WO2008059252A3 - Methods and composition fro t cell receptors which recognize 5t4 antigen - Google Patents

Methods and composition fro t cell receptors which recognize 5t4 antigen Download PDF

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Publication number
WO2008059252A3
WO2008059252A3 PCT/GB2007/004361 GB2007004361W WO2008059252A3 WO 2008059252 A3 WO2008059252 A3 WO 2008059252A3 GB 2007004361 W GB2007004361 W GB 2007004361W WO 2008059252 A3 WO2008059252 A3 WO 2008059252A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
recognize
fro
cell receptors
composition
Prior art date
Application number
PCT/GB2007/004361
Other languages
French (fr)
Other versions
WO2008059252A2 (en
WO2008059252A9 (en
Inventor
Kevin Myers
Irina Redchenko
William Shingler
Richard Harrop
Stuart Naylor
Alan Kingsman
Susan Kingsman
Original Assignee
Oxford Biomedica Ltd
Kevin Myers
Irina Redchenko
William Shingler
Richard Harrop
Stuart Naylor
Alan Kingsman
Susan Kingsman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0622805A external-priority patent/GB0622805D0/en
Application filed by Oxford Biomedica Ltd, Kevin Myers, Irina Redchenko, William Shingler, Richard Harrop, Stuart Naylor, Alan Kingsman, Susan Kingsman filed Critical Oxford Biomedica Ltd
Publication of WO2008059252A2 publication Critical patent/WO2008059252A2/en
Publication of WO2008059252A9 publication Critical patent/WO2008059252A9/en
Publication of WO2008059252A3 publication Critical patent/WO2008059252A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.
PCT/GB2007/004361 2006-11-15 2007-11-15 Methods and composition fro t cell receptors which recognize 5t4 antigen WO2008059252A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86601206P 2006-11-15 2006-11-15
GB0622805A GB0622805D0 (en) 2006-11-15 2006-11-15 Methods and compositions for T cell receptors which recognize 5T4 antigen
GB0622805.0 2006-11-15
US60/866,012 2006-11-15

Publications (3)

Publication Number Publication Date
WO2008059252A2 WO2008059252A2 (en) 2008-05-22
WO2008059252A9 WO2008059252A9 (en) 2008-09-18
WO2008059252A3 true WO2008059252A3 (en) 2008-12-04

Family

ID=39235985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/004361 WO2008059252A2 (en) 2006-11-15 2007-11-15 Methods and composition fro t cell receptors which recognize 5t4 antigen

Country Status (1)

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WO (1) WO2008059252A2 (en)

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CN106039307A (en) 2008-08-05 2016-10-26 东丽株式会社 Pharmaceutical composition for treatment and prevention of cancer
HUE027332T2 (en) * 2008-08-05 2016-09-28 Toray Industries Cancer detection method
WO2011096528A1 (en) 2010-02-04 2011-08-11 東レ株式会社 Pharmaceutical composition for treatment and/or prevention of cancer
AU2011211700B2 (en) 2010-02-04 2015-06-11 Toray Industries, Inc. Medicament for treating and/or preventing cancer
DK2532366T3 (en) 2010-02-04 2017-01-02 Toray Industries PHARMACEUTICAL COMPOSITION FOR TREATMENT AND / OR CANCER PREVENTION
KR101805520B1 (en) 2010-02-04 2017-12-07 도레이 카부시키가이샤 Pharmaceutical composition for treatment and/or prevention of cancer
PL2532680T3 (en) 2010-02-04 2015-10-30 Toray Industries Medicinal composition for treating and/or preventing cancer
RU2598258C2 (en) 2010-02-04 2016-09-20 Торэй Индастриз, Инк. Pharmaceutical composition for treatment and/or prevention of cancer
US9796775B2 (en) 2011-08-04 2017-10-24 Toray Industries, Inc. Method for detecting pancreatic cancer
PL3351630T3 (en) 2011-08-04 2020-05-18 Toray Industries, Inc. Pharmaceutical composition comprising anti caprin-1 antibodies for treating and/or preventing cancer
JP6065592B2 (en) 2011-08-04 2017-01-25 東レ株式会社 Pharmaceutical composition for treatment and / or prevention of cancer
PL2740489T3 (en) 2011-08-04 2017-06-30 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of pancreatic cancer
RU2610428C2 (en) 2011-08-04 2017-02-10 Торэй Индастриз, Инк. Pharmaceutical composition for treating and/or preventing malignant growth
KR101968498B1 (en) 2011-08-04 2019-04-12 도레이 카부시키가이샤 Drug composition for cancer treatment and/or prevention
US9181348B2 (en) 2011-08-04 2015-11-10 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prophylaxis of cancer
WO2013125636A1 (en) 2012-02-21 2013-08-29 東レ株式会社 Pharmaceutical composition for treatment and/or prevention of cancer
AU2013223137B2 (en) 2012-02-21 2017-10-19 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of cancer
IN2014KN01715A (en) 2012-02-21 2015-10-23 Toray Industries
PT2824114T (en) 2012-02-21 2019-08-05 Toray Industries Pharmaceutical composition for treatment of cancer
HUE036425T2 (en) 2012-03-30 2018-07-30 Toray Industries Pharmaceutical composition for treatment and/or prevention of gallbladder cancer
MX358224B (en) 2012-03-30 2018-08-10 Toray Industries Pharmaceutical composition for treatment and/or prevention of liver cancer.
EP2876446B1 (en) 2012-07-19 2018-12-26 Toray Industries, Inc. Method for detecting cancer
RU2646464C2 (en) 2012-07-19 2018-03-05 Торэй Индастриз, Инк. Method for cancer detection
RU2678138C2 (en) 2013-08-09 2019-01-23 Торэй Индастриз, Инк. Pharmaceutical composition for treatment and/or prevention of cancer
EP3395834A4 (en) * 2015-12-24 2019-10-23 XDCExplorer (Shanghai) Co., Ltd. Tpbg antibody and preparation method therefor, conjugate and use thereof
WO2019109047A1 (en) * 2017-12-01 2019-06-06 Fred Hutchinson Cancer Research Center Binding proteins specific for 5t4 and uses thereof
WO2019217831A1 (en) * 2018-05-11 2019-11-14 Memorial Sloan-Kettering Cancer Center Methods for identifying antigen-specific t cell receptors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816496A2 (en) * 1996-06-24 1998-01-07 Roche Diagnostics GmbH T-cells specific for kidney carcinoma
GB2370572A (en) * 1998-11-18 2002-07-03 Oxford Biomedica Ltd Use of professional antigen presenting cells
WO2003068816A1 (en) * 2002-02-13 2003-08-21 Oxford Biomedica Uk Limited Mhc class i peptide epitopes from the human 5t4 tumor-associated antigen
WO2004060145A2 (en) * 2002-12-31 2004-07-22 Baylor College Of Medicine Isolation and identification of cross-reactive t cells
WO2005062959A2 (en) * 2003-12-22 2005-07-14 The University Of Tennessee Research Foundation Isolated t lymphocyte receptors specific for human autoantigens complexed with human mhc molecules and methods of making and using same
WO2006120473A2 (en) * 2005-05-13 2006-11-16 Oxford Biomedica (Uk) Limited Mhc class i and ii peptide antigens derived from tumour antigen 5t4

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816496A2 (en) * 1996-06-24 1998-01-07 Roche Diagnostics GmbH T-cells specific for kidney carcinoma
GB2370572A (en) * 1998-11-18 2002-07-03 Oxford Biomedica Ltd Use of professional antigen presenting cells
WO2003068816A1 (en) * 2002-02-13 2003-08-21 Oxford Biomedica Uk Limited Mhc class i peptide epitopes from the human 5t4 tumor-associated antigen
WO2004060145A2 (en) * 2002-12-31 2004-07-22 Baylor College Of Medicine Isolation and identification of cross-reactive t cells
WO2005062959A2 (en) * 2003-12-22 2005-07-14 The University Of Tennessee Research Foundation Isolated t lymphocyte receptors specific for human autoantigens complexed with human mhc molecules and methods of making and using same
WO2006120473A2 (en) * 2005-05-13 2006-11-16 Oxford Biomedica (Uk) Limited Mhc class i and ii peptide antigens derived from tumour antigen 5t4

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CLAY T ET AL: "Efficient transfer of a tumor antigen reactive TCR to human peripheral blood lymphocytes confers anti tumor reactivity", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 163, 1 January 1999 (1999-01-01), pages 507 - 513, XP002169636, ISSN: 0022-1767 *
ENGELS BORIS ET AL: "Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes", HUMAN GENE THERAPY, MARY ANN LIEBERT, NEW YORK ,NY, US, vol. 16, no. 7, 1 July 2005 (2005-07-01), pages 799 - 810, XP002460992, ISSN: 1043-0342 *
REDCHENKO IRINA ET AL: "IDENTIFICATION OF THE FIRST CD8+ T CELL EPITOPE WITHIN TUMOR-ASSOCIATED ANTIGEN 5T4", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATIONFOR CANCER RESEARCH, NEW YORK, NY, vol. 44, 14 July 2003 (2003-07-14), pages 361,ABSTRACT1857, XP008072044, ISSN: 0197-016X *
SMYTH L J C ET AL: "CD8 T-cell recognition of human 5T4 oncofetal antigen", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 119, no. 7, 1 October 2006 (2006-10-01), pages 1638 - 1647, XP002409262, ISSN: 0020-7136 *
ZHAO YANGBING ET AL: "Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell lines", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 174, no. 7, 1 April 2005 (2005-04-01), pages 4415 - 4423, XP002343301, ISSN: 0022-1767 *

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Publication number Publication date
WO2008059252A2 (en) 2008-05-22
WO2008059252A9 (en) 2008-09-18

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