CN104784370A - Antioxidant pharmaceutical composition capable of scavenging free radicals and preparation method thereof - Google Patents
Antioxidant pharmaceutical composition capable of scavenging free radicals and preparation method thereof Download PDFInfo
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- CN104784370A CN104784370A CN201510219697.6A CN201510219697A CN104784370A CN 104784370 A CN104784370 A CN 104784370A CN 201510219697 A CN201510219697 A CN 201510219697A CN 104784370 A CN104784370 A CN 104784370A
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- fructus schisandrae
- schisandrae chinensis
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Abstract
The invention discloses an antioxidant pharmaceutical composition capable of scavenging free radicals and a preparation method thereof. The antioxidant pharmaceutical composition capable of scavenging the free radicals is prepared from the following components in percentage by weight: schisandra chinensis, auxiliary materials and grape seeds or commercially available procyanidine compound. The preparation method of the antioxidant pharmaceutical composition capable of scavenging the free radicals comprises the step of adding the auxiliary materials into schisandra chinensis extract, grape seed extract or commercially available procyanidine compound and preparing into tablets, pills, powder, tea bags, granules, capsules, oral liquid, drink, a facial mask or toning lotion. The antioxidant pharmaceutical composition capable of scavenging the free radicals is prepared from schisandra chinensis and grape seeds, the schisandra chinensis contains polysaccharide and lignin ingredients, the grape seeds are rich in procyanidine ingredients, both the schisandra chinensis and the grape seeds have strong antioxidation effect, the free radicals can be scavenged more effectively after the schisandra chinensis and the grape seeds are combined, damage on a life body due to oxidation is resisted, and the antioxidant pharmaceutical composition capable of scavenging the free radicals can be applied to preparation of a medicine, cosmetics, health products, health food, food and beautifying or making-up products and realizes the effects of slowing down senility, enhancing immunity and health protecting or beautifying effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, specifically a kind of can the anti-oxidation medicine composition and method of making the same of scavenging free radicals.
Background technology
Oxidation a kind ofly makes electronics from substance transfer to the chemical reaction of oxidant, can generate free radical, and then start chain reaction in process.When chain reaction occurs in cell, cell is damaged or apoptosis.Antioxidation then can scavenging free radicals, stops chain reaction and suppresses the generation of other oxidation reaction.
Free radical is one group of material with Strong oxdiative activity, very easily reacts.Their attack cells film, mitochondrial membranes, with the unsaturated fatty acids acid reaction in cell membrane, cause the integrity of membrane structure to be damaged, cause the extensive injuries such as mitochondrion, DNA, RNA, lipid peroxidation product is decomposed into again more free radical and hazardous compound.Vicious cycle will make protein connect side chain generation alkylation, forms the protein molecular of a large amount of distortion, causes gene mutation, form a large amount of cancerous cell thus cause various diseases.With age, the ability of human body opposing free radical also declines thereupon; Supplement polyphenoils in time if fail, cell will be damaged or apoptosis, so disease produces.As inflammation, cancer, coronary heart disease, altitude sickness, asthma, diabetes and amyotrophic lateral sclerosis etc.
Free radical is not only relevant with aging, but also has relation with many diseases relevant with aging, such as arteriosclerosis, hypertension, rheumatoid arthritis, cataract, senile dementia, parkinson and neurodegeneration etc.Increasing medical research and clinical trial evidence display, interior free yl content more the high life shorter, free radical is the source of ten thousand diseases.
Although previous preliminary study infer supplement antioxidant may promotion health, afterwards the result that a large amount of clinical trial obtains is carried out to a part of antioxidant and does not demonstrate supplementary benefit.As common vitamin C, selenium, vitamin E and glutathion.Find that vitimin supplement C does not demonstrate due benefit, even find that the relative risk that supplementary some antioxidant such as selenium, vitamin E of generally acknowledging heavy dose of can make to suffer from some disease rises one to five percentage points.
Some other antioxidant obtains in food without the need to passing through but can be synthesized by human body self.Such as pantothenylol is difficult to obtain from intestinal absorption but synthesize generation by human body by mevalonate pathway.By the glutathion that supplementary aminoacid synthesizes in human body, because glutathion can all be hydrolyzed into free cysteine, glycine and glutamic acid before being absorbed by the body in intestinal, even if heavy dose of oral concentration that also cannot improve body glutathion inside.Supplement acetylcysteine although a large amount of and can increase glutathion, also not evidence show that the adult of precursor to health of this kind of glutathion of a large amount of absorption is useful.
Be limited to the limitation of traditional antioxidants, the compositions of the effective ingredient of Fructus Schisandrae Chinensis and Semen Vitis viniferae then looks for another way as antioxidative pharmaceutical composition, Fructus Schisandrae Chinensis contains polysaccharide and lignin composition, Semen Vitis viniferae contains abundant procyanidin constituents, the two all has stronger antioxidation, synergistic application, drug effect strengthens, and is oxidized and free radical too much in purged body will widely be applied by anti-body.
Summary of the invention
The object of the present invention is to provide a kind of cost low, easy to make can the anti-oxidation medicine composition and method of making the same of scavenging free radicals, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
Can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 5-93%, Semen Vitis viniferae or commercially available procyanidin compounds 5-85%, adjuvant 0.1-90%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis, adjuvant, Semen Vitis viniferae or commercially available procyanidin compounds respectively according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) Fructus Schisandrae Chinensis is added pure water to extract, obtain the water extract of Fructus Schisandrae Chinensis, or the ethanol adding 60-70% extracts, obtain the ethanol extraction of Fructus Schisandrae Chinensis;
(3) Semen Vitis viniferae is added pure water to extract, obtain the water extract of Semen Vitis viniferae, or the ethanol adding 60-70% extracts, obtain the ethanol extraction of Fructus Schisandrae Chinensis;
(4) extract of Semen Vitis viniferae is mixed with Fructus Schisandrae Chinensis extrat; Or commercially available procyanidin compounds is mixed with Fructus Schisandrae Chinensis extrat;
(5) in the mixture of the extract of Fructus Schisandrae Chinensis extrat and Semen Vitis viniferae, add adjuvant and make oral agents, facial film, astringent, or in the mixture of commercially available procyanidin compounds and Fructus Schisandrae Chinensis extrat, add adjuvant make oral agents, facial film, astringent.
As the further scheme of the present invention: described adjuvant is excipient or additive.
As the present invention's further scheme: described oral agents is tablet, pill, powder, teabag, granule, capsule, oral liquid, beverage.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention is made up of Fructus Schisandrae Chinensis, Semen Vitis viniferae or commercially available procyanidin compounds, and Fructus Schisandrae Chinensis contains polysaccharide and lignin composition, and Semen Vitis viniferae contains abundant procyanidin constituents, and the two all has stronger antioxidation, synergistic application, and drug effect strengthens.Can more effectively remove life interior free yl, slow down or prevent the infringement that Oxidation causes life entity, put forward the ability of life entity free radical resisting damage, reduce the generation that free radical causes body disease, have and make medicine, health product, health food, food, food preservative, beauty treatment and cosmetics aspect purposes, play the effect of reducing human aging, enhancing immunity and health and beauty.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 45%, commercially available procyanidin compounds 45%, carboxymethyl starch 7%, dextrin 3%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis, carboxymethyl starch, dextrin and commercially available procyanidin compounds according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) Fructus Schisandrae Chinensis pulverizer is pulverized, add pure water and extract, obtain Fructus Schisandrae Chinensis extrat, dry;
(3) commercially available procyanidin compounds is mixed with Fructus Schisandrae Chinensis extrat, be crushed to 80-100 order with pulverizer;
(4) in the mixture of commercially available procyanidin compounds and Fructus Schisandrae Chinensis extrat, carboxymethyl starch is added and tablet made by dextrin.
Embodiment 2
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 50%, Semen Vitis viniferae 45%, refined honey 5%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis, refined honey and Semen Vitis viniferae according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) Fructus Schisandrae Chinensis pulverizer is pulverized, add pure water and extract, obtain Fructus Schisandrae Chinensis extrat, dry;
(3) mix with the Fructus Schisandrae Chinensis extrat after pulverizing after Semen Vitis viniferae pulverizer being pulverized, obtain the two mixture;
(4) in the mixture of Semen Vitis viniferae and Fructus Schisandrae Chinensis extrat, add refined honey and make pill.
Embodiment 3
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 50%, Semen Vitis viniferae 50%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis and Semen Vitis viniferae according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) Fructus Schisandrae Chinensis pulverizer is pulverized, add pure water and extract, obtain Fructus Schisandrae Chinensis water extract, dry, pulverize to 80-100 order;
(3) rear for the pulverizing of Semen Vitis viniferae pulverizer and Fructus Schisandrae Chinensis water extract are carried out being mixed and made into powder.
Embodiment 4
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 52%, Semen Vitis viniferae 48%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis and Semen Vitis viniferae according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) Fructus Schisandrae Chinensis pulverizer is crushed to 40 orders, adds pure water and extract, obtain Fructus Schisandrae Chinensis water extract;
(3) Semen Vitis viniferae is mixed homogeneously with Fructus Schisandrae Chinensis water extract, be crushed to 20 orders with pulverizer, carry out pack sterilizing and obtain teabag.
Embodiment 5
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 40%, commercially available procyanidin compounds 50%, sucrose 5%, dextrin 5%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis, commercially available procyanidin compounds, sucrose and dextrin according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) in Fructus Schisandrae Chinensis, add pure water extract, obtain Fructus Schisandrae Chinensis water extract, crushed after being dried;
(3) commercially available procyanidin compounds is mixed with Fructus Schisandrae Chinensis water extract, add sucrose and dextrin mixing make granule, subpackage obtains granule.
Embodiment 6
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 45%, commercially available procyanidin compounds 55%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis and commercially available procyanidin compounds according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) in Fructus Schisandrae Chinensis, add pure water extract, obtain Fructus Schisandrae Chinensis water extract, crushed after being dried;
(3) commercially available procyanidin compounds is mixed with Fructus Schisandrae Chinensis water extract, granulate, incapsulate, obtain capsule.
Embodiment 7
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 60%, Semen Vitis viniferae 40%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis and Semen Vitis viniferae according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) by Fructus Schisandrae Chinensis and Semen Vitis viniferae mix homogeneously, add pure water and extract;
(3), after extracting solution being filtered, carry out sterilization filling and obtain oral liquid.
Embodiment 8
In the embodiment of the present invention, a kind of can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 5%, commercially available procyanidin compounds 5%, pure water 88%, sucrose 2%
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis and commercially available procyanidin compounds according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) in Fructus Schisandrae Chinensis, add pure water extract, obtain Fructus Schisandrae Chinensis water extract;
(3) Fructus Schisandrae Chinensis extractive solution filtered and mix homogeneously with commercially available procyanidin compounds after concentrating, after adding pure water and sucrose, carrying out sterilizing, fill obtains beverage.
Embodiment 9
In the embodiment of the present invention, can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 13%, Semen Vitis viniferae 7%, glycerol 7%, hyaluronate sodium 0.1%, Polyethylene Glycol-40 castor oil hydrogenated 10%, hydroxyethyl-cellulose 0.4%, antiseptic 0.1%, essence 0.1%, pure water 62.3%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis, Semen Vitis viniferae according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) by Fructus Schisandrae Chinensis and Semen Vitis viniferae mix homogeneously, the ethanol adding 60% extracts;
(3) extracting solution carried out filtering and after concentrating, add Polyethylene Glycol-40 castor oil hydrogenated mix homogeneously, obtain mixture first;
(4) by hyaluronate sodium, pure water and glycerol mix homogeneously, mixture second is obtained;
(5) by mixture first and mixture second mix homogeneously, add hydroxyethyl-cellulose, antiseptic, essence, divide and be filled in the aluminium plastic bag of face paper, sealing, obtains facial film.
Embodiment 10
In the embodiment of the present invention, can the antioxidant compositions of scavenging free radicals, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 13%, commercially available procyanidin compounds 7%, glycerol 7%, hyaluronate sodium 0.1%, Polyethylene Glycol-40 castor oil hydrogenated 10%, antiseptic 0.1%, essence 0.1%, pure water 62.7%.
Described can the preparation method of antioxidant compositions of scavenging free radicals, comprise the steps:
(1) take Fructus Schisandrae Chinensis and commercially available procyanidin compounds according to above-mentioned weight portion, get Fructus Schisandrae Chinensis removing impurity;
(2) Fructus Schisandrae Chinensis pulverizer is crushed to 40 orders, adds the ethanol extraction of 70%, obtain Fructus Schisandrae Chinensis ethanol extract;
(3) Fructus Schisandrae Chinensis extractive solution filtered and after concentrating, add commercially available procyanidin compounds, polyglycols-40 castor oil hydrogenated mix homogeneously, obtain mixture first;
(4) by hyaluronate sodium, pure water and glycerol mix homogeneously, mixture second is obtained;
(5) by mixture first and mixture second mix homogeneously, after adding antiseptic, essence, fill obtains astringent.
Embodiment 11
Zoopery
(1) material: superoxide dismutase SOD test kit, malonaldehyde MDA test kit, glutathion GSH test kit, oral liquid obtained in embodiment 7 is concentrated into the medicinal liquid that concentration is respectively 1.17mg/ml, 0.65mg/ml and 0.13mg/ml.
(2) divide into groups: get Kun Ming mice 80, male, body weight 25-30g, is divided into 5 groups at random, often organize 16, be set as respectively blank group, model group, administration high dose group, dosage group and administration low dose group in administration.
(3) administration: except blank group, all the other respectively group often group neck dorsal sc and modelings of lumbar injection intersection, injection of d-galactose, it is 12mg/g that injection volume presses Mouse Weight conversion, and every day injects once, continuous modeling 6 weeks, adopt the blood sampling of the ophthalmic corner of the eyes, measure the value of malonaldehyde MDA, according to the horizontal random packet of malonaldehyde MDA 4 groups, be respectively dosage group and administration low dose group in model group, administration high dose group, administration.Blank group and model group be gavage feedwater 0.1ml/10g respectively, each administration group gastric infusion every day amount 0.1ml/10g, in administration high dose group, administration, the liquor strength of dosage group and the administration of administration low dose group is respectively 1.17mg/ml, 0.65mg/ml and 0.13mg/ml, simultaneously, in model group, administration high dose group, administration, dosage group and administration low dose group continue neck dorsal sc and abdominal cavity and intersect injection and give D-galactose, continue 30 days.
(4) detect: continue medication after within 30 days, terminating, adopt the blood sampling of the ophthalmic corner of the eyes, carry out the detection of indices.
(5) as shown in table 1 to the measuring result of malonaldehyde MDA in mice serum and organs and tissues:
The measuring result of malonaldehyde MDA in table 1 mice serum and organs and tissues
Δ p≤0.05 shows to compare with blank group have significance; * p≤0.05 shows to compare with model group have significance.
(6) as shown in table 2 to the measuring result of the superoxide dismutase SOD in mice serum and each tissue:
The measuring result of superoxide dismutase SOD in table 2 mice serum and organs and tissues
Δ p≤0.05 shows to compare with blank group have significance; * p≤0.05 shows to compare with model group have significance.
(7) as shown in table 3 to the measuring result of the glutathion GSH in mice serum and each tissue:
The measuring result of table 3 mice serum and organs and tissues GSH-PX activity GSH
Δ p≤0.05 shows to compare with blank group have significance; * p≤0.05 shows to compare with model group have significance.
(8) result: experimental result shows, in administration high dose group, administration, dosage group and administration low dose group are compared with model group, malonaldehyde MDA content in serum, liver and cerebral tissue obviously reduces, superoxide dismutase SOD content in serum, liver and cerebral tissue and glutathion GSH obviously raise, show it and there is good removing interior free yl, antioxidation.
The present invention is made up of Fructus Schisandrae Chinensis, Semen Vitis viniferae or commercially available procyanidin compounds, and Fructus Schisandrae Chinensis contains polysaccharide and lignin composition, and Semen Vitis viniferae contains abundant procyanidin constituents, and the two all has stronger antioxidation, synergistic application, and drug effect strengthens.Can more effectively remove life interior free yl, slow down or prevent the infringement that Oxidation causes life entity, put forward the ability of life entity free radical resisting damage, reduce the generation that free radical causes body disease, have and make medicine, cosmetics, health product, health food, food, food preservative aspect purposes, play the effect of reducing human aging, enhancing immunity and health and beauty.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.
Claims (4)
1. can the antioxidant compositions of scavenging free radicals, it is characterized in that, comprise according to the content of percentage by weight: Fructus Schisandrae Chinensis 5-93%, Semen Vitis viniferae or commercially available procyanidin compounds 5-85%, adjuvant 0.1-90%.
2. as claimed in claim 1 can the preparation method of antioxidant compositions of scavenging free radicals, it is characterized in that, comprise the steps:
(1) take Fructus Schisandrae Chinensis, adjuvant, Semen Vitis viniferae or commercially available procyanidin compounds according to above-mentioned percentage by weight, get Fructus Schisandrae Chinensis removing impurity;
(2) Fructus Schisandrae Chinensis is added pure water to extract, obtain the water extract of Fructus Schisandrae Chinensis, or the ethanol adding 60-70% extracts, obtain the ethanol extraction of Fructus Schisandrae Chinensis;
(3) Semen Vitis viniferae is added pure water to extract, obtain the water extract of Semen Vitis viniferae, or the ethanol adding 60-70% extracts, obtain the ethanol extraction of Fructus Schisandrae Chinensis;
(4) extract of Semen Vitis viniferae is mixed with Fructus Schisandrae Chinensis extrat; Or commercially available procyanidin compounds is mixed with Fructus Schisandrae Chinensis extrat;
(5) in the mixture of the extract of Fructus Schisandrae Chinensis extrat and Semen Vitis viniferae, add adjuvant and make oral agents, facial film, astringent, or in the mixture of commercially available procyanidin compounds and Fructus Schisandrae Chinensis extrat, add adjuvant make oral agents, facial film, astringent.
3. according to claim 1 can the antioxidant compositions of scavenging free radicals, it is characterized in that, described adjuvant is excipient or additive.
4. according to claim 2 can the preparation method of antioxidant compositions of scavenging free radicals, it is characterized in that, described oral agents is tablet, pill, powder, teabag, granule, capsule, oral liquid, beverage.
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| CN106071018A (en) * | 2016-07-14 | 2016-11-09 | 广州六顺生物科技有限公司 | A kind of pressed candy with antitumor action and preparation method and application |
| CN106389180A (en) * | 2015-07-29 | 2017-02-15 | 云南康恩贝植物研究院有限公司 | Ginkgo proanthocyanidin-polysaccharide mixing extract, preparation method and applications thereof |
| CN108066217A (en) * | 2017-12-28 | 2018-05-25 | 无限极（中国）有限公司 | A kind of antioxidant composition and its preparation method and application |
| WO2018196045A1 (en) * | 2017-04-26 | 2018-11-01 | 无限极（中国）有限公司 | Skin anti-ageing program and application thereof |
| WO2018196047A1 (en) * | 2017-04-26 | 2018-11-01 | 无限极（中国）有限公司 | Skin anti-ageing program and application thereof |
| CN109362967A (en) * | 2018-11-05 | 2019-02-22 | 华中农业大学 | It is a kind of to alleviate pig oxidative stress, the plant extract feed additive of improvement meat and application |
| CN115153020A (en) * | 2022-07-29 | 2022-10-11 | 武汉橙炻科技有限公司 | Medicinal and edible food capable of efficiently removing harmful free radicals from human body and preparation method of medicinal and edible food |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106389180A (en) * | 2015-07-29 | 2017-02-15 | 云南康恩贝植物研究院有限公司 | Ginkgo proanthocyanidin-polysaccharide mixing extract, preparation method and applications thereof |
| CN106389180B (en) * | 2015-07-29 | 2018-12-11 | 云南康恩贝植物研究院有限公司 | A kind of ginkgo procyanidine-polysaccharide mixed extract and its preparation method and application |
| CN106071018A (en) * | 2016-07-14 | 2016-11-09 | 广州六顺生物科技有限公司 | A kind of pressed candy with antitumor action and preparation method and application |
| WO2018196045A1 (en) * | 2017-04-26 | 2018-11-01 | 无限极（中国）有限公司 | Skin anti-ageing program and application thereof |
| WO2018196047A1 (en) * | 2017-04-26 | 2018-11-01 | 无限极（中国）有限公司 | Skin anti-ageing program and application thereof |
| CN108066217A (en) * | 2017-12-28 | 2018-05-25 | 无限极（中国）有限公司 | A kind of antioxidant composition and its preparation method and application |
| CN108066217B (en) * | 2017-12-28 | 2020-04-14 | 无限极（中国）有限公司 | Antioxidant composition and preparation method and application thereof |
| CN109362967A (en) * | 2018-11-05 | 2019-02-22 | 华中农业大学 | It is a kind of to alleviate pig oxidative stress, the plant extract feed additive of improvement meat and application |
| CN115153020A (en) * | 2022-07-29 | 2022-10-11 | 武汉橙炻科技有限公司 | Medicinal and edible food capable of efficiently removing harmful free radicals from human body and preparation method of medicinal and edible food |
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