WO2009084030A3 - Improved process for the preparation of (1-benzyl-4-(5,6,- dimethoxyind anone-2-yl)methylpiperidine) hydrochloride-form iii - Google Patents

Improved process for the preparation of (1-benzyl-4-(5,6,- dimethoxyind anone-2-yl)methylpiperidine) hydrochloride-form iii Download PDF

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Publication number
WO2009084030A3
WO2009084030A3 PCT/IN2008/000805 IN2008000805W WO2009084030A3 WO 2009084030 A3 WO2009084030 A3 WO 2009084030A3 IN 2008000805 W IN2008000805 W IN 2008000805W WO 2009084030 A3 WO2009084030 A3 WO 2009084030A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrochloride
methylpiperidine
benzyl
form iii
dimethoxyind
Prior art date
Application number
PCT/IN2008/000805
Other languages
French (fr)
Other versions
WO2009084030A2 (en
Inventor
Arul Ramakrishnan
Guruswamy Bathani
Haribabu Bandari
Ravi Shankar Gopu
Original Assignee
Neuland Laboratories Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuland Laboratories Ltd. filed Critical Neuland Laboratories Ltd.
Publication of WO2009084030A2 publication Critical patent/WO2009084030A2/en
Publication of WO2009084030A3 publication Critical patent/WO2009084030A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Abstract

The present invention is directed to an improved industrially viable, cost effective process for manufacturing pure racemic crystalline anhydrous form of (1-benzyl-4-(5,6,- dimethoxyindanone-2yl)methylpiperidine) hydrochloride Form III commonly known as Donepezil hydrochloride with a purity level of greater than 99.9%.
PCT/IN2008/000805 2007-12-03 2008-12-02 Improved process for the preparation of (1-benzyl-4-(5,6,- dimethoxyind anone-2-yl)methylpiperidine) hydrochloride-form iii WO2009084030A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2863CH2007 2007-12-03
IN2863/CHE/2007 2007-12-03

Publications (2)

Publication Number Publication Date
WO2009084030A2 WO2009084030A2 (en) 2009-07-09
WO2009084030A3 true WO2009084030A3 (en) 2011-03-17

Family

ID=40824845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000805 WO2009084030A2 (en) 2007-12-03 2008-12-02 Improved process for the preparation of (1-benzyl-4-(5,6,- dimethoxyind anone-2-yl)methylpiperidine) hydrochloride-form iii

Country Status (1)

Country Link
WO (1) WO2009084030A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7994328B2 (en) 2006-02-16 2011-08-09 Aurobindo Pharma Ltd. Process for the preparation of donepezil hydrochloride
WO2011061591A1 (en) 2009-11-18 2011-05-26 Jubilant Life Sciences Limited Improved process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanone)-2-yl)methyl piperidine hydrochloride form-iii

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046526A1 (en) * 1996-06-07 1997-12-11 Eisai Co., Ltd. Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
EP1323712A1 (en) * 2000-09-25 2003-07-02 Eisai Co., Ltd. Process for producing multiform crystal of donepezil hydrochloride

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046526A1 (en) * 1996-06-07 1997-12-11 Eisai Co., Ltd. Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
EP1323712A1 (en) * 2000-09-25 2003-07-02 Eisai Co., Ltd. Process for producing multiform crystal of donepezil hydrochloride

Also Published As

Publication number Publication date
WO2009084030A2 (en) 2009-07-09

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