WO2011028781A1 - Methods of treating poxviral infections - Google Patents
Methods of treating poxviral infections Download PDFInfo
- Publication number
- WO2011028781A1 WO2011028781A1 PCT/US2010/047498 US2010047498W WO2011028781A1 WO 2011028781 A1 WO2011028781 A1 WO 2011028781A1 US 2010047498 W US2010047498 W US 2010047498W WO 2011028781 A1 WO2011028781 A1 WO 2011028781A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substituted
- unsubstituted
- groups
- virus
- alkyl group
- Prior art date
Links
- 0 CC1(C*)N(*)CCCCCCC1 Chemical compound CC1(C*)N(*)CCCCCCC1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
- C07D307/48—Furfural
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2772807A CA2772807A1 (en) | 2009-09-04 | 2010-09-01 | Methods of treating poxviral infections |
CN201080048401.4A CN102625801B (zh) | 2009-09-04 | 2010-09-01 | 治疗痘病毒感染的方法 |
KR1020127007710A KR101459530B1 (ko) | 2009-09-04 | 2010-09-01 | 폭스바이러스 감염의 치료 방법 |
ES10814414.8T ES2485623T3 (es) | 2009-09-04 | 2010-09-01 | Procedimiento para el tratamiento de infecciones por poxvirus |
JP2012528005A JP5575246B2 (ja) | 2009-09-04 | 2010-09-01 | ポックスウイルス感染の治療方法 |
EP10814414.8A EP2473493B1 (en) | 2009-09-04 | 2010-09-01 | Methods of treating poxviral infections |
HK13100313.5A HK1173723A1 (en) | 2009-09-04 | 2013-01-09 | Methods of treatlng poxviral infections |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27225209P | 2009-09-04 | 2009-09-04 | |
US61/272,252 | 2009-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011028781A1 true WO2011028781A1 (en) | 2011-03-10 |
Family
ID=43649619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/047498 WO2011028781A1 (en) | 2009-09-04 | 2010-09-01 | Methods of treating poxviral infections |
Country Status (9)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015039010A2 (en) | 2013-09-16 | 2015-03-19 | Unither Virology, Llc | Deoxynojirimycin derivatives and methods of their using |
EP2968300A4 (en) * | 2013-03-15 | 2016-09-28 | Unither Virology Llc | ANTIBACTERIAL COMPOUNDS |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102655746B (zh) | 2009-02-23 | 2016-08-03 | 联合治疗公司 | 亚氨基糖以及治疗病毒性疾病的方法 |
CA2875975A1 (en) | 2012-06-06 | 2013-12-12 | Unither Virology, Llc | Novel iminosugars and their applications |
BR112017008898B1 (pt) | 2014-11-05 | 2022-11-29 | Emergent Virology Llc | Compostos de iminoaçúcares, suas composições farmacêuticas e usos dos mesmos para tratar doenças virais |
WO2017201030A1 (en) * | 2016-05-16 | 2017-11-23 | Emergent Virology Llc | Methods of treating viral infection |
US10176965B1 (en) * | 2017-07-05 | 2019-01-08 | ICT Integrated Circuit Testing Gesellschaft für Halbleiterprüftechnik mbH | Aberration-corrected multibeam source, charged particle beam device and method of imaging or illuminating a specimen with an array of primary charged particle beamlets |
Citations (2)
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WO2006124676A1 (en) * | 2005-05-17 | 2006-11-23 | The Interthyr Corporation | Methods and compositions for the treatment of autoimmune and inflammatory diseases associated with toll-like receptors |
US20070275998A1 (en) * | 2006-05-24 | 2007-11-29 | Butters Terry D | Deoxynojirimycin and d-arabinitol analogs and methods of using |
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DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
US5144037A (en) * | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
US5103008A (en) * | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
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US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
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US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
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-
2010
- 2010-09-01 KR KR1020127007710A patent/KR101459530B1/ko not_active IP Right Cessation
- 2010-09-01 CA CA2772807A patent/CA2772807A1/en not_active Abandoned
- 2010-09-01 WO PCT/US2010/047498 patent/WO2011028781A1/en active Application Filing
- 2010-09-01 US US12/873,705 patent/US20110065753A1/en not_active Abandoned
- 2010-09-01 JP JP2012528005A patent/JP5575246B2/ja not_active Expired - Fee Related
- 2010-09-01 ES ES10814414.8T patent/ES2485623T3/es active Active
- 2010-09-01 CN CN201080048401.4A patent/CN102625801B/zh not_active Expired - Fee Related
- 2010-09-01 EP EP10814414.8A patent/EP2473493B1/en not_active Not-in-force
-
2013
- 2013-01-09 HK HK13100313.5A patent/HK1173723A1/xx not_active IP Right Cessation
-
2016
- 2016-05-04 US US15/145,992 patent/US20160243097A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006124676A1 (en) * | 2005-05-17 | 2006-11-23 | The Interthyr Corporation | Methods and compositions for the treatment of autoimmune and inflammatory diseases associated with toll-like receptors |
US20070275998A1 (en) * | 2006-05-24 | 2007-11-29 | Butters Terry D | Deoxynojirimycin and d-arabinitol analogs and methods of using |
Non-Patent Citations (2)
Title |
---|
BUTTERS ET AL.: "Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses", GLYCOBIOLOGY, vol. 15, no. 10, 2005, pages 43R - 52R, XP000812586 * |
See also references of EP2473493A4 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2968300A4 (en) * | 2013-03-15 | 2016-09-28 | Unither Virology Llc | ANTIBACTERIAL COMPOUNDS |
US9623016B2 (en) | 2013-03-15 | 2017-04-18 | Emergent Virology Llc | Antibacterial compounds |
WO2015039010A2 (en) | 2013-09-16 | 2015-03-19 | Unither Virology, Llc | Deoxynojirimycin derivatives and methods of their using |
EP3046558A4 (en) * | 2013-09-16 | 2017-06-07 | Emergent Virology LLC | Deoxynojirimycin derivatives and methods of their using |
US10144727B2 (en) | 2013-09-16 | 2018-12-04 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
Also Published As
Publication number | Publication date |
---|---|
US20160243097A1 (en) | 2016-08-25 |
JP5575246B2 (ja) | 2014-08-20 |
US20110065753A1 (en) | 2011-03-17 |
CN102625801A (zh) | 2012-08-01 |
CN102625801B (zh) | 2015-09-09 |
CA2772807A1 (en) | 2011-03-10 |
EP2473493B1 (en) | 2014-04-30 |
HK1173723A1 (en) | 2013-05-24 |
EP2473493A4 (en) | 2013-01-09 |
ES2485623T3 (es) | 2014-08-13 |
EP2473493A1 (en) | 2012-07-11 |
JP2013503882A (ja) | 2013-02-04 |
KR20120048697A (ko) | 2012-05-15 |
KR101459530B1 (ko) | 2014-11-07 |
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