WO2011051957A3 - A process for the preparation of donepezil hydrochloride - Google Patents

A process for the preparation of donepezil hydrochloride Download PDF

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Publication number
WO2011051957A3
WO2011051957A3 PCT/IN2009/000615 IN2009000615W WO2011051957A3 WO 2011051957 A3 WO2011051957 A3 WO 2011051957A3 IN 2009000615 W IN2009000615 W IN 2009000615W WO 2011051957 A3 WO2011051957 A3 WO 2011051957A3
Authority
WO
WIPO (PCT)
Prior art keywords
donepezil hydrochloride
preparation
dimethoxyindanone
benzyl
methylpiperidine
Prior art date
Application number
PCT/IN2009/000615
Other languages
French (fr)
Other versions
WO2011051957A2 (en
Inventor
Arul Ramakrishnan
Guruswamy Batthini
Original Assignee
Neuland Laboratories Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuland Laboratories Ltd. filed Critical Neuland Laboratories Ltd.
Priority to PCT/IN2009/000615 priority Critical patent/WO2011051957A2/en
Publication of WO2011051957A2 publication Critical patent/WO2011051957A2/en
Publication of WO2011051957A3 publication Critical patent/WO2011051957A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Abstract

The present invention is directed to an improved industrially viable, cost effective process for manufacturing 1 -benzyl-4-(5,6,-dimethoxyindanone-2-yl)methylpiperidine hydrochloride commonly known as donepezil hydrochloride in a substantially pure form with a purity level of greater than 99.9% and a novel crystalline form of 1- benzyl-4-(5,6,-dimethoxyindanone-2-yI)methylpiperidine in a substantially pure form.
PCT/IN2009/000615 2009-10-30 2009-10-30 A process for the preparation of donepezil hydrochloride WO2011051957A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IN2009/000615 WO2011051957A2 (en) 2009-10-30 2009-10-30 A process for the preparation of donepezil hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2009/000615 WO2011051957A2 (en) 2009-10-30 2009-10-30 A process for the preparation of donepezil hydrochloride

Publications (2)

Publication Number Publication Date
WO2011051957A2 WO2011051957A2 (en) 2011-05-05
WO2011051957A3 true WO2011051957A3 (en) 2012-10-04

Family

ID=43922721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000615 WO2011051957A2 (en) 2009-10-30 2009-10-30 A process for the preparation of donepezil hydrochloride

Country Status (1)

Country Link
WO (1) WO2011051957A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109503482B (en) * 2017-09-14 2023-04-25 上海华升生物科技有限公司 Preparation method of varenicline key intermediate
WO2022091141A1 (en) * 2020-10-30 2022-05-05 Vihita Chem Private Limited An improved process of donepezil hydochloride

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004016589A2 (en) * 2002-08-14 2004-02-26 Finetech Laboratories Ltd. Process for production of highly pure donepezil hydrochloride
WO2007057226A2 (en) * 2005-11-18 2007-05-24 Synthon B.V. Process for making donepezil
WO2008010235A2 (en) * 2006-07-19 2008-01-24 Torrent Pharmaceuticals Limited An improved process for the preparation of donepezil
EP1939178A1 (en) * 2005-10-14 2008-07-02 Eisai R&D Management Co., Ltd. Process for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine or hydrochloride thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004016589A2 (en) * 2002-08-14 2004-02-26 Finetech Laboratories Ltd. Process for production of highly pure donepezil hydrochloride
EP1939178A1 (en) * 2005-10-14 2008-07-02 Eisai R&D Management Co., Ltd. Process for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine or hydrochloride thereof
WO2007057226A2 (en) * 2005-11-18 2007-05-24 Synthon B.V. Process for making donepezil
WO2008010235A2 (en) * 2006-07-19 2008-01-24 Torrent Pharmaceuticals Limited An improved process for the preparation of donepezil

Also Published As

Publication number Publication date
WO2011051957A2 (en) 2011-05-05

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