WO2011138603A1 - Étage pour un instrument optique - Google Patents

Étage pour un instrument optique Download PDF

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Publication number
WO2011138603A1
WO2011138603A1 PCT/GB2011/050868 GB2011050868W WO2011138603A1 WO 2011138603 A1 WO2011138603 A1 WO 2011138603A1 GB 2011050868 W GB2011050868 W GB 2011050868W WO 2011138603 A1 WO2011138603 A1 WO 2011138603A1
Authority
WO
WIPO (PCT)
Prior art keywords
stage
component according
component
specimen holder
relative
Prior art date
Application number
PCT/GB2011/050868
Other languages
English (en)
Inventor
Maurice Leo Bowe
Richard Albert Norman
Original Assignee
Objective Imaging Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Objective Imaging Limited filed Critical Objective Imaging Limited
Publication of WO2011138603A1 publication Critical patent/WO2011138603A1/fr

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor

Definitions

  • the present invention relates to a component for use in an improved stage for an optical instrument, a stage comprising the component, and an optical instrument comprising the stage.
  • the invention also relates to a method of making the component, stage and optical instrument.
  • optical instrument e.g. microscope
  • stage and hence specimens located on a specimen holder mounted on the stage
  • Conventional motorised stages comprise at least 3 plates:- a static intermediate plate, on which are guides (in the form of grooves or the like) for a motorised upper plate and a motorised lower plate.
  • a static intermediate plate on which are guides (in the form of grooves or the like) for a motorised upper plate and a motorised lower plate.
  • One of the motorised plates moves in the x axis and the other moves in the y axis.
  • the motor used is a stepper motor although DC servo motors may also be used for this purpose.
  • Stepper motors are useful in this context, as they allow for fairly precise adjustment of the position of the stage. However, they do suffer from a number of disadvantages, including "backlash" in which, when the motor reverses direction there is a lag, during which there is no movement of the stage. This can lead to a loss of accuracy in the position of the stage.
  • Such backlash typically arises because of the manner in which motive force is transmitted from the motor to the stage.
  • Conventionally motorised stages are driven by one or more stepper motors, the motors acting to rotate a ballscrew (also referred to as a "leadscrew") which is engaged with a screw thread on the stage. It is necessary to provide some tolerance in the physical engagement between the ballscrew and the thread. As a result, there is inevitably a small gap between the trailing edge of the ballscrew and the nearest thread.
  • the motor reverses direction what was previously the trailing edge of the ballscrew becomes the leading edge, and the initial movement of the motor is needed to close the gap between the leading edge and the screw thread, leading to loss of accuracy.
  • the loss is initially small, it accumulates with each reversal of direction of the stage and so can become significant and is a major disadvantage.
  • the prevalence of mechanical backlash in conventional stages necessitates compensatory movements through software and/or electronics to ensure accurate positioning.
  • stage is usually attached to the optical instrument via a geared coupling, to allow the stage to be raised or lowered.
  • the large mass of the motorised stage can, over time, cause a slight gradual downward drift of the gear wheel. This is a particular problem when using the microscope to perform time-lapse photography - the gradual slight downward movement of the stage can cause loss of focus.
  • stage assembly is rather thick: the ideal stage, from the microscopist's viewpoint, would be essentially planar, to facilitate manipulation of the specimen on the stage.
  • the invention provides a stage component for use in manufacturing a motorised stage for an optical instrument, the component comprising a base member, a top member and an intermediate member; wherein the top member is supported on, and is movable in a first axis relative to, the intermediate member; and wherein the intermediate member is supported on, and is movable in a second axis relative to, the base member; characterised in that at least a selected one of the stage members is arranged such that, in use, it is supported at a proximal end region, the opposed distal end region being unsupported such that a specimen holder formed on or to be attached to the distal end region projects outwards from the selected stage member.
  • first and second axes are orthogonal to one another and desirably are both substantially horizontal.
  • first and second axes are ⁇ ' and 'X' axes such that, for a user, one axis of movement (Y) is directly towards or away from the user of the optical instrument, and the other axis of movement (X) is to the left and right of the user.
  • the intermediate member takes the form of a generally horizontal platform, mounted on the base member, so as to be movable in one horizontal axis relative to the base member, whilst the top member takes the form of a further generally horizontal platform mounted on the intermediate member so as to be movable in a horizontal axis relative to the intermediate member, the two aforementioned horizontal axes being essentially orthogonal.
  • the invention provides a motorised stage for use with an optical instrument, the stage comprising: the component of the first aspect of the invention; a drive or motor to cause movement of the top member relative to the intermediate member, and a drive or motor to cause movement of the intermediate member relative to the base member; and one or more inputs for electrical power for the said drive(s) or motor(s).
  • the invention provides an optical instrument comprising the motorised stage of the second aspect or the component of the first aspect.
  • the optical instrument is a microscope, especially an instrument adapted and configured for performing transmission light microscopy, but the instrument could in principle be any optical instrument where precise controlled movement of a sample relative to the instrument is desired, e.g. a micro-lithographic instrument or the like.
  • the stage component of the first aspect of the invention may be provided in generic form to manufacturers of optical instruments in a simplified configuration e.g. without a specimen holder, so that the instrument manufacturer may attach a suitable specimen holder dedicated for use with the particular instrument concerned.
  • the stage component will preferably include the associated motor drive(s) for the stage members, and the component will preferably comprise a plurality of attachment points to allow, for example, attachment of the stage component to different sizes or types of apparatus and/or in different orientations.
  • the stage component of the first aspect of the invention will be in a form specifically configured and adapted for use with a transmission light microscope.
  • the stage component will conveniently comprise a specimen holder already formed on, or attached to, the distal end of the selected stage member.
  • the component will also be configured for attachment to a light microscope and will conveniently be compatible with universal or common stage mounting brackets or attachments.
  • the selected stage member which is arranged to have a supported proximal end region and an opposed unsupported distal end region is the top member.
  • the supported end region is supported on a lower stage member, such as the intermediate stage member (where the selected stage member is the top member).
  • the supported proximal "end region" of the selected stage member is not restricted to the support being provided solely at the very end of the stage member, but may extend from the proximal end by some amount.
  • the depth of the supported proximal end region may extend by an amount approximately equal to the width of the lower stage member. This may be a width of at least 5 cm, typically at least 6 cm and conveniently about 7 cm.
  • the selected supported stage member will be movable relative to the lower stage member, it is conceivable and envisaged that, in use, the supported stage member may be in a relatively retracted position, such that the proximal end of the stage member may be withdrawn so far as to overhang the lower stage member, although this will not normally be the case.
  • the distal end region of the selected stage member will always extend beyond the edge of the lower stage member, even when the selected stage member is maximally retracted relative to the lower stage member.
  • the centre of the specimen holder will be positioned about at least 5 cm beyond the lower stage member, preferably at least about 6 cm, and more preferably at least 6.5-7.5 cm.
  • the centre of the specimen holder will be positioned at least about 8 cm beyond the lower stage member, preferably at least about 9 cm.
  • the distal end region of the stage member will project in such a way that the specimen holder (and any specimen mounted thereon) will be positioned in the light path of light passing through the functional optics of the instrument.
  • the overall effect of the arrangement of the invention is such that specimen holder is effectively 'suspended' in free space above the stage, but in the light path. This is highly advantageous in terms of allowing unhindered access to the specimen holder and/or to any specimen mounted thereon.
  • such an arrangement is highly counter-intuitive to the person skilled in the art, because it would be expected to be unstable and thus highly susceptible to movement, vibration etc. which would interfere with analysis of the specimen.
  • the specimen holder will typically be dimensioned so as to accommodate a conventionally-sized microscope slide.
  • the specimen holder will desirably comprise some form of biasing or urging means, typically a spring means such as a sprung clip, for retaining a microscope slide in a fixed position on or within the specimen holder.
  • the specimen holder is cantilevered on one of the members of the microscope stage component, preferably on the top member.
  • the specimen holder is provided at one edge of the top member and is desirably not otherwise supported.
  • the top member is provided with a groove or recess at an edge thereof, and an edge of the specimen holder is accommodated within the groove or recess.
  • other fixture means to fix the specimen holder to the top member may alternatively or additionally be used.
  • the preferred embodiments of the invention have the specimen holder projecting into space, with little or no stage components immediately adjacent above or below the specimen holder to impede access to, or manipulation of, a specimen on the specimen holder.
  • the stage of the invention and optionally also the component of the first aspect of the invention, comprises a drive or motor, typically an electric motor. It is conceivable that a single motor may be employed to cause the movement of both the top member and the intermediate member (relative to the intermediate and bottom members respectively). It is however greatly preferred that a separate motor is used to cause the movement of the respective members. It is a highly preferred feature of the invention that the motor is such that it directly drives movement of the stage, without requiring any intervening transmission member. This may conveniently be accomplished by use of a linear shaft motor (LSM). Desirably two LSMs are provided, one causing movement of the top plate (relative to the intermediate member), and one causing movement of the intermediate member (relative to the base member).
  • LSM linear shaft motor
  • a magnetic shaft runs through an aperture in a coil of the motor.
  • Application of an electric current to the coil induces movement of the coil relative to the magnetic shaft.
  • the coil may be fixed, in which case the shaft is forced to move through the coil or, more conventionally, the shaft is fixed and the coil moves along the shaft. Direct attachment of the coil, or shaft, as appropriate, to the stage member thus brings about direct driving of the movement of the stage member.
  • the top member and the intermediate member are preferably independently movable, in at least one axis, relative to the base member.
  • the bottom member is static (at least in respect of the X and Y axes). Accordingly, the intermediate member is driven by a motor to cause the said movement of intermediate member relative to the base member.
  • the stage component of the first aspect of the invention is arranged to be movable in the vertical Z, axis.
  • This Z axis movement may be accomplished manually, by a user.
  • Z axis movement is accomplished by a motor or drive means.
  • the motor or drive may move the entire stage, or may move part of the stage, such as a stage member or a specimen holder mounted on or attached to a stage member.
  • the amount of travel required in the Z axis is less then that required in the X or Y axes, for example, to adjust focus.
  • a preferred drive comprises a piezoelectric device, and a suitable piezoelectric device is available from the Cedrat Groupe (15 Chemin de Malacher, 38246 Meylan Cedex, France).
  • the top member is supported at a proximal end region but is unsupported at a distal end region.
  • This arrangement helps to minimise the mass of the stage component and of a stage comprising the component.
  • the reduction in mass of the stage components in turn allows for a reduced size motor to drive the stage with lower power consumption, relative to conventional stages.
  • the lighter stage is far less prone to slight downward drift under its own weight, and is therefore especially useful when employing time-lapse photography.
  • a guide mechanism is provided to guide the relative movement of the top and intermediate members.
  • the guide mechanism comprises one or more guide rails or a guide channel on one of the members between which relative movement occurs, and a guide follower provided on the other member.
  • the guide follower comprises a carriage which runs along a guide rail provided on the other member of the pair of members.
  • the guide rail may be formed from a durable substance, typically metal, and the carriage may employ devices such as re-circulating ball bearings to substantially eliminate friction between the carriage and the rail.
  • the stage component of the first aspect of the invention, and the stage of the second aspect of the invention, will advantageously comprise a position detecting mechanism to detect the relative position of the top and intermediate members relative to one another and/or relative to the bottom member.
  • the position detecting means will comprise an optical element which detects one or more markings provided on at least one of the members.
  • the position detecting means comprises an optical encoder.
  • the optical encoder is located on the guide follower.
  • the guide rail or channel followed by the guide follower is provided with at least one reference mark and a plurality of other marks detectable by the optical encoder, such that the relative position of the guide follower, and hence of the member on which the guide follower is mounted, can be determined.
  • the plurality of detectable marks are, in one embodiment, laser etched on the guide rail or guide channel, typically at regular intervals.
  • position detecting means are of course suitable for use in the invention. Examples include magnetic encoders, strain gauges, Hall-effect sensors and similar devices for accurately determining position.
  • Another advantage of the invention is that it reduces the depth of the stage and allows the space around the objective lens, the specimen holder, and the sub-stage condenser, to remain uncluttered relative to conventional motorised stage microscopes, thus facilitating manipulation of the sample, objective lens and condenser.
  • Figure 1 is a perspective view of an embodiment of a motorised stage in accordance with the invention.
  • Figure 2 is a plan view of the embodiment shown in Figure 1 ;
  • Figure 3 is a side elevation of the embodiment shown in Figure 1 ;
  • Figure 4 is a perspective view of the embodiment shown in Figure 1 , but with a cover removed to show more clearly the internal features of the apparatus;
  • Figures 5 and 6 are a plan view and side elevation, respectively, of the embodiment shown in Figure 4;
  • Figure 7 is a perspective view, from the underside, of a second embodiment of apparatus in accordance with the invention.
  • Figure 8 is a cut-away drawing, to a different scale, of part of the embodiment shown in Figure 7;
  • Figure 9 is an exploded perspective view of a different embodiment of a stage component in accordance with the first aspect of the invention.
  • an embodiment of a motorised stage in accordance with the invention comprises a X/Y axis-static base member 4, an intermediate member 6, and a top member 8.
  • the entire stage is for mounting on a microscope and is arranged so as to be movable in the z axis (i.e. vertically up or down) relative to an objective lens assembly of the microscope, so as to allow adjustment of focus.
  • the base member takes the form of a platform with a substantially horizontal planar upper surface, about 220 mm long and 140 mm wide, and is formed from anodised aluminium.
  • a substantially circular aperture 10 is formed in the base member 4.
  • the motorised stage is intended for use with a transmission light microscope, and the aperture 10 allows light to pass through the base member 4 to illuminate specimens placed in a specimen holder 12, which is borne by the top member 8.
  • the aperture 10 allows for possible close approach to the stage of a sub-stage assembly component of the microscope (the sub-stage assembly comprising e.g. one or more of a light source, one or more filters, a condenser and the like).
  • the base member is large, so as to facilitate attachment to a transmission light microscope via a conventional stage mounting bracket, but otherwise the base member could be made considerably smaller if some other attachment means were utilised.
  • the intermediate member 6 is considerably smaller than the base member 4.
  • Intermediate member 6 is also formed primarily from anodised aluminium and is a generally rectangular, thin platform with essentially horizontal upper and lower surfaces. The intermediate member is mounted so as to be horizontally movable in the X axis relative to the static base member 4.
  • the intermediate member 6 is about 100 mm long and 70 mm wide.
  • the top member 8 is generally similar to the intermediate member, in that it too is a generally rectangular, thin platform with essentially horizontal upper and lower surfaces. However, the top member 8 is mounted on the intermediate member orthogonally, and is arranged so as to be horizontally movable in the Y axis relative to the intermediate member 6.
  • the top member is cantilevered on the intermediate member, such that the top member is entirely supported thereon at a proximal end region of the top member, whilst a distal end region of the top member is unsupported and projects into free space above the base member 4, and more specifically, above the aperture 10 in the base member.
  • the top member is about 130 mm long and 100 mm wide, and is formed from aircraft-quality pre-stressed aluminium. Use of this material makes the top member very light but strong and stable, resistant to vibration.
  • the specimen holder 12 At one end of the top member there is a narrow, rectangular-section groove provided in the edge thereof. An edge of the specimen holder 12 is inserted into this groove, such that the specimen holder is attached to, and supported by, the top member.
  • the specimen holder takes the form of a substantially square or rectangular frame 14 defining a rectangular aperture 16. Within the aperture 16 are small flanged portions 18, at opposite ends thereof. A microscope slide of conventional dimensions can be inserted into the aperture 16 and is supported by the flanged portions. A sprung clip 20 is also provided to hold an inserted slide firmly within the specimen holder.
  • the specimen holder 12 is formed as an integral part of the top member.
  • the cantilevered arrangement of the top member, and the way in which the specimen holder projects from an edge of the top member, allows the specimen holder to be positioned such that it is readily accessible from above or below, enabling the specimen to be manipulated with ease.
  • the invention thus provides a motorised stage which confers ease of manipulation of a specimen mounted on a specimen holder attached to the stage.
  • Movement of the intermediate and top members in the X and Y axes respectively, and relative movement of the entire stage in the Z axis, can position a specimen on the specimen holder in any position in three dimensional space (within the limits of travel of the components) relative to an objective lens used to inspect the specimen.
  • the significant operable portions of the base, intermediate and top members are at least partially protected against shock, dust, liquid spills etc. by a shield 22, which is fitted to the base member 4 and forms a cover over an end portion of the motorised stage.
  • the shield 22 is formed from a moulded polymer material.
  • the shield surrounds a central aperture, within which is placed a transparent window 24, made of synthetic plastics material.
  • the transparent window allows for superficial inspection of the components of the stage 2 without requiring removal of the shield.
  • the shield may be entirely opaque.
  • a guide mechanism is provided to guide the movement of the intermediate member 6 relative to the base member 4.
  • the base member 4 comprises a recessed channel portion 30. Within the channel 30 is a metal guide rail 32.
  • a carriage (not shown in the drawings) on the underside of the intermediate member 6 is engaged with the guide rail 32 and acts as a guide follower.
  • the bottom member 4 comprises a further channel portion 34, which is narrower than channel portion 30.
  • a thin metal rod 36 of circular section Within channel 34 is fixed a thin metal rod 36 of circular section.
  • the rod 36 forms the shaft of a linear shaft motor (LSM).
  • the motor coil which runs on fixed shaft 36 is mounted on the underside of the intermediate member 6.
  • the motor coil is provided with a small printed circuit board (PCB) which controls movement of the motor along the fixed shaft 36.
  • the LSM provides about 80mm of travel in the X axis. There is a small gap (about l-2mm) between the shaft and the motor coil which runs along it. Accordingly, the motor has no wear and is very quiet in operation.
  • the apparatus is provided with position detecting means.
  • the guide rail 32 has a very precise laser-engraved scale marked thereon.
  • the scale is read by an optical reader mounted on the underside of the intermediate member 6, such that the position of the intermediate member on the X axis (relative to the base member) can be accurately determined.
  • the system is accurate to about 1 ⁇ .
  • Optical encoders are commercially available from, inter alia, Renishaw, Sony and Numerik Jena.
  • the orientation of the guide rail, and the motor shaft is at 90° to those provided to cause movement of the intermediate member since of course the top member moves orthogonally relative to the intermediate member.
  • the motor coil is fixed, and the shaft is free to move.
  • the intermediate member 6 comprises a recessed rectangular-section channel. Within the channel is fixed a motor coil.
  • a guide rail and guide follower arrangement guides the movement of the top member relative to the intermediate member and, as with the bottom/intermediate member arrangement, a laser-engraved scale on the guide rail is ready by an optical reader to allow precise determination of the position of the top member, along the Y axis, relative to the intermediate member.
  • the maximum travel along the Y axis is about 50mm.
  • the stage also comprises a microprocessor (and associated circuitry) to process positional data provided by the position detecting means associated with the members, and to control the movement of the linear shaft motors.
  • the processor and associated circuitry are, for the most part accommodated within a covered compartment 42 located on top of the top member 8.
  • an electrical power input to accept electrical power from a power source.
  • a power source Any suitable power source may be utilised.
  • the power source will be mains source which is rectified and/or transformed to provide e.g. a 12v D.C. supply.
  • the electrical power is required to operate the motors and associated electronics.
  • Figures 7 and 8 illustrate a second embodiment of a motorised stage in accordance with the invention.
  • the embodiment shown in Figures 7 and 8 is very similar to the embodiment shown in Figures 1-6 and, in general, comprises substantially identical features.
  • the second embodiment differs in particular from the first embodiment in the manner in which the specimen holder is secured to the member of the stage component.
  • a screw at each side of the apparatus secures the specimen holder to the top stage member 8.
  • Each screw passes through a respective annular component 50 located on the underside of the stage member 8.
  • One such component 50 is visible in Figure 7.
  • FIG 8 drawn to a different scale compared to Figure 7, shows the arrangement more clearly.
  • Screw 52 passes through annular component 50 and top stage member 8 and is secured by a screw-threaded engagement with the specimen holder 12.
  • Annular component 50 comprises a groove, within which is seated compression spring 54, such that tightening of the screw 52 forces spring 54 into compression, the spring 54 therefore acting as urging means. Accordingly, adjustment of the screw 52 and/or its counterpart screw on the other side of the apparatus, can be made to alter level of the specimen holder. Normally the specimen holder will be adjusted so as to approach as closely as possible to horizontality, but the arrangement also allows for the plane of the specimen holder to be deliberately made non-horizontal, if desired.
  • Figure 9 is a perspective exploded view of one embodiment of a stage component in accordance with the first aspect of the invention, supplied in generic form for use with a variety of optical instruments (not necessarily a transmission light microscope).
  • the stage component comprises an X/Y -static base member, an intermediate member 6, and a top member.
  • the base member comprises a base plate 4a and a base cover 4b.
  • the top member 8 comprises a top plate 8a and a top cover 8b.
  • the base member is provided with an LSM drive (not shown) to drive the intermediate member 6 relative to the base member, and the intermediate member 6 is provided with an LSM drive 60 to drive the top member relative to the intermediate member.
  • the stage members are formed with guide rails 32 and guide followers and optically- read position detecting means, in a manner analogous to the embodiment shown in Figures 1-8.
  • the top plate 8a is shaped and configured to receive one of a variety of different specimen holders at an unsupported distal end 62 thereof, and includes a plurality of differently-sized circular apertures drilled therein to receive a variety of different types of attachment pins, screws, lugs etc.
  • the base plate 4a also comprises a plurality of differently-sized circular apertures, to facilitate mounting of the stage component in a number of different optical instruments.
  • Other embodiments of the invention can, of course, be envisaged, within the scope of the appended claims.

Abstract

L'invention porte sur un composant d'étage destiné à être utilisé dans la fabrication d'un étage motorisé pour un instrument optique, le composant comprenant : un élément de base, un élément supérieur et un élément intermédiaire; l'élément supérieur étant supporté sur, et pouvant se déplacer dans un premier axe par rapport à, l'élément intermédiaire; et l'élément intermédiaire étant supporté sur, et pouvant se déplacer dans un second axe par rapport à, l'élément de base; caractérisé en ce qu'au moins un élément choisi parmi les éléments d'étage est agencé de telle sorte que, en utilisation, il est supporté à une région d'extrémité proximale, la région d'extrémité distale opposée n'étant pas supportée, de telle sorte qu'un porte-échantillon formé sur, ou devant être fixé à, la région d'extrémité distale fait saillie vers l'extérieur à partir de l'élément d'étage choisi.
PCT/GB2011/050868 2010-05-04 2011-05-04 Étage pour un instrument optique WO2011138603A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1007322.9A GB201007322D0 (en) 2010-05-04 2010-05-04 Improvements in or relating to stages for optical instruments
GB1007322.9 2010-05-04

Publications (1)

Publication Number Publication Date
WO2011138603A1 true WO2011138603A1 (fr) 2011-11-10

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WO (1) WO2011138603A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104898266A (zh) * 2015-06-26 2015-09-09 上海交通大学 一种线性电动物镜切换装置
WO2015185805A1 (fr) 2014-06-06 2015-12-10 Johan Lundin Porte-lame destiné à un microscope optique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248679A2 (fr) * 1986-06-06 1987-12-09 David L. Gibbs Méthode et appareil d'emploi d'un microscope
US6193199B1 (en) * 1998-07-15 2001-02-27 Nanomotion, Inc. Sample stage including a slider assembly
WO2006024967A1 (fr) * 2004-09-02 2006-03-09 3D Histech Kft. Procede de focalisation pour une numerisation grande vitesse de lames de microscopes et dispositif de deplacement des lames, optiques de focalisation et telemetre optique
WO2006110536A1 (fr) * 2005-04-08 2006-10-19 Applied Precision, Llc Platine de microscope avec axe de flexion

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248679A2 (fr) * 1986-06-06 1987-12-09 David L. Gibbs Méthode et appareil d'emploi d'un microscope
US6193199B1 (en) * 1998-07-15 2001-02-27 Nanomotion, Inc. Sample stage including a slider assembly
WO2006024967A1 (fr) * 2004-09-02 2006-03-09 3D Histech Kft. Procede de focalisation pour une numerisation grande vitesse de lames de microscopes et dispositif de deplacement des lames, optiques de focalisation et telemetre optique
WO2006110536A1 (fr) * 2005-04-08 2006-10-19 Applied Precision, Llc Platine de microscope avec axe de flexion

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015185805A1 (fr) 2014-06-06 2015-12-10 Johan Lundin Porte-lame destiné à un microscope optique
US10191269B2 (en) 2014-06-06 2019-01-29 Johan LUNDIN Slide holder for an optical microscope
CN104898266A (zh) * 2015-06-26 2015-09-09 上海交通大学 一种线性电动物镜切换装置

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