WO2007054969A3 - Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride - Google Patents

Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride Download PDF

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Publication number
WO2007054969A3
WO2007054969A3 PCT/IN2006/000376 IN2006000376W WO2007054969A3 WO 2007054969 A3 WO2007054969 A3 WO 2007054969A3 IN 2006000376 W IN2006000376 W IN 2006000376W WO 2007054969 A3 WO2007054969 A3 WO 2007054969A3
Authority
WO
WIPO (PCT)
Prior art keywords
lercanidipine
preparation
amorphous form
hydrochloride
lercanidipine hydrochloride
Prior art date
Application number
PCT/IN2006/000376
Other languages
French (fr)
Other versions
WO2007054969A2 (en
Inventor
V V Shrinivas Rao A
Original Assignee
Torrent Pharmaceuticals Ltd
V V Shrinivas Rao A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd, V V Shrinivas Rao A filed Critical Torrent Pharmaceuticals Ltd
Priority to EP06842760A priority Critical patent/EP1963254A2/en
Publication of WO2007054969A2 publication Critical patent/WO2007054969A2/en
Publication of WO2007054969A3 publication Critical patent/WO2007054969A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to new, improved and industrially viable process for the preparation of Lercanidipine or its pharmaceutically acceptable salts using novel derivatives of 2,N-dimethyl-N-(3,3-diphenylpropyl)-l -amino compounds and novel polymorphs of Lercanidipine hydrochloride, its process of preparation.
PCT/IN2006/000376 2005-09-21 2006-09-19 Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride WO2007054969A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06842760A EP1963254A2 (en) 2005-09-21 2006-09-19 Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1164/MUM/2005 2005-09-21
IN1164MU2005 2005-09-21
IN1593/MUM/2005 2005-12-19
IN1593MU2005 2005-12-19

Publications (2)

Publication Number Publication Date
WO2007054969A2 WO2007054969A2 (en) 2007-05-18
WO2007054969A3 true WO2007054969A3 (en) 2007-11-01

Family

ID=38023682

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000376 WO2007054969A2 (en) 2005-09-21 2006-09-19 Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride

Country Status (2)

Country Link
EP (1) EP1963254A2 (en)
WO (1) WO2007054969A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR052918A1 (en) 2005-02-25 2007-04-11 Recordati Ireland Ltd LERCANIDIPINE AMORFO CHLORHYDRATE
DK2164349T3 (en) 2006-08-04 2014-12-15 Shs Int Ltd protein-FORMULA
KR100928995B1 (en) * 2007-10-31 2009-11-26 (주)에이에스텍 Amorphous anhydrous lercanidipine and its improved preparation
CN102686594A (en) 2009-12-16 2012-09-19 熙德隆研究基金会 Polymorphs of darunavir
EP2571355B1 (en) 2010-05-20 2016-09-07 Hetero Research Foundation Crystalline hydrochloride salt of darunavir
EP2444394A1 (en) * 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Process for the preparation of amorphous form of lercanidipine HCI

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153016A2 (en) * 1984-02-14 1985-08-28 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153016A2 (en) * 1984-02-14 1985-08-28 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEONARDI A ET AL: "Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 33, no. 5, June 1998 (1998-06-01), pages 399 - 420, XP004127371, ISSN: 0223-5234 *

Also Published As

Publication number Publication date
WO2007054969A2 (en) 2007-05-18
EP1963254A2 (en) 2008-09-03

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