WO2011154403A3 - Isolierung von mesenchymalen stammzellen - Google Patents
Isolierung von mesenchymalen stammzellen Download PDFInfo
- Publication number
- WO2011154403A3 WO2011154403A3 PCT/EP2011/059393 EP2011059393W WO2011154403A3 WO 2011154403 A3 WO2011154403 A3 WO 2011154403A3 EP 2011059393 W EP2011059393 W EP 2011059393W WO 2011154403 A3 WO2011154403 A3 WO 2011154403A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- mesenchymal stem
- isolation
- collagen
- peptides
- Prior art date
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 title abstract 3
- 238000002955 isolation Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000007079 Peptide Fragments Human genes 0.000 abstract 2
- 108010033276 Peptide Fragments Proteins 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102100037362 Fibronectin Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 102000004264 Osteopontin Human genes 0.000 abstract 1
- 108010081689 Osteopontin Proteins 0.000 abstract 1
- 102000007000 Tenascin Human genes 0.000 abstract 1
- 108010008125 Tenascin Proteins 0.000 abstract 1
- 102000007614 Thrombospondin 1 Human genes 0.000 abstract 1
- 108010046722 Thrombospondin 1 Proteins 0.000 abstract 1
- 108010031318 Vitronectin Proteins 0.000 abstract 1
- 102100035140 Vitronectin Human genes 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 108010057670 laminin 1 Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Abstract
Die vorliegende Erfindung betrifft die Verwendung eines Peptids, das ausgewählt ist aus der Gruppe umfassend Laminin-1, Kollagen-1, Kollagen-3, Kollagen-4, Tenascin, Thrombospondin-1, Osteopontin, Fibronectin, Vitronectin, oder Fragmente oder Mischungen davon, zur Isolierung und/oder Identifizierung von mesenchymalen Stammzellen (MSC), insbesondere von Peptid-Fragmenten dieser Peptide. Ferner betrifft die Erfindung die Verwendung dieser Peptide/Peptid-Fragmente in der Behandlung von Wunden, Verletzungen und/oder degeneriertem Gewebe.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11725901.0A EP2576771A2 (de) | 2010-06-07 | 2011-06-07 | Isolierung von mesenchymalen stammzellen |
US13/706,308 US20130156819A1 (en) | 2010-06-07 | 2012-12-05 | Isolation of mesenchymal stem cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010023837.6 | 2010-06-07 | ||
DE102010023837A DE102010023837A1 (de) | 2010-06-07 | 2010-06-07 | Isolierung von mesenchymalen Stammzellen |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/706,308 Continuation US20130156819A1 (en) | 2010-06-07 | 2012-12-05 | Isolation of mesenchymal stem cells |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011154403A2 WO2011154403A2 (de) | 2011-12-15 |
WO2011154403A3 true WO2011154403A3 (de) | 2012-04-12 |
Family
ID=44278849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2011/059393 WO2011154403A2 (de) | 2010-06-07 | 2011-06-07 | Isolierung von mesenchymalen stammzellen |
Country Status (4)
Country | Link |
---|---|
US (1) | US20130156819A1 (de) |
EP (1) | EP2576771A2 (de) |
DE (1) | DE102010023837A1 (de) |
WO (1) | WO2011154403A2 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017235446A1 (en) * | 2016-03-16 | 2018-11-08 | Cell Medicine, Inc. | Mesenchymal stem cells with enhanced efficacy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006091675A2 (en) * | 2005-02-23 | 2006-08-31 | Surmodics, Inc. | Implantable medical articles having laminin coatings and methods of use |
DE102005021435A1 (de) * | 2005-05-04 | 2006-11-09 | Universitätsklinikum Freiburg | Verfahren zur serum-/proteinfreien Kultur von Stamm- und Progenitorzellen |
WO2006116793A1 (en) * | 2005-05-04 | 2006-11-09 | Australian Stem Cell Centre Limited | Selecting, culturing and creating lineage committed hematopoietic stem cells |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978352A (en) * | 1989-06-07 | 1990-12-18 | Fedorov Svjatoslav N | Process for producing collagen-based cross-linked biopolymer, an implant from said biopolymer, method for producing said implant, and method for hermetization of corneal or scleral wounds involved in eye injuries, using said implant |
-
2010
- 2010-06-07 DE DE102010023837A patent/DE102010023837A1/de not_active Withdrawn
-
2011
- 2011-06-07 EP EP11725901.0A patent/EP2576771A2/de not_active Withdrawn
- 2011-06-07 WO PCT/EP2011/059393 patent/WO2011154403A2/de active Application Filing
-
2012
- 2012-12-05 US US13/706,308 patent/US20130156819A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006091675A2 (en) * | 2005-02-23 | 2006-08-31 | Surmodics, Inc. | Implantable medical articles having laminin coatings and methods of use |
DE102005021435A1 (de) * | 2005-05-04 | 2006-11-09 | Universitätsklinikum Freiburg | Verfahren zur serum-/proteinfreien Kultur von Stamm- und Progenitorzellen |
WO2006116793A1 (en) * | 2005-05-04 | 2006-11-09 | Australian Stem Cell Centre Limited | Selecting, culturing and creating lineage committed hematopoietic stem cells |
Non-Patent Citations (8)
Title |
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BELKIN A M ET AL: "Integrins as receptors for laminins", MICROSCOPY RESEARCH AND TECHNIQUE, WILEY-LISS, CHICHESTER, GB, vol. 51, no. 3, 1 November 2000 (2000-11-01), pages 280 - 301, XP007907145, ISSN: 1059-910X, DOI: DOI:10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O * |
COVAS D T ET AL: "Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146<+> perivascular cells and fibroblasts", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC, US, vol. 36, no. 5, 1 May 2008 (2008-05-01), pages 642 - 654, XP022619850, ISSN: 0301-472X, [retrieved on 20080304], DOI: DOI:10.1016/J.EXPHEM.2007.12.015 * |
HALFON SVETLANA ET AL: "Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging", STEM CELLS AND DEVELOPMENT, MARY ANN LIEBERT, INC, NEW ROCHELLE, NY, US, vol. 20, no. 1, 1 January 2011 (2011-01-01), pages 53 - 66, XP009150670, ISSN: 1557-8534 * |
HIDEYUKI KOGA ET AL: "Mesenchymal stem cell-based therapy for cartilage repair: a review", KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY, SPRINGER, BERLIN, DE, vol. 17, no. 11, 31 March 2009 (2009-03-31), pages 1289 - 1297, XP019755747, ISSN: 1433-7347, DOI: DOI:10.1007/S00167-009-0782-4 * |
KATIE C. RUSSELL ET AL: "In Vitro High-Capacity Assay to Quantify the Clonal Heterogeneity in Trilineage Potential of Mesenchymal Stem Cells Reveals a Complex Hierarchy of Lineage Commitment", STEM CELLS, vol. 28, no. 4, 1 April 2010 (2010-04-01), pages 788 - 798, XP055003591, ISSN: 1066-5099, DOI: 10.1002/stem.312 * |
KUSCHEL ET AL.: "Cell adhesion profiling using extracellular matrix protein microarrays", BIOTECHNIQUES, vol. 40, 2006, pages 523 - 531, XP001539676 * |
LINDOLFO DA SILVA MEIRELLES ET AL: "Methodology, biology and clinical applications of mesenchymal stem cells", FRONTIERS IN BIOSCIENCE, vol. Volume, no. 14, 1 January 2009 (2009-01-01), pages 4281 - 4298, XP055003899, ISSN: 1093-9946, DOI: 10.2741/3528 * |
SCHWAB K E ET AL: "Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium", HUMAN REPRODUCTION, OXFORD UNIVERSITY PRESS, GB, vol. 22, no. 11, 1 November 2007 (2007-11-01), pages 2903 - 2911, XP002512778, ISSN: 0268-1161, [retrieved on 20070914], DOI: DOI:10.1093/HUMREP/DEM265 * |
Also Published As
Publication number | Publication date |
---|---|
US20130156819A1 (en) | 2013-06-20 |
EP2576771A2 (de) | 2013-04-10 |
DE102010023837A1 (de) | 2011-12-08 |
WO2011154403A2 (de) | 2011-12-15 |
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