WO2011030351A3 - Compositions pharmaceutiques au goût masqué - Google Patents
Compositions pharmaceutiques au goût masqué Download PDFInfo
- Publication number
- WO2011030351A3 WO2011030351A3 PCT/IN2010/000589 IN2010000589W WO2011030351A3 WO 2011030351 A3 WO2011030351 A3 WO 2011030351A3 IN 2010000589 W IN2010000589 W IN 2010000589W WO 2011030351 A3 WO2011030351 A3 WO 2011030351A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- taste
- tablets
- pde
- pharmaceutical compositions
- inhibitor
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Abstract
La présente invention concerne des compositions pharmaceutiques au goût masqué comprenant des inhibiteurs de phosphodiestérase-5 (PDE-5). Lesdites compositions pharmaceutiques au goût masqué pour administration orale comprennent au moins un inhibiteur de PDE-5, au moins un agent masqueur de goût, et au moins un excipient pharmaceutiquement acceptable. En outre, les compositions d'inhibiteur de PDE-5 au goût masqué sont fournies sous la forme de formulations au goût agréable adaptées à une administration orale, telle que des comprimés à désintégration orale, des comprimés à dispersion rapide, des comprimés croquables, des comprimés dispersibles, et des comprimés effervescents ou analogues. L'invention porte en outre sur un procédé de masquage du goût désagréable de l'inhibiteur de PDE-5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2021MU2009 | 2009-09-03 | ||
IN2021/MUM/2009 | 2009-09-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011030351A2 WO2011030351A2 (fr) | 2011-03-17 |
WO2011030351A3 true WO2011030351A3 (fr) | 2011-06-30 |
Family
ID=43567799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2010/000589 WO2011030351A2 (fr) | 2009-09-03 | 2010-09-03 | Compositions pharmaceutiques au goût masqué |
Country Status (1)
Country | Link |
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WO (1) | WO2011030351A2 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20130058160A (ko) * | 2011-11-25 | 2013-06-04 | 한국유나이티드제약 주식회사 | 쓴맛이 차폐된 실데나필 시트레이트의 저작정 및 이의 제조방법 |
MX366768B (es) * | 2011-12-08 | 2019-07-17 | Laboratorios Liomont S A De C V | Tableta orodispersable de sildenafil y metodo para preparar la misma. |
WO2013085276A1 (fr) * | 2011-12-08 | 2013-06-13 | 에스케이케미칼 주식회사 | Film pour administration orale contenant du mirodénafil ou l'un de ses sels pharmaceutiquement acceptables |
WO2014092661A1 (fr) * | 2012-01-18 | 2014-06-19 | Mahmut Bilgic | Formulations particulaires de tadalafil sous forme effervescente |
WO2013109221A1 (fr) * | 2012-01-18 | 2013-07-25 | Mahmut Bilgic | Nouvelles formulations effervescentes comprenant une composition édulcorante |
EP2641477B2 (fr) | 2012-03-19 | 2022-06-08 | Symrise AG | Compositions de matière |
EP2867199B1 (fr) * | 2012-07-02 | 2018-04-18 | Hetero Research Foundation | Compositions stables de fésotérodine |
CN102727456B (zh) * | 2012-07-03 | 2016-06-22 | 北京科信必成医药科技发展有限公司 | 药物口腔崩解片及其制备方法 |
CN102727455B (zh) * | 2012-07-03 | 2016-06-29 | 北京科信必成医药科技发展有限公司 | 一种他达那非口腔崩解片及其制备方法 |
KR101953735B1 (ko) * | 2012-12-14 | 2019-03-04 | 한미약품 주식회사 | 포스포다이에스터라제-5 억제제를 포함하는 츄정 |
US20140271847A1 (en) * | 2013-03-13 | 2014-09-18 | SatisPharma, LLC | Formulations and methods for rapid penile erections |
WO2014148883A1 (fr) * | 2013-03-20 | 2014-09-25 | Natureceuticals Sdn Bhd | Formulations d'herbes médicinales |
CN104352461B (zh) * | 2013-04-28 | 2017-07-14 | 南京海融医药科技股份有限公司 | 他达拉非的口服药物制剂 |
CN103271885A (zh) * | 2013-05-23 | 2013-09-04 | 浙江华海药业股份有限公司 | 他达拉非口腔崩解片及其制备方法 |
EP3003285B1 (fr) * | 2013-06-03 | 2022-02-16 | McNeil AB | Forme dosifiée pharmaceutique solide de libération d'au moins deux principes pharmaceutiques actifs dans la cavité buccale |
KR102239291B1 (ko) * | 2013-06-28 | 2021-04-14 | 한미약품 주식회사 | 타다라필 또는 이의 약학적으로 허용가능한 염을 포함하는 저작정 제제 |
CN104644574B (zh) * | 2013-11-18 | 2017-08-01 | 深圳海王医药科技研究院有限公司 | 一种枸橼酸西地那非掩味制剂 |
EP3082428A4 (fr) * | 2013-12-09 | 2017-08-02 | Respira Therapeutics, Inc. | Formulations en poudre d'inhibiteur pde5 et procédés y associés |
KR101485177B1 (ko) * | 2014-02-10 | 2015-01-23 | 한국유나이티드제약 주식회사 | 쓴맛이 차폐된 실데나필 시트레이트의 저작정 및 그 제조방법 |
CN105213333A (zh) * | 2014-06-30 | 2016-01-06 | 深圳海王药业有限公司 | 一种他达拉非药物组合物及其制备方法 |
KR101561406B1 (ko) * | 2015-02-02 | 2015-10-16 | 환인제약 주식회사 | 두타스테라이드 함유 고체 분산체 및 이를 포함하는 조성물 |
TN2017000507A1 (en) | 2015-07-07 | 2019-04-12 | H Lundbeck As | Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
US10342886B2 (en) | 2016-01-26 | 2019-07-09 | S.C. Johnson & Son, Inc. | Extruded wax melt and method of producing same |
US10010638B2 (en) | 2016-06-14 | 2018-07-03 | S. C. Johnson & Son, Inc. | Wax melt with filler |
MX2019006938A (es) | 2016-12-14 | 2019-09-06 | Respira Therapeutics Inc | Metodos y composiciones para trataminto de hipertension pulmonar y otros trastornos del pulmon. |
CN107694476B (zh) * | 2017-07-25 | 2020-07-10 | 江苏远鸿新材料科技有限公司 | 一种高强度球型干燥剂的成型制造方法 |
WO2019081451A1 (fr) * | 2017-10-26 | 2019-05-02 | Mw Encap Limited | Formulations remplies liquides d'inhibiteurs de pde5 |
IT201800003507A1 (it) * | 2018-03-13 | 2019-09-13 | Fulton Medicinali S P A | Compressa sublinguale comprendente sildenafil citrato |
JP2021535908A (ja) * | 2018-08-31 | 2021-12-23 | イマラ インク. | 鎌状赤血球症を処置するためのpde9阻害剤 |
CN111110683B (zh) * | 2018-10-31 | 2023-08-15 | 广东东阳光药业股份有限公司 | 一种索利那新掩味组合物及其制备方法 |
CA3137260A1 (fr) * | 2019-04-18 | 2020-10-22 | Ellamed Ip & Services Pte. Ltd. | Compositions liquides de citrate de sildenafil |
KR102249155B1 (ko) * | 2019-07-26 | 2021-05-07 | 주식회사 코아팜바이오 | 유데나필을 함유하는 약제학적 조성물 |
WO2022216294A1 (fr) | 2021-04-09 | 2022-10-13 | Auson Pharmaceuticals Inc. | Poudre pour suspension orale contenant du tadalafil |
CN114957332A (zh) * | 2022-05-30 | 2022-08-30 | 苏州正永生物医药有限公司 | 一种阿伐那非磷酸酯类化合物及其制备方法和应用 |
EP4316468A1 (fr) * | 2022-08-03 | 2024-02-07 | Recordati Industria Chimica E Farmaceutica SPA | Complexation innovante d'extrait de serenoa lipido-stérol avec du tadalafil |
CN115990140A (zh) * | 2023-02-15 | 2023-04-21 | 北京悦康科创医药科技股份有限公司 | 一种那非类化合物冻干片及其制备方法 |
CN117243927A (zh) * | 2023-10-17 | 2023-12-19 | 深圳市泰力生物医药有限公司 | 含安全有效掩味剂的盐酸卡利拉嗪口溶膜制剂及其制备方法 |
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WO2004017976A1 (fr) * | 2002-08-21 | 2004-03-04 | Phoqus Pharmaceuticals Limited, | Forme psologique orale a gout masque, a dissolution rapide et comprenant du sildenafil |
WO2004087111A1 (fr) * | 2003-04-04 | 2004-10-14 | Ranbaxy Laboratories Limited | Compositions pharmaceutiques orales a gout masque |
WO2006047493A2 (fr) * | 2004-10-21 | 2006-05-04 | Eurand Pharmaceuticals Limited | Compositions pharmaceutiques a saveur masquee avec substances porogenes gastrosolubles |
US20060127479A1 (en) * | 2004-10-08 | 2006-06-15 | Natrajan Kumaraperumal | Solvent free taste masked pharmaceutical compositions |
WO2009074995A1 (fr) * | 2007-12-10 | 2009-06-18 | Ajanta Pharma Limited | Compositions à croquer de citrate de sildénafil au goût masqué |
Family Cites Families (8)
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GT199900061A (es) | 1998-05-15 | 2000-10-14 | Pfizer | Formulaciones farmaceuticas. |
KR20060093355A (ko) | 1999-08-03 | 2006-08-24 | 릴리 아이코스 엘엘씨 | 베타-카르볼린 약학 조성물 |
CA2599378A1 (fr) | 2005-02-25 | 2006-08-31 | Teva Pharmaceutical Industries Ltd. | Tadalafil possedant des dimensions importantes des particules et procede de fabrication correspondant |
CA2612917A1 (fr) | 2005-06-23 | 2007-01-04 | Schering Corporation | Formulations orales a absorption rapide d'inhibiteurs de la pde5 |
ES2308750T3 (es) | 2005-08-29 | 2008-12-01 | Teva Pharmaceutical Industries Ltd | Tadalafil en particulas solidas que presenta una distribucion de particulas bimodal. |
CA2622200A1 (fr) | 2005-09-13 | 2007-03-22 | Elan Pharma International, Limited | Formulations nanoparticulaires de tadalafil |
AU2007232098A1 (en) | 2006-03-31 | 2007-10-11 | Rubicon Research Private Limited | Directly compressible composite for orally disintegrating tablets |
WO2008005039A1 (fr) | 2006-07-07 | 2008-01-10 | Teva Pharmaceutical Industries Ltd. | Compositions solides comprenant du tadalafil et au moins un véhicule |
-
2010
- 2010-09-03 WO PCT/IN2010/000589 patent/WO2011030351A2/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004017976A1 (fr) * | 2002-08-21 | 2004-03-04 | Phoqus Pharmaceuticals Limited, | Forme psologique orale a gout masque, a dissolution rapide et comprenant du sildenafil |
WO2004087111A1 (fr) * | 2003-04-04 | 2004-10-14 | Ranbaxy Laboratories Limited | Compositions pharmaceutiques orales a gout masque |
US20060127479A1 (en) * | 2004-10-08 | 2006-06-15 | Natrajan Kumaraperumal | Solvent free taste masked pharmaceutical compositions |
WO2006047493A2 (fr) * | 2004-10-21 | 2006-05-04 | Eurand Pharmaceuticals Limited | Compositions pharmaceutiques a saveur masquee avec substances porogenes gastrosolubles |
US20060105039A1 (en) * | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
WO2009074995A1 (fr) * | 2007-12-10 | 2009-06-18 | Ajanta Pharma Limited | Compositions à croquer de citrate de sildénafil au goût masqué |
Also Published As
Publication number | Publication date |
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WO2011030351A2 (fr) | 2011-03-17 |
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