WO2007054969A3 - Procede atypique de preparation de lercanidipine - Google Patents

Procede atypique de preparation de lercanidipine Download PDF

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Publication number
WO2007054969A3
WO2007054969A3 PCT/IN2006/000376 IN2006000376W WO2007054969A3 WO 2007054969 A3 WO2007054969 A3 WO 2007054969A3 IN 2006000376 W IN2006000376 W IN 2006000376W WO 2007054969 A3 WO2007054969 A3 WO 2007054969A3
Authority
WO
WIPO (PCT)
Prior art keywords
lercanidipine
preparation
amorphous form
hydrochloride
lercanidipine hydrochloride
Prior art date
Application number
PCT/IN2006/000376
Other languages
English (en)
Other versions
WO2007054969A2 (fr
Inventor
V V Shrinivas Rao A
Original Assignee
Torrent Pharmaceuticals Ltd
V V Shrinivas Rao A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd, V V Shrinivas Rao A filed Critical Torrent Pharmaceuticals Ltd
Priority to EP06842760A priority Critical patent/EP1963254A2/fr
Publication of WO2007054969A2 publication Critical patent/WO2007054969A2/fr
Publication of WO2007054969A3 publication Critical patent/WO2007054969A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un nouveau procédé amélioré et industriellement viable de préparation de Lercanidipine ou ses sels pharmaceutiquement acceptables utilisant des dérivés atypiques de composés de 2,N-diméthyle-N-(3,3-diphénylpropyle)-l -amino et des polymorphes atypiques de chlorhydrate de Lercanidipine et son procédé de préparation.
PCT/IN2006/000376 2005-09-21 2006-09-19 Procede atypique de preparation de lercanidipine WO2007054969A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06842760A EP1963254A2 (fr) 2005-09-21 2006-09-19 Procede de preparation de la lercanidipine et forme amorphe d'hydrochlorure de lercanidipine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1164MU2005 2005-09-21
IN1164/MUM/2005 2005-09-21
IN1593MU2005 2005-12-19
IN1593/MUM/2005 2005-12-19

Publications (2)

Publication Number Publication Date
WO2007054969A2 WO2007054969A2 (fr) 2007-05-18
WO2007054969A3 true WO2007054969A3 (fr) 2007-11-01

Family

ID=38023682

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000376 WO2007054969A2 (fr) 2005-09-21 2006-09-19 Procede atypique de preparation de lercanidipine

Country Status (2)

Country Link
EP (1) EP1963254A2 (fr)
WO (1) WO2007054969A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
AU2007280272A1 (en) 2006-08-04 2008-02-07 Shs International Ltd Protein free formula
KR100928995B1 (ko) * 2007-10-31 2009-11-26 (주)에이에스텍 무정형 무수 염산 레르카니디핀 및 그것의 개선된 제조방법
PT2513116E (pt) * 2009-12-16 2015-10-14 Hetero Research Foundation Polimorfos de darunavir
WO2011145099A1 (fr) 2010-05-20 2011-11-24 Hetero Research Foundation Sel de chlorhydrate cristallin de darunavir
EP2444394A1 (fr) * 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Procédé de préparation de forme amorphe de lercanidipine HCI

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153016A2 (fr) * 1984-02-14 1985-08-28 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Diesters asymétriques d'acide 1,4-dihydro-2,6-diméthyl-pyridine-3,5-dicarboxylique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153016A2 (fr) * 1984-02-14 1985-08-28 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Diesters asymétriques d'acide 1,4-dihydro-2,6-diméthyl-pyridine-3,5-dicarboxylique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEONARDI A ET AL: "Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 33, no. 5, June 1998 (1998-06-01), pages 399 - 420, XP004127371, ISSN: 0223-5234 *

Also Published As

Publication number Publication date
WO2007054969A2 (fr) 2007-05-18
EP1963254A2 (fr) 2008-09-03

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