WO2011098799A3 - Traitement de maladie respiratoire - Google Patents

Traitement de maladie respiratoire Download PDF

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Publication number
WO2011098799A3
WO2011098799A3 PCT/GB2011/050224 GB2011050224W WO2011098799A3 WO 2011098799 A3 WO2011098799 A3 WO 2011098799A3 GB 2011050224 W GB2011050224 W GB 2011050224W WO 2011098799 A3 WO2011098799 A3 WO 2011098799A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyridin
ethoxy
benzyl
hydroxy
ethyl
Prior art date
Application number
PCT/GB2011/050224
Other languages
English (en)
Other versions
WO2011098799A2 (fr
Inventor
Harry Finch
Craig Fox
Original Assignee
Pulmagen Therapeutics (Inflammation) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pulmagen Therapeutics (Inflammation) Limited filed Critical Pulmagen Therapeutics (Inflammation) Limited
Publication of WO2011098799A2 publication Critical patent/WO2011098799A2/fr
Publication of WO2011098799A3 publication Critical patent/WO2011098799A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une composition pharmaceutique contenant le composé 5-{4-[2-(5-éthyl-pyridin-2-yl)-2-hydroxy-éthoxy]-benzyl}-thiazolidine-2,4-dιone ou un sel pharmaceutiquement acceptable de ce dernier ainsi qu'un ou plusieurs véhicules et/ou excipients. La composition est caractérisée en ce qu'au moins 95% en poids de la teneur en 5-{4-[2-(5-éthyl-pyridin-2-yl)-2- hydroxy-éthoxy]-benzyl}-thiazolidine-2,4-dione de la composition est la forme diastéréomère 5(R)-{4-[2-(5-éthyl-pyridin-2-yI)=2(S)-hydroxy-éthoxy]=benzyl}- thiazolidιne-2,4-dione et en ce que moins de 5% en poids est constitué d'une ou plusieurs des trois formes diastéréomères.
PCT/GB2011/050224 2010-02-10 2011-02-09 Traitement de maladie respiratoire WO2011098799A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1002224.2 2010-02-10
GBGB1002224.2A GB201002224D0 (en) 2010-02-10 2010-02-10 Respiratory disease treatment

Publications (2)

Publication Number Publication Date
WO2011098799A2 WO2011098799A2 (fr) 2011-08-18
WO2011098799A3 true WO2011098799A3 (fr) 2015-09-11

Family

ID=42110492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/050224 WO2011098799A2 (fr) 2010-02-10 2011-02-09 Traitement de maladie respiratoire

Country Status (2)

Country Link
GB (1) GB201002224D0 (fr)
WO (1) WO2011098799A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8722710B2 (en) 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
US8969581B2 (en) 2013-03-14 2015-03-03 Deuterx, Llc 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
EP3666273A3 (fr) 2014-01-15 2020-10-28 Poxel SA Procédés de traitement de troubles neurologiques, métaboliques et d'autres troubles utilisant de la pioglitazone enrichie en deutérium énantiopur
CN107249621A (zh) * 2014-09-08 2017-10-13 哥谭生物制药股份有限公司 用于治疗肺结节病的粘液溶解剂
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007109088A2 (fr) * 2006-03-16 2007-09-27 Metabolic Solutions Development Company Therapies d'association d'analogues de la thiazolidinedione
WO2010015818A1 (fr) * 2008-08-07 2010-02-11 Argenta Discovery Limited Traitement de maladie respiratoire
WO2010150014A1 (fr) * 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited Glitazones 5r-5–deutérés pour le traitement de maladies respiratoires

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GB201002224D0 (en) 2010-03-31
WO2011098799A2 (fr) 2011-08-18

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