WO2011129567A2 - Gas storage vessel, hydrogen-charging method, and hydrogen-charging apparatus - Google Patents

Abstract

The present invention relates to a technique for delivering gases into the human body or generating gases inside the human body, such as a method for encapsulating gases and a gas storage vessel. The present invention relates to a gas storage capsule and to a method for producing the gas storage capsule, wherein the capsule is dissolved in water such that the air-tightness thereof is gradually degraded and the gas contained in the capsule can be gradually leaked to the outside of the capsule. The present invention also relates to a hydrogen-generating material which directly generates hydrogen gases in vivo, and to a hydrogen-generating candy for directly encapsulating hydrogen using the material and delivering the thus-encapsulated hydrogen into the intestines, as well as to a method for producing the candy.

Description

Gas storage container, hydrogen filling method and hydrogen filling device

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a gas storage container, a hydrogen sealing method, and a hydrogen filling device, and more particularly to a technique for directly supplying or generating gas into a body such as a container filled with hydrogen, a candy that generates hydrogen, and the like.

Capsules are widely used for storage and packaging of health foods or medicines taken orally, and may be called hard capsules and soft capsules depending on the capsule material, and are used for storing powders or liquids. Capsule containers are often not an essential element, depending on their contents.

Hard candy is sometimes used as a packaging container for oral health foods, medicines or favorite foods. In the manufacturing method of sugar-free hard candy, a hydrogenated saccharide is used in a carbohydrate composition (syrup) to help ultra-crystallization (crystallization of crystalline polyols) in order to stabilize when water content is high. It is introduced in the publication 0163252.

A capsule with a hollow candy body and a vacant space in the main body, containing a variety of contents and soluble in water, and various contents (liquid, powder, solid) in the capsule's coating A capsule candy consisting of a patent is disclosed in Patent Publication No. 10-2009-009794.

Soft capsules are prepared by mixing the main ingredients and excipients, or preparing a fillable solution through solubilization using a surfactant, and then, when filling the solution, the thickness of the film is generally 0.60 to 0.80 mm. Drug delivery systems that are prepared orally and absorbed in the stomach or intestines are commonly used.

Soft capsules are mainly made of gelatin, in which the molten gelatin is placed in a spreader box, and then spread between the pair of die rollers by spreading the molten gelatin in the form of a sheet on a rotating drum roller at the desired thickness in the spreader box. It is generally molded into the form of a capsule by passing through.

Patent No. 10-0647034, published on November 23, 2006, discloses a "soft capsule and its manufacturing method," and was registered on September 11, 2009 as a device for manufacturing a recently disclosed soft capsule. 20-0445951 There is a design. The apparatus of the present invention comprises a sheet forming unit having a spreader box and a cooling drum, a capsule forming unit having a die roller and a stock solution discharging nozzle, and a capsule recovering unit for recovering the molded capsule. The melted gelatin is placed in a spreader box to spread the melted gelatin in the form of a sheet on a rotating drum roller to a desired thickness, and the gel gelatin sheet is cut and bonded while injecting the contents from the contents stock discharge nozzle while passing between a pair of die rollers. A capsule is manufactured by this.

Such conventional soft capsules have been mainly used as containers for packaging solid or liquid contents, and have been used to package such solid powders or liquids (eg, omega three) for easy oral administration.

Attention is now paid to the role of hydrogen in relation to human health. Excessive active oxygen is widely known to be harmful to the human body, and abundant hydrogen, aka hydrogen-rich water, has been found to be excellent in preventing and treating geriatric diseases such as cancer and diabetes. have. Moreover, the theory that water containing abundant hydrogen is effective in eliminating active oxygen which causes various diseases and suppressing the oxidation of active oxygen has attracted much attention in the medical community in recent years.

Hydrogen, carbon dioxide and some of the mixed gas containing methane are produced during the process of fermentation into the large intestine and the fermentation of bacteria in the large intestine due to enzymes not found or lacking in the digestive system. It is known from many experiments and reports published under the name fart and breath hydrogen. This is mainly due to the inconvenience of living due to overproduction of farts, pathophysiological symptoms such as biobiorhythms and gas production, or chronic celiac deasese, or intestinal gas generation to improve or treat them. Research on inhibition and ways to improve it are known.

Recently, the theory that hydrogen molecules are transported inside the cell along the respiratory, digestive, and various blood vessels has an effective antioxidant effect, and researches biochemical preventive methods using edible crops that can be seen as part of food chemistry. As a result, many reports on the effects of hydrogen molecules in the intestine through many animal experiments and some clinical trials are gradually increasing in Japan, China and the United States. In particular, the meeting of the Japanese Hydrogen Research Society deals with reports on the effects of hydrogen molecules caused by gut bacteria. In addition, because some diabetes drugs and obesity drugs are mechanisms that prevent carbohydrates from being absorbed in the small intestine, a large amount of gas containing hydrogen gas is generated in the large intestine.

As a device for producing a beverage containing abundant hydrogen, a hydrogen reduced water filter structure for generating hydrogen reduced water by attaching a hydrogen reduced water group using a hydrogen reduced catalyst to a conventional water purifier using electrolysis is disclosed. Introduced at -0686945.

A hydrogen-rich water supply cold and warm water purifier for generating hydrogen by attaching a bubble generator and a ceramic rod to a conventional water purifier is introduced in Korean Patent Publication No. 10-0552003.

Hydrogen rich water producing method and hydrogen rich water generator which converts beverage into hydrogen rich water containing rich hydrogen and purifies beverage by silver particles It is introduced in JP 10-0529006.

Hydrogen reduction water and bubble generator using electrolysis cannot be used where no water purifier is installed and power is required. Therefore, it is difficult to be restricted in terms of range of use and supplyability, and calcium in ceramic rods is produced by reaction with water. There is a limit to the dissolution of metal hydroxides, while hydrogen-rich water generators that produce hydrogen-rich water by reacting magnesium particles in beverages must be periodically infused with magnesium particles (hydrogen sticks) containing magnesium particles. In addition, the sanitary management of PET bottles and bags is difficult, and it is difficult to be constrained by the location and time to drink hydrogen-rich water.

In the research and development of the method of selectively ingesting substances extracted from small sugars, polysaccharides and edible spices in edible crops to minimize the generation of unnecessary gas by the bacteria in the large intestine and induce the production of beneficial hydrogen gas. Nothing is known yet.

The method of directly generating hydrogen gas in the body using the characteristics of small or polysaccharides has not been introduced until now.

There is no introduction of hydrogen gas stored in solid hard candy or soft film, and there is no known method of storing gas with pressure and fluidity such as hydrogen to keep it airtight and safely supply it to the body. No bar

The present invention seeks to provide a method of packaging a gas, a gas storage container, and the like to convey a gas into a human body or generate a gas in the human body.

The present invention is to provide a gas container and a method for manufacturing the same and a method for packaging the contents in a capsule.

The present invention is to provide a gas storage capsule in which a capsule container is melted by water as a gas storage container so that airtightness is gradually destroyed so that the gas inside is gradually leaked to the outside.

According to the present invention, after the hydrogen gas is packaged in a sealed container and orally administered, after a predetermined time, the airtightness of the container is destroyed so that the hydrogen gas is leaked. To provide a way.

The present invention seeks to provide a method for producing hydrogen hard candy in capsule form as a container for storing hydrogen.

The present invention provides a gas storage container that can reduce the amount of heat ingested compared to hydrogen gas to be consumed by using a material having a smaller calorie content as a capsule and increasing the storage capacity per container by using a soft coating material. It is to provide a method for filling and sealing hydrogen in gas storage containers.

The present invention is to provide a hydrogen generating material for generating hydrogen gas directly in the body using the properties of small sugars or polysaccharides, and means and method for directly packaging and transporting hydrogen to the intestine using the material.

The present invention selects substances extracted from small sugars, polysaccharides and edible spices, which are present in edible crops, in order to be fermented by bacteria in the large intestine to produce beneficial hydrogen gas. I would like to provide one candy ingredient.

The present invention selectively adds substances extracted from small sugars, polysaccharides, edible spices, etc., which are ingested by humans and fermented by bacteria in the large intestine to produce hydrogen gas. The present invention provides a capsule-type hydrogen storage container and a method of manufacturing the same, which combines hydrogen gas stored in a container and hydrogen gas generated from a candy container material to produce more hydrogen generation effects.

The present invention is made of polyethylene jackets containing water or refractory antifreeze in order to package and safely transport or store the hydrogen storage container or hydrogen-generated candy container, and melted to release water or refractory antifreeze when it is 120 degrees Celsius or more. To provide packaging materials.

The present invention is made of a material which is made of a material which is dissolved in contact with water without passing through a gas to be stored, and has a closed empty space therein for storing gas. It will slowly break down to allow gas inside to leak out.

The gas storage container can withstand the pressure change of atmospheric pressure in consideration of the pressure applied to the inside and outside of the cylinder, the outer diameter is 5 ~ 10mm preferably 8mm, the length of the outer cylinder 8 ~ 20mm preferably 14mm, And the total length of the container 2 which combined the hard plates 10 of both ends is 10-25 mm, Preferably it is 22 mm.

The container of the present invention includes sugars such as sugar, malt sugar, and syrup, and carbohydrate syrup mixtures such as starch, maltitol, mannitol, sorbitol, isomalt, and xylitol, and polyols. ), One selected from gelatin, glycerin, ferrous ( ferrous fumarate), vitamin C, vitamin E, polyphenol, carotene, calcium, etc. The above additive is added.

The gas stored in the container is hydrogen gas, the purity of which is 99.999% or more, preferably 99.99999% or more.

The present invention is a method for filling and sealing hydrogen in a small container, using a container material that melts the gas storage container in the heat, the hydrogen filling nozzle having a volume of the size of the space to be filled with hydrogen temporarily inserted in one state from the inside Temporary container forming step of forming a container, a thermocompression band is attached to a portion except the length of a predetermined hydrogen filling space, and the air in the interior of the temporary container is extracted through the hydrogen filling nozzle, and then hydrogen is kept at atmospheric pressure. Filling the reactor, retracting the hydrogen filling nozzle to the end of the thermocompression band, applying heat to the thermocompression band and tightening the band to seal the temporary container inlet, and then completely retracting the hydrogen charging nozzle out of the temporary container and sealing Finishing the finished places. In the temporary container forming step, one or more container materials are selected from sugars, maltose, and syrup, sugars, starch, maltitol, mannitol, sorbitol, carbohydrate syrup mixtures such as isomalt and xylitol, and polyols, and the like. Make a masque, optionally adding one or more additives selected from gelatin, glycerin, ferrous fumarate, vitamin C, vitamin E, polyphenol, carotene, calcium, calcium hydride, etc. It is good to put in the mold. The container material has good air tightness at least, low heat, good heat deformation when compressed with heat, glass transition temperature is mixed or selected to have a moisture content of more than 3% to 38 ^o C The purity of the hydrogen gas filled in the container is preferably 99.999% or more.

The apparatus of the present invention is composed of n hydrogen filling nozzles and auxiliary devices to be inserted into a temporary container molded in the mold frame, the hydrogen filling nozzle unit for pumping the gas inside the temporary container during the hydrogen charging period with a vacuum or filling hydrogen gas And a hydrogen filling mesh pipe connected to the hydrogen filling nozzle part to become a passage of vacuum gas or a passage of hydrogen gas, a vacuum pumping part connected to the hydrogen filling mesh pipe and pumping the inside of the temporary container into a vacuum, and a hydrogen filling mesh type. It includes a hydrogen gas supply unit connected to the pipe to supply hydrogen gas and control the flow rate and pressure, and a nitrogen gas supply unit connected to the hydrogen filling network pipe and responsible for purging and safety of the hydrogen gas filling system.

The present invention also has an inner space larger than the volume of the gas storage container outside the gas storage container, and additionally coated with a hard capsule for accommodating the gas storage container inside and sealing the outside, so as to be below atmospheric pressure inside the gas storage container. The stored hydrogen gas is primarily to maintain the airtightness of the hydrogen gas by the external atmospheric pressure, to supplement the airtightness of the hydrogen gas secondly by the hard capsule, and to buffer the pressure change by the space between the gas storage container and the hard capsule. .

By providing hydrogen gas in an oral container by storing hydrogen gas, it provides a hydrogen capsule that can be inserted deep into the digestion period of life.

Among the gas storage containers of the present invention, the soft film gas storage container is gas sealed in a container formed of a soft film that is soluble in water but insoluble in an organic solvent.

This gas is hydrogen, the container is formed by considering the pressure change of atmospheric pressure, and the thickness of the cooled and dried film is 0.7 to 1.0mm, the thickness of the joint is 0.6 to 0.95mm, and the thickness of the restored nozzle insert is 0.7 to 1.0mm. .

The material forming the soft coating is sorbitol, sorbitan, or sorbite, polyglycitol syrup, sucrose, mannitol, xylitol, maltose, reduced maltose syrup as general gelatin, succinate gelatin, glycerin, starch, plasticizer or softener. , Maltitol, polyethylene glycol, or a mixture of one or two or more selected from purified water, black iron oxide, red iron oxide and the like to select one or more to use as a base of the film.

In the gas storage container, hydrogen gas is 70 to 97% by volume, soybean oil, safflower oil, refined fish oil, refined oil, sesame oil, red pepper seed oil, wheat germ oil, grape seed oil, olive oil, rapeseed oil, evening primrose oil, fruit flavor oil. Allow 3 to 30% by volume of one or more components selected.

The method of the present invention is a method of filling and sealing hydrogen gas in a gas-tight container made of a soft film, and preparing a sealed soft-film temporary container by inserting a fat or oil inside the soft film, and inserting a hydrogen filling nozzle into the temporary container. And extracting the oil in the temporary container, injecting hydrogen gas, pulling the hydrogen filling nozzle out of the container, and sealing the nozzle insertion hole drilled in the temporary container by the hydrogen filling nozzle with a grouting material. Here, the hydrogen discharge nozzle is pointed like a needle and leaves 3 to 30% of the oil when the oil is withdrawn from the temporary container.

Based on the fact that hydrogen gas is produced in the large intestine of the human colon, find a substance that produces hydrogen gas well in the large intestine and mix it with candy or make it into a container for storing hydrogen gas, To produce hydrogen.

The present invention is a hydrogen-producing candy made by mixing a substance that generates hydrogen gas in the colon by colon bacteria flora (candy) at a rate of 30% to 70% of the candy.

The candy of the present invention is a substance generating hydrogen gas, and at least one selected from lactose, lactulose, raffinose, stakiose, burbascose, curcumin, capsaicin, inulin, gingerol, allicin, succinate, glutenin, and the like. .

The present invention comprises a candy and a substance that produces hydrogen gas in the colon by the intestinal bacterial group, the substance is mixed with at least 30% with respect to the candy, and a candy container containing hydrogen contained in the candy container Hydrogen-generated candy containers.

The present invention is a method for producing hydrogen-produced sugar, a mixture of one or more of sugar alcohol (polyols), such as Miltitol, mannitol, sorbitol, isomalt, xylitol, boils to 150 ~ 200 ℃ under atmospheric pressure to evaporate most of the moisture Making massecuites from which the candy is dehydrated; Selecting at least one from lactose, lactulose, raffinose, stachiose, burbascose, curcumin, capsaicin, inulin, gingerol, allicin, colchicine, glutenine, etc. and adding to the masset; It comprises a candy molding step of molding or injecting the masset.

In another aspect, the present invention provides a method for producing a hydrogen-produced candy container, the step of boiling the mixture to evaporate most of the moisture to make the massecuites from which the moisture of the candy is removed; Selecting at least one from lactose, lactulose, raffinose, stachiose, burbascose, curcumin, capsaicin, inulin, gingerol, allicin, colchicine, glutenine, etc. and adding to the masset; Shaping the candy container by molding or injecting the mascuit; and filling and sealing hydrogen gas into the formed candy container.

The present invention consists of a thin cushioned polyethylene jacket containing water or a refractory antifreeze to package and safely transport or store the hydrogen-produced candy container, and melts to release water or a refractory antifreeze when it is 120 degrees Celsius or more. will be.

According to the present invention, the gas can be filled, stored and transported in a micro container which has a closed empty space therein and water is destroyed by contact with water.

When the hydrogen storage container of the present invention is orally administered with general drinking water or dissolved in drinking water, hydrogen gas can be supplied into the living body.

The present invention can be freed from the constraints of time and place where the active hydrogen can be ingested.

By using the method and apparatus for producing a hydrogen storage container of the present invention, even a gas other than hydrogen can be micro-packaged.

When the hydrogen storage container is manufactured by the apparatus and method of the present invention, the intake of hydrogen gas can be easily adjusted, the supply of active hydrogen relative to the amount of active oxygen generated can be adjusted appropriately, and can be supplied at a lower price than the conventional method. can do.

When the flexible film gas storage container of the present invention is used as a hydrogen storage container, hydrogen gas storage capacity per container is remarkably improved, elasticity corresponding to an external temperature is improved, and heat intake can be reduced.

The present invention can expand the amount of hydrogen supply to the body harmless to the human body without using a conventional method of ingesting the calcined metals or forbidden material to generate metal hydroxides to generate hydrogen in the body.

According to the present invention, a person can usually produce a lot of beneficial hydrogen gas by adjusting the gas generated in the intestine while ingesting food.

The present invention is superior in terms of human safety than ingesting calcium hydride calcined calcium carbonate.

The present invention can solve the limitations of time and space that the electrolytic reduced water, hydrogen water in the pouch, hydrogen-rich water produced in the stick, and the like, and the concentration decrease.

The present invention can increase the efficiency of human intake of hydrogen by increasing the hydrogen supply capacity larger than the micro-container using a candy having only a function of storing hydrogen or a micro-container using a soft film.

According to the present invention, since it can be carried out in capsule units at the time of administration to the inside of the human body, there is an effect that it is possible to reliably measure the quality and quantity which are difficult to solve by the conventional method.

The packaging material of the hydrogen-producing candy container of the present invention has an effect of preventing the hydrogen storage containers are exposed to a fire or inadvertent even when the stored hydrogen leaks due to carelessness.

1 a) and b) are cross-sectional views of a hydrogen storage container housed in a gas storage container / hard capsule according to an embodiment of the present invention.

Figure 2 a), b), c), d), e) shows a flow chart for forming the gas storage container and the hydrogen gas in accordance with an embodiment of the present invention.

3 a), b) is a schematic diagram of the hydrogen gas filling system of the present invention,

4 is a cross-sectional view and a front view of the soft capsule (soft film gas storage container) of the present invention.

5 and 6 are process explanatory diagrams for explaining the hydrogen injection and sealing method of the present invention.

7 is a structural diagram of a grouting nozzle and a solid adhesive rod for sealing after gas injection in a storage container of the present invention.

8 is a plan view and a side view showing a material jacket constituting the hydrogen-producing candy storage container of the present invention.

** Description of the main reference numerals

1: Hydrogen storage container 2: Gas storage container 16: Hard capsule

6: container cylinder 7: hydrogen gas 21: temporary container

22: top sealed container 25: hydrogen filling nozzle

26: circular thermocompression band 41; Maintenance Pump,

42; Pumped maintenance control valves; Oil Retention Valve (Drain Valve)

45; Pumped oil holding valve, 46; Pumped maintenance mesh pipe,

62; Hydrogen gas, 51; Soft film gas storage containers, 52; Outside of the container,

53; The interior of the container, 54; Seam of the container, 55; The outer length of the container,

56; outside diameter of the container, 57; Restored nozzle inlet, 58; Maintenance

61; Soft film temporary containers, 62; Maintenance contents, 63; Hydrogen charging nozzle insert,

64; Hydrogen filling nozzle, 65; Damaged nozzle inlet, 66; Grouting nozzle.

71; Melt adhesive rod inlet (nozzle), 72; Solid adhesive rod heating part (Hita),

73; Solid adhesive rod support (holder), 74; Solid adhesive

81; Unit water jacket 82; Convex part of the water jacket,

83; Concave portion of the water jacket, 84; male hook,

85; Male hook

Hereinafter, embodiments of the present invention will be described with reference to FIGS. 1 to 8.

Hydrogen filled in a hydrogen storage container for absorbing hydrogen to the human body has a purity of 99.999% or more that can be absorbed or metabolized in the human body, and impurities of hydrogen gas are preferably lower than the concentrations in Table 1 below. .

Table 1

Item	O 2	H 2 O	CO	CO 2	CH 4	N 2	Ar
Impurities in Hydrogen Gas (ppm)	0.2	2	0.2	0.2	0.2	N / A	N / A
Impurities of Purified Hydrogen (ppb)	10	10	10	10	10	10	10

However, it is recommended that the dust contained is not more than 1 particle per cubic foot (ft ³ ) of particles of 0.1 micrometer (um) or less.

Hydrogen gas is a flammable material, a colorless, odorless, tasteless, non-toxic, and asphyxiating gas that has a ignition point of 550 ° C and explodes within a limit of 4% to 74% in volume in air and 18% to 59% in volume in limited space. It should be able to be stored or used within the range, and the hydrogen atom is the smallest and lightest among the elements, so it can be easily released from water molecules, rapidly diffuses in the air, disappears into the air, and can pass through human skin cells. .

According to some published theories of hydrolytic enzymes, bacterial hydrolases present in soil microorganisms are enzymes that promote the reversible oxidation of hydrogen molecules and play an important role in anaerobic metabolism. On the contrary, hydrogen molecules are separated and separated into hydrogen ions and electrons, and a mechanism using iron as a catalyst has been recently discovered.

Hydrogen molecules (H ₂ ) are hydrogen ionized by giving and oxidizing electron acceptors such as oxygen (O ₂ ), carbon dioxide (CO ₂ ), and the like. Low molecular weight compounds and proteins such as ferredoxins and cytochrome c are known to be electron donors and electron acceptors in relation to hydrolases.

H ₂ + A _ox- > 2H ⁺ + A _red

  2H⁺ + D_red->                  H₂ + D_ox             

The enzymes involved in this electron transport are known to maintain a low redox potential (ORP) is essential for anaerobic metabolism.

Hydrogen gas in a hydrogen storage container that is orally added to drinking water or dissolved in drinking water is a hydrogen molecule that is decomposed by hydrogenase in microorganisms present in the body during metabolism. It is known to be separated. The separated hydrogen ions are active hydrogens that are hydrogen atoms, and serve to eliminate active oxygen.

In general, it is known that about 2% of oxygen inhaled into the lungs is converted into free radicals. The amount of oxygen inhaled in one minute is about 2,000 cc, and the amount of free radicals is changed to 40cc per minute, and 57,600cc in 24 hours. . On the other hand, according to Hayashi Hidemitsu's book, “Revolutionary Hydrogen Rich Water,” the dissolved hydrogen content of hydrogen saturated water that can be dissolved in tap water is 1.49 ppm, and the dissolved hydrogen content of hydrogen rich water by magnetic sticks. Is 1.203 ppm, any form of hydrogen rich water shows a positive limit to supply hydrogen gas into the human body, the hydrogen storage container of the present invention is set the ratio of the active hydrogen to the active oxygen much higher than the hydrogen rich water It is to provide a method for supplying hydrogen gas.

In order for hydrogen to be absorbed by the human body, it is necessary to develop a suitable oral hydrogen gas packaging container. And after a certain period of time, orally administered, it will reach the intestine, whereby a container that allows hydrogen to leak out and diffuse, that is, a container whose contact with water will not be destroyed for a certain period of time, will then be destroyed. This is necessary. One suitable choice for this purpose is a capsule-shaped container of candy.

As a container material in the form of a capsule for storing hydrogen gas, the candy should be selected to have a condition capable of safely storing hydrogen gas inside the candy for a long time in an environment where temperature and pressure change.

The material of the candy is the conventional soft candy, amorphous hard candy, sugar-free hard candy, etc., according to the conventional candy manufacturing method, the airtightness to the air or nitrogen gas is complete, the airtightness to the hydrogen gas is well, the heat amount is 10Kcal per capsule Less than, high tensile strength, good thermal deformation in the process of manufacturing a container for storing hydrogen, the glass transition temperature is more than 38 ^℃ at 3% or more moisture content, the structure and composition of the glass at room temperature It is desirable to make similar mixtures.

Conventional candy materials that can be applied to the mixture include sugars, maltose, sugars and the like, and carbohydrate syrup mixtures such as starch, maltitol, mannitol, sorbitol, isomalt, and xylitol, and mixtures of polyols. It may be composed of a mixture of more than that, gelatin, glycerin and the like used as a raw material of the capsule may also be used as an additive.

When the mold is put into a mold with an open top in the shape of a capsule which can be injected orally from a predetermined moisture-depleted mass produced by these raw materials, a cylindrical thin space with one side open inside the candy is formed. The space is vacuumed first, and then filled with hydrogen gas below atmospheric pressure, and the open area is compressed and sealed to form a hydrogen storage container storing hydrogen gas. If the composition and structure of the candy is similar to glass, the outside air does not penetrate inside, but some of the hydrogen molecules inside may leak to the outside of the candy, but the internal pressure below atmospheric pressure does not leak. In order to safely store hydrogen gas, the gas storage container is accommodated in a conventional hard capsule with good airtightness, and the airtightness is secondarily improved, and the upper and lower parts are put in a pocket-type packaging structure made of aluminum layer and thermally compressed. In addition, a hydrogen storage container is prepared.

Hard candies are also commonly referred to as hard sweets or hard boiled candies. They are basically amorphous and hard sugars that are obtained by strongly dehydrating carbohydrate syrups. Essentially amorphous hard sugars, including so-called sugar-free or polyols, can also be obtained using hydrogenated carbohydrate syrups or slightly digested carbohydrate syrups. Sugar-free hard candies are increasingly in the spotlight because sugar-free hard candy exhibits similar sensory properties while suppressing tooth corrosion and producing less calories than conventional sugar hard candies. Sugar-free hard sugar is generally prepared by boiling a mixture of polyols dissolved in water. The mixture of these polyols is boiled under atmospheric pressure to 150 ° C-200 ° C to evaporate most of the moisture. In order to further reduce the water content, a process of boiling in vacuum is usually performed, in which the normal water content is lowered to 2.5% or less, even lower to 1.5% or less. The massecuite thus obtained is added with various substances, for example, pharmaceuticals, pigments, potent sweeteners, acids, plant extracts, vitamins and active pharmaceuticals, which are then cooled again and placed in molds or on rolls or extruded. Makes shape by The description of such hard candy is well described in Korean Patent Registration No. 0163252.

Hereinafter, a hydrogen storage container and a method of manufacturing the same according to an embodiment of the present invention will be described with reference to the accompanying drawings.

The same parts as in Fig. 1 and Fig. 2 are given the same reference numerals, and detailed description thereof will be omitted.

Example 1.

As shown in Figure 1a, the gas storage container of the present invention is a voxel made to store the hydrogen gas by making a capsule-shaped candy. Gas storage container (2) is made to include a hard capsule 16 having a free space therein. The gas storage container 2 is placed inside and the upper portion 4 of the hard capsule and the lower portion 3 of the hard capsule are bonded to each other under a nitrogen gas atmosphere. Therefore, the hydrogen storage container 1 in which the adhesive part 5 is formed in the hard capsule is made.

As shown in the cross-sectional view of the gas storage container of FIG. 1B, the gas storage container 2 has a hemispherical shape at both ends of the container cylinder 6, the cylinder outer part 8 of the container, the cylinder inner part 9 of the candy, and the cylinder outer part. The hard plate 10 is integrally formed, and the hydrogen gas (7) below atmospheric pressure is stored in the cylinder (9), and is manufactured in a size capable of oral injection.

Considering the pressure applied to the inside and the outside of the container cylinder 6, the tensile strength is a condition that can withstand 1.1 times the atmospheric pressure, the outer diameter (D, 14) is 8mm, the length of the outer cylinder (L2) is 14mm And, the total length (L1) of the container combined with the end plate 10 of both ends does not exceed 22mm.

As shown in Table 2 below, the pressure fluctuation of the hydrogen gas stored in the hydrogen storage container 1 according to the external temperature change is assumed to be an ideal gas, and the hydrogen gas charged at 15 at 1 ° C. is assumed to be an ideal gas. Is the space between the container and the capsule between the gas reservoir (2) and the hard capsule (16) in response to temperature changes, such as 0.87 kg / cm ² at -30 ° C and 1.09 kg / cm ² at 30 ° C. (17), the space is spaced at least 1% of the outer diameter (14) of the container cylinder so that when the pressure in the cylinder (9) of the container is higher than the pressure in the cylinder (8), the hydrogen in the cylinder (9) When a part of the gas 7 penetrates into the outer cylinder 8, it is trapped together with nitrogen in the space 17 of the container and the capsule. On the contrary, if the pressure in the cylinder 9 becomes lower than the pressure of the outer cylinder 8. The trapped hydrogen gas causes reversible permeation back to the cylinder interior (9). As a result, a part of the pressure change applied to the gas storage container 2 can be absorbed to act as a buffer.

TABLE 2

Temperature	-45	-30	-15	0	15	30	45
K	228.15	243.15	258.15	273.15	288.15	303.15	318.15
Hydrogen gas charging pressure (kg / cm 2 )				0.98
Pressure fluctuation of hydrogen gas (kg / cm 2 )	0.82	0.87	0.93	0.98	1.03	1.09	1.14
Volume change inside cylinder (1 at 15 ° C )				0.95	1.00	1.05	1.10
Outer cylinder diameter change (1 at 15 ° C )					1.00	1.03	1.05
Required gap between capsule and candy% of cylinder outer diameter					0	2	3

The material of the gas storage container (2) is, in conventional candy, amorphous hard candy, sugar-free hard candy, etc. according to the conventional manufacturing method of candy, the airtightness to the air or nitrogen gas is complete, the airtightness to the hydrogen gas is well, Less than 10Kcal per capsule, high tensile strength, good heat deformation during the manufacturing of candy containers for storing hydrogen, the glass transition temperature is more than 38 ℃ at 3% or more moisture content of the glass at room temperature It is desirable to make a mixture similar in composition and composition.

Conventional candy materials that can be applied to the mixture include one or more of sugars, maltose, sugars and the like, and mixtures of carbohydrate syrup mixtures such as starch, maltitol, mannitol, sorbitol, isomalt, xylitol and polyols. It may be composed of the above mixture, gelatin, glycerin and the like used as a raw material of the capsule may also be used as an additive.

The purity of the hydrogen gas filled in the gas storage container 2 is 99.999% or more, and the dust contained in the hydrogen gas is 1 or less per 1 ft ³ of the particle machine of 0.1 micrometer or less. The hydrogen gas 7 which is charged below atmospheric pressure is blocked from air or nitrogen gas flowing from the outside of the gas storage container 2, but the hydrogen gas inside the gas storage container 2 is outside the hydrogen container 6 when the atmospheric pressure is higher than atmospheric pressure. Some leakage may occur, but when the pressure of hydrogen gas inside the gas storage container is equal to or lower than atmospheric pressure, no leakage of hydrogen gas occurs.

Example 2;

The method of filling hydrogen gas into the gas storage container 2 is as shown in the flow chart of filling the hydrogen gas of the present invention of Figure 2,

a) According to the choice of the material of the conventional candy, the necessary additives were cooled in predetermined moisture-free mass (Massecuites) made from a mixture of sugars, carbohydrate syrups, and a mixture of polyols, and then cooled as shown in the drawing. Put it in to make a shape. The additives, the iron (Ferrous fumarate) promoter for decomposing hydrogen molecules into hydrogen atoms (active hydrogen), vitamin C, vitamin E to assist the antioxidant role, polyphenols (Polyphenol), carotene (Carotene), calcium, etc. May be included. Preferably, iron does not exceed 4 mg per capsule.

The mold of the container is the same as the method for molding a conventional candy, the mold is made of a shape and structure that can be molded in the temporary container 21 of Figure 2a), the lower part is a capsule shape and the upper row is a circular row The upper projection 24 of the container to be compressed by the crimping band 26 has a structure and is formed in the center of the temporary container 21 with the lower portion of the hydrogen filling nozzle 25 made of metal inserted Has The length of the temporary container 21 is equal to the total length (L1) of the container plus the height of the container upper closing portion 28 and the width of the circular thermocompression band 26 is equal to the thickness of the hard plate 10 of the container.

b) The upper protrusion part 24 of the temporary container 21 is filled with a circular thermocompression band 26, and the inside of the hydrogen filling nozzle 25 is pumped to a vacuum degree of about 10 ^-1 Torr by a vacuum pump. Then, the hydrogen gas is charged to atmospheric pressure from the hydrogen gas supply unit.

c) The hydrogen filling nozzle 25 is heated above the glass transition temperature by a built-in heater, and as shown in FIG.

) And the width of the circular thermocompression band 26 are retracted to the end of the container by the combined length. At this time, the cylinder length of the temporary container 21 is the length of the inside of the cylinder of the container (

) Is equal to the sum of the widths of the circular thermocompression band 26. When the hydrogen filling nozzle retreats, the upper portion of the vessel 24 is deformed by a heater installed in the circular thermocompression band 26 to raise the temperature above the glass transition temperature. 27) the thermocompression band 26 is tightened until it is completely compressed and sealed to the same length as the lower circumference of the temporary container 21 and corresponding to the width of the circular thermocompression band 26. After the tightening for sealing is completed inside the cylinder (9) of the container inside the temporary container 21, only the upper end portion 28 of the container remains. In order to prevent cracking of the container in the process of compressing and sealing the upper protrusion part 24, a control device controls the temperature and moisture to be balanced in the temporary container 21.

d) The cylinder inner portion 9 of the container 22, the upper portion of which is sealed as shown in d) of FIG.

Hydrogen gas (7) is charged to below atmospheric pressure and the top of the cylindrical outer (8) has a height of the sum of the thickness of the hard plate 10 and the upper finish portion 28, the hydrogen filling nozzle (25) completely out Retract and remove the circular thermocompression band (26). Unavoidable gaps are grouted as raw materials for candy.

e) leaving the thickness of the hard plate 10 while removing the upper finish portion 28 while applying heat to a temperature at which the upper finish portion 28 of the upper sealed container 22 may be deformed, and then e) of FIG. As described above, the upper plate 10 is finished in a hemispherical shape to manufacture the gas storage container 2 shown in FIG. 1.

Example 3;

Figure 3 is a schematic diagram of the hydrogen gas filling system of the present invention, as shown in Figure 3a, when the hydrogen-filled network pipe connected to the hydrogen filling nozzle unit is used as a pumping and charging as a reference,

The hydrogen gas filling system includes a hydrogen filling nozzle unit 31 including n hydrogen filling nozzles 25 and auxiliary devices, a hydrogen filling network pipe 32 connected to the hydrogen filling nozzle unit 31, and a hydrogen filling network type. A vacuum pump having a vacuum pump 41 and pumping gas control valves 42 connected to the pipe 32, a hydrogen gas supply pipe 33, and a hydrogen gas pressure regulator 34 connected to the hydrogen filling network pipe 32. ), A hydrogen gas supply unit having a hydrogen gas control valve 35 and hydrogen gas filters 36 and a hydrogen gas supply unit connected to the hydrogen filling network pipe 32 in parallel with the nitrogen gas supply source 37 and nitrogen gas. Nitrogen gas supply section including pressure regulator 38, nitrogen gas control valve 39 and nitrogen gas filters 40, pumping gas exhaust valve 44 for exhausting pumping gas, and supply gas exhaust for purging supply gas The valve 43 is provided.

3 b is a case where the hydrogen filling mesh pipe connected to the hydrogen filling nozzle part and the pumping gas mesh pipe are separated and used, the hydrogen filling nozzle part 31 composed of n hydrogen filling nozzles 25 and auxiliary devices and The hydrogen filling nozzle part 31 and the hydrogen filling mesh pipe 32 are separated by the n pumping gas separation valves 45 and connected to the pumping gas mesh pipe 46 connected to the hydrogen filling nozzle part 31. The vacuum pump part having the vacuum pump 41 and the pumping gas control valves 42 and the hydrogen filling nozzle part 31 and the hydrogen filling mesh pipe 32 are connected by n pumping gas separation valves 45. And the hydrogen gas supply unit connected to the hydrogen filling network pipe 32, the nitrogen gas supply unit connected in parallel with the hydrogen gas supply unit to the hydrogen filling network pipe 32, and a pumping gas exhaust valve for exhausting the pumping gas. 44, the feed gas exhaust valve 43 for purging the feed gas and the pumping gas It is equipped with hydrogen gas filling system.

In the hydrogen gas filling system according to the present invention, a charging process of FIG. 3 a) is described. The hydrogen gas control valve 35, the nitrogen gas control valve 39, the supply gas exhaust valve 43 and the pumping gas control valve (42) is closed and the pumping gas exhaust valve 44 is opened, the vacuum pump 41 is operated and put into operation, the pumping gas exhaust valve 44 is closed, and the pumping gas control valve 42 is opened to open the hydrogen. The inside of the n hydrogen filling nozzles 25 of the filling mesh pipe 32 and the hydrogen filling nozzle unit 31 is pumped to increase the vacuum degree to 10 ⁻¹ Torr. When the n hydrogen charging nozzles 25 and the passage reach a predetermined vacuum degree, the pumping gas control valve 42 is closed, and the hydrogen gas control valve 35 of the hydrogen gas supply unit is opened to open the n hydrogen charging nozzles 25. The hydrogen gas is charged from the hydrogen gas supply source 33 via the hydrogen gas pressure regulator 34 and the filter 36 until they reach atmospheric pressure. When the predetermined hydrogen gas filling is completed, the hydrogen gas control valve 35 is closed to stop the supply, and the upper projections of the hard candy can be formed by the circular thermocompression bands 26 according to the thermocompression procedures as described above. 24) is pressed to seal the charged hydrogen gas.

Nitrogen gas from the nitrogen gas supply unit is used for purging the interior of the filling system during maintenance or emergency. The nitrogen gas control valve 39 is opened to open the nitrogen gas pressure regulator 38 and the filter from the nitrogen gas supply 37. Nitrogen gas is supplied via (40). Nitrogen gas can also be used to seal the nitrogen in the system at the time of facility shutdown, and the supply gas exhaust valve 43 may open the valve as necessary to exhaust hydrogen gas or exhaust nitrogen gas.

In the hydrogen gas filling system according to the present invention, referring to the filling process of FIG. 3B, the pumping gas control valve 42 is separated from the hydrogen filling mesh pipe 32 by closing the n pumping gas separation valves 45. The pumping gas exhaust valve 44 is opened and the vacuum pump 41 is operated to be in operation. After the pumping gas exhaust valve 44 is closed, the pumping gas control valve 42 is opened to open the pumping gas mesh pipe 46. The degree of vacuum is increased to 10 ⁻¹ Torr by pumping the inside of the n hydrogen charging nozzles 25 of the over-hydrogen charging nozzle unit 31. When the interior of the n hydrogen filling nozzles 25 and the passage reaches a predetermined degree of vacuum, the pumping gas control valve 42 is closed, and the n pumping gas separation valves 45 are closed to pass through the hydrogen filled mesh pipe 32. After that, the hydrogen gas control valve 35 of the hydrogen gas supply unit is opened, and the hydrogen gas pressure regulator 34 and the filter 36 are discharged from the hydrogen gas supply source 33 until the n hydrogen filling nozzles 25 reach atmospheric pressure. Fill the hydrogen gas through. When the predetermined hydrogen gas filling is completed, the hydrogen gas control valve 35 is closed to stop the supply, and each circular thermocompression band 26 of the upper projection 24 of each candy is made according to the thermocompression procedure described above. The lower part is pressed to seal the charged hydrogen gas. The function of the nitrogen gas supply unit is as described above.

The summary of the manufacturing process is as follows.

Prepare the candy from which moisture is removed from the raw materials of the candy, cool it by adding the necessary additives, prepare the mold of the candy, install the hydrogen filling nozzle at the center in the proper position at the set height, and set the hydrogen inside the mold. The temporary container is formed by inserting the masquet with the filling nozzle inserted.

Fill a circular thermocompression band on the upper projection of the temporary container, vacuum pump the inside of the hydrogen filling nozzle, fill the hydrogen gas inside the hydrogen filling nozzle, raise the temperature of the hydrogen gas filling nozzle, and retreat to the end of the upper projection. Is formed inside.

The upper thermocompression band is pressed until it is sealed by the circular thermocompression band, and when it is tightened, the upper part is sealed.

After fully retracting the hydrogen filling nozzle and removing the circular thermocompression band, grouting as necessary, the upper end of the sealed container is removed, and the upper plate is finished to form the gas storage container.

When the gas storage container is placed in a hard capsule under a nitrogen atmosphere, bonded and sealed, the production of the hydrogen storage container of the present invention is completed. The finished hydrogen storage container is packaged in a pocket-type drug structure with aluminum layers on the top and bottom.

Example 4.

The method for producing a non-hard and soft gas storage container by further improving the container for gas storage will be described.

The material used for the preparation of the temporary gas storage container of the soft coating is to be used for the manufacture of a normal soft capsule, succinic acid gelatin which improves disintegration stability by replacing the normal gelatin extracted from natural collagen and the amino group with a carboxyl group, One or more mixtures of sorbitol sorbitan or sorbite series, polyglycitol syrup, sucrose, mannitol, xylitol, maltose, reduced maltose syrup, maltitol, polyethylene glycol as glycerin, concentrated glycerin, starch, plasticizer or softener And one or more species are selected from purified water, black iron oxide, and red iron oxide, mixed, swelled, dissolved, and defoamed to prepare a gel mass of the film.

Since the contents inside the flexible film temporary container will be replaced by hydrogen gas after the container is manufactured, the fat or oil is used as a material that can stabilize the film and the content of the film without a surfactant. The base oil or fat is one or more fats and oils selected from soybean oil, safflower oil, refined fish oil, refined oil, sesame oil, red pepper seed oil, wheat germ oil, grape seed oil, olive oil, rapeseed oil, evening primrose seed oil, and oil of keratin flavor oil.

The method of making a soft film temporary container, like the conventional manufacturing method, puts the contents in the center of two film bases and bonds the two films in an oval shape to make a temporary soft capsule in which the contents are internally sealed.

In a conventional rotary type automatic filling machine (molding machine), a film having a uniform film thickness is made, cooled by gelling with a cold air of about 12 to 20 ^o C and a relative humidity of about 20 to 30%, and then transferred to a molding machine. The contents are charged by a predetermined amount through the charger.

By uniformly pulling the film on both ends of the spread box of the charger and sealing and bonding both sides of the film by the mechanical pressure and electrical heat of the die roll (35-40 ^o C) The leakage of the contents and the equilibrium of moisture are prevented from occurring at the adhesive portion of the sealed encapsulation film so as not to cause deformation of the properties.

As shown in the cross-sectional view of FIG. 4, the soft film gas storage container has an external shape such as a rugby ball in which the longitudinal cross section is elliptical and the cross section is circular. The gas storage container is a soft film gas storage container 51 in which a soft film is formed into a capsule, and the hydrogen gas 7 having a predetermined pressure is used as the base of the contents, and a small amount of the remaining amount 58 is stored. This may have a structure that can be accommodated with a predetermined space inside the hard capsule so as to be protected by the hard capsule outside thereof.

The soft coating gas storage container 51 is formed with a nozzle insert 57 in which the outer portion 52 of the container, the inner portion 53 of the container, the joint portion 54 of the container, and the hard plate portion damaged during hydrogen charging are restored. The inner 53 of the vessel has a structure in which hydrogen gas 7 not exceeding twice the atmospheric pressure and a residual amount 58 of 3 to 30% are stored, and the outer length 55: L of the vessel The outer diameter (56: D) of the container is manufactured to a standard that can be orally added. .

The dissolution time of the flexible film gas storage container should be within 12 minutes if it is reinforced with hard capsules, and within 30 minutes if it is to be taken with soft capsules alone, and the specification should take into account the pressure applied to the inside and outside of the gas storage container. In order to allow the tension or elasticity to withstand 1.1 times the predetermined pressure, the thickness of the soft coating temporary container 61 during molding is 0.8 to 1.1 mm, and the thickness after cooling and drying in a conventional manner. Should be 0.7 to 1.0mm. The thickness of the joint 54 of the container is 0.6 to 0.95 mm on the basis of the cooling and drying, and the thickness of the restored nozzle insert 57 is 0.7 to 1.0 mm on the basis of the cooling and drying.

The manufacturing method of a soft-film gas storage container consists of the shaping | molding process of a soft-film gas storage container, and a process of filling and sealing hydrogen gas.

In the forming process of the soft coating temporary container 61, a process of manufacturing a soft capsule in which oil is sealed inside as in the conventional technique, discharging the inside of the soft capsule, and encapsulating hydrogen gas is shown in the process diagram of FIG. As shown in

First, as shown in FIG. 5A, the present method performs a process of manufacturing the flexible film gas storage container 51 by filling and sealing hydrogen gas into the ultra-soft flexible film temporary container 61. By providing a predetermined thickness to the components of the soft coating to be used to reinforce the tension and elasticity, to create a soft coating temporary container 61 having the joint portion 54 of the container filled with the holding contents 62 therein and sealed. .

Next, as shown in b) of FIG. 5, the hydrogen charging nozzle insertion port 63 is defined at the joint 54 of the container in the lower light plate part of the container while the temporary container 61 is vertically positioned, and the insertion hole 63 of the nozzle is 63. The needle-shaped hydrogen filling nozzle 64, which is sharp from below, is inserted into the temporary container 61 in the length corresponding to the center of the holding depth.

Subsequently, as shown in (c) of FIG. 5, after confirming the airtightness of the hydrogen filling nozzle insertion port 63, the hydrogen filling nozzle 64 is moved to a length corresponding to the depth of the remaining amount of the remaining inside of the temporary container 61. After the holding contents 62 are pumped out through a hydrogen filling nozzle, the holding residues 58 in the temporary container remaining after filling the hydrogen gas are laid on the bottom of the container of 3 to 30%. The gas 7 is filled to a predetermined pressure. At this time, the charging pressure should not exceed twice the atmospheric pressure.

Next, as shown in (d) of FIG. 5, the hydrogen filling nozzle 64 is completely retracted through the filling nozzle insertion hole 63 of the temporary container 61, and the airtight holding membrane is formed by itself by the holding residual amount 58. The airtightness is kept temporarily in the nozzle insertion hole 65 damaged by the elasticity of the film itself.

As shown in FIG. 5E, the material of the soft coat is injected into the damaged nozzle insert 65 by the grouting nozzle 66 while the temporary container 61 is temporarily sealed. The grouting process is performed by an electrical temperature (200 ^° C. or less) to ensure adhesion.

As shown in FIG. 7, the grouting nozzle 66 used in the grouting process is melt-bonded to inject a molten solid-state adhesive rod in contact with the damaged nozzle insert 65 so as to penetrate the damaged nozzle insert 65. The rod injection section 71, the solid-state adhesive rod warming unit 72 having an electric heater and a heat conductor capable of heating up to 200 ^° C., and the cylindrical passage and passage through which the solid adhesive rod can move toward the nozzle It consists of a solid adhesive rod support 73 having a pusher (pusher), and a solid adhesive rod 74 inserted into the solid adhesive rod support.

The material of the soft coating for grouting is a solid adhesive rod with gelatin as the main component of the soft coating material of the main body and strong adhesiveness so that it can be melted to be able to penetrate the damaged part even at 200 ^° C or less.

In the method of injecting the soft coating material, the direction of the temporary container 61 is adjusted so that the damaged nozzle insertion opening 65 is positioned upward, and the solid welding rod 74 is inserted into the solid adhesive rod support 73. , The nozzle of the injection portion 71 of the molten adhesive rod is brought into close contact with the damaged nozzle insert 65, and the solid adhesive rod is pushed in the direction of the injection portion 71 of the molten adhesive rod using the push rod in the solid state adhesive rod support portion 73. When the electric heater of the heating part 72 is put in, the front part of the solid-state welding rod 74 melts at 200 ^° C. or less, and is penetrated and fused to the damaged nozzle insert 65 through the injection part 71 of the molten adhesive rod, thereby inserting the nozzle insert 57. Is restored and sealed.

Thus, as shown in f) of FIG. 5, the soft film gas storage container 51 in which the hydrogen gas and the residual amount are sealed inside is prepared, and the preparation is ready to be accommodated in the protective hard capsule.

As a system for hydrogen charging in this embodiment, as described in the third embodiment, the hydrogen gas filling system shown in FIG. 3B is used.

First, the temporary container for filling the hydrogen gas and the temporary container sealed inside the holding oil are charged to the hydrogen filling nozzle unit, and the n filling pump separation valves 45 are closed to separate the hydrogen filling nozzle unit from the hydrogen filling mesh pipe 32. In this state, the pump holding control valve 42 is closed, the holding discharge valve 44 is opened, the holding pump 41 is operated to discharge the holding of the holding pump inlet line, and then the holding pump is kept in operation. By closing the discharge valve 44 and opening the pumping maintenance control valve 42, the n hydrogen filling nozzles 64 and the soft film gas storage container 51 of the pumping maintenance mesh pipe 46 and the hydrogen filling nozzle unit 31 are provided. The oil in the fields is pumped out. At this time, the amount of oil and fat attached to the container and the amount of oil and fat attached to the filling nozzle 64 are maintained so that the remaining amount 58 in the temporary container remaining after filling the hydrogen gas is 3 to 30%. need. Thus, when the pressure at the pump inlet reaches a predetermined negative pressure magnitude so that the oil remains in the n hydrogen filling nozzles 64 and the passage thereof, the pumping holding control valve 42 is closed and the n pumping holding separation valves ( 45) to open the hydrogen filling nozzle portion to communicate with the hydrogen filled mesh pipe (32). After this, the hydrogen gas control valve 35 of the hydrogen gas supply unit is opened, and the hydrogen gas pressure regulator 34 and the filter from the hydrogen gas supply source 33 until the n hydrogen filling nozzles 25 reach a predetermined pressure. Hydrogen gas is charged via (36). When the predetermined hydrogen gas filling is completed, the hydrogen gas control valve 35 is closed to stop the supply of hydrogen gas, the hydrogen gas filling nozzle is retracted and removed from the temporary container, and instead, the grouting nozzle 66 is inserted into the nozzle insert of the temporary container. A grouting process is performed by injecting the material of the soft coat into the damaged nozzle insert 65 at a predetermined injection pressure and temperature (200 ^° C. or less). In this case, the flexible film gas storage container 51 in which the hydrogen gas and the residual amount of the seal are sealed is manufactured, and the preparation is ready to be accommodated in the protective hard capsule.

Example 5:

It describes a hydrogen-producing candy made by mixing the candy with the candy so that 30% to 70% of the substance that generates hydrogen gas in the colon by the intestinal bacteria group.

Flatulence is a mixed gas that is produced as a by-product of mammalian digestion and is transported to the rectum by the peristallic action of the same digestive system that causes feces to come down from the large intestine. The components are generally known as Table 3 below.

TABLE 3

Item	nitrogen	Oxygen	Hydrogen	carbon dioxide	methane
main ingredient	20 to 90%	0 to 10%	0 to 30%	10 to 30%	0 to 10%
Average	55%	5%	15%	20%	5%
Generate circle	When inhaling air	When inhaling air	Fermentation in the large intestine	Fermentation in the large intestine	Fermented in large intestine (30% of adults only)

Nitrogen and oxygen come from the air we swallow, in a non-toxic, odorless fart. Oxygen is absorbed by the human body, but nitrogen is not absorbed, so it is released through the fart. On the other hand, a large amount of hydrogen gas from the large intestine, carbon dioxide and methane gas is carried through the blood vessels, but most of the useless carbon dioxide and methane gas is released through the fart.

On the other hand, the malodorous fart is composed of meat proteins such as stol, indole, and ammonia, and sulfur-containing compounds such as methaneethiol, hydrogen sulfide, and dimethylthylsulfide. About 1% of the gas produced.

People with adult reference to emit by dividing the 500 ~ 700 cm ³ gas per day about 15 circuit, the hydrogen gas that is generated from that is the 75 ~ 105 cm ³ per day, such as some of the other gas through the anus in that The other part enters the bloodstream of the intestine by a process of diffusion if it is higher than its partial pressure in the blood through the lumen, the passage through which nutrients in the intestine pass. Hydrogen gas transported along the bloodstream penetrates into the cells, some of which come back out of the blood as it passes through the lungs and are released with exhale. Most of the carbon dioxide and methane produced together are released through the anus and some enter the bloodstream of the barrier and merge with other carbon dioxide from the varicose veins.

Research data supporting fermented by bacterial groups in the colon to produce hydrogen, which is a powerful antioxidant;

Breath hydrogen testing as a physiology laboratory exercise for medical students, Ramon G. Montes, Richard F. Gottal, School of Medicine, Johns Hopkins University, accepted Dec 23 1991-A method of identifying the reduction of carbohydrate absorption in the breathing hydrogen test, which is a BHT as a learning tool, which uses gas chromatography to analyze samples collected during exhalation through nasal prong technology. As a result, students who consumed lactose, fructose and lactulose were found to have more hydrogen gas due to poor absorption in the small intestine than those who consumed monosaccharide glucose or sucrose. This is due to deficiency.

Respiratory hydrogen test results are influenced by factors related to quantitative or qualitative aspects of the gut flora. The aim of the study was to determine whether hydrogen gas release capacity changes after oral administration of lactulose in case of loss in the colon. Influence of colectomy on hydrogen excretion in breath, Francesc Casellas, Francesc Casellas, A. Torrejon, accepted Oct 14 2008 Is a report of significantly lower emissions.

In order to induce female students to ingest alpha-di galactosidase, an enzyme that hydrolyzes raffinose, and to trace patterns of biorhythms, we used the BHT (Circadian rhythm of breath). Hydrogen in young women, Mieko Kagaya, Mayumi Iwata, accepted Jan 23. 1998)-The results of the tests in this report were higher when no intake (24 ppm) of non-digalactosidase was consumed (17 ppm). The low 7 ppm and higher dietary fiber intake could result in more hydrogen gas, which can be inferred by the fact that female students consume more dietary fiber containing small sugars.

Eight healthy subjects were ingested with curry containing the turmeric of curcumin, the source of curcumin, and curry, and the sample samples were analyzed by gas chromatography. Effect on dietary turmeric on breath hydrogen, Akito Shimouchi, Kazutoshi Nose, Dig Dis Sci. 2009; 54 (8): 1725 ~ 1729-Results show that curry containing turmeric significantly increases respiratory hydrogen and shortens the elapsed time of the small intestine than curry that does not, and activates the intestinal force and carbohydrate fermentation in the colon It is a report.

Curcumin's antioxidant and anti-inflammatory effects, mode of action and therapeutic effects on pathological conditions. Antioxidant and anti-inflammatory properties of curcumin, Venugopal P, Menon and Adluri Ram Sudheer, I.E. Magazine, Sep 2001-Cylooxygenase-2, Lypooxygenase and derivatives of curcumin are nitric oxide synthase enzymes that mediate inflammatory processes. Inflammation is closely related to tumor palpation, which has chemopreventive properties against carcinogens, and that peroxidative damage of lipid membranes involving free radicals, and oxidative damage of DNA and proteins associated with chronic pathological complications. As a report, it is inferred to be associated with curcumin intestinal hydrogen production.

Curcumin has been shown to protect against carcinogenesis of the skin, mouth, small intestine, and colon, and to inhibit the angiogenesis and metastasis of new blood vessels from existing blood vessels in tumor models in many animals.- Cancer chemopreventive curcumin inhibits cancer cell proliferation by capturing them at various stages of the cell cycle and inducing programmed cell death at various stages of the cell cycle. effects of curcumin, Young-Joon Surh, Kyung-Soo Chun, Advances in Experimental Medicine and Biology, vol 595 In addition, curcumin suppresses the cytochrome P450 isozyme, which is detoxified by the electron transfer chain, thereby inhibiting the biological activation of carcinogens. It is also inferred to be related to curcumin intestinal-generated hydrogen gas.

Hyculipidemic and antioxidant effects of dietary curcumin and curcumin, capsaicin, and edible spices were evaluated to determine the synergistic effects of bioactive compounds in hyperlipidemic rats on the effects of healthy lipid lowering and antioxidant activity. capsaicin in induced hypercholesterolemic rats, H. Manjunatha and K. Srinivasan, published on line, Oct. 2007- Curcumin and Capsaicin lowered liver and blood peroxide levels in hyperlipidemic rats, enhanced liver ascorbic acid in normal rats, and glutathione, also a reducing agent in hyperlipidemic rats. It is inferred to be associated with enteric gas produced by capsaicin.

Enzymes that are not present or lacking in the human digestive system cannot be absorbed due to hydrolysis in the small intestine and eventually fermented as food for bacterial soldier bacteria in the colon, a part of the large intestine. As a substance which accelerates generation of odorless gas;

First, lactose, fructose, and artificially synthesized lactulose, which are contained in dairy products including milk and are carbohydrates, are hydrolyzed by adults. It is due to the lack of enzyme lactase (lactase) that can not be broken down in the small intestine.

Second, the raffinose strain (RFO), which is contained in legumes, cabbage, broccoli, and asparagus, is a trisaccharide of carbohydrates, and contains three sugars, raffinose, and four sugars, stachyose and The five sugars, verbascose, are representative, and the enzyme hydrolyzing the enzyme, alpha-galactosidase (a-GAL), is absent in the small intestine because it is absent in the human digestive system. .

Third, turmeric curcumin used as an edible spice, capsaicin belonging to the acid amides of red pepper, polysaccharide inulin, pig ginger, burdock, etc. Sulfur compounds in allicin (allicin), etc. contained in garlic are not digested and absorbed in the small intestine because the enzymes that hydrolyze each of them in the human digestive system.

Fourth, the gluten in the endosperm of wheat, rye, barley, oats, etc. is composed of proteins called gliadin and glutenin, and glutenin is involved in the cross-linking of the network. Because it has a sulfur atom, the enzyme that hydrolyzes the adrenal gland is deficient in humans, so it cannot be absorbed by the small intestine.

As a manufacturing method of the candy, in the step of removing the predetermined moisture which is made from the mixture as a raw material in Example 2 a), a compound which induces the candy container or the candy to produce beneficial hydrogen gas in the intestine is added. In the step, one or more compounds are added, such as lactose extracted from dairy products including milk and lactulose artificially synthesized fructose and galactose, or legumes, cruciferous vegetables such as cabbage and broccoli. Raffinose (RFO) saccharides extracted from aspargas, kale, radish, cabbage, etc., raffinose, 4 saccharides stachyose and 5 saccharides, such as verbascose or Adding more compounds, curcumin extracted from turmeric used as an edible spice, capsaicin of red pepper, Add one or more compounds from inulin extracted from swine potatoes, burdock, gingerin from ginger, allicin from garlic, or from endosperm such as wheat, rye, barley or oats. Intestinal hydrogen-producing candy is prepared by adding one or more compounds from extracted gluten and glutenin to cool the mesequate for molding or injection.

In the step of adjusting the components of the mesequate first, in the step of adding a compound which induces the candy gas to the candy to produce a beneficial hydrogen gas in the intestine, lactose, lactulose, raffinose, starchiose, burvas Intestinal hydrogen-producing candy is prepared by adding one or more compounds from cousin, curcumin, capsaicin, inulin, gingerol, allicin, corticosteroid, glutenine and the like to cool the mesecate for molding or injection.

For mesecute made from mixtures of sugar alcohols, in order to further increase hydrogen gas production in the intestine, add only those compounds that remove the function of storing hydrogen gas in the intestine and lead to the production of more beneficial hydrogen gas in the intestine. Hazardous, lactose, lactulose, raffinose, stachiose, burbascose, curcumin, capsaicin, inulin, gingerol, allicin, corticosteroid, glutenine, etc. may be selected and added to form or injection The cute is cooled to produce enteric hydrogen-producing candy, with no particular restrictions on the shape and specification of the candy.

The ideal method for measuring the additional beneficial gas produced in the intestine by ingesting intestinal hydrogen-producing sugar follows the conventional breath hydrogen test (BHT) method. Within 12 hours of ingestion of the test subjects, the Nasal prong system is sucked into the plastic syringe with each unit into the plastic syringe for sufficient analysis. Analysis of the hydrogen gas contained in the sucked sample is carried out by gas chromatography for semiconductors. In BHT, normal adults have a respiratory hydrogen level of 6 to 14 ppm, and when ingesting hydrogenated candy, the increase in hydrogen gas is combined to 2-10 ppm, preferably 2 ppm or more, combined with hydrogen stored in the container. Adjust the amount of hydrogen gas in the container or components of the message.

Example 6

In order to dissolve the gas storage container (2) orally with drinking water to dissolve in the intestine of the human body after a certain time, the gas container (2) was placed in the lower portion (3) of the conventional hard capsules under nitrogen gas atmosphere and covered with the upper portion (4) of the hard capsules. Next, when the adhesive part 5 of the hard capsule, which is a portion where the lower part 3 and the upper part 4 of the hard capsule overlap, is bonded, the production of the hydrogen storage container 1 is completed.

Hard capsule 16 is a conventional manufacturing method, but in order to increase the airtightness, moisture resistance and tensile strength of the capsule than the conventional pharmaceutical capsule containing a granule or powder, the area of the adhesive portion overlapping the upper and lower capsules As shown in FIG. 1, it is made as large as possible, and the position of the adhesion part is made into the center part of the hard capsule 16, as shown in FIG.

Hard capsules may be made of water-soluble cellulose derivatives, gelling agents, or the like, gelatin (PEG), glycerin or the like, or nanosilver coating may be added. The dissolution test was performed in warm purified water and selected to be dissolved within 15 minutes.

The soft film gas storage container may be packaged as it is, but once in a hard shell cell to prevent breakage due to inadvertent transportation and to dissolve the gas storage container orally with drinking water to dissolve after a certain time in the human intestine. It is good to pack more. Therefore, under a nitrogen gas atmosphere, a flexible film gas storage container filled with hydrogen gas is placed in the lower part of the conventional hard capsule, and the upper part of the hard capsule is covered, and then the adhesive part of the hard capsule, which is a portion where the upper part and the upper part of the hard capsule overlap, is treated with hydrogen. The manufacturing of the storage container is finished.

In selecting the packaging method of the hydrogen storage container (1), in the pocket-type drug packaging structure developed in consideration of long-term storage and safety from fire, nylon layer, high density polyethylene (HDPE), tere Laminate and heat-punch either phthalate (PET) or polyvinyl chloride (PVC) to form an upper film formed with an open dome, and then put the hydrogen storage container (1) in the dome. (Press through pack foil) as the bottom film to be in close contact with each other, and it can be selected from those that can be sealed by heat sealing with vinyl resin, polyurethane resin or thermosetting adhesive resin, and blocking effect against the penetration of external humid air and sunlight. In order to increase the dry air layer between the aluminum film and HDPE of the top film may be used.

In order to carry out long-term storage or transport of the packaging structures of the hydrogen storage container, it is more preferable to use an aluminum pack that is compact and pressurized and sealed.

Figure 8 shows an exemplary view of a water jacket for fire protection according to an embodiment of the present invention, the upper figure is a plan view of the water jacket, the lower figure is a side view of the water jacket.

For the safe storage and transportation of the candy container for storing hydrogen gas and the packaged product thereof, as shown in Figure 8, as one or more compounds from polypropylene, low density polyethylene, high density polyethylene, etc. To make a cushion-shaped unit material jacket (1). Water or refractory antifreeze may be contained therein and the convex and concave portions 3 of the jacket may be alternately arranged to fold in accordance with the specification. At one end of the long end of the unit jacket 1, a plastic hook or a female hook 4 and a male hook 5 are arranged at the other end, so as to be connected to each other.

When the actual hydrogen-produced candy container is packaged, it can be wound in two directions by using two pockets. One rolls back and forth, the other rolls left and right. This can be wrapped with a material jacket and packed in a box as usual.

In other words, all six sides of the packaged product, which are cross-crossed and wrapped, are put in a storage or transport box so that fire prevention, fire extinguishing and cooling at high temperature can be performed. Two hooks are available to connect several sheets together.

Example 7

The gas storage container, which is a cylindrical capsule container made of a material that stores gas and is dissolved when it comes in contact with water, leaks gas, and is filled with carbon monoxide, nitrogen monoxide, xenon, helium, etc. in addition to hydrogen to supply the human body. It can have a medical effect.

There are pharmacological gas molecules that provide a medical solution. In addition to the traditional well-known medical gas molecules, oxygen (O ₂ ) and nitrous oxide (N ₂ O), carbon monoxide (CO) and nitrogen monoxide have been developed in accordance with the development of medical technology. Medical reports on the role of NO, Xe and Helium have been published recently.

In summary, the effects of molecular gases on the human body, hydrogen gas (Hydrogen), as described previously, is the most extensive antioxidant activity that protects tissues by preventing and healing cellular damage caused by oxidation in mammals, including humans. In particular, it has been reported to have many effects on the removal of hydroxy radicals ( _* OH) and peroxynitrite (ONOO ⁻ ), which correspond to strong active oxygen generated in each part of the human body.

Carbon monoxide is a toxic gas that lowers the oxygen transport capacity of blood at high concentrations and causes hypoxia of cellular tissues.However, carbon monoxide acts as an antioxidant at low concentrations (ppm units) to hypoxia such as ischemic perfusion disorders. It is reported to prevent the oxidative damage of cells caused by the cell, to remove superoxide radicals (O ₂ ⁻ ) generated in the mitochondria that synthesize energy in the body, and to increase the effect of the combined treatment with hydrogen gas. .

Nitric oxide increases the blood supply in blood vessels as a signaling molecule in the body at low concentrations, and protects tissues from oxidative damage to cells, but at high concentrations peroxynitrite is one of the free radicals It is reported that care must be taken to maintain balance because it has an adverse effect of increasing peroxynitrite.

Xenon and Helium are inert rare gases that have been reported to help prevent the oxidation of cells by helping to activate the signal at low concentrations in the body, thereby preventing myocardial ischemia perfusion disorder.

Each of these molecular gases can be supplied to the human body by being sealed in a gas storage container. The gas storage container, filling method, and container manufacturing method can be applied to the techniques described above for sealing hydrogen gas.

Claims (19)

1. A gas storage container which is a cylindrical capsule-type container made of a material that stores gas and melts when it comes in contact with water.
2. The method according to claim 1,

   The material of the container includes sugars such as sugar, malt sugar, and crude syrup, and carbohydrate syrup mixtures such as starch, maltitol, mannitol, sorbitol, isomalt, and xylitol, and polyols, which are used as soft candy, amorphous hard candy, and sugar free hard candy. Or a mixture of polyols, such as one or more mixtures of mesequate,

   The material of the container is a gas storage container characterized by adding one or more additives selected from gelatin, glycerin, ferrous ( ferrous fumarate), vitamin C, vitamin E, polyphenol, carotene, calcium, and the like. .
3. The method according to claim 1,

   Gas storage container, characterized in that to store the hydrogen by installing a hard capsule thinner than the outer shape and thinner than the cylindrical capsule-type container in a double.
4. A packaging method for sealing hydrogen inside a small container,

   Temporary container forming step of forming a temporary container surrounding the hydrogen filling nozzle having a volume of the size of the space to be filled with hydrogen, using a material soluble in heat,

   Attaching the thermocompression band to the portion except the length of the hydrogen filling space, extracting the air in the space inside the temporary container through the hydrogen filling nozzle, and then filling the hydrogen to atmospheric pressure; and

   Retracting the hydrogen filling nozzle to the end of the thermocompression band, applying heat to the thermocompression band and tightening the band to seal the inlet of the temporary container.
5. The method according to claim 4,

   In the temporary container forming step, the container material is a sugar, maltose, syrup and other sugars, carbohydrate syrup mixtures such as starch, maltitol, mannitol, sorbitol, isomalt, xylitol and a mixture of polyols (polyols), etc. Select it,

   Make a masque by adding one or more additives selected from gelatin, glycerin, ferrous fumarate, vitamin C, vitamin E, polyphenol, carotene, calcium, etc. Hydrogen sealing method characterized in that.
6. The method of claim 4, wherein in the temporary container forming step,

   The material of the container is at least airtight, the heat content is low, the heat deformation is good at the time of pressing with heat, and the glass transition temperature is chosen to be 38 ^° C or more at 3% or more.

   Hydrogen sealing method, characterized in that the purity of hydrogen gas charged in the container is more than 99.999%
7. The method according to claim 1,

   The cylindrical capsule-type container is a gas storage container, characterized in that the container is composed of a soft film that is soluble in water but not soluble in an organic solvent.
8. The method according to claim 7,

   The material for forming the soft coat is sorbitol, sorbitan, or sorbite series, polyglycitol syrup, sucrose, mannitol, xylitol, maltose, reduced maltose as general gelatin, succinate gelatin, glycerin, starch, plasticizer or softener. A gas storage container comprising one or two or more mixtures selected from syrup, maltitol, polyethylene glycol, and one or more selected from purified water, black iron oxide, red iron oxide, and the like.
9. The method according to claim 7,

   In the container, the hydrogen gas is 70 to 97% by volume, soybean oil, safflower oil, refined fish oil, refined oil, sesame oil, red pepper seed oil, wheat germ oil, grape seed oil, olive oil, rapeseed oil, evening primrose oil, fruit flavor oil, selected from A gas storage container characterized by at least 3 to 30% by volume of one or more components.
10. The method according to claim 7,

    The gas is hydrogen, the container is formed in consideration of the pressure change in atmospheric pressure and the thickness of the cooled and dried coating is 0.7 ~ 1.0mm, the thickness of the joint is 0.6 ~ 0.95mm and the thickness of the restored nozzle insert is 0.7 ~ 1.0mm. Characteristic gas storage container.
11. As a method of filling and sealing hydrogen gas into a gas-tight container made of a soft coating,

    A step of making a sealed soft film temporary container by putting fats and oils inside the soft film,

    Inserting a hydrogen filling nozzle into the temporary container to draw out the oil in the temporary container and injecting hydrogen gas;

    Removing the hydrogen filling nozzle out of the container, and sealing the nozzle insertion hole drilled in the temporary container by the hydrogen filling nozzle with a grouting material.
12. The method according to claim 11,

    The hydrogen filling nozzle is pointed like a needle,

    Hydrogen gas charging method which is characterized by leaving 3 ~ 30% of oils and fats when extracting oils and oils in temporary container
13. A hydrogen-producing candy made by mixing a substance that generates hydrogen gas in the large intestine by the intestinal bacterial group with the candy so as to be 30% to 70% of the candy.
14. Substances that produce hydrogen gas in the large intestine by a group of intestinal bacteria: Candy containers made by mixing sugar (30 ~ 70) :( 70 ~ 30),

    Hydrogen-generated candy characterized by filling hydrogen inside the candy container.
15. The method according to claim 13 or 14,

    The material generating the hydrogen gas,

    Hydrogen-produced candy characterized by using one or more selected from lactose, lactulose, raffinose, stachiose, burbascose, curcumin, capsaicin, inulin, gingerol, allicin, butyric, glutenine and the like.
16. As a method for producing hydrogenated candy,

    Making a masquerade using the mixture as a raw material;

    Selecting one or more from lactose, lactulose, raffinose, stachiose, burbascose, curcumin, capsaicin, inulin, gingerol, allicin, colchicine, glutenine, and the like, and adding them to massose;

    Method of producing a hydrogen-produced candy comprising a candy molding step of molding or injection of a massegyu.
17. The method according to claim 16,

    Forming a candy container so that the gas can be stored in the candy forming step, filling the hydrogen gas into the candy container and sealing hydrogen producing candy.
18. The method according to claim 1,

    The cylindrical capsule-shaped container is a gas storage container, characterized in that for storing one selected from medical gases hydrogen gas, carbon monoxide, nitrogen monoxide, xenon, helium.
19. Hydrogen, characterized in that it is made of polyethylene jackets containing water or refractory antifreeze, which melts and releases water or refractory antifreeze at temperatures above 120 degrees Celsius for the purpose of packaging and safely transporting or storing hydrogen storage containers or hydrogen-generated candy. Packaging material for the produced candy containers.

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