WO2011052940A3 - 클로피도그랠 황산수소염 ⅰ형 제조방법 - Google Patents

클로피도그랠 황산수소염 ⅰ형 제조방법 Download PDF

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Publication number
WO2011052940A3
WO2011052940A3 PCT/KR2010/007321 KR2010007321W WO2011052940A3 WO 2011052940 A3 WO2011052940 A3 WO 2011052940A3 KR 2010007321 W KR2010007321 W KR 2010007321W WO 2011052940 A3 WO2011052940 A3 WO 2011052940A3
Authority
WO
WIPO (PCT)
Prior art keywords
clopidogrel hydrogensulfate
hydrogensulfate form
preparing clopidogrel
preparing
particle size
Prior art date
Application number
PCT/KR2010/007321
Other languages
English (en)
French (fr)
Other versions
WO2011052940A2 (ko
Inventor
김문성
유무희
김용직
최준호
성시영
임홍규
차대원
손병화
류기문
Original Assignee
동아제약주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 동아제약주식회사 filed Critical 동아제약주식회사
Publication of WO2011052940A2 publication Critical patent/WO2011052940A2/ko
Publication of WO2011052940A3 publication Critical patent/WO2011052940A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 큰 입자 크기를 가지며 0.1%이하의 불순물을 함유하는 클로피도그랠 황산수소염 I형의 제조방법 및 이에 의해 제조되는 클로피도그랠 황산수소염 I형에 관한 것이다. 본 발명에 따른 제조방법에 의해서 클로피도그랠 황산수소염 Ⅰ형은 약제학적으로 유용한 입자 크기와 균일한 구형의 입자형태를 가질 수 있도록 제조되며, 불순물을 0.1%이하로 함유되도록 제조될 수 있다.
PCT/KR2010/007321 2009-10-29 2010-10-25 클로피도그랠 황산수소염 ⅰ형 제조방법 WO2011052940A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0103823 2009-10-29
KR1020090103823A KR101130445B1 (ko) 2009-10-29 2009-10-29 클로피도그랠 황산수소염 ⅰ형 제조방법

Publications (2)

Publication Number Publication Date
WO2011052940A2 WO2011052940A2 (ko) 2011-05-05
WO2011052940A3 true WO2011052940A3 (ko) 2011-10-20

Family

ID=43922784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/007321 WO2011052940A2 (ko) 2009-10-29 2010-10-25 클로피도그랠 황산수소염 ⅰ형 제조방법

Country Status (2)

Country Link
KR (1) KR101130445B1 (ko)
WO (1) WO2011052940A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101324862B1 (ko) * 2011-07-12 2013-11-01 (주)에이에스텍 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법
CN104817571B (zh) * 2014-12-31 2016-04-20 天津大学 一种制备球形硫酸氢氯吡格雷i晶型的方法
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN105061459B (zh) * 2015-07-21 2016-08-24 深圳信立泰药业股份有限公司 一种硫酸氢氯吡格雷i晶型球形结晶的制备方法
CN114369100B (zh) * 2021-12-15 2023-06-20 浙江车头制药股份有限公司 一种硫酸氢氯吡格雷球形晶型i的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040066917A (ko) * 2001-12-18 2004-07-27 테바 파마슈티컬 인더스트리즈 리미티드 클로피도그렐 황산수소염의 다형
KR20050058492A (ko) * 2002-08-27 2005-06-16 젠티바, 에이.에스. 클로피도그렐 황산수소염의 결정질 형태 1의 제조 방법
KR100511238B1 (ko) * 1998-06-15 2005-08-31 사노피-아벤티스 클로피도그렐 황산수소염의 다형체 형태
KR20090086903A (ko) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 개선된 클로피도그렐의 제조 방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100511238B1 (ko) * 1998-06-15 2005-08-31 사노피-아벤티스 클로피도그렐 황산수소염의 다형체 형태
KR20040066917A (ko) * 2001-12-18 2004-07-27 테바 파마슈티컬 인더스트리즈 리미티드 클로피도그렐 황산수소염의 다형
KR20050058492A (ko) * 2002-08-27 2005-06-16 젠티바, 에이.에스. 클로피도그렐 황산수소염의 결정질 형태 1의 제조 방법
KR20090086903A (ko) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 개선된 클로피도그렐의 제조 방법

Also Published As

Publication number Publication date
WO2011052940A2 (ko) 2011-05-05
KR101130445B1 (ko) 2012-03-27
KR20110047068A (ko) 2011-05-06

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