WO2011018909A1 - Dispositif pour administrer une substance - Google Patents

Dispositif pour administrer une substance Download PDF

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Publication number
WO2011018909A1
WO2011018909A1 PCT/JP2010/055313 JP2010055313W WO2011018909A1 WO 2011018909 A1 WO2011018909 A1 WO 2011018909A1 JP 2010055313 W JP2010055313 W JP 2010055313W WO 2011018909 A1 WO2011018909 A1 WO 2011018909A1
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WO
WIPO (PCT)
Prior art keywords
plug
container body
substance
substance supply
supply device
Prior art date
Application number
PCT/JP2010/055313
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English (en)
Japanese (ja)
Inventor
尚哉 宮野
昌一 木村
誠 竹原
岫一 素木
光功 島田
Original Assignee
深江化成株式会社
日機装株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深江化成株式会社, 日機装株式会社 filed Critical 深江化成株式会社
Publication of WO2011018909A1 publication Critical patent/WO2011018909A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen

Definitions

  • the present invention relates to a substance supply device that is attached to the skin of a living body and supplies a substance such as a drug percutaneously, and relates to a substance supply apparatus that supplies a substance by inserting a fine needle into the skin.
  • this substance supply apparatus is manufactured using a semiconductor or a metal as a material.
  • the tip of the needle is a sphere, it can be freely designed with a diameter of several ⁇ m or less and a needle length of about 10 to 100 ⁇ m as the shortest length. Since there is no nerve tissue in the stratum corneum and epidermis of the skin, no pain is felt even if such fine needles are inserted into the epidermis. In addition, hardening of the skin tissue is reduced.
  • Patent Document 1 a substance supply apparatus using a fine needle made of natural sugar is proposed.
  • a fine needle is produced using a mixture of a substance to be supplied such as a drug and a sugar.
  • a needle is inserted into the skin and only the needle part is broken and left on the skin.
  • a substance to be supplied is applied to the needle surface, and this substance is supplied to the skin when the needle is withdrawn from the skin.
  • Natural sugars are safe for the human body and easy to dispose of because they are water soluble. However, since sugar has high viscosity and poor fluidity, it is difficult to mold it into a needle shape or to form a needle array.
  • the sugar material in order to ensure the fluidity of sugar when a supply substance such as a drug is mixed in the sugar, the sugar material must be heated to about 100 ° C., and the supply substance is easily denatured by heat. Furthermore, a feed material that chemically reacts with sugar and loses its function is meaningless to mix, and the available feed materials are limited.
  • a fine needle made of natural sugar even if a hollow hole for passing a solution of a supply substance is provided inside the fine needle, natural sugar is water-soluble. As a result, the fine needle itself is dissolved, and the hollow hole is not used.
  • Patent Document 2 describes that the needle material is a material that decomposes in the skin.
  • a bag containing liquid is accommodated in a housing, and a protrusion is provided on the bottom wall of the housing. By pushing the flexible top cover member of the housing, the bag is pressed against the protrusion on the bottom wall and the bag is torn. The liquid is discharged into the housing, and the liquid is supplied to the skin from the fine needle provided on the bottom wall.
  • Patent Document 3 in a device that attaches a device to the body surface and supplies a necessary substance into the body, it is desired to continuously supply the substance for a relatively long time, or to continue different kinds of substances. There is a request to supply.
  • the present invention provides an apparatus capable of supplying an additional supply substance in order to continuously supply a substance over a relatively long period of time, and continuously supplying different types of substances depending on the usage. With the goal.
  • a substance supply apparatus is a substance supply apparatus that supplies a substance to a living body through a fine needle pierced on the skin, wherein a housing space is defined inside, an opening is formed at one end, and a bottom is formed at the other end.
  • a plug that fits into the opening so as to be movable in the cylindrical axis direction and seals the accommodation space.
  • a solution chamber in which a solution containing the substance is enclosed is provided inside the plug, and a film is stretched on the surface of the solution chamber that faces the bottom of the container body.
  • a membrane rupture projection is provided that contacts and breaks the membrane stretched on the plug, and faces the cylindrical inner surface of the container main body and the inner cylindrical surface of the container main body.
  • an engagement structure capable of holding the plug is provided so that the membrane is positioned away from the rupture projection.
  • the engagement structure is provided on a cylindrical inner side surface of the container body, and a groove extending in the circumferential direction over the entire circumference, a flange provided in the outer side surface of the plug and extending in the circumferential direction over the entire circumference, The plug is held in the above-described position by engaging the groove and the flange.
  • the engagement structure may have a female screw provided on the inner side surface of the cylinder of the container body and a male screw provided on the outer side of the plug and screwed to the female screw.
  • the material of the container body and the fine needle can be a biocompatible material.
  • the material of the container main body and the fine needle can be a mixture of polylactic acid and polyethylene glycol.
  • the molecular weight of the polyethylene glycol can be in the range of 10,000 to 35,000, and the mixing ratio of polylactic acid and polyethylene glycol can be such that the weight concentration of polyethylene glycol is 10 to 50%.
  • the film stretched in the solution chamber can be a stretched film.
  • the film stretched in the solution chamber can be formed of an elastic material, and can be contracted when it is stretched in a tensioned state and is torn by a tearing protrusion.
  • the opening of the passage of the fine needle to the outside can be sealed with a material that can be melted in vivo.
  • FIG. 1 is a cross-sectional view illustrating a schematic configuration of a medicine supply device 10. It is a figure which shows the detail of the structure of the engaging part of the container main body 12 and the plug 14.
  • FIG. 3 is a cross-sectional view showing a usage state of the medicine supply device 10.
  • FIG. 6 is a cross-sectional view showing an example of a tear film protrusion 50.
  • FIG. 5 is a perspective view showing a ruptured protrusion 50 in FIG. 4. It is a perspective view which shows another tear film protrusion 52.
  • FIG. 3 is a cross-sectional view showing a schematic configuration of a medicine supply device 60.
  • FIG. It is a perspective view which shows a rupture process protrusion.
  • FIG. 9A It is sectional drawing which shows the detailed structure of a fine needle
  • FIG. 1 shows a cross-sectional view of a drug supply device 10 for transdermally supplying a drug.
  • the medicine supply device 10 includes a container body 12 and a plug 14 that are formed separately.
  • the container main body 12 has a main body side wall 16 whose inner surface is cylindrical, and one end of the main body side wall is open, and a bottom plate 18 is provided at the other end.
  • the length of the main body side wall 16 is shortened with respect to the diameter, and the shape of the container main body 12 looks like a dish shape or a small bowl shape.
  • a space surrounded by the main body side wall 16 and the bottom plate 18 and having one opened becomes a housing space 20 for housing a part of the plug 14.
  • a flange 22 is provided on the outer periphery of the main body side wall 16 at a position where the bottom plate 18 is extended over the entire outer periphery or a part thereof.
  • a sticking sheet 24 is fixed to the flange 22 by a technique such as adhesion. A portion extending further outward than the flange of the sticking sheet 24 is stuck to the surface of the skin, and the medicine supply device 10 is fixed.
  • the plug 14 has a cylindrical plug side wall 26 whose outer surface faces the inner side surface of the main body side wall 16, and an upper plate 28 that covers one end of the cylinder of the plug side wall 26.
  • the side opposite to the end provided with the upper plate 28 of the plug side wall 26 is open.
  • a sealing film 30 is stretched over the opening to form a sealed chemical chamber 32 surrounded by the plug side wall 26, the upper plate 28 and the sealing film 30.
  • a chemical solution is stored in the chemical chamber 32.
  • a flange 34 is provided on the outer periphery of the plug side wall 26 on the entire periphery or a part of the periphery. The flange 34 is preferably provided at the end where the upper plate 28 of the plug side wall 26 is provided.
  • the plug 14 is coupled so that the plug side wall 26 is fitted into the inner side surface of the main body side wall 16.
  • a space surrounded by the main body side wall 16, the plug side wall 26, the bottom plate 18, and the upper plate 28 is formed inside the combined container body 12 and plug 14, and this space is divided into two by a sealing film 30.
  • a fine needle 36 is disposed on the outer surface of the bottom plate 18 of the container body.
  • a plurality of fine needles 36 can be provided, and they may be arranged in a row or in a two-dimensional array.
  • the fine needle 36 of this embodiment has a substantially conical shape, but may have a pyramid shape.
  • the fine needle 36 is provided with a through hole 38 that connects the accommodation space 20 and the outside along the axis.
  • the through hole 38 opens at the tip of the fine needle 36, but the present invention is not limited to this, and the through hole 38 may open at the side surface.
  • the bottom plate 18 is further provided with a ruptured protrusion 40 on its inner surface. The film breakage protrusion 40 breaks the sealing film 30 when the plug 14 is pushed in and the sealing film 30 contacts the protrusion.
  • the rupture projection 40 has a conical shape.
  • any shape such as a pyramid or a blade shape can be used as long as it can break the sealing film 30 when it comes into contact. good.
  • the rupture protrusion 40 may be one or plural, and in the case of plural, the rupture protrusions 40 may be arranged in a line or in a two-dimensional array.
  • FIG. 2 is a diagram showing details of the engagement structure between the container main body 12 and the plug 14.
  • an engagement rod 42 extending in the circumferential direction is provided over the entire circumference.
  • an engagement groove 44 extending in the circumferential direction is provided over the entire circumference on the inner peripheral surface of the opening side end portion of the main body side wall 16.
  • a crushing shelf 46 is provided on the inner peripheral surface of the main body side wall 16 adjacent to the bottom plate 18 over the entire circumference.
  • the crushing rack portion 46 has a smaller inner diameter than the other part of the inner peripheral surface of the main body side wall 16, and when the plug 14 is pushed in and the engagement rod 42 rides on this, the engagement rod 42 is pushed strongly, The joint 42 and the crushing shelf 46 are in close contact with each other. Thereby, it is suppressed that a chemical
  • the container body 12 and the fine needles 36 may be integrally formed with a resin, and preferably a biocompatible material.
  • a biocompatible material refers to a material that dissolves or decomposes even if it remains in a living body. More specifically, for example, polylactic acid, a material made of a mixture of polylactic acid and polyethylene glycol, and the like can be mentioned.
  • the molecular weight of polyethylene glycol can be selected in the range of 10,000 to 35,000.
  • the mixing ratio of polyethylene glycol can be selected in the range of 10 to 50% by weight concentration.
  • Polyethylene glycol is mixed in order to increase the fluidity of the material, so that the processability during production is improved and the production yield is improved. Furthermore, polylactic acid and polyethylene glycol can be incinerated at a temperature comparable to that of general combustible waste, and disposal after use becomes easy.
  • the material of the fine needle 36 other biocompatible materials such as hyaluronic acid can be used, and further, a metal such as stainless steel or titanium, or an inorganic material such as silicon can be used.
  • the plug 14 may be made of resin. It does not need to be a biocompatible material since it does not remain in the skin. As will be described later, in order to push and deform the upper plate 28 to push out the chemical solution, it is made of a material having deformability.
  • Sealing film 30 may be made of a stretched film.
  • the stretched film is a thin film material produced by extending a resin film in one direction, and has a characteristic that when stress is concentrated by being pressed by a protrusion or the like, the film is easily broken.
  • the sealing film 30 may be made of an elastic thin film material such as thin rubber. When the plug side wall 26 is stretched over the opening, the thin film is in a tensioned state and contracts when it is broken by the protrusion, thereby preventing the through hole 38 of the fine needle from being blocked.
  • FIG. 3 is a cross-sectional view showing a state when the drug supply device 10 is used.
  • the medicine supply device 10 is attached to the skin surface of the living body 48 such as a human body by the attaching sheet 24.
  • the plug 14 in which the sealing film 30 shown in FIG. 1 is located away from the tear film protrusion 40 is pushed into a position where the tear film protrusion 40 shown in FIG.
  • the sealing film 30 is broken, the chemical chamber 32 and the storage space 20 communicate with each other, and the chemical in the chemical chamber 32 flows out into the storage space.
  • the chemical solution is supplied into the living body 48 percutaneously from the accommodation space 20 through the through hole 38.
  • the upper plate 28 of the plug can be pushed in such a way that the top is concave in FIG.
  • the engaging rod 42 provided on the plug side wall climbs onto the crushing shelf 46 and comes into close contact with it, so that the chemical solution in the storage space 20 is prevented from leaking from the gap between the main body side wall 16 and the plug side wall 26. ing.
  • the ruptured protrusion 50 is disposed in the vicinity of the periphery of the bottom plate 18 of the container body, and has a wedge shape whose height increases toward the outside as shown in the figure.
  • the outer end of the ruptured protrusion 50 is disposed at a position where the inner side surface of the plug side wall 26 rubs and contacts when the plug 14 is pushed.
  • the plug side wall 26 enters between the tear film protrusion 50 and the main body side wall 16, and the sealing film 30 is sheared and broken by the plug side wall 26 and the tear film protrusion 50.
  • the rupture protrusion may be formed in a U-shape at the edge of the portion facing the main body side wall 16 as in the rupture protrusion 52 shown in FIG.
  • FIG. 7 shows a cross-sectional view of a drug supply device 60 of another embodiment.
  • FIG. 8 is a diagram showing details of the ruptured protrusion 66.
  • the connection between the container body 12 and the plug 14 is by screw connection.
  • a female thread 62 is formed on the main body side wall 16 of the container body, and a male thread 64 is formed on the plug side wall 26. These female screw 62 and male screw 64 are screwed together, and the plug 14 can be held at a certain position with respect to the container body 12.
  • the plug 14 Prior to use of the drug supply device 60, the plug 14 is held at a position where the sealing film 30 does not contact the rupture projection 66. At the time of use, the plug 14 is screwed and sent to the inner side of the container body 12, and the sealing film 30 is broken by the film breaking projection 66.
  • a flange 68 provided on the outer periphery of the upper end of the plug side wall 26 in FIG. 7 is shaped so that it can be easily turned when the plug 14 is screwed. For example, in the state seen from the upper side of FIG. 7, it can be set as polygons, such as a hexagon and a rectangle. Further, the rough shape may be a circle, and the anti-slip unevenness may be provided by knurling the peripheral surface.
  • a portion of the bottom plate 18 of the container main body with which the lower end of the plug side wall 26 abuts is provided with a sealing rod 70 that extends over the entire circumference in the circumferential direction.
  • a tear film protrusion 66 is provided on the surface of the bottom plate 18 adjacent to the inside of the position where the lower end of the plug side wall 26 abuts.
  • the shape of the rupture projection 66 of this embodiment is an oblique triangular pyramid, and a line segment (ridge line) connecting one vertex of the triangle on the bottom surface and the top vertex of the triangular pyramid is substantially perpendicular to the surface of the bottom plate 18. It has become. This vertical ridge line is located on the leading side with respect to the plug that rotates when the plug 14 is screwed.
  • the structure related to the rupture may be the cone-shaped rupture protrusion 40 shown in FIG. 1 or the wedge-shaped rupture protrusions 50 and 52 shown in FIGS.
  • the plug 14 When the plug 14 is rotated during use, the plug 14 is sent to the back of the container body 12 by screw connection, and the sealing film 30 abuts against the rupture projection 66. Further, when the plug 14 is rotated, the tear film protrusion 66 and the sealing film 30 move relatively, and the sealing film 30 is torn at the top of the tear film protrusion 66. When the plug 14 is further fed, the lower end of the plug side wall 26 or the sealing film 30 stretched and integrated there comes into contact with the sealing collar 70 and deforms it. Thereby, sealing of the container main body 12 and the plug 14 is achieved, and leakage of the chemical liquid flowing out from the chemical liquid chamber 32 is prevented.
  • the chemical liquid that has flowed out of the chemical liquid chamber 32 into the accommodation space 20 is transcutaneously supplied to the living body through the through hole 38 of the fine needle 36.
  • the plug 14 is rotated reversely along the screw.
  • a new plug 14 is mounted on the container body 12, and the plug is screwed again as described above to supply the medicine.
  • FIG. 9A and 9B are cross-sectional views showing the detailed shape of the fine needle 36.
  • FIG. 9A and 9B are upside down from the orientations of FIGS. 1 and 7.
  • 9A is a front view and FIG. 9B is a side view.
  • the fine needle 36 has a substantially conical shape whose bottom surface is a circle having a diameter (b) of 250 to 350 ⁇ m, and its tip is cut obliquely.
  • the base of the fine needle and the connection portion with the container are smoothly connected by a curved surface.
  • the tip diameter (a) is 10 to 60 ⁇ m
  • the needle length (h) is 100 to 1000 ⁇ m.
  • the diameter (d) of the through hole 38 is 50 ⁇ m or less.
  • the needle length is 500 ⁇ m
  • the tip diameter is 50 ⁇ m
  • the passage hole diameter is about 50 ⁇ m.
  • the fine needles 36 can be arranged in a two-dimensional array at a pitch of 1 mm, for example, in a 1 cm square. Due to the dimensions of the fine needle 36 described above, it is possible to insert the needle with no pain or slight pain.
  • FIG. 10 is a view showing an example in which a coating layer 72 of a hydrolyzable substance is provided at the tip of the needle in order to more reliably prevent the tip of the fine needle 36 from being contaminated. Also in FIG. 10, the top and bottom are shown opposite to FIGS.
  • the coating layer 72 closes the opening outside the through hole 38 of the fine needle.
  • the hydrolyzable substance for example, polyethylene glycol having a molecular weight of 1000 to 10,000 can be used.
  • This coating layer 72 can be applied to any of the aforementioned drug supply devices.
  • FIG. 11A and FIG. 11B are enlarged views showing a structure example around the fine needle 36 applicable to the container body 12 described above. 11A and 11B are also shown upside down from FIGS.
  • FIG. 11A is a cross-sectional view
  • FIG. 11B is a diagram showing the state viewed from the inside of the container with the sealing film 30 removed.
  • a slit 76 is provided on the inner surface of the container so as to pass through the opening 74 on the inner surface of the through hole 38.
  • the two slits 76 shown in the figure are orthogonal to each other in the opening 74 of the through hole, but the arrangement is not limited to this. There may be one slit 76 or three or more slits 76.
  • the slit 76 preferably extends to the base of the protrusion 40 or to the vicinity of the base.
  • substances to be supplied include insulin, influenza vaccine, ascorbic acid, methyl salicylate analgesic agent, morphine, interferon for hepatitis C treatment, cosmetic whitening, stain remover, and serum.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Le dispositif pour administrer une substance ci-décrit administre des substances telles que des agents pharmaceutiques à un corps vivant via de fines aiguilles, et facilite l'administration d'une quantité supplémentaire de ladite substance et l'administration successive de différents types de substances. Un bouchon (14) qui encapsule une solution thérapeutique dans un compartiment pour solution thérapeutique (32) peut être placé sur, et retiré, d'un corps de récipient (12). Le bouchon s'ajuste de manière amovible sur le corps de récipient et si l'on enfonce le bouchon, une membrane faisant étanchéité (30) qui scelle la solution thérapeutique à l'intérieur du bouchon entre en contact avec des protubérances de rupture de membrane (40), qui rompent la membrane faisant étanchéité. En conséquence, la solution thérapeutique s'écoule hors du compartiment pour solution thérapeutique, et est administrée au corps vivant par voie transdermique via les trous débouchants (38) des fines aiguilles (36). Si la solution thérapeutique doit être complétée ou remplacée, le bouchon (14) est retiré et remplacé par un nouveau bouchon (14).
PCT/JP2010/055313 2009-08-13 2010-03-26 Dispositif pour administrer une substance WO2011018909A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009-187664 2009-08-13
JP2009187664A JP5558047B2 (ja) 2009-08-13 2009-08-13 物質供給装置

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WO2011018909A1 true WO2011018909A1 (fr) 2011-02-17

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Cited By (5)

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JP2013094224A (ja) * 2011-10-28 2013-05-20 Toppan Printing Co Ltd マイクロニードルデバイスおよびその製造方法
JP2015521910A (ja) * 2012-06-29 2015-08-03 イーエルシー マネージメント エルエルシー １つ以上の封入された化粧品成分を含む可溶性マイクロニードル
JP2015522342A (ja) * 2012-06-29 2015-08-06 イーエルシー マネージメント エルエルシー １つ以上の化粧品成分を含むマイクロニードル
EP3037124A1 (fr) * 2014-12-22 2016-06-29 Universite Libre De Bruxelles Dispositif d'administration de médicament à micro-aiguilles
GB2546550A (en) * 2016-01-25 2017-07-26 Ndm Tech Ltd Device and method

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US8696637B2 (en) * 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
JP5879927B2 (ja) * 2011-10-26 2016-03-08 凸版印刷株式会社 マイクロニードルデバイスおよびその製造方法
JP2013166363A (ja) * 2012-02-17 2013-08-29 Toppan Printing Co Ltd 微細針チップ射出成形用金型及びその微細針チップを射出成形する方法
JP6106922B2 (ja) * 2012-02-24 2017-04-05 凸版印刷株式会社 微細ノズルの製造方法
CN111420266B (zh) 2014-04-30 2022-05-27 索伦托治疗有限公司 透皮药物递送设备和方法
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 薬剤送達方法及びシステム
EP3280484A1 (fr) * 2015-04-07 2018-02-14 LTS Lohmann Therapie-Systeme AG Système à microaiguilles pour l'application de formulations liquides
WO2017130793A1 (fr) * 2016-01-28 2017-08-03 株式会社リコー Réseau de micro-aiguilles, et feuille de micro-aiguilles
US20190374482A1 (en) * 2016-12-05 2019-12-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
JP6977258B2 (ja) * 2016-12-20 2021-12-08 株式会社リコー 中空構造体
WO2018129304A1 (fr) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Dispositifs et methodes d'administration transdermique de medicament
JP2019013524A (ja) * 2017-07-07 2019-01-31 凸版印刷株式会社 マイクロニードル
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems
WO2021015285A1 (fr) * 2019-07-25 2021-01-28 シンクランド株式会社 Capsule à aiguilles et procédé de fabrication de capsule à aiguilles

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JP2005503899A (ja) * 2001-09-28 2005-02-10 ヒューレット・パッカード・カンパニー 皮膚投与システム

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JP2006149818A (ja) * 2004-11-30 2006-06-15 Nitto Denko Corp 経皮投薬デバイス

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JP2004503341A (ja) * 2000-07-17 2004-02-05 ベクトン　ディキンソン　アンド　カンパニー 物質を経皮的に投与する投与器具
JP2005503899A (ja) * 2001-09-28 2005-02-10 ヒューレット・パッカード・カンパニー 皮膚投与システム

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013094224A (ja) * 2011-10-28 2013-05-20 Toppan Printing Co Ltd マイクロニードルデバイスおよびその製造方法
JP2015521910A (ja) * 2012-06-29 2015-08-03 イーエルシー マネージメント エルエルシー １つ以上の封入された化粧品成分を含む可溶性マイクロニードル
JP2015522342A (ja) * 2012-06-29 2015-08-06 イーエルシー マネージメント エルエルシー １つ以上の化粧品成分を含むマイクロニードル
EP3037124A1 (fr) * 2014-12-22 2016-06-29 Universite Libre De Bruxelles Dispositif d'administration de médicament à micro-aiguilles
GB2546550A (en) * 2016-01-25 2017-07-26 Ndm Tech Ltd Device and method

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JP2011036491A (ja) 2011-02-24

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