WO2010054024A3 - Nouveaux composés en tant que ligands des récepteurs cannabinoïdes - Google Patents

Nouveaux composés en tant que ligands des récepteurs cannabinoïdes Download PDF

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Publication number
WO2010054024A3
WO2010054024A3 PCT/US2009/063318 US2009063318W WO2010054024A3 WO 2010054024 A3 WO2010054024 A3 WO 2010054024A3 US 2009063318 W US2009063318 W US 2009063318W WO 2010054024 A3 WO2010054024 A3 WO 2010054024A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiazol
derivatives
receptor ligands
cannabinoid receptor
compounds
Prior art date
Application number
PCT/US2009/063318
Other languages
English (en)
Other versions
WO2010054024A2 (fr
Inventor
William A. Carroll
Teodozyj Kolasa
Tongmei Li
Derek W. Nelson
Meena V. Patel
Sridhar Peddi
Arturo Perez-Medrano
Xuequing Wang
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to MX2011004749A priority Critical patent/MX2011004749A/es
Priority to CN2009801536988A priority patent/CN102272111A/zh
Priority to CA2741047A priority patent/CA2741047A1/fr
Priority to EP09752053A priority patent/EP2344463A2/fr
Priority to JP2011534908A priority patent/JP2012508176A/ja
Publication of WO2010054024A2 publication Critical patent/WO2010054024A2/fr
Publication of WO2010054024A3 publication Critical patent/WO2010054024A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention porte sur des composés contenant de l'isothiazolylidène de formule (I) dans laquelle R1, R2, R3, R4, et L sont tels que définis dans la description, sur des compositions comprenant de tels composés et sur des méthodes permettant de traiter des pathologies et des troubles à l'aide de tels composés et de telles compositions.
PCT/US2009/063318 2008-11-04 2009-11-04 Nouveaux composés en tant que ligands des récepteurs cannabinoïdes WO2010054024A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
MX2011004749A MX2011004749A (es) 2008-11-04 2009-11-04 Nuevos compuestos como ligandos del receptor de canabinoide.
CN2009801536988A CN102272111A (zh) 2008-11-04 2009-11-04 作为大麻素受体配体的1,2-噻唑基衍生物
CA2741047A CA2741047A1 (fr) 2008-11-04 2009-11-04 Nouveaux composes en tant que ligands des recepteurs cannabinoides
EP09752053A EP2344463A2 (fr) 2008-11-04 2009-11-04 Nouveaux composés en tant que ligands des récepteurs cannabinoïdes
JP2011534908A JP2012508176A (ja) 2008-11-04 2009-11-04 カンナビノイド受容体リガンドとしての１，２−チアゾリル誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11104108P 2008-11-04 2008-11-04
US61/111,041 2008-11-04

Publications (2)

Publication Number Publication Date
WO2010054024A2 WO2010054024A2 (fr) 2010-05-14
WO2010054024A3 true WO2010054024A3 (fr) 2010-07-01

Family

ID=42078841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/063318 WO2010054024A2 (fr) 2008-11-04 2009-11-04 Nouveaux composés en tant que ligands des récepteurs cannabinoïdes

Country Status (6)

Country Link
EP (1) EP2344463A2 (fr)
JP (1) JP2012508176A (fr)
CN (1) CN102272111A (fr)
CA (1) CA2741047A1 (fr)
MX (1) MX2011004749A (fr)
WO (1) WO2010054024A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101448800A (zh) 2006-05-31 2009-06-03 艾博特公司 作为大麻素受体配体的新型化合物及其用途
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
JP2010522760A (ja) 2007-03-28 2010-07-08 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしての１，３−チアゾール−２（３ｈ）−イリデン化合物
US8501794B2 (en) * 2007-04-17 2013-08-06 Abbvie Inc. Compounds as cannabinoid receptor ligands
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
EP2160393A1 (fr) 2007-05-18 2010-03-10 Abbott Laboratories Nouveaux composés en tant que ligands de récepteurs cannabinoïdes
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
AU2009293319A1 (en) 2008-09-16 2010-03-25 Abbott Laboratories Substituted benzamides as cannabinoid receptor ligands
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
HRP20220790T1 (hr) 2017-05-04 2022-09-16 Bayer Cropscience Aktiengesellschaft Derivati 2-{[2-(feniloksimetil)piridin-5-il]oksi}etanamina i srodni spojevi kao pesticidi, primjerice namijenjeni zaštiti bilja
KR20210090609A (ko) * 2018-08-20 2021-07-20 베서, 파마 엘엘씨 공지된 신규 칸나비노이드의 응용

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008130953A2 (fr) * 2007-04-17 2008-10-30 Abbott Laboratories Nouveaux composés en tant que ligands du récepteur cannabinoïde

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008130953A2 (fr) * 2007-04-17 2008-10-30 Abbott Laboratories Nouveaux composés en tant que ligands du récepteur cannabinoïde

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANADIAN JOURNAL OF CHEMISTRY , 54(24), 3879-83 CODEN: CJCHAG; ISSN: 0008-4042, 1976 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1977, CHAUHAN, MOHINDER S. ET AL: "The reaction of some heterocyclic thiones with ethyl azidoformate", XP002577535, retrieved from STN Database accession no. 1977:171299 *
GOERDELER J ET AL: "Isothiazoles. VIII. Synthesis of sulfonylaminoisothiazoles and sulfonyliminoisothiazolines from sulfonyl isothiocyanates, Ueber Isothiazole, VIII. Synthese von Sulfonylamino-isothiazolen und Sulfonylimino-isothiazolinen aus Sulfonylsenfoelen", CHEMISCHE BERICHTE, VERLAG CHEMIE GMBH. WEINHEIM, DE LNKD- DOI:10.1002/CBER.19691020716, vol. 102, no. 7, 1 January 1969 (1969-01-01), pages 2273 - 2284, XP002494655, ISSN: 0009-2940 *

Also Published As

Publication number Publication date
CA2741047A1 (fr) 2010-05-14
JP2012508176A (ja) 2012-04-05
MX2011004749A (es) 2011-06-01
EP2344463A2 (fr) 2011-07-20
WO2010054024A2 (fr) 2010-05-14
CN102272111A (zh) 2011-12-07

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