CN103520148A - Preparation for auxiliary protection against chemical liver injury - Google Patents
Preparation for auxiliary protection against chemical liver injury Download PDFInfo
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- CN103520148A CN103520148A CN201310535589.0A CN201310535589A CN103520148A CN 103520148 A CN103520148 A CN 103520148A CN 201310535589 A CN201310535589 A CN 201310535589A CN 103520148 A CN103520148 A CN 103520148A
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- liver injury
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- chemical liver
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Abstract
The invention discloses a preparation for auxiliary protection against chemical liver injury. The preparation is mainly prepared by deoxyschizandrin and procyanidine, and has a precise curative effect on liver injuries of various types.
Description
Technical field
The invention belongs to biomedicine field, be specifically related to a kind of preparation that chemical liver injury is had to auxiliary protection function.
Background technology
In China, the hepatopath who causes because of factors such as chemicals, pathogen or excessive consumptions of alcohol has exceeded ten million, and hepatitis is one of main illness of serious threat China people's health.Hepatitis is the general name of liver generation inflammatory lesion, in the clinical treatment of hepatitis, generally adopts Synthetic therapy, i.e. antiviral agents, immunostimulant and hepatoprotective partner treatment.Antiviral agents, immunostimulant focus on the virus of removing in body, and hepatoprotective focuses on the recovery of liver.Real at present effectively antiviral agents is very few, as anti-hepatic-B virus medicines such as lamivudine, famciclovirs, also cannot suppress virus completely.The generally acknowledged effective immunostimulant of anti-hepatitis virus is interferon at present, also cannot overcome viral knock-on problem.Therefore in the treatment of viral hepatitis, antiviral agents, immunostimulant and hepatoprotective are all very important, especially need hepatic in the treatment of the damaging hepatitis of chemical toxicant, so the market of hepatoprotective is huge.
At present, very active to the research of Chinese herbal medicine anti-liver injury both at home and abroad, the effective monomer that has Chinese herbal folk, Chinese herb compound and extract from Chinese herbal medicine of domestic research.
1. Chinese herbal folk
The people such as Wang Yaojun study and find that Cordyceps has liver-protective effect, can prevent hepatocyte spotty necrosis and focal necrosis, suppress the formation of liver pseudolobuli.The Radix Astragali can make rat liver fibrosis degree obviously reduce, and reduces total collagen I, III, the deposition of IV Collagen Type VI in liver.Radix Salviae Miltiorrhizae is a kind of up-and-coming anti-liver injury Chinese medicine, and its mechanism of action is many-sided, as improves microcirculation in liver, suppresses lipid peroxidation, protection hepatocyte, the collagen degradation of promotion deposition and heavily absorption etc.Radix Notoginseng has the effect of activating blood circulation to dissipate blood stasis, can suppress fibroblastic activity in liver, reduces the generation of collagen fiber.In addition, acting on of the anti-liver injury of the Chinese medicine such as Radix Glycyrrhizae, Poria, Fructus Schisandrae Chinensis, Radix Bupleuri, Flos Carthami, Herba Sedi, Herba Silybi mariani also obtained confirmation in experimentation.
2. Chinese herbal compound preparation
Except classical compound preparation, outside Herba Sidae Rhombifoliae soup, TAOHONG SIWU TANG etc., in conjunction with theory of Chinese medical science, effective single medicinal material reasonable combination, form new compound preparation, can improve the effect of anti-liver injury.Wang Baoen etc. form activating blood circulation to dissipate blood stasis prescription by Radix Salviae Miltiorrhizae, the Radix Astragali, Caulis Spatholobi, can obviously prevent the formation of CCl4 institute liver fibrosis due regulating liver-QI sclerosis.The prescription being comprised of Radix Codonopsis, the Radix Astragali, Fructus Jujubae has the effect of righting tonify deficiency, can alleviate hepatocellular degeneration necrosis, suppresses the formation of hepatocyte proliferation of fibrous tissue and pseudolobuli, and liver cirrhosis is had to certain preventive and therapeutic effect.
3. the effective monomer extracting in Chinese herbal medicine
Have oleanolic acid and the Cucurbitacin B of early research pass through protection hepatocyte, reduce and stimulate, and indirectly suppress startup and the development of hepatic fibrosis.Glycyrrhizin can obviously suppress the formation of liver cirrhosis.The researchs such as Chen Zhong show that ligustrazine can obviously reduce the content of malonaldehyde in rat blood serum glutamate pyruvate transaminase, malonaldehyde, III procollagen type and hepatic tissue, improve the activity of superoxide dismutase in hepatic tissue.Tetrandrine is a kind of bisbenzylisoquinoline alkaloid extracting from Radix Stephaniae Tetrandrae root piece, and the effect of its anti-liver injury is confirmed.Oxymatrine is a kind of alkaloid extracting from plant Radix Sophorae Tonkinensis, and chronic hepatitis C is had to good therapeutic effect, and cultured cell in vitro research finds that oxymatrine on rat liver Ito cell proliferation has inhibitory action.
Along with the continuous change of living standards of the people and life style, various Chinese medicine liver-protecting products arise at the historic moment, but majority all exists the shortcomings such as effect is unsatisfactory, does not have so far liver-protecting product of great satisfaction.
Summary of the invention
The object of the present invention is to provide a kind of preparation that chemical liver injury is had to auxiliary protection function, said preparation has auxiliary protection function to chemical liver injury.
For achieving the above object, the present invention is to be that primary raw material preparation obtains by deoxyschizandrin, procyanidin, and the weight proportion of deoxyschizandrin, procyanidin is 1:10.
Preparation of the present invention, basic upper at mentioned component, directly or again adds suitable edible or pharmaceutic adjuvant, can make the various dosage forms such as capsule, tablet, granule.The above-mentioned edible or pharmaceutic adjuvant that can add comprises: diluent, suspending agent, disintegrating agent, antioxidant, emulsifying agent, adhesive and antiseptic.
The specific embodiment
Embodiment 1: chemical liver injury is had to the preparation of auxiliary protection function, its raw material and weight portion are: 10 parts of deoxyschizandrins, 100 parts of procyanidins, add appropriate amount of auxiliary materials, make capsule, tablet, granule etc.
Embodiment 2: to CCl
4the protective effect of induced mice chemical liver injury
By tested mice random packet, 10 every group, successive administration 7 days, 1 hour subcutaneous injection 0.5%CCl after last administration
4oil solvent 0.1mg/kg carries out copying of acute hepatic injury model, posterior orbit venous plexus blood sampling in 16 hours, separation of serum, the content of mensuration serum alt, AST.Administration is respectively organized to indicator and model group and do T-test check.
With the comparison of blank group,<sup TranNum="70">#</sup>p<0.05; With model control group comparison,<sup TranNum="71">*</sup>p<0.05
Test shows, administration treated animal serum AST of the present invention, ALT value are starkly lower than model control group, and close to blank group, show that preparation of the present invention has definite curative effect to chemical liver injury, and there is effective fast, short treating period, the feature such as cost is low, side effect is little.
Claims (2)
1. pair chemical liver injury has the preparation of auxiliary protection function, it is characterized by: it is to be that primary raw material preparation obtains by deoxyschizandrin, procyanidin.
2. the preparation that chemical liver injury is had to auxiliary protection function according to claim 1, is characterized by: the weight proportion of deoxyschizandrin, procyanidin is 1:10.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310535589.0A CN103520148A (en) | 2013-11-02 | 2013-11-02 | Preparation for auxiliary protection against chemical liver injury |
Applications Claiming Priority (1)
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CN201310535589.0A CN103520148A (en) | 2013-11-02 | 2013-11-02 | Preparation for auxiliary protection against chemical liver injury |
Publications (1)
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CN103520148A true CN103520148A (en) | 2014-01-22 |
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Family Applications (1)
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CN201310535589.0A Pending CN103520148A (en) | 2013-11-02 | 2013-11-02 | Preparation for auxiliary protection against chemical liver injury |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104784370A (en) * | 2015-04-30 | 2015-07-22 | 陈大忠 | Antioxidant pharmaceutical composition capable of scavenging free radicals and preparation method thereof |
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2013
- 2013-11-02 CN CN201310535589.0A patent/CN103520148A/en active Pending
Non-Patent Citations (2)
Title |
---|
张明华等: "五味子甲素和五味子醇甲对四氯化碳所致肝脏损伤的保护作用", 《武警医学》 * |
邹金发等: "原花青素在肝损伤中的作用", 《中国医学工程》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104784370A (en) * | 2015-04-30 | 2015-07-22 | 陈大忠 | Antioxidant pharmaceutical composition capable of scavenging free radicals and preparation method thereof |
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Application publication date: 20140122 |