WO2011008312A3 - Dérivés indole et indoline et leurs procédés d’utilisation - Google Patents

Dérivés indole et indoline et leurs procédés d’utilisation Download PDF

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Publication number
WO2011008312A3
WO2011008312A3 PCT/US2010/027931 US2010027931W WO2011008312A3 WO 2011008312 A3 WO2011008312 A3 WO 2011008312A3 US 2010027931 W US2010027931 W US 2010027931W WO 2011008312 A3 WO2011008312 A3 WO 2011008312A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
indole
indoline derivatives
compounds
compositions
Prior art date
Application number
PCT/US2010/027931
Other languages
English (en)
Other versions
WO2011008312A2 (fr
Inventor
Michael R. Schrimpf
Chih-Hung Lee
Tao Li
Gregory A. Gfesser
Kathleen H. Mortell
Ramin Faghih
Diana L. Nersesian
Kevin B. Sippy
William H. Bunnelle
Marc Scanio
Lei Shi
Murali Gopalakrishnan
Diana L. Donnelly-Roberts
Min Hu
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/568,085 external-priority patent/US9063126B2/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of WO2011008312A2 publication Critical patent/WO2011008312A2/fr
Publication of WO2011008312A3 publication Critical patent/WO2011008312A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Cette invention concerne des dérivés indole et indoline de formule (I), (II), (III), (IV), (V) ou (VI), a, R1, R2, R3, R4, R5, U, V, W, X, Y et Z étant tels que définis dans la description. Cette invention concerne également des compositions comprenant ces composés, et des procédés de traitement de pathologies en utilisant ces composés et ces compositions, et des procédés d’identification de ces composés.
PCT/US2010/027931 2009-07-14 2010-03-19 Dérivés indole et indoline et leurs procédés d’utilisation WO2011008312A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22545209P 2009-07-14 2009-07-14
US61/225,452 2009-07-14
US12/568,085 US9063126B2 (en) 2008-09-29 2009-09-28 Indole and indoline derivatives and methods of use thereof
US12/568,085 2009-09-28

Publications (2)

Publication Number Publication Date
WO2011008312A2 WO2011008312A2 (fr) 2011-01-20
WO2011008312A3 true WO2011008312A3 (fr) 2011-03-17

Family

ID=43450045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/027931 WO2011008312A2 (fr) 2009-07-14 2010-03-19 Dérivés indole et indoline et leurs procédés d’utilisation

Country Status (1)

Country Link
WO (1) WO2011008312A2 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006234B2 (en) 2009-09-23 2015-04-14 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
US9035056B2 (en) 2011-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9034865B2 (en) 2010-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9040519B2 (en) 2010-02-18 2015-05-26 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9045482B2 (en) 2009-09-23 2015-06-02 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
US9079904B2 (en) 2009-09-23 2015-07-14 Medivation Technologies, Inc. Pyrido[3,4-B]indoles and methods of use
US9096591B2 (en) 2007-10-25 2015-08-04 Medivation Technologies, Inc. Tetracyclic compounds
US9187471B2 (en) 2010-02-19 2015-11-17 Medivation Technologies, Inc. Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use
US9193728B2 (en) 2010-02-18 2015-11-24 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9199985B2 (en) 2011-02-18 2015-12-01 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US9255094B2 (en) 2009-04-29 2016-02-09 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
US9409910B2 (en) 2008-10-31 2016-08-09 Medivation Technologies, Inc. Azepino[4,5-B]indoles and methods of use
US9434747B2 (en) 2011-02-18 2016-09-06 Medivation Technologies, Inc. Methods of treating diabetes
US9527854B2 (en) 2011-02-18 2016-12-27 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013057944A1 (fr) 2011-10-19 2013-04-25 興和株式会社 Nouveau composé de spiroindoline, et agent thérapeutique le contenant
CN104977383A (zh) * 2015-06-18 2015-10-14 中山鼎晟生物科技有限公司 一种螺旋藻类食品中微囊毒素的快速定量检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009370A2 (fr) * 2003-07-23 2005-02-03 Pharmacia Corporation Composes de beta-carboline ainsi que leurs analogues et leur utilisation en tant qu'inhibiteurs de proteine kinase-2 activee par proteine kinase activee par des mitogenes

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US3409628A (en) 1966-05-12 1968-11-05 Hoffmann La Roche 5-(3-pyridylethyl)pyridoindole derivatives
WO2001017968A1 (fr) 1999-09-02 2001-03-15 Shionogi & Co., Ltd. Inhibiteur d'integrase contenant des derives heterocycliques aromatiques
JP2005023207A (ja) 2003-07-02 2005-01-27 Pentel Corp ボールペン用水性インキおよびこれを使用したボールペン
US7309699B2 (en) 2003-12-22 2007-12-18 Abbott Laboratories 3-Quinuclidinyl amino-substituted biaryl derivatives
CA2557856C (fr) 2004-03-09 2010-06-29 Boehringer Ingelheim Pharmaceuticals, Inc. 3-'4-heterocyclyl -1,2,3,-triazol-1-yl!-n-aryl-benzamides en tant qu'inhibiteurs de la production de cytokines pour le traitement de maladies inflammatoires
JP5495206B2 (ja) 2006-10-24 2014-05-21 コンジエニア・ソシエタ・ア・レスポンサビリタ・リミタータ 変性性組織障害をｍｐｔの阻害により防止するための薬剤としてのフェニル置換マレイミド

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009370A2 (fr) * 2003-07-23 2005-02-03 Pharmacia Corporation Composes de beta-carboline ainsi que leurs analogues et leur utilisation en tant qu'inhibiteurs de proteine kinase-2 activee par proteine kinase activee par des mitogenes

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096591B2 (en) 2007-10-25 2015-08-04 Medivation Technologies, Inc. Tetracyclic compounds
US9181240B2 (en) 2007-10-25 2015-11-10 Medivation Technologies, Inc. Tetracyclic compounds
US9481676B2 (en) 2008-10-31 2016-11-01 Medivation Technologies, Inc. Azepino[4,5-B]indoles and methods of use
US9409910B2 (en) 2008-10-31 2016-08-09 Medivation Technologies, Inc. Azepino[4,5-B]indoles and methods of use
US9255094B2 (en) 2009-04-29 2016-02-09 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
US9271971B2 (en) 2009-09-23 2016-03-01 Medivation Technologies, Inc. Pyrido[3,4-B]indoles and methods of use
US9085580B2 (en) 2009-09-23 2015-07-21 Medivation Technologies, Inc. Pyrido[3,4-B]indoles and methods of use
US9079904B2 (en) 2009-09-23 2015-07-14 Medivation Technologies, Inc. Pyrido[3,4-B]indoles and methods of use
US9045482B2 (en) 2009-09-23 2015-06-02 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
US9580425B2 (en) 2009-09-23 2017-02-28 Medivation Technologies, Inc. Pyrido[3,4-b] indoles and methods of use
US9006234B2 (en) 2009-09-23 2015-04-14 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
US9199996B2 (en) 2009-09-23 2015-12-01 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
US9040519B2 (en) 2010-02-18 2015-05-26 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9193728B2 (en) 2010-02-18 2015-11-24 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9034865B2 (en) 2010-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9433626B2 (en) 2010-02-18 2016-09-06 Medivation Technologies, Inc. Pyrido[4,3-B]indole and pyrido[3,4-B]indole derivatives and methods of use
US9187471B2 (en) 2010-02-19 2015-11-17 Medivation Technologies, Inc. Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use
US9211287B2 (en) 2011-02-18 2015-12-15 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9199985B2 (en) 2011-02-18 2015-12-01 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US9434747B2 (en) 2011-02-18 2016-09-06 Medivation Technologies, Inc. Methods of treating diabetes
US9035056B2 (en) 2011-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9527854B2 (en) 2011-02-18 2016-12-27 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US9550782B2 (en) 2011-02-18 2017-01-24 Medivation Technologies, Inc. Compounds and methods for treating diabetes

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Publication number Publication date
WO2011008312A2 (fr) 2011-01-20

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