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
WO2018127719A2 (en) 2017-01-06 2018-07-12 Evolveritas Kft. Novel proteins and use thereof
WO2018127719A3 (en) * 2017-01-06 2018-11-15 Evolveritas Kft. Novel proteins and use thereof
JP2021525728A (ja) * 2018-05-29 2021-09-27 オメロス コーポレーション Masp−2阻害剤および使用方法
US11807641B2 (en) 2019-12-04 2023-11-07 Omeros Corporation MASP-2 inhibitors and methods of use
WO2024069200A2 (en) 2022-09-29 2024-04-04 Evolveritas Biotechnológiai Korlátolt Felelősségű Társaság A modified protein scaffold and use thereof

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