WO2011129804A1 - Compositions nettoyantes liquides à facteur de protection solaire (spf) - Google Patents

Compositions nettoyantes liquides à facteur de protection solaire (spf) Download PDF

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Publication number
WO2011129804A1
WO2011129804A1 PCT/US2010/030692 US2010030692W WO2011129804A1 WO 2011129804 A1 WO2011129804 A1 WO 2011129804A1 US 2010030692 W US2010030692 W US 2010030692W WO 2011129804 A1 WO2011129804 A1 WO 2011129804A1
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WO
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Prior art keywords
spf
liquid cleansing
ultraviolet radiation
treated
lathering
Prior art date
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PCT/US2010/030692
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English (en)
Inventor
Clay J. Cockerell
Catherine S. Stibon
Sergio Nacht
Jack R. Frautschi
Original Assignee
Cockerell Dermatology Development, Ltd.
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Priority to PCT/US2010/030692 priority Critical patent/WO2011129804A1/fr
Publication of WO2011129804A1 publication Critical patent/WO2011129804A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated
    • A61K2800/612—By organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/651—The particulate/core comprising inorganic material

Definitions

  • the present invention relates to liquid skin cleansing compositions which, after rinsing, deposit on a substrate (e.g., skin or hair) a film that blocks or attenuates ultraviolet radiation.
  • a substrate e.g., skin or hair
  • the present application relates to a facial and/or body wash composition that after rinsing provides a sun protection factor ("SPF") of at least about 6 comprising:
  • At least one organic sunscreen agent having a log P of greater than about 4.0 that blocks or absorbs ultraviolet radiation in the wavelength range of from about 290 nm to about 400 nm;
  • the present application relates to a liquid skin cleaning composition that after rinsing leaves a deposit on a substrate and thereby provides protection from ultraviolet radiation, expressed as SPF, of at least about 6 comprising:
  • Surface-treated metal oxide pigments that block ultraviolet radiation wavelength range of from about 290 nm to about 400 nm suitable for use in the present invention include, but are not limited to, the following: micronized zinc oxide surface-treated with an alkoxysilane; micronized titanium dioxide surface-treated with alkoxysilane;
  • dimethicone/methicone copolymer a dimethicone/methicone copolymer
  • micronized zinc oxide surface-treated with an alkpxycaprylylsilane a micronized titanium dioxide surface-treated with an alkpxycaprylylsilane
  • a particularly preferred micronized titanium dioxide pigment that is surface- treated with an alkoxycaprylylsilane is titanium dioxide coated with trimethoxycaprylyl- silane, available from Degussa under the tradename TEGO Sun T 805.
  • the SPF liquid skin cleansing composition of the present invention comprises titanium dioxide coated with trimethoxycaprylyl-silane at a concentration of from about 1.0% to about 5% based on the total weight of the composition. (Unless otherwise noted, where the concentration of an individual ingredient is expressed as a percentage, the percentage is to be understood as the percentage by weight of the ingredient based on the weight of the total composition.) More preferably, the titanium dioxide coated with trimethoxycaprylylsilane is present in compositions of the present invention at a concentration of from about 1.5% to about 2.5%.
  • a particularly preferred micronized zinc oxide pigment that is surface-treated with an alkoxycaprylylsilane is zinc oxide coated with triethoxycaprylylsilane, available from BASF under the tradename Z-Cote HP1.
  • the SPF liquid skin cleansing composition of the present invention comprises zinc oxide coated with triethoxycaprylylsilane at a concentration of from about 5% to about 10%. More preferably, the zinc oxide coated with
  • triethoxycaprylylsilane is present at a concentration of from about 7.5% to about 8.5%
  • the SPF liquid skin cleansing composition of the present invention comprises two surface-treated metal oxide pigments that block ultraviolet radiation in the wavelength range of from about 290 nm to about 400 nm. More preferably, the two surface-treated metal oxide pigments are present at a combined concentration (based on the total weight of the composition) of at least about 8.5%.
  • the at least one organic sunscreen agent having a log P of greater than about 4 that blocks or absorbs ultraviolet radiation in the wavelength range of from about 290 nm to about 400 nm includes sunscreens currently approved by the FDA and listed in the Sunscreen Drug Products for Over-The-Counter Human Use Final Monograph published in the Federal Register on May 21 , 1999 at Volume 64, Number 98, pages 27666-27693 as well as organic sunscreen agents approved by regulatory agencies in countries other than the United States.
  • Log P is a term known to those of skill in the chemical arts. It is a measure of differential solubility of a compound in two solvents. More particularly, it is a partition coefficient expressed as the log ratio of the concentrations of the solute in the solvent.
  • the at least one organic sunscreen agent having a log P of greater than about 4.0 that blocks or absorbs ultraviolet radiation in the wavelength range of from about 290 nm to about 400 nm is selected from the group consisting of octylmethoxycinnamate, octocrylene and octyl salicylate.
  • a particularly preferred organic sunscreen agent having a log P of greater than about 4.0 that blocks or absorbs ultraviolet radiation in the wavelength range of from about 290 nm to about 400 nm is octocrylene, a cyano-diphenylacrylate.
  • the SPF liquid skin cleansing compositions of the present invention contain at least two lathering surfactants, one anionic and one non-ionic.
  • lathering surfactant is meant a surfactant having a log P of less than about 2.5 that produces foam when mixed with and agitated in water. Without wishing to be bound by a theory, it is believed that surfactants having a log P of greater than 2.5 impede deposition of sunscreens and sun-blocking agents (i.e., metal oxide pigment that blocks ultraviolet radiation) after rinsing.
  • the anionic lathering surfactant is a sulfate.
  • Preferred sulfates suitable for use in compositions of the present invention are alkyl sulfates and alkyl ether sulfates. Two particularly preferred sulfates are sodium laureth sulfate and ammonium laureth sulfate.
  • Sodium laureth sulfate is an article of commerce available from a number of sources, including under the tradename Steol CS-370 from Stepan. It has a molecular formula CH3(CH2)ioCH 2 (OCH 2 CH 2 ) 2 OS0 3 Na and conforms to the following structure:
  • the SPF liquid skin cleansing composition of the present invention comprises sodium laureth sulfate a concentration of from about 10% to about 15%.
  • ammonium laureth sulfate is used in combination with an alkyl glucoside, preferably decyl glucoside.
  • alkyl glucoside preferably decyl glucoside.
  • decyl glucoside sold under the tradename Plantaren PS-100 by Cognis.
  • ammonium laureth sulfate in combination with decyl glucoside is present in compositions of the present invention at a concentration of from about 5% to about 10%, more preferably from about 7.5% to about 8.5%.
  • the SPF liquid skin cleansing composition of the present invention comprises two anionic lathering surfactants, preferably two sulfates. Still more preferably, the first sulfate is a sodium laureth sulfate and the second sulfate is ammonium laureth sulfate in combination with decyl glucoside. In this especially preferred embodiment, the two sulfates are present at a combined concentration of from about 15% to about 25%.
  • a preferred class of non-ionic surfactants having a log P of less than about 2.5 suitable for use in the SPF liquid cleansing compositions of the present invention is alkoxylated alcohols.
  • a preferred class of alkoxylated alcohols is polyoxyethylene alkyl ethers.
  • a particularly preferred polyoxyethylene alkyl ether is the polyethylene glycol ether of stearyl alcohol conforming to the structure:
  • n has an average value of 21.
  • the SPF liquid skin cleansing compositions of the present invention may comprise one or more additional surfactants selected from the group consisting of sarcosinates, isethionates and taurates.
  • Sarcosinates, isethionates and taurates are well- known to persons having ordinary skill in the art and include those disclosed in USPN 7, 1 15,551 , McCutcheon 's Detergents and Emulsifiers ( 1986) and McCutcheon 's Functional Materials ( 1992), the disclosures of which are incorporated herein by reference.
  • One preferred additional surfactant is sodium lauroylsarcosine.
  • sodium lauroylsarcosine in addition to the anionic and non-ionic lathering surfactants disclosed in the preceding paragraphs, sodium lauroylsarcosine is present at a concentration of from about 4% to about 8%.
  • Sodium lauroylsarcosine is available under the tradename Crodasinic LS95 from Croda.
  • compositions of the present invention may also include acrylate salts.
  • One preferered acrylate salt suitable for use in the SPF liquid cleansing compositions of the present invention is sodium acrylates in combination with caprylic triglyceride. This combination, available commercially from BASF under the tradename Luvigel EM, is preferably used in compositions of the present invention at a concentration of from about 1 % to about 5%.
  • Red petrolatum is an essential element of the present invention. It is an article of commerce available from a variety of suppliers, including Penreco. In preferred embodiments of the present invention, red petrolatum is present at a concentration of from about 4% to about 10%, more preferably from about 7% to about 9%.
  • SPF liquid cleansing compositions of the present invention also comprise an alkyl silicone, also known in the art as a silicone wax, preferably at a concentration of from about 0.5% to about 3.0%.
  • One preferred alkyl silicone is C3o-c45 alkyl methicone and C30-45 olefin available from Dow Corning under the tradename AMS-C30 Cosmetic Wax. This alkyl silicone conforms to the formula:
  • C30-C45 alkyl methicone and C3 0- 45 olefin is present at a concentration of from about 0.5% to about 1.5%.
  • Another preferred alkyl silicone is phenyl isopropyl dimethicone, available under the tradename Silwax DO-MS from Siltech Corp. (Toronto, Ontario, Canada). Phenyl isopropyl dimethicone is polydimethylsiloxane with methyl styrene groups attached soluble in both mineral oil and cyclosiloxane has viscosity of 100 centistokes at 25°C.
  • Yet another preferred alkyl silicone suitable for use in the SPF liquid cleansing compositions of the present invention conforms to the following structure:
  • a is an integer ranging from 1 to 20;
  • b is an integer ranging from 1 to 20;
  • c is an integer ranging from 1 to 20;
  • d is an integer ranging from 7 to 17;
  • the ratio of a to c is from about 0.75 to about 1.5.
  • SPF liquid cleansing compositions of the present invention also comprise a cyclic volatile silicone conforming to the formula:
  • Volatile cyclic silicones are articles of commerce available from a number of suppliers including Dow Corning Corporation, General Electric and Shinetsu.
  • the term "volatile” means that the silicone has a measurable vapor pressure.
  • volatile cyclic silicones is cyclopentasiloxane.
  • a preferred volatile cyclic silicone is polydimethylcyclosiloxane composed mainly of cyclopentasiloaxane having a heat of vaporization (measured at 25°C) of about 157 kJ kg.
  • This volatile cyclic silicone is commercially available under the tradename Dow Corning 245 Fluid from Dow Corning.
  • the SPF liquid cleansing compositions of the present invention comprises melanin or a melanin precursor selected from the group consisting of L-dopa, tyrosine, tryptophan, and cysteine.
  • the melanin or melanin precursor is present in a concentration of from about 0.1 % to about 20%, preferably from about 0.2% to about 10%.
  • the melanin or melanin precursor may be in a suitable solution or in an encapsulated form as described in US Patent Nos. 4,855, 144 and 4,806,360.
  • the SPF liquid cleansing compositions of the present invention comprises iron oxide pigments (e.g. , yellow, red, black).
  • the surfaces of the iron oxide pigment may be treated with a coating sufficient to render them water repel lant (i.e. , hydrophobic) or oil dispersible (i.e. , lipophilic).
  • Coated iron oxide pigments suitable for use in the present invention and the process for making them are described in US Patent No. 5, 143,722, particularly at Col. 2, line 43 - Col. 3, line 62.
  • the SPF liquid cleansing composition is aerosolized.
  • Embodiments according to this aspect of the invention are comprised of
  • an SPF liquid cleansing concentrate comprised of (i) red petrolatum;
  • the propellant is a mixture of isobutane, butane and propane, known in the art as A46.
  • the following blends of ' isobutane, butane and propane are also suitable for use in the present invention: AP30 (1 1 % Propane, 29% Isobutane, 60% n-butane); AP40 (22% Propane, 24% Isobutane, 54% n- butane); and AP70 (31 % Propane, 23% Isobutane, 46% n-butane).
  • Containers that are suitable for storing and dispensing aerosolized SPF liquid cleansing products are well known in the art and are typically comprised of a metal container body, a valve and an actuator or button.
  • the container body and valve are made of materials compatible with the essential (and optional) chemical ingredients of the compositions of the present invention.
  • the container body is preferably made of aluminum. More preferably, the interior surface of the container body is coated with an inert material. Still more preferably, the interior surface of an aluminum can is coated with an epoxy.
  • the temperature of aerosolized SPF liquid cleansing composition may rise to around 50°C. Accordingly, the filled aerosol container (i.e., concentrate charged with propellant) is immersed in a hot water bath for sufficient time to allow the contents to reach the internal pressure that would be achieved if the aerosol was allowed to equilibrate at a temperature of from about 50°C to 55°C.
  • the filled aerosol container i.e., concentrate charged with propellant
  • the equilibration is accomplished after two to three minutes of immersion.
  • compositions of the present invention including aerosolized
  • embodiments may contain one or more of the following personal care ingredients commonly-used in cleansing compositions: rheology modifiers, pH modifiers, moisturizers, humectants, emollients (e.g., caprylic/capric triglycerides), structuring agents (e.g., beeswax, candelilla wax, paraffin), stabilizers, lubricants, fragrances, preservatives, or coloring agents, including those listed in the following U.S.
  • personal care ingredients commonly-used in cleansing compositions rheology modifiers, pH modifiers, moisturizers, humectants, emollients (e.g., caprylic/capric triglycerides), structuring agents (e.g., beeswax, candelilla wax, paraffin), stabilizers, lubricants, fragrances, preservatives, or coloring agents, including those listed in the following U.S.
  • Cleansing compositions are comprised of iron oxide pigments as well as red petrolatum, at least one, preferably two, anionic lathering surfactants, a non-ionic lathering surfactant, surface-treated zinc oxide pigments, surface-treated titanium dioxide pigments, an organic sunscreen having a log P of at least about 4.0, an alkyl silicone and a volatile cyclic silicone, each at the concentrations set out above.
  • one aspect of the present invention is directed to a cleansing composition that after rinsing leaves a residual deposit on a substrate to provide an SPF of at least about 6. SPF after rinsing is measured according to the method described in Example 2 below.
  • cleansing compositions of the present invention may leave a residual deposit after rinsing that provides a desired SPF on a variety of non-living surfaces, including natural and synthetic fabrics, woven and non-woven, plastics and wood
  • a preferred aspect of the present invention is directed to leaving a desired SPF after rinsing on human or mammalian skin or hair.
  • Stepan Sodium Laureth Sulfate (Steol CS-370, Stepan) 1 1.40 10.0 - 15.0 Polyoxyethylene Stearyl Ether (Brij 721 , Uniqema) 6.50 5.0 - 8.0 Decyl Glucoside and Ammonium Laureth Sulfate 8.30 5.0 - 10.0 (Plantaren PS- 100, Cognis)
  • Octocrylene (Uvinul N 539 T, BASF) 4.08 2.0 - 7.0
  • Part C Preservative. Fragrance
  • Methylisothiazolinone ( athon CG, Rohm & Haas)
  • a suitable container weigh out the formula amount of water of Phase A and with Lighting agitation, beginning at a minimum of 1 ,000 RPM and slowly sprinkling Natrosol into the vortex. As the viscosity thickens, increase the speed of the mixer to 1 ,500 to 2,500 RPM or until the full product forms a vortex. Addition of the Natrosol should take at about 15 to 20 minutes to complete. Begin heating to, and hold at 60°C, for 45 - 60 minutes, with mixing, until the product is clear and gelled. Add one ingredient at a time from the Surfactant Phase A with proper agitation, mixing between additions.
  • Phase B In a separate container, weigh and combine all the materials of Phase B and begin to heat to 70°C to 75°C. Combine the Phase B ingredients together using a homogenizer (starting at 2,500 RPM) and increasing as needed for at least 15 to 20 minutes until a uniform, non-grainy dispersion is achieved. Slowly add Phase B to Phase A, mixing until uniform. Heat Phase A / Phase B mixture to 70°C to 75°C. Mix for approximately 30 minutes at temperature until completely uniform and creamy. Discontinue heating. Allow Phase A / Phase B mixture to cool to 40°C to 45°C with continuous lightning. Add preservative and essential oil. Mix well.
  • Example 2 Aerosolized Liquid SPF Cleansing Composition
  • composition according to Example 1 serves as a concentrate is combined with A46 propellant at a ratio of 96% concentrate to 4% propellant.
  • the concentrate is added to an aluminum can to which a valve is crimped.
  • Propellant is then charged into the crimped container at a pressure of 46 psig, +/- 8 psi.
  • the valve opens releasing the aerosolized SPF liquid composition.
  • the product Upon application to the skin, the product is a shiny, flowable, tinted product which within seconds increases in volume and appears as a mousse.
  • a study to determine SPF before and after cleansing was performed over a three-day period. On the first day of the study, each subject received a series of measured UV doses from a xenon arc solar simulator to an unprotected site on the mid-back.
  • the minimal erythema dose was determined as the lowest UV dose which produced mild erythema reaching the borders of the exposure site.
  • 50 cm 2 test areas were drawn on the backs of study participants.
  • the body wash formulation of Example 1 was applied to separate 50 cm 2 areas as follows: First, the skin was wet with 10 ml of distilled water at 100°F. Then, 100 mg of the SPF liquid cleansing composition was applied by "spotting" the product across the test area. The products were then rubbed into the skin for 1 minute. In a separate, adjacent test, 50 cm 2 area on the subject's back, 100 mg of the formulation of Example 1 was applied and rubbed into the dry skin for 1 minute.
  • HMS 8% homosalate
  • UV doses ranging from 0.64 to 1.56 times the product of the MED and 6 were administered to the area protected by the SPF liquid cleansing composition.
  • the irradiation source was a calibrated xenon arc lamp solar simulator with an 8 mm liquid light guide (Model 16S, Solar Light Company, Philadelphia) that has an output spectrum in compliance with the 2007 Colipa Guideline.
  • UV doses ranging from 0.64 to 1.56 times the product of the MED and 4 were administered to the area protected by the HMS standard sunscreen. A series of UV doses were also administered to an unprotected area.
  • the MED was determined for the protected sites (those to which the SPF cleansing compositions and the HMS standard had been applied) and the unprotected site.
  • the SPF was calculated as the ratio of the MED for each protected site to the MED for the unprotected site.
  • Example 4 Photostability
  • ⁇ is equal to 1 the relationship between the applied and transmitted doses is linear, and the sunscreen is considered photostable; if ⁇ is substantially greater than 1 , the transmitted UV dose increases with applied dose, and the sunscreen is considered photolabile.
  • Applied and transmitted UV was measured at 1 nm intervals form 290 to 400 nm using a calibrated spectroradiometer (Model OL 756, Optronic Laboratories, Orlando).
  • PMMA Substrates were Helioplates® (HelioScreen, Marseilles).
  • Transmission spectra were interpolated as necessary to obtain spectra corresponding to UV doses Dx, 17.6 J/cm2 and 2/3 the labeled SPF in MEDs. Successive measured transmission spectra and the source irradiance were used to compute x and y. Based on the above photostability equation, the body wash of Example 1 was determined to be photostabile.

Abstract

La présente invention concerne une composition pour le nettoyage du visage et/ou du corps qui, après rinçage, fournit un facteur de protection solaire d'au moins environ 6 ,comprenant (i) du pétrolatum rouge ; (ii) au moins un pigment d'oxyde métallique traité en surface qui bloque le rayonnement ultraviolet dans la plage de longueurs d'onde d'environ 290 nm à environ 400 nm ; (iii) au moins un agent écran solaire organique ayant un log P supérieur à environ 4,0 qui bloque ou absorbe le rayonnement ultraviolet dans la plage de longueurs d'onde d'environ 290 nm à environ 400 nm ; (iv) au moins un agent tensio-actif anionique moussant ; (v) au moins un agent tensio-actif non ionique moussant ; (vi) un alkyl silicone; et (vii) un silicone cyclique volatil.
PCT/US2010/030692 2010-04-12 2010-04-12 Compositions nettoyantes liquides à facteur de protection solaire (spf) WO2011129804A1 (fr)

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CN103945823B (zh) * 2011-11-18 2017-10-20 荷兰联合利华有限公司 包含成膜树脂的均匀沉积和低擦除性乳液

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