WO2011105825A3 - 프리온 질병의 치료 및 예방에 효과를 갖는 레스베라트롤 - Google Patents

프리온 질병의 치료 및 예방에 효과를 갖는 레스베라트롤 Download PDF

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Publication number
WO2011105825A3
WO2011105825A3 PCT/KR2011/001288 KR2011001288W WO2011105825A3 WO 2011105825 A3 WO2011105825 A3 WO 2011105825A3 KR 2011001288 W KR2011001288 W KR 2011001288W WO 2011105825 A3 WO2011105825 A3 WO 2011105825A3
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WO
WIPO (PCT)
Prior art keywords
resveratrol
present
prion diseases
nerve cells
treating
Prior art date
Application number
PCT/KR2011/001288
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English (en)
French (fr)
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WO2011105825A2 (ko
Inventor
박상열
서재숙
정재교
문명희
이유진
Original Assignee
전북대학교산학협력단
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Application filed by 전북대학교산학협력단 filed Critical 전북대학교산학협력단
Publication of WO2011105825A2 publication Critical patent/WO2011105825A2/ko
Publication of WO2011105825A3 publication Critical patent/WO2011105825A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 프리온 질병의 치료 및 예방에 효과를 갖는 레스베라트롤에 관한 것으로, 더욱 구체적으로 레스베라트롤(resveratrol)을 유효성분으로 함유하는 프리온 질병 치료 및 예방용 조성물에 관한 것이다. 본 발명에 따르면, 본 발명의 레스베라트롤은 신경세포를 보호하는 효과를 갖으며, 본 발명의 레스베라트롤을 신경세포에 처리하는 경우 신경세포의 서투인1(Sirtuin 1)의 발현 및 활성을 증가시켰으며, 프리온의 세포독성으로부터 신경세포를 보호함으로써 세포의 아팝토시스(apoptosis)를 억제시켰다. 따라서 본 발명의 레스베라트롤을 유효성분으로 함유하는 조성물은 프리온 질병 예방 및 치료용 조성물로써 인체로의 적용이 용이한 의약품으로써 실용화할 수 있으며, 축산동물로의 적용이 용이한 사료첨가제로써 개발 가능하다.
PCT/KR2011/001288 2010-02-24 2011-02-24 프리온 질병의 치료 및 예방에 효과를 갖는 레스베라트롤 WO2011105825A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0016748 2010-02-24
KR1020100016748A KR20110097100A (ko) 2010-02-24 2010-02-24 프리온 질병의 치료 및 예방에 효과를 갖는 레스베라트롤

Publications (2)

Publication Number Publication Date
WO2011105825A2 WO2011105825A2 (ko) 2011-09-01
WO2011105825A3 true WO2011105825A3 (ko) 2012-01-12

Family

ID=44507439

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/001288 WO2011105825A2 (ko) 2010-02-24 2011-02-24 프리온 질병의 치료 및 예방에 효과를 갖는 레스베라트롤

Country Status (2)

Country Link
KR (1) KR20110097100A (ko)
WO (1) WO2011105825A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101315261B1 (ko) * 2010-12-29 2013-10-10 대한민국 민들레 추출물을 포함하는 소해면상뇌증의 예방 또는 치료용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040004538A (ko) * 2001-08-23 2004-01-13 질랜드 파마 에이/에스 세포간 커뮤니케이션을 촉진시켜주는 화합물의 신규한의약적 용도
US20060002914A1 (en) * 2004-06-04 2006-01-05 Jeffrey Milbrandt Methods and compositions for treating neuropathies
US20090156668A1 (en) * 2004-03-19 2009-06-18 The Trustees Of Columbia University In The City Of New York Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof
US20090253782A1 (en) * 2006-07-18 2009-10-08 Ratan Rajiv R Compounds for Enhancing Arginase Activity and Methods of USe Thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040004538A (ko) * 2001-08-23 2004-01-13 질랜드 파마 에이/에스 세포간 커뮤니케이션을 촉진시켜주는 화합물의 신규한의약적 용도
US20090156668A1 (en) * 2004-03-19 2009-06-18 The Trustees Of Columbia University In The City Of New York Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof
US20060002914A1 (en) * 2004-06-04 2006-01-05 Jeffrey Milbrandt Methods and compositions for treating neuropathies
US20090253782A1 (en) * 2006-07-18 2009-10-08 Ratan Rajiv R Compounds for Enhancing Arginase Activity and Methods of USe Thereof

Also Published As

Publication number Publication date
WO2011105825A2 (ko) 2011-09-01
KR20110097100A (ko) 2011-08-31

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