WO2011008312A3 - Dérivés indole et indoline et leurs procédés dutilisation - Google Patents
Dérivés indole et indoline et leurs procédés dutilisation Download PDFInfo
- Publication number
- WO2011008312A3 WO2011008312A3 PCT/US2010/027931 US2010027931W WO2011008312A3 WO 2011008312 A3 WO2011008312 A3 WO 2011008312A3 US 2010027931 W US2010027931 W US 2010027931W WO 2011008312 A3 WO2011008312 A3 WO 2011008312A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- indole
- indoline derivatives
- compounds
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Cette invention concerne des dérivés indole et indoline de formule (I), (II), (III), (IV), (V) ou (VI), a, R1, R2, R3, R4, R5, U, V, W, X, Y et Z étant tels que définis dans la description. Cette invention concerne également des compositions comprenant ces composés, et des procédés de traitement de pathologies en utilisant ces composés et ces compositions, et des procédés didentification de ces composés.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22545209P | 2009-07-14 | 2009-07-14 | |
US61/225,452 | 2009-07-14 | ||
US12/568,085 | 2009-09-28 | ||
US12/568,085 US9063126B2 (en) | 2008-09-29 | 2009-09-28 | Indole and indoline derivatives and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011008312A2 WO2011008312A2 (fr) | 2011-01-20 |
WO2011008312A3 true WO2011008312A3 (fr) | 2011-03-17 |
Family
ID=43450045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/027931 WO2011008312A2 (fr) | 2009-07-14 | 2010-03-19 | Dérivés indole et indoline et leurs procédés dutilisation |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011008312A2 (fr) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9045482B2 (en) | 2009-09-23 | 2015-06-02 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9079904B2 (en) | 2009-09-23 | 2015-07-14 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9096591B2 (en) | 2007-10-25 | 2015-08-04 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
US9527854B2 (en) | 2011-02-18 | 2016-12-27 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2781521A4 (fr) | 2011-10-19 | 2015-03-04 | Kowa Co | Nouveau composé de spiroindoline, et agent thérapeutique le contenant |
CN104977383A (zh) * | 2015-06-18 | 2015-10-14 | 中山鼎晟生物科技有限公司 | 一种螺旋藻类食品中微囊毒素的快速定量检测方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009370A2 (fr) * | 2003-07-23 | 2005-02-03 | Pharmacia Corporation | Composes de beta-carboline ainsi que leurs analogues et leur utilisation en tant qu'inhibiteurs de proteine kinase-2 activee par proteine kinase activee par des mitogenes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409628A (en) | 1966-05-12 | 1968-11-05 | Hoffmann La Roche | 5-(3-pyridylethyl)pyridoindole derivatives |
ATE504572T1 (de) | 1999-09-02 | 2011-04-15 | Shionogi & Co | Derivate von aromatische heterocyclen enthaltende integraseinhibitoren |
JP2005023207A (ja) | 2003-07-02 | 2005-01-27 | Pentel Corp | ボールペン用水性インキおよびこれを使用したボールペン |
US7309699B2 (en) | 2003-12-22 | 2007-12-18 | Abbott Laboratories | 3-Quinuclidinyl amino-substituted biaryl derivatives |
EA011634B1 (ru) | 2004-03-09 | 2009-04-28 | Бёрингер Ингельхайм Фармасьютиклз, Инк. | 3-[4-гетероциклил-1,2,3-триазол-1-ил]-n-арилбензамиды в качестве ингибиторов продуцирования цитокинов, предназначенные для лечения хронических воспалительных заболеваний |
JP5495206B2 (ja) | 2006-10-24 | 2014-05-21 | コンジエニア・ソシエタ・ア・レスポンサビリタ・リミタータ | 変性性組織障害をmptの阻害により防止するための薬剤としてのフェニル置換マレイミド |
-
2010
- 2010-03-19 WO PCT/US2010/027931 patent/WO2011008312A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009370A2 (fr) * | 2003-07-23 | 2005-02-03 | Pharmacia Corporation | Composes de beta-carboline ainsi que leurs analogues et leur utilisation en tant qu'inhibiteurs de proteine kinase-2 activee par proteine kinase activee par des mitogenes |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9096591B2 (en) | 2007-10-25 | 2015-08-04 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9181240B2 (en) | 2007-10-25 | 2015-11-10 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9481676B2 (en) | 2008-10-31 | 2016-11-01 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9271971B2 (en) | 2009-09-23 | 2016-03-01 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9085580B2 (en) | 2009-09-23 | 2015-07-21 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9079904B2 (en) | 2009-09-23 | 2015-07-14 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9045482B2 (en) | 2009-09-23 | 2015-06-02 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9580425B2 (en) | 2009-09-23 | 2017-02-28 | Medivation Technologies, Inc. | Pyrido[3,4-b] indoles and methods of use |
US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9199996B2 (en) | 2009-09-23 | 2015-12-01 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9433626B2 (en) | 2010-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Pyrido[4,3-B]indole and pyrido[3,4-B]indole derivatives and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9211287B2 (en) | 2011-02-18 | 2015-12-15 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
US9527854B2 (en) | 2011-02-18 | 2016-12-27 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9550782B2 (en) | 2011-02-18 | 2017-01-24 | Medivation Technologies, Inc. | Compounds and methods for treating diabetes |
Also Published As
Publication number | Publication date |
---|---|
WO2011008312A2 (fr) | 2011-01-20 |
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