WO2011025267A3 - 메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 - Google Patents

메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 Download PDF

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Publication number
WO2011025267A3
WO2011025267A3 PCT/KR2010/005709 KR2010005709W WO2011025267A3 WO 2011025267 A3 WO2011025267 A3 WO 2011025267A3 KR 2010005709 W KR2010005709 W KR 2010005709W WO 2011025267 A3 WO2011025267 A3 WO 2011025267A3
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WIPO (PCT)
Prior art keywords
same
metformin
methanesulfonate
pharmaceutical composition
combined formulation
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PCT/KR2010/005709
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English (en)
French (fr)
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WO2011025267A2 (ko
Inventor
김성욱
전성수
민창희
구자성
강민석
김용은
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한올바이오파마주식회사
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Publication of WO2011025267A2 publication Critical patent/WO2011025267A2/ko
Publication of WO2011025267A3 publication Critical patent/WO2011025267A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제를 제공한다. 본 발명의 메트포르민 메탄설폰산염은 우수한 안정성 및 정제의 가공 용이성을 가지며, 독성이 낮고, 우수한 AMPKα의 활성화 작용을 나타내어, 당뇨, 당뇨병, 대사성 증후군, 당뇨병 합병증, 월경불순, 고혈압, 고지혈증, 지방간, 관상동맥질환, 골다공증, 다낭성 난소증후군, 암, 근육통, 근육세포 독성증, 횡문근융해증 및/또는 폐경기증후군 등에 효과적이다.
PCT/KR2010/005709 2009-08-25 2010-08-25 메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 WO2011025267A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0078549 2009-08-25
KR20090078549 2009-08-25

Publications (2)

Publication Number Publication Date
WO2011025267A2 WO2011025267A2 (ko) 2011-03-03
WO2011025267A3 true WO2011025267A3 (ko) 2011-07-21

Family

ID=43628601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/005709 WO2011025267A2 (ko) 2009-08-25 2010-08-25 메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제

Country Status (2)

Country Link
KR (2) KR20110021691A (ko)
WO (1) WO2011025267A2 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102886045A (zh) 2005-02-03 2013-01-23 综合医院公司 治疗吉非替尼耐药性癌症的方法
KR101354828B1 (ko) 2005-11-04 2014-02-18 와이어쓰 엘엘씨 ｍＴＯＲ 저해자, 헤르셉틴, 및/또는 ＨＫＩ-272의항신생물성 조합
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
EP3135285B1 (en) 2008-06-17 2018-08-15 Wyeth LLC Antineoplastic combinations containing hki-272 and vinorelbine
EP2326329B1 (en) 2008-08-04 2017-01-11 Wyeth LLC Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
DK3000467T3 (da) 2009-04-06 2023-03-27 Wyeth Llc Behandling med neratinib mod brystkræft
ES2729677T3 (es) 2009-11-09 2019-11-05 Wyeth Llc Esferoides de fármacos recubiertos y sus usos para eliminar o reducir condiciones, como la emesis y la diarrea
KR101432892B1 (ko) * 2012-09-17 2014-08-21 가톨릭대학교 산학협력단 메트포민을 이용한 루프스를 포함하는 면역질환의 예방 또는 치료용 조성물
KR101373097B1 (ko) * 2013-05-07 2014-03-11 재단법인 통합의료진흥원 육미지황탕 추출물을 포함하는 당뇨병 치료용 조성물
CN105330575A (zh) * 2015-10-14 2016-02-17 吉林海格力斯医药生物科技发展有限公司 一种用于治疗放疗、化疗引起的骨髓损伤的化合物
WO2017063155A1 (zh) * 2015-10-14 2017-04-20 吉林海格力斯医药生物科技发展有限公司 一种用于治疗放疗、化疗引起的骨髓损伤的化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005092311A1 (en) * 2004-03-12 2005-10-06 Fournier Laboratories Ireland Limited Use of metformin and orlistat for the treatment or prevention of obesity
KR100774774B1 (ko) * 2006-07-20 2007-11-07 일동제약주식회사 메트포르민 서방성 제제 및 그 제조방법
WO2008112167A1 (en) * 2007-03-09 2008-09-18 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihypertensive agents for the treatment of diabetic hyperglycemia and diabetic complications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005092311A1 (en) * 2004-03-12 2005-10-06 Fournier Laboratories Ireland Limited Use of metformin and orlistat for the treatment or prevention of obesity
KR100774774B1 (ko) * 2006-07-20 2007-11-07 일동제약주식회사 메트포르민 서방성 제제 및 그 제조방법
WO2008112167A1 (en) * 2007-03-09 2008-09-18 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihypertensive agents for the treatment of diabetic hyperglycemia and diabetic complications

Also Published As

Publication number Publication date
KR20110021691A (ko) 2011-03-04
WO2011025267A2 (ko) 2011-03-03
KR20120065308A (ko) 2012-06-20

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