WO2011070459A1 - Procédé de fabrication d'acides 8-aryloctanoïques énantiomériquement purs tels que l'aliskiren - Google Patents

Procédé de fabrication d'acides 8-aryloctanoïques énantiomériquement purs tels que l'aliskiren Download PDF

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Publication number
WO2011070459A1
WO2011070459A1 PCT/IB2010/055185 IB2010055185W WO2011070459A1 WO 2011070459 A1 WO2011070459 A1 WO 2011070459A1 IB 2010055185 W IB2010055185 W IB 2010055185W WO 2011070459 A1 WO2011070459 A1 WO 2011070459A1
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WO
WIPO (PCT)
Prior art keywords
compound
formula
alkyl
alkylaryl
arylalkyl
Prior art date
Application number
PCT/IB2010/055185
Other languages
English (en)
Inventor
Milan Soukup
Original Assignee
CarboDesign LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CarboDesign LLC filed Critical CarboDesign LLC
Publication of WO2011070459A1 publication Critical patent/WO2011070459A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention porte sur un nouveau procédé de fabrication et de nouveaux intermédiaires utiles dans la synthèse de composés pharmaceutiquement actifs, en particulier d'inhibiteurs de la rénine, tels que l'aliskiren. L'invention porte sur une préparation d'acides 8-aryloctanoïques énantiomériquement purs représentés par la formule générale (I) à partir d'un intermédiaire clé aisément disponible, un cis-diacide chiral de formule (II), d'aziridine de formule (XI) et d'un composé monocyclique de formule (III). Formule (I) Formule (II) Formule (III) Formule (XI).
PCT/IB2010/055185 2009-12-07 2010-11-16 Procédé de fabrication d'acides 8-aryloctanoïques énantiomériquement purs tels que l'aliskiren WO2011070459A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28361609P 2009-12-07 2009-12-07
US61/283,616 2009-12-07

Publications (1)

Publication Number Publication Date
WO2011070459A1 true WO2011070459A1 (fr) 2011-06-16

Family

ID=44082656

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/055185 WO2011070459A1 (fr) 2009-12-07 2010-11-16 Procédé de fabrication d'acides 8-aryloctanoïques énantiomériquement purs tels que l'aliskiren

Country Status (2)

Country Link
US (1) US20110137047A1 (fr)
WO (1) WO2011070459A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20131170A1 (it) * 2013-07-11 2015-01-12 Zach System Spa Processo di preparazione di acidi 8-arilottanoici

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2551260A1 (fr) * 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Procédé chimique pour l'ouverture de composés cycliques
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007045420A2 (fr) * 2005-10-17 2007-04-26 Novartis Ag Composes organiques
WO2008155338A2 (fr) * 2007-06-19 2008-12-24 Novartis Ag Composés organiques
US20090221848A1 (en) * 2005-10-28 2009-09-03 Reuter Chemischer Apparatebau Kg Process for preparing octenoic acid derivatives
EP2189442A1 (fr) * 2008-11-20 2010-05-26 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé et intermédiaires pour la préparation d'aliskiren

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007045420A2 (fr) * 2005-10-17 2007-04-26 Novartis Ag Composes organiques
US20090221848A1 (en) * 2005-10-28 2009-09-03 Reuter Chemischer Apparatebau Kg Process for preparing octenoic acid derivatives
WO2008155338A2 (fr) * 2007-06-19 2008-12-24 Novartis Ag Composés organiques
EP2189442A1 (fr) * 2008-11-20 2010-05-26 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé et intermédiaires pour la préparation d'aliskiren

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20131170A1 (it) * 2013-07-11 2015-01-12 Zach System Spa Processo di preparazione di acidi 8-arilottanoici
WO2015003988A1 (fr) * 2013-07-11 2015-01-15 Zach System S.P.A. Procédé de préparation d'acides 8-aryloctanoïques

Also Published As

Publication number Publication date
US20110137047A1 (en) 2011-06-09

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