WO2010143271A1 - 血管機能検査装置 - Google Patents
血管機能検査装置 Download PDFInfo
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- WO2010143271A1 WO2010143271A1 PCT/JP2009/060562 JP2009060562W WO2010143271A1 WO 2010143271 A1 WO2010143271 A1 WO 2010143271A1 JP 2009060562 W JP2009060562 W JP 2009060562W WO 2010143271 A1 WO2010143271 A1 WO 2010143271A1
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- blood
- viscosity
- flow velocity
- shear rate
- blood vessel
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- 0 C1C2C1CC*2 Chemical compound C1C2C1CC*2 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
Definitions
- the present invention relates to a technique for non-invasively evaluating a vasodilator function of a living body.
- a blood vessel function inspection device that measures blood flow velocity distribution in a blood vessel by ultrasonic Doppler measurement is known.
- this is the blood vessel function testing device described in Patent Document 1.
- the blood vessel function testing device of Patent Document 1 calculates blood viscosity distribution and blood shear rate distribution in the blood vessel from the measured blood flow velocity distribution. Further, the blood vessel function testing device calculates a blood shear stress distribution from the calculated blood viscosity distribution and blood shear rate distribution.
- the blood vessel function test apparatus calculates the blood viscosity distribution based on the blood flow velocity distribution by performing calculations along the well-known Navier-Stokes equations.
- Patent Document 2 discloses a blood vessel function inspection device that calculates the shear stress in the FMD inspection.
- JP 2006-166974 A Japanese Patent No. 3785084
- the blood vessel function test apparatus of Patent Document 2 calculates the shear stress as described above. Since the shear stress is calculated based on the blood viscosity, the blood viscosity is calculated prior to the calculation of the shear stress. Need to be sought. This blood viscosity is usually obtained by measuring blood collected from a subject with a measuring instrument. However, the blood viscosity changes at the time of blood collection, and further changes according to the blood flow velocity (strictly the shear rate). Therefore, the shear stress is calculated using the viscosity of the collected blood. In this case, there has been an unknown problem that the shear stress lacks accuracy.
- the blood flow velocity distribution that changes with the passage of time is measured during the measurement period of the diameter change rate of the blood vessel after the release of ischemia in the FMD test using the blood vessel function test apparatus of Patent Document 1. Then, it is conceivable to calculate the blood viscosity distribution based on all blood flow velocity distributions during the measurement period. However, since the calculation of the blood viscosity distribution requires calculation according to the Navier-Stokes equation, if it is performed for all the blood flow velocity distributions during the measurement period, the computation load is reduced. It is thought that the problem of increasing will arise.
- the present invention has been made against the background of the above circumstances, the purpose of which is to accurately calculate the blood shear stress at the time when measuring the diameter change rate of the blood vessel after release of ischemia,
- An object of the present invention is to provide a blood vessel function testing device capable of reducing the calculation load when calculating the blood shear stress.
- a vascular function testing device is directed to (a) a blood vessel in a living body within a predetermined blood vessel diameter measurement period after release of ischemia.
- a blood vessel function testing device comprising a blood vessel diameter measuring means for non-invasively measuring a diameter change rate of a blood vessel by emitted ultrasonic waves, (b) before the release of the ischemia or after the passage of the blood vessel diameter measurement period.
- the blood flow velocity distribution measuring means for non-invasively measuring the blood flow velocity distribution in the blood vessel by the ultrasonic wave, and the viscosity shear velocity relationship which is the relationship between the blood viscosity and the blood shear velocity is measured by the blood flow velocity distribution measurement.
- Viscosity shear rate relationship calculating means for calculating based on the blood flow velocity distribution measured by the means, in parallel with the measurement of the blood vessel diameter change rate within the predetermined blood vessel diameter measurement period after the release of the ischemia. Blood flow in the blood vessel Degrees were measured, the blood shear stress calculating means for calculating the blood shear stress based on the measured blood flow velocity using the viscosity-shear rate relationship is to contain.
- the blood flow velocity distribution measuring means measures the blood flow velocity distribution before the release of the ischemia
- the viscosity shear rate relationship calculating means is before the release of the ischemia.
- the viscosity shear rate relationship is calculated.
- the blood shear stress can be calculated by, for example, real-time processing with a light calculation load.
- the blood shear stress is calculated by real-time processing in this way, it is possible to quickly obtain an index value in the FMD test.
- the blood shear stress calculating means includes: (a) an average within the blood vessel in parallel with the measurement of the diameter change rate of the blood vessel within the predetermined blood vessel diameter measuring period after the release of the ischemia.
- First blood flow velocity measuring means for measuring blood flow velocity; and
- first blood shear velocity calculation for calculating blood shear velocity based on the average blood flow velocity measured by the first blood flow velocity measuring means.
- Blood viscosity calculating means Blood viscosity calculating means; and (d) blood shear stress is calculated based on the blood shear rate calculated by the first blood shear rate calculating means and the blood viscosity calculated by the first blood viscosity calculating means.
- First blood Ri and stress calculation means is equipped. In this way, by measuring the average blood flow velocity, it is possible to reduce the calculation load in the process from the measurement until the blood viscosity is calculated and the blood shear stress is calculated. Therefore, it is possible to calculate blood shear stress by, for example, real-time processing in parallel with the measurement of the average blood flow velocity without requiring high calculation capability.
- the first blood shear rate calculation means sets the blood shear rate as a value obtained by dividing the average blood flow rate by the blood vessel diameter. In this way, the blood shear rate can be calculated immediately from the average blood flow rate, and the calculation load can be reduced. As a result, it is possible to calculate the blood shear stress by, for example, real-time processing in parallel with the measurement of the average blood flow velocity with a light calculation load.
- the average blood flow velocity and the blood vessel diameter change with time, for example, the average blood flow velocity and the blood vessel diameter for calculating the blood shear rate are synchronized with each other in time. It is measured.
- the average blood flow velocity is an average value of blood flow velocity for each heartbeat in the blood vessel.
- the first blood shear stress calculating means calculates the blood shear stress for each heartbeat, and the calculation load is increased compared to the case where the blood shear stress is calculated a plurality of times during one heartbeat. It can be lightened.
- the first blood shear stress calculating means calculates the blood shear stress for each heartbeat within the predetermined blood vessel diameter measurement period. In this way, the blood shear stress is calculated by real-time processing, and an index value in the FMD test can be obtained quickly.
- the viscosity shear rate relationship calculating means calculates a blood viscosity distribution and a blood shear rate distribution based on the blood flow velocity distribution measured by the blood flow velocity distribution measuring means, and the blood viscosity The viscosity shear rate relationship is calculated based on the blood viscosity and blood shear rate extracted at a plurality of points set in advance in the blood vessel within the distribution and the blood shear rate distribution. In this way, it is possible to more accurately calculate the viscosity shear rate relationship individually matched to the blood vessel and blood to be examined.
- the viscosity shear rate relationship calculating means calculates the blood viscosity distribution based on the blood flow velocity distribution measured by the blood flow velocity distribution measuring means from a previously stored Navier-Stokes equation. To do. In this way, the blood viscosity distribution can be calculated based on the blood flow velocity distribution in a practical vascular function testing device.
- the blood shear stress calculating means is configured to distribute the blood flow velocity in the blood vessel in parallel with the measurement of the blood vessel diameter within the predetermined blood vessel diameter measurement period after the release of the ischemia.
- a second blood shear velocity calculating means for calculating a maximum value of the blood shear velocity based on the blood flow velocity distribution measured by the second blood velocity velocity measuring means, Second blood viscosity calculation for calculating blood viscosity based on the maximum value of the blood shear rate calculated by the second blood shear rate calculation unit from the viscosity shear rate relationship calculated by the viscosity shear rate relationship calculation unit
- the predetermined blood vessel diameter measurement period based on the maximum value of the blood shear rate calculated by the second blood shear rate calculating unit and the blood viscosity calculated by the second blood viscosity calculating unit
- Second blood shear stress calculating means for calculating blood shear stress, and (b) when a predetermined calculation method switching condition is satisfied, the first blood flow velocity measuring means is configured to output the average blood.
- the second blood flow velocity measuring means measures the blood flow velocity distribution.
- the blood shear stress calculated by the second blood shear stress calculating means is more accurate than the case of calculating by the first blood shear stress calculating means.
- the load is considered to be large, it is possible to switch how the blood shear stress is calculated according to the predetermined calculation method switching condition according to the calculation load predicted after the release of ischemia, for example. Is possible.
- the blood vessel function testing device is characterized in that the value related to the blood shear stress calculated by the first blood shear stress calculating means or the second blood shear stress calculating means and the blood vessel diameter measurement.
- Index value calculation means for calculating a ratio of the diameter change rate of the blood vessel after release of the ischemia measured by the means.
- the measurement result of the blood vessel diameter change rate can be evaluated based on the blood shear stress. For example, a plurality of FMD test results can be compared and evaluated based on blood shear stress.
- the ultrasonic probe that radiates the ultrasonic waves toward the blood vessel is a longitudinal ultrasonic array in which a plurality of ultrasonic oscillators are linearly arranged in the longitudinal direction of the blood vessel.
- the longitudinal super The blood flow velocity in the blood vessel is measured by ultrasonic waves from the ultrasonic array probe, and the blood vessel diameter is measured by ultrasonic waves from the orthogonal ultrasonic array probe.
- the measurement of the blood flow velocity and the measurement of the blood vessel diameter can be performed in parallel using an ultrasonic probe that has been put into practical use.
- the blood flow velocity measurement and the blood vessel diameter measurement are performed in parallel by operating the longitudinal ultrasonic array probe and the orthogonal ultrasonic array probe alternately in a very short cycle. Can be done.
- the ultrasonic probe that radiates the ultrasonic waves toward the blood vessel is a longitudinal ultrasonic array in which a plurality of ultrasonic oscillators are linearly arranged in the longitudinal direction of the blood vessel.
- a probe, and (b) the longitudinal ultrasonic array probe includes an operation for measuring a blood flow velocity in the blood vessel and an operation for measuring the blood vessel diameter over time. Let it happen alternately. In this way, the measurement of the blood flow velocity and the measurement of the blood vessel diameter can be performed in parallel using an ultrasonic probe that has been put into practical use. For example, the operation for measuring the blood flow velocity in the blood vessel and the operation for measuring the blood vessel diameter are alternately performed in a very short cycle by the longitudinal ultrasonic array probe.
- the predetermined calculation method switching condition is that the pulse rate at the time of release of the ischemia is equal to or higher than a predetermined pulse rate determination value, and the predetermined calculation method switching condition is The case where is satisfied is a case where the pulse rate at the time of releasing the ischemic is equal to or greater than the predetermined pulse rate determination value.
- FIG. 3 It is a figure showing the whole structure of the blood vessel function test
- emitted from the ultrasonic probe of FIG. 3 is a time chart illustrating an example of a change in blood vessel lumen diameter after release of ischemia measured by ultrasound from the ultrasound probe of FIG. 2.
- FIG. 2 is an image diagram of blood viscosity distribution calculated based on the blood flow velocity distribution in the blood vessel function testing device of FIG. 1. It is the figure which illustrated the state in which the space in the blood vessel from which the blood flow velocity distribution was measured with the ultrasonic wave from the ultrasonic probe of FIG. 2 was divided
- FIG. 2 is an image diagram of blood shear rate distribution calculated based on the blood flow velocity distribution in the blood vessel function testing device of FIG. 1.
- FIG. 2 is a diagram illustrating the relationship between blood viscosity and blood shear rate extracted from the blood viscosity distribution and blood shear rate distribution in the blood vessel function testing device of FIG. 1.
- FIG. 3 is a flowchart of a first embodiment for explaining a main part of a control operation of the vascular function test apparatus of FIG. 1, that is, a control operation for calculating a viscosity shear rate relationship from a measurement result at rest before release of ischemia.
- FIG. 13 is a flowchart illustrating a control operation of the vascular function test apparatus of FIG.
- FIG. 1 shows a blood flow velocity in a blood vessel 20 located immediately below the skin 18 of the upper arm 16 of the living body 14 and the blood flow rate of the blood vessel 20 using the hybrid probe unit 12 held in the sensor holder 10. It is a figure showing the whole structure of the vascular function test
- the hybrid probe unit 12 functions as a sensor for detecting biological information related to the blood vessel 20, that is, a blood vessel parameter.
- the hybrid probe unit 12 has two rows of first short-axis ultrasonic array probes A and first parallel to each other. 2.
- An H-shaped probe comprising a short-axis ultrasonic array probe B and a long-axis ultrasonic array probe C connecting the central portions in the longitudinal direction on a flat probe surface 27.
- the ultrasonic probe 24 and a multi-axis drive device (positioning device) 26 for positioning the ultrasonic probe 24 are provided.
- the first short-axis ultrasonic array probe A, the second short-axis ultrasonic array probe B, and the long-axis ultrasonic array probe C are, for example, a large number of piezoelectric ceramics. It is configured respectively in the longitudinal shape by the ultrasonic transducer (ultrasonic oscillator) a 1 ⁇ a n are linearly arranged.
- the first short axis ultrasonic array probe A corresponds to the orthogonal ultrasonic array probe of the present invention
- the long axis ultrasonic array probe C corresponds to the longitudinal ultrasonic array probe of the present invention. Corresponds to the tentacles.
- FIG. 2 is a diagram for explaining the x 0 y 0 z 0 axis orthogonal coordinate axes used in this embodiment, and is parallel to the longitudinal direction of the first short axis ultrasonic array probe A and its first short axis.
- the direction that is located directly below the axial ultrasonic array probe A and passes through or near the blood vessel 20 is defined as the z 0 axis, and is parallel to the longitudinal direction of the long axis ultrasonic array probe C and orthogonal to the z 0 axis.
- the direction is the x 0 axis, passes through the intersection of the longitudinal direction of the first short axis ultrasonic array probe A and the long direction of the long axis ultrasonic array probe C, and the x 0 axis direction and z 0.
- the direction perpendicular to the axial direction is taken as the y 0 axis.
- the ultrasonic probe 24 is translated by the multi-axis drive device 26 in the z 0 axis direction and rotated around the y 0 axis and the z 0 axis.
- the blood vessel 20 that is, for example, the brachial artery has a three-layer structure including an intima L 1 , a media L 2 , and an adventitia L 3 . Since the reflection of ultrasonic waves occurs at different parts of the acoustic impedance, the boundary surface between the blood in the blood vessel lumen and the intima L 1 and the boundary surface between the media L 2 and the outer membrane L 3 are actually displayed in white. Organizations are displayed in black and white groups. In the image, the boundary surface between the intima L 1 and the blood but hardly appears, measures the distance as vessel diameter, it is desired to use an extension ratio R of the change rate ie lumen diameter.
- the blood vessel function testing device 22 includes an electronic control device 28 including a so-called microcomputer having a CPU that processes an input signal in accordance with a program stored in the ROM in advance while using the temporary storage function of the RAM.
- a drive signal is supplied from the ultrasonic drive control circuit 32 by the electronic control unit 28, and the first short axis ultrasonic array probe A and the second short axis ultrasonic array of the ultrasonic probe 24 of the hybrid probe unit 12 are used.
- Ultrasonic waves are emitted from the probe B and the long-axis ultrasonic array probe C, and the first short-axis ultrasonic array probe A and the second short-axis ultrasonic array probe B and By receiving the ultrasonic reflection signal detected by the long axis ultrasonic array probe C and processing the ultrasonic reflection signal, an ultrasonic image under the skin 18 is generated, and the monitor screen display device 30. Is displayed.
- the monitor screen display device 30 includes an ultrasonic image by the first short-axis ultrasonic array probe A, an ultrasonic image by the second short-axis ultrasonic array probe B, and a long-axis ultrasonic image.
- Ultrasonic images from the acoustic array probe C are displayed in predetermined image display areas, respectively. Furthermore, these image display areas have a common vertical axis indicating the depth from the skin 18.
- the monitor screen display device 30 displays the rate of change of the intima diameter, that is, the lumen diameter expansion rate R in time series when evaluating the FMD.
- the ultrasonic probe 24 is at a predetermined measurement position with respect to the blood vessel 20.
- the multi-axis driving device 26 supplied with the driving signal from the three-axis driving motor control circuit 34 by the electronic control device 28 is driven and positioned.
- the predetermined measurement position is a position where the first short-axis ultrasonic array probe A and the second short-axis ultrasonic array probe B are orthogonal to the blood vessel 20, and a long-axis super-position. This is a position where the acoustic wave array probe C is parallel to the blood vessel 20. Further, this is a position where the diameter of the blood vessel 20 appears in the longitudinal sectional image of the blood vessel 20 by the long-axis ultrasonic array probe C.
- the sensor holder 10 is in a state in which the blood vessel 20 positioned immediately below the skin 18 of the upper arm 16 of the living body 14 is lightly contacted at a desired position in the three-dimensional space, that is, the predetermined measurement position so as not to deform.
- the hybrid probe unit 12 is held in a desired posture.
- the ultrasonic probe 24 of the hybrid probe unit 12 is generally well-known between the end face of the ultrasonic probe 24 and the skin 18 in order to clarify an ultrasonic image by suppressing ultrasonic attenuation, reflection and scattering at the boundary surface.
- a coupling agent such as jelly is interposed.
- a water bag in which water is confined in a resin bag olive oil, glycerin, or the like can be used.
- the sensor holder 10 includes, for example, a magnet base 36 that is fixed to a desk, a pedestal, etc. by magnetic attraction, a unit fixture 38 to which the hybrid probe unit 12 is fixed, a magnet base 36 and a unit fixture 38.
- Connecting members 44, 45 having one end fixed and a spherically formed tip portion 42, and via these connecting members 44, 45, the magnet base 36 and the unit fixture 38 are connected and supported so as to be relatively movable.
- a universal arm 40 that performs the operation.
- the universal arm 40 includes two links 46 and 47 that are rotatably connected to each other, and a distal end portion 42 of which one end of the links 46 and 47 is energized with a predetermined resistance.
- Multiaxis driving device 26, and z 0 axis rotation (yawing) mechanism that is fixed to the unit fixing tool 38 to position the rotational position around z 0 axis of the ultrasonic probe 24 by z 0 axis rotation actuator , z 0 by the shaft rotation actuator and z 0 axis translation mechanism for positioning the z 0 of the axial translation position of the ultrasonic probe 24, the rotational position around y 0 axis of the ultrasonic probe 24 by y 0 axis actuator And a y 0 axis rotation mechanism for positioning the lens.
- the ultrasonic drive control circuit 32 is arranged in accordance with a command from the electronic control device 28, for example, a large number of ultrasonic transducers arranged in a line constituting the first short-axis ultrasonic array probe A. a 1 to one of a n, the ultrasonic transducer a 1 et of the end, a certain number of the ultrasonic transducer groups for example 15 a 1 to a 15 a frequency of about 10MHz while applying a predetermined phase difference for each
- the beam forming drive that is driven at the same time causes the convergent ultrasonic beam to be sequentially emitted toward the blood vessel 20 in the arrangement direction of the ultrasonic transducers, and the ultrasonic beam is scanned while shifting the ultrasonic transducers one by one.
- a reflected wave for each radiation at the time of (scanning) is received and input to the electronic control unit 28.
- the electronic control unit 28 synthesizes an image based on the reflected wave, generates a cross-sectional image (short axis image) or a vertical cross-sectional image (long axis image) of the blood vessel 20 under the skin 18, and displays the monitor screen. The information is displayed on the device (image display device) 30. Further, the electronic control unit 28 calculates or measures the diameter of the blood vessel 20 or the inner diameter (luminal diameter) d 1 which is the diameter of the inner skin 70 from the image.
- FIG 4 is a ischemia (avascularization) a time chart illustrating the change in the vessel lumen diameter d 1 after opening.
- t1 point represents the time ischemic opened, it begins to expand vascular lumen diameter d 1 from time t2, vascular lumen diameter d 1 at the time t3 has reached its maximum value d MAX It is shown. Therefore, the expansion rate R of the blood vessel lumen diameter calculated by the electronic control unit 28 is maximized at time t3.
- the ischemia for FMD evaluation is controlled by a cuff pressure control unit 56 (cuff pressure control means 56) provided in the electronic control device 28 using a pressure control valve 60 to control the original pressure from the air pump 58. Then, the pressure is supplied to the cuff 62 wound around the upper arm 16 and the pressure (cuff pressure) of the cuff 62 is increased to a predetermined ischemic cuff pressure exceeding the maximum blood pressure of the living body 14. At this time, the cuff pressure control unit 56 detects the cuff pressure by a signal from the pressure sensor 64 for detecting the cuff pressure.
- a cuff pressure control unit 56 cuff pressure control means 56
- the cuff pressure control unit 56 maintains the cuff pressure at the ischemic cuff pressure for a predetermined time before the release of the ischemia, that is, a predetermined time before the time t1, and when the ischemia is released (time t1). Immediately reduce the cuff pressure to atmospheric pressure.
- the electronic control device 28 of FIG. 1 noninvasively blood in the blood vessel 20 by ultrasonic waves emitted from the long-axis ultrasonic array probe C toward the blood vessel in the living body. Measure the flow velocity SPD.
- the electronic control unit 28 measures the blood flow velocity SPD in the blood vessel 20 at the same measurement site as the blood vessel lumen diameter d 1 in parallel with the measurement of the blood vessel lumen diameter d 1 in the FMD evaluation. . Then, the blood shear stress SS is calculated from the measured blood flow velocity SPD.
- the electronic control unit 28 operates the first short-axis ultrasonic array probe A and the long-axis ultrasonic array probe C alternately in a very short cycle, whereby the blood vessel lumen diameter d 1
- the measurement of the blood vessel lumen diameter expansion rate R and the blood flow velocity SPD can be performed in parallel.
- the electronic control unit 28 operates to measure the blood flow velocity SPD in the long-axis ultrasonic array probe C without using the first short-axis ultrasonic array probe A.
- the measurement of the blood flow velocity SPD and the measurement of the blood vessel lumen diameter d 1 can be performed in parallel by alternately performing the operation for measuring the blood vessel lumen diameter d 1 in a very short cycle. it can.
- FIG. 5 is a functional block diagram for explaining a main part of the control function provided in the vascular function inspection device 22 (vascular function evaluation unit 100).
- the blood vessel function evaluation unit 100 in the electronic control unit 28 includes a blood flow rate distribution measuring unit 102 as a blood flow rate distribution measuring unit and a viscosity shear rate relationship calculating unit.
- Viscosity shear rate relationship calculating means 104, blood vessel diameter measuring means 110 as a blood vessel diameter measuring section, blood shear stress calculating means 112 as a blood shear stress calculating section, and index value calculating means 114 as an index value calculating section I have.
- the viscosity shear rate relationship calculating means 104 includes a blood viscosity distribution calculating means 106 as a blood viscosity distribution calculating unit and a blood shear rate distribution calculating means 108 as a blood shear rate distribution calculating unit.
- the blood shear stress calculation means 112 includes a blood flow velocity measurement execution determination means 116 as a blood flow velocity measurement execution determination section, a first blood flow velocity measurement means 118 as a first blood flow velocity measurement section, First blood shear rate calculating means 120 as a blood shear rate calculating section, first blood viscosity calculating means 122 as a first blood viscosity calculating section, and first blood shear stress calculating means as a first blood shear stress calculating section 124, a second blood flow rate measuring unit 126 as a second blood flow rate measuring unit, a second blood shear rate calculating unit 128 as a second blood shear rate calculating unit, and a second blood viscosity calculating unit as a second blood viscosity calculating unit.
- the blood flow velocity distribution measuring means 102 measures the blood flow velocity distribution DS in the blood vessel 20 in a non-invasive manner using the Doppler effect with ultrasound before releasing the ischemia in the FMD evaluation. Specifically, the blood flow velocity distribution DS is measured at rest before the release of the ischemia. The blood flow velocity distribution DS measured at rest is referred to as rest blood flow velocity distribution DS RT . The blood flow velocity distribution measuring means 102 measures the resting blood flow velocity distribution DS RT . More specifically, the ultrasonic scattered wave (reflection) received by the long-axis ultrasonic array probe C of the ultrasonic probe 24 is measured.
- a tomographic image is created using waves and echoes to identify the position of the blood vessel 20, and at the same time, a two-dimensional velocity vector distribution in the two-dimensional tomographic plane is obtained.
- the two-dimensional velocity vector distribution is defined as a resting blood flow velocity distribution DS RT .
- the obtained velocity vector distribution may be two-dimensional or three-dimensional. However, in order to perform simple processing, the two-dimensional velocity vector distribution is obtained. If the blood flow velocity distribution DS at a certain moment (resting blood flow velocity distribution DS RT ) is shown as an example, the blood flow velocity distribution DS is as indicated by a solid line L01 shown in the image diagram of FIG.
- the blood flow velocity distribution measuring means 102 continuously or intermittently measures a resting blood flow velocity distribution DS RT for at least one heartbeat as time passes.
- the two-dimensional velocity vector distribution or the three-dimensional velocity vector distribution is obtained by, for example, using two ultrasonic tomographic images or three-dimensional volume images that are temporally continuous at a certain time interval to determine the movement amount of blood cells. It can be obtained by a correlation method and obtained by dividing the amount of movement by the time interval between two images.
- the blood flow velocity distribution measuring means 102 obtains a velocity component in the ultrasonic radiation direction, which is one velocity component of a two-dimensional velocity vector, by a method similar to the well-known color Doppler method, and is orthogonal thereto.
- the other two-dimensional velocity vector distribution can also be obtained by using the non-compressed condition in the fluid dynamics represented by the following formula (1) stored in advance.
- the blood flow velocity distribution measuring unit 102 non-invasively uses the ultrasonic wave radiated toward the blood vessel 20 in the living body 14 to release the resting blood flow velocity distribution DS RT in the blood vessel 20 after ischemia is released. Prior to the measurement of the diameter change rate R of the blood vessel 20, the measurement is performed in advance.
- the ultrasonic probe 24 is at the predetermined measurement position with respect to the blood vessel 20 prior to the measurement. So that it is positioned. As shown in FIG.
- x in the following formula (1) represents a position in a direction orthogonal to the ultrasonic beam axis
- y represents a position in the ultrasonic beam axis direction (ultrasonic radiation direction).
- U represents a velocity component in the x direction
- v represents a velocity component in the ultrasonic beam axis direction, that is, a velocity component in the y direction.
- the viscosity shear rate relationship calculating means 104 calculates the viscosity shear rate relationship VCSR, which is the relationship between the blood viscosity ⁇ and the blood shear rate SR, before the release of the ischemia, and the resting blood flow measured by the blood flow velocity distribution measuring means 102. Based on the velocity distribution DS RT , it is calculated in advance prior to the measurement of the diameter change rate R of the blood vessel 20 after release of ischemia.
- the viscosity shear rate relationship VCSR is calculated in advance so that the blood viscosity ⁇ can be immediately calculated from the blood shear rate SR, it may be a relational expression between the blood viscosity ⁇ and the blood shear rate SR, or blood It may be a table or a graph showing the correspondence between the viscosity ⁇ and the blood shear rate SR.
- the viscosity shear rate relationship calculating unit 104 first calculates the blood viscosity distribution DV based on the resting blood flow rate distribution DS RT measured by the blood flow rate distribution measuring unit 102.
- Blood viscosity distribution DV Blood shear rate distribution DV
- blood shear rate distribution DSR blood shear rate distribution DSR
- the blood viscosity distribution calculating unit 106 and the blood shear rate distribution calculating unit 108 included in the viscosity shear rate relationship calculating unit 104 calculate the blood viscosity distribution DV and the blood shear rate distribution DSR as follows. .
- the blood viscosity distribution calculating means 106 is a resting blood flow measured by the blood flow velocity distribution measuring means 102 from a pre-stored two-dimensional Navier-Stokes equation expressed by the following equations (2) and (3). Based on the velocity distribution DS RT , the viscosity distribution DV of blood in the blood vessel 20 to be measured is calculated.
- the blood viscosity distribution DV calculated based on the resting blood flow velocity distribution DS RT is referred to as resting blood viscosity distribution DV RT .
- the blood viscosity distribution DV at a certain moment is illustrated by the solid line L02 shown in the image diagram of FIG.
- the resting blood flow velocity distribution DS RT is a three-dimensional velocity vector distribution
- the three-dimensional Navier-Stokes equation is used to calculate the resting blood viscosity distribution DV RT .
- x, y, u, v in the above equations (2) and (3) are the same as those in the above equation (1), “t” is time, “p” is pressure, and “ ⁇ ” is The density of blood, “ ⁇ ”, represents kinematic viscosity (also referred to as “kinematic viscosity”). Further, the kinematic viscosity ⁇ is calculated by the above formula (4) when the blood viscosity (also referred to as “viscosity”) is “ ⁇ ”. The kinematic viscosity ⁇ can be obtained from the above formula (5) derived from the above formula (2) and the above formula (3) by eliminating the term of the pressure “p” included in the formula by the differential operation. it can. “ ⁇ ” in the equation (5) is the vorticity, calculated by the above equation (6), and defined from only the velocity vector component as can be seen from the equation (6).
- the blood viscosity distribution calculating means 106 calculates the resting blood viscosity distribution DV RT based on the resting blood flow velocity distribution DS RT , it is assumed that the blood is incompressible, as shown in FIG.
- the space in the blood vessel 20 is divided into a plurality of virtually subdivided sub-regions 150, and the blood density ⁇ and blood viscosity ⁇ are constant in the sub-region 150. Apply the Navier-Stokes equation. Then, the blood viscosity distribution DV RT at rest is calculated by integrating the blood viscosity ⁇ calculated for each sub-region 150.
- the blood shear rate distribution calculating unit 108 calculates the shear rate distribution DSR of blood in the blood vessel 20 to be measured based on the resting blood flow rate distribution DS RT measured by the blood flow rate distribution measuring unit 102. Specifically, the blood shear velocity distribution calculating means 108 obtains a two-dimensional strain velocity tensor based on the resting blood flow velocity distribution DS RT (two-dimensional velocity vector distribution), and sets the direction of the two-dimensional velocity vector as the tangential direction. A direction perpendicular to the stream line is approximated as the normal direction of the blood vessel 20, and the two-dimensional strain rate component is subjected to rotational coordinate conversion using the approximated normal direction of the blood vessel 20 as a base axis (FIG. 7).
- the shear component e xy0 obtained by the arrow AR1 is extracted as the blood shear rate SR, and the blood shear rate distribution DSR is calculated.
- the blood shear rate distribution DSR calculated based on the resting blood flow rate distribution DS RT is referred to as a resting blood shear rate distribution DSR RT . If an example of the blood shear rate distribution DSR (resting blood shear rate distribution DSR RT ) at a certain moment is shown as an example, the blood shear rate distribution DSR is as indicated by a solid line L03 shown in the image diagram of FIG.
- the shear component e xy0 is expressed by the following formula (7), and the following formula (7) is stored in the blood shear rate distribution calculating means 108 in advance.
- the three-dimensional strain velocity tensor is used for calculating the resting blood shear velocity distribution DSR RT .
- x 0 , y 0 , u 0 , v 0 in the following formula (7) is obtained by rotating coordinate transformation of x, y, u, v in the formula (1) (see arrow AR1 in FIG. 7), As shown in FIGS. 2 and 7, the y 0 axis coincides with the normal direction of the blood vessel wall, and the x 0 axis coincides with the longitudinal (long axis) direction of the blood vessel 20.
- the y axis coincides with the ultrasonic beam axis direction
- the x axis coincides with the orthogonal direction of the ultrasonic beam axis.
- U 0 represents a velocity component in the x 0 direction
- v 0 represents a velocity component in the y 0 direction.
- FIG. 10 is expressed based on the absolute value of the resting blood shear rate distribution DSR RT which is the difference result of the resting blood flow velocity distribution DS RT in the coordinate system of the figure.
- the blood shear rate distribution calculating means 108 is similar to the case of calculating the resting blood viscosity distribution DV RT .
- the space in the blood vessel 20 is divided into a plurality of virtually subdivided sub-regions 150, and the formula (7) is applied to each sub-region 150, and the blood shear for each sub-region 150.
- the shear component e xy0 as the speed SR is calculated.
- a resting blood shear rate distribution DSR RT is calculated.
- the viscosity shear rate relationship calculating unit 104 The viscosity shear rate relationship VCSR based on the extracted blood viscosity ⁇ and the blood shear rate SR at a plurality of points preset in the blood vessel 20 in the resting blood viscosity distribution DV RT and resting blood shear rate distribution DSR RT . Is calculated. Specifically, the viscosity shear rate relationship VCSR is calculated based on the extracted blood viscosity ⁇ and blood shear rate SR as follows.
- the viscosity shear rate relationship calculating means 104 extracts a plurality of combinations of blood viscosity ⁇ and blood shear rate SR from the calculated resting blood viscosity distribution DV RT and resting blood shear rate distribution DSR RT .
- a plurality of preset points that is, a plurality of sampling points, are stored in the blood vessel 20.
- the plurality of sampling points are arbitrarily distributed and set within the blood vessel 20 in a range where the resting blood viscosity distribution DV RT and resting blood shear rate distribution DSR RT are calculated, for example.
- the viscosity shear rate relationship calculating means 104 extracts the blood viscosity ⁇ and the blood shear rate SR at each of the plurality of sampling points from the resting blood viscosity distribution DV RT and the resting blood shear rate distribution DSR RT .
- the extracted set of blood viscosity ⁇ and blood shear rate SR are extracted by spatially matching each other in the blood vessel 20 at the sampling point, but the resting blood viscosity distribution DV RT and rest are extracted.
- the hourly blood shear rate distribution DSR RT is not instantaneous but continuous or intermittent with time, they are extracted in time with each other.
- the viscosity shear rate relationship calculating means 104 extracts the blood viscosity ⁇ and the blood shear rate SR at the plurality of sampling points, and then represents or approximates the relationship between the extracted blood viscosity ⁇ and the blood shear rate SR. Calculate one viscosity shear rate relationship VCSR.
- This viscosity shear rate relationship VCSR is, for example, a curve connecting the relationship points indicating the blood viscosity ⁇ and the blood shear rate SR at the plurality of sampling points in the coordinate system having the blood viscosity ⁇ and the blood shear rate SR as parameters.
- viscosity shear rate relation line or as a relational expression (viscosity shear speed relational expression) between blood viscosity ⁇ and blood shear rate SR indicating the viscosity shear rate relation line.
- the viscosity shear rate relationship VCSR is at least 2. More specifically, the viscosity shear rate relationship line is an approximate curve composed of approximate points of the viscosity shear rate relationship points at the plurality of sampling points, and the viscosity shear rate relationship line is calculated.
- the speed relational expression is a relational expression between the blood viscosity ⁇ and the blood shearing speed SR indicating the approximate curve (viscosity shear rate relation line).
- the calculation of the viscosity shear rate relationship VCSR will be described with reference to FIG.
- FIG. 11 is a diagram illustrating the viscosity shear rate relationship line representing the relationship between the blood viscosity ⁇ and the blood shear rate SR extracted from the resting blood viscosity distribution DV RT and the resting blood shear rate distribution DSR RT .
- FIG. 11 shows an example in which three sets of blood viscosity ⁇ and blood shear rate SR are extracted, and blood viscosity ⁇ of a healthy person having normal blood with a hematocrit value (normal value) Ht 0 as a comparison target.
- the relationship with the blood shear rate SR is indicated by a solid line L04.
- a first sampling point P A in blood viscosity mu A and the blood shear rate SR A is extracted with three sampling points
- first 2 of the blood viscosity mu B in the sampling point P B and the blood shear rate SR B is extracted
- the third sampling point P C in blood viscosity mu C and the blood shear rate SR C are extracted.
- the blood viscosity ⁇ A, ⁇ B, ⁇ C and the blood shear rate SR A, SR B the relationship is formed as indicated by the example dashed line L05 represents 11 and SR C.
- the broken line L05 is the viscosity shear rate relationship line based on the relationship between the blood viscosity ⁇ and the blood shear rate SR at the plurality of sampling points, that is, the blood viscosity ⁇ and the blood shear rate indicated by the broken line L05.
- the relationship with SR is the viscosity shear rate relationship VCSR.
- the viscosity shear rate relationship calculating means 104 calculates the viscosity shear rate relationship VCSR as the viscosity shear rate relationship equation, for example, the viscosity shear rate relationship VCSR (broken line L05) is expressed by the following equation (8).
- the constants “A” and “ ⁇ ” in the following equation (8) are obtained based on the relationship between the blood viscosity ⁇ and the blood shear rate SR at the plurality of sampling points. Calculate the viscosity shear rate relationship VCSR.
- the blood vessel diameter measuring means 110 synthesizes an image with ultrasonic waves emitted from the first short-axis ultrasonic array probe A of the ultrasonic probe 24 toward the blood vessel 20 in the living body 14 and non-invasively from the image. to measure the vessel lumen diameter d 1.
- the blood vessel diameter measuring means 110 in FMD evaluation, in order to measure the diameter change rate of the blood vessel 20 after ischemia open (possible expansion vessel lumen diameter d 1 R), at rest before ischemia open
- the blood vessel lumen diameter d a (resting diameter d a ) is measured and recorded in advance.
- the blood vessel diameter measuring means 110 measures the blood vessel lumen diameter d 1 within a predetermined blood vessel diameter measuring period TIME1 after the release of the ischemia, and further measures the measured blood vessel lumen diameter d for FMD evaluation. 1 and calculating the diameter change ratio R of the blood vessel 20 from said rest diameter d a measure. For example, as shown in FIG. 4, the blood vessel diameter measuring means 110 continuously measures the blood vessel lumen diameter d 1 that changes thereafter from when the ischemia is released over the blood vessel diameter measuring period TIME1 over time.
- a measurement time of the blood vessel lumen diameter d 1 is expected to be substantially maximized one or more experimentally based on the time of ischemic opened, by measuring the blood vessel lumen diameter d 1 at the measurement point Also good.
- the blood vessel diameter measuring time period TIME1 is intravascular stored in vessel diameter measuring means 110 is experimentally set on the basis of the time ischemic opened to measure the maximum value d MAX vascular lumen diameter d 1 after ischemia open lumen diameter d is one of the measurement time, starting from the vessel lumen diameter d 1 is and when ischemia opening includes a time point (t3 time) to reach its maximum value d MAX (t1 time) as shown in FIG.
- the viscosity shear rate relationship VCSR is calculated in advance before the release of the ischemia, but after the release of the ischemia, the viscosity shear rate relationship VCSR is used to process the blood flow velocity SPD in real time.
- the blood shear stress SS is calculated based on the blood flow velocity SPD. This point will be described.
- the blood shear stress calculation means 112 measures the blood flow velocity SPD in the blood vessel 20 within the blood vessel diameter measurement period TIME1 after release of ischemia, and based on the measured blood flow velocity SPD using the viscosity shear velocity relationship VCSR. Blood shear stress SS is calculated. Steps up to the calculation of the blood shear stress SS from measurements of the blood flow velocity SPD is the line in parallel with the measurement of the diameter change rate of the blood vessel 20 by the blood vessel diameter measuring means 110 (expansion ratio of the vessel lumen diameter d 1 R) Is called. Specifically, blood shear stress SS is calculated by real-time processing as follows.
- the blood flow velocity measurement execution determination means 116 includes a first blood flow velocity measurement means 118 and a second blood flow velocity measurement means 126 as blood flow velocity measurement means by which the blood shear stress calculation means 112 measures the blood flow velocity SPD. Since it is provided, it is a determination means provided to determine which blood flow velocity measurement means measures the blood flow velocity SPD. Blood flow velocity measurement execution determination means 116 determines whether or not a predetermined calculation method switching condition is satisfied.
- the calculation method switching condition is a determination condition set to determine which of the first blood flow velocity measuring means 118 and the second blood flow velocity measuring means 126 should measure the blood flow velocity SPD.
- the calculation method switching condition is that the pulse rate PR at the time of ischemia release (pulse rate PR at the time of ischemia release) is not less than a predetermined pulse rate determination value PR1, that is, The case where the calculation method switching condition is satisfied is a case where the pulse rate PR when the ischemia is released is equal to or higher than the pulse rate determination value PR1.
- the blood flow velocity measurement execution determining means 116 determines that the calculation method switching condition is satisfied when the ischemia-opening pulse rate PR is equal to or greater than the pulse-rate determination value PR1, while the ischemia-opening pulse rate.
- PR is less than the pulse rate determination value PR1
- the pulse rate PR at the time of ischemia release is larger, the fluctuation in blood flow velocity SPD after ischemia release is larger and the calculation load until blood shear stress SS is calculated from the blood flow velocity SPD is predicted to increase.
- the pulse rate determination value PR1 is a determination value for determining the calculation load after the predicted ischemia release.
- the above-mentioned pulse rate PR at the time of release of the ischemia is preferably measured at the time of release of the ischemia immediately before the release of the ischemia in consideration of the pulse measurement time and the judgment time in order to measure the blood flow velocity SPD from the time of the release of the ischemia. For example, it is measured before the predetermined time when a control signal for commanding release of blood issuance is output by setting the cuff pressure from the cuff pressure control unit 56 to atmospheric pressure.
- the pulse rate of the living body 14 can be detected by, for example, a pulse meter or an electrocardiograph.
- the first blood flow velocity measuring means 118 when the blood flow velocity measurement execution determining means 116 determines that the pulse rate PR at the time of ischemia release is equal to or higher than the pulse rate determination value PR1, the blood vessel diameter after the release of the ischemia.
- the first blood flow velocity measuring means 118 measures the average blood flow velocity SPD AVG continuously or at predetermined time intervals until the blood vessel diameter measurement period TIME1 elapses as time elapses immediately after the ischemia is released.
- the first blood flow velocity measuring unit 118 measures the blood flow velocity distribution DS by the same method as the blood flow velocity distribution measuring unit 102, and the blood flow.
- the average blood flow velocity SPD AVG is calculated from the velocity distribution DS and measured.
- the average blood flow velocity SPD AVG is stored in a storage device or the like together with the elapsed time from when the ischemia is released to when it is measured.
- the first blood flow velocity measuring means 118 calculates the average blood flow velocity SPD AVG by integrating the blood flow velocity SPD in the blood flow velocity distribution DS over the entire blood vessel cross-sectional area and dividing it by the blood vessel cross-sectional area.
- the average blood flow velocity SPD AVG is obtained by multiplying the blood flow velocity SPD at a specific location (for example, the blood vessel center) in the blood vessel 20 in the blood flow velocity distribution DS by a correction coefficient obtained experimentally in advance. It may be calculated.
- the average blood flow velocity SPD AVG measured by the first blood flow velocity measuring means 118 may be an average value (instantaneous average value) of the blood flow velocity SPD obtained from the instantaneous blood flow velocity distribution DS. Therefore, in this embodiment, the average value of the blood flow velocity SPD is obtained by averaging the instantaneous average value of the blood flow velocity SPD in one heart beat. Therefore, the first blood flow velocity measuring means 118 of the present embodiment will output the average blood flow velocity SPD AVG measurements per heart beat, in other words, the average blood flow velocity SPD AVG for each heart beat Will be measured.
- the first blood shear rate calculating unit 120 calculates the blood shear rate SR based on the average blood flow rate SPD AVG measured by the first blood flow rate measuring unit 118.
- the first blood shear rate calculating means 120 performs the calculation of the blood shear rate SR by real-time processing for the measurement of the average blood flow velocity SPD AVG by the first blood flow velocity measuring means 118.
- the blood flow velocity distribution DS in the blood vessel 20 to be measured has a substantially laminar flow distribution. As shown in the equation (9), a blood shear rate SR is obtained by dividing the average blood flow velocity SPD AVG by the blood vessel diameter (for example, the blood vessel lumen diameter d 1 ).
- the blood vessel lumen diameter d 1 used for the calculation of the blood shear rate SR is the blood vessel diameter measuring means 110 in time synchronization with the measurement of the average blood flow velocity SPD AVG which is the basis for calculating the blood shear rate SR. It is measured by.
- SPD AVG average blood flow velocity
- the conditions for adopting the blood vessel lumen diameter d 1 used for calculating the blood shear rate SR may be determined in advance. For example, an average value or a maximum value for each heartbeat is employed.
- the first blood viscosity calculating unit 122 calculates the blood shear rate SR calculated by the first blood shear rate calculating unit 120 based on the viscosity shear rate relationship VCSR calculated in advance by the viscosity shear rate relationship calculating unit 104 before releasing the ischemia. Based on the above, blood viscosity ⁇ is calculated.
- the first blood viscosity calculating means 122 calculates the blood viscosity ⁇ every time the first blood shear rate calculating means 120 calculates the blood shear rate SR, that is, the average blood by the first blood flow rate measuring means 118. Flow velocity SPD AVG measurement is performed in real time.
- the first blood shear stress calculating unit 124 calculates the blood shear stress SS based on the blood shear rate SR calculated by the first blood shear rate calculating unit 120 and the blood viscosity ⁇ calculated by the first blood viscosity calculating unit 122. calculate. Specifically, the first blood shear stress calculation means 124 stores in advance a Newtonian viscosity law expression expressed by the following formula (10), and the calculated blood shear rate SR is calculated from the Newtonian viscosity law expression. And the blood shear stress SS is calculated based on the blood viscosity ⁇ .
- the first blood shear stress calculating means 124 calculates the blood shear stress SS every time the first blood shear rate calculating means 120 calculates the blood shear rate SR and the first blood viscosity calculating means 122 calculates the blood viscosity ⁇ .
- the measurement of the average blood flow velocity SPD AVG by the first blood flow velocity measuring means 118 is performed in real time.
- the first blood shear stress calculating unit 124 outputs the measurement result of the average blood flow velocity SPD AVG for each heartbeat because the first blood flow velocity measuring unit 118 outputs one heartbeat within the blood vessel diameter measurement period TIME1.
- Blood shear stress SS is calculated every time.
- the blood shear stress SS is a state quantity that fluctuates even during one heartbeat.
- the blood shear stress SS calculated by the first blood shear stress calculation means 124 in this way is an average value of the blood flow velocity SPD for each heartbeat. Since it is calculated based on the measured average blood flow velocity SPD AVG , it can be said that it is one heart rate average shear stress SS AVG averaged over time for each heart rate. Note that the first blood shear stress calculating unit 124 immediately displays the blood shear stress SS on the monitor screen display device 30 every time the blood shear stress SS is calculated in this way, for example.
- the second blood flow velocity measuring means 126 when the blood flow velocity measurement execution determining means 116 determines that the pulse rate PR at the time of ischemia release is less than the pulse rate determination value PR1, the blood vessel diameter after the release of the ischemia.
- the blood flow velocity distribution DS in the blood vessel 20 is measured noninvasively in parallel with the measurement of the diameter change rate R of the blood vessel 20 by the blood vessel diameter measuring means 110. Then, the measured blood flow velocity distribution DS is stored in a storage device or the like together with the elapsed time from the time of release of ischemia to the time of measurement.
- the blood flow velocity distribution DS measured after the release of ischemia is referred to as the blood flow velocity distribution DS2 after the release of ischemia.
- the second blood flow velocity measuring means 126 continuously measures the blood flow velocity distribution DS2 after release of ischemia until the blood vessel diameter measurement period TIME1 elapses as time elapses immediately after the release of ischemia. Specifically, the second blood flow velocity measuring means 126 measures the blood flow velocity distribution DS2 after the release of the ischemia by the same method as the blood flow velocity distribution measuring means 102 when measuring the blood flow velocity distribution DS2.
- the second blood shear rate calculating means 128 calculates the maximum value SR2 MAX of the blood shear rate SR based on the post-ischemic blood flow velocity distribution DS2 measured by the second blood flow velocity measuring means 126. Specifically, the second blood shear rate calculating unit 128 calculates the blood shear rate distribution DSR based on the blood flow rate distribution DS2 after ischemia release by the same method as the blood shear rate distribution calculating unit 108, and then blood. The maximum value SR2 MAX of the blood shear rate SR in the shear rate distribution DSR is extracted and calculated.
- the blood shear rate SR at a predetermined position near the blood vessel wall in the blood shear rate distribution DSR is the maximum value. It may be calculated as SR2 MAX .
- the second blood shear rate calculating means 128 calculates the maximum value SR2 MAX of the blood shear rate SR by real-time processing for the measurement of the blood flow velocity distribution DS2 after the ischemia release by the second blood flow velocity measuring means 126. Do.
- the second blood viscosity calculating unit 130 calculates the blood shear rate SR calculated by the second blood shear rate calculating unit 128 from the viscosity shear rate relationship VCSR calculated by the viscosity shear rate relationship calculating unit 104 in advance before the release of ischemia.
- the blood viscosity ⁇ is calculated based on the maximum value SR2 MAX of.
- the second blood viscosity calculation means 130 performs the calculation of the blood viscosity ⁇ by real time processing for the calculation of the maximum value SR2 MAX of the blood shear rate SR by the second blood shear rate calculation means 128. That is, the second blood viscosity calculating means 130 performs the calculation of the blood viscosity ⁇ by real-time processing with respect to the measurement of the blood flow velocity distribution DS2 after ischemia release by the second blood flow velocity measuring means 126.
- the second blood shear stress calculating unit 132 is based on the maximum value SR2 MAX of the blood shear rate SR calculated by the second blood shear rate calculating unit 128 and the blood viscosity ⁇ calculated by the second blood viscosity calculating unit 130.
- Blood shear stress SS is calculated within the blood vessel diameter measurement period TIME1.
- the second blood shear stress calculating means 132 stores in advance a Newtonian viscosity law expression expressed by the above equation (10), and the calculated blood shear rate SR is calculated from the Newtonian viscosity law expression.
- the blood shear stress SS is calculated on the basis of the maximum value SR2 MAX and the blood viscosity ⁇ .
- the second blood shear stress calculating unit 132 calculates the blood shear stress SS by calculating the maximum value SR2 MAX of the blood shear rate SR by the second blood shear rate calculating unit 128 and the above by the second blood viscosity calculating unit 130.
- the calculation of blood viscosity ⁇ is performed by real-time processing. That is, the second blood shear stress calculation means 132 performs the calculation of the blood shear stress SS by real-time processing with respect to the measurement of the blood flow velocity distribution DS2 after the release of ischemia by the second blood flow velocity measurement means 126.
- the second blood shear stress calculating unit 132 continuously calculates the blood shear stress SS accordingly.
- the second blood shear stress calculating means 132 displays the blood shear stress SS on the monitor screen display device 30 in real time as soon as the blood shear stress SS is calculated, for example.
- the blood flow velocity distribution DS2 after ischemia release which is the basis for calculating the blood shear stress SS, is instantaneous. Therefore, the blood shear stress SS is instantaneous as well as the blood flow velocity distribution DS2 after ischemia release. Value. Therefore, the second blood shear stress calculation means 132 averages the calculated blood shear stress SS for each heart beat in time, and calculates the average value for each heart beat as the one heart beat average shear stress SS AVG . For example, a blood shear stress SS within one heartbeat time is drawn and integrated over time, and a value obtained by dividing the integrated value by the one heartbeat time is defined as one heartbeat average shear stress SS AVG .
- the second blood shear stress calculating means 132 calculates the one-beat average shear stress SS AVG for each heartbeat within the blood vessel diameter measuring period TIME1, and then the blood flow velocity after release of ischemia by the second blood flow velocity measuring means 126. Perform real-time processing as the measurement of distribution DS2 progresses.
- the second blood shear stress calculating means 132 displays the one-beat average shear stress SS AVG on the monitor screen display apparatus 30 immediately in real time as for calculating the one-beat average shear stress SS AVG.
- one-beat average shear stress SS AVG and the second blood shear stress calculating means 132 calculated by 1 represents the one-beat average shear stress SS AVG calculated by the first blood shear stress calculating means 124 as SS1 AVG
- the one-beat average shear stress SS AVG calculated by the second blood shear stress calculating means 132 is SS2 AVG. It shall be expressed as
- the index value calculating means 114 is a blood vessel measured by the blood vessel diameter measuring means 110 after the lapse of the blood vessel diameter measuring period TIME1, that is, after the measurement of the blood vessel lumen diameter d 1 by the blood vessel diameter measuring means 110 after release of the ischemia.
- the value SS X (blood shear stress related value SS X ) related to the blood shear stress SS calculated by the first blood shear stress calculating means 124 or the second blood shear stress calculating means 132 and the calculated post-ischemic release
- a ratio with the maximum value R MAX of the diameter change rate of the blood vessel 20 (blood vessel diameter change rate maximum value R MAX ) is calculated and displayed on the monitor screen display device 30.
- the ratio of the vessel diameter change rate maximum value R MAX after the blood shear stress related value SS X ischemia opening may be a value which either is is the denominator, but for example, the index value calculating means 114, related blood shear stress The ratio is calculated using the value SS X as the denominator.
- the blood shear stress related value SS X for example, the maximum value of blood shear stress SS calculated by the first blood shear stress calculating means 124 or the second blood shear stress calculating means 132, ischemic opened immediately or ischemia open
- the average value of one-beat average shear stress SS AVG or the average value of blood shear stress SS at a predetermined heart rate after a predetermined time has elapsed can be considered.
- FIG. 12 is a diagram for explaining the main part of the control operation of the vascular function testing device 22 (electronic control device 28), that is, the control operation for calculating the viscosity shear rate relationship VCSR from the measurement result at rest before release of the ischemia. It is a flowchart. This flowchart is executed at rest before the release of ischemia.
- step the first short axis of the ultrasonic probe 24 is rested before the ischemia is released.
- images by ultrasonic waves radiated toward the ultrasonic array probe a to the blood vessel 20 in the body 14 is synthesized from its image non-invasively rest diameter d a is measured and recorded.
- the resting blood flow velocity distribution DS RT is measured by the ultrasonic wave emitted from the long-axis ultrasonic array probe C of the ultrasonic probe 24 toward the blood vessel 20 in the living body 14. Is done.
- echoes transmitted and received in the y 0 axis direction of FIG. 7 are used for measuring the blood vessel lumen diameter d 1
- echoes transmitted and received in the y axis direction of FIG. 7 are used for measuring the blood flow velocity SPD.
- the resting blood viscosity distribution DV RT is calculated based on the resting blood flow velocity distribution DS RT measured in SA1.
- resting blood shear rate distribution DSR RT is calculated based on resting blood flow rate distribution DS RT measured in SA1.
- the viscosity shear rate relationship VCSR has a plurality of preset values in the blood vessels 20 in the resting blood viscosity distribution DV RT and resting blood shear rate distribution DSR RT . It is calculated based on the extracted blood viscosity ⁇ and the blood shear rate SR at the point.
- the viscosity shear rate relationship VCSR is calculated before ischemia is released.
- the viscosity shear rate relationship VCSR is calculated as, for example, a relational expression between the blood viscosity ⁇ and the blood shear rate SR as in the above equation (8).
- FIG. 13 shows the main part of the control operation of the blood vessel function testing device 22 (electronic control device 28), that is, the control operation for calculating the blood shear stress SS by the real-time processing for the measurement of the blood flow velocity SPD after the release of the ischemia. It is a flowchart for demonstrating. The flowchart of FIG. 13 is executed after the calculation of the viscosity shear rate relationship VCSR in SA4 of FIG. The flowchart in FIG. 13 is started as soon as possible after the measurement of the resting blood flow velocity distribution DS RT in SA1 in FIG. 12 in order to maintain high accuracy of the viscosity shear rate relationship VCSR calculated in SA4. It is desirable.
- SB1 corresponding to the blood flow velocity measurement execution determination means 116, it is determined whether or not the pulse rate PR at the time of ischemia is greater than or equal to the pulse rate determination value PR1.
- the above-mentioned pulse rate PR at the time of the ischemia release is measured in detail before the ischemia is released, for a predetermined time before the ischemia is released.
- a determination of SB1 is made immediately before opening. If the determination of SB1 is affirmative, that is, if the pulse rate PR at the time of release of the ischemic is equal to or higher than the pulse rate determination value PR1, the process proceeds to SB2. On the other hand, when the determination of SB1 is negative, the process proceeds to SB4.
- SB2 it is determined whether or not ischemia release for FMD evaluation has been performed. For example, in SB2, when the cuff pressure control unit 56 (cuff pressure control means 56) outputs a control signal for setting the cuff pressure to atmospheric pressure in order to execute the ischemia release, it is determined that the ischemia release has been performed. . In the time chart of FIG. 4, the determination of SB2 is denied before time t1, and the determination of SB2 is switched to a positive determination at time t1. When the determination of SB2 is affirmed, that is, when the above-mentioned ischemia release is performed, SB3 is executed.
- FIG. 14 shows the main part of the control operation executed in SB3 of FIG. 13, that is, the diameter change rate R of the blood vessel 20 and the average blood flow rate SPD AVG are measured after the ischemia is released, and based on the average blood flow rate SPD AVG. It is a flowchart for demonstrating the control action
- the flowchart of FIG. 14 is repeatedly executed with an extremely short cycle time of, for example, about several milliseconds to several tens of milliseconds.
- the blood vessel lumen diameter d 1 is measured, further, the diameter change ratio R of the blood vessel 20 is calculated and measured from the vessel lumen diameter d 1 which is the measured and the rest diameter d a .
- the average blood flow velocity SPD AVG in the blood vessel 20 is measured and recorded.
- the average blood flow velocity SPD AVG is an average value of blood flow velocity SPD for each heartbeat obtained by further averaging the instantaneous average value of the blood flow velocity SPD in the blood vessel 20 in one heartbeat.
- SC1 corresponds to the blood vessel diameter measuring means 110 and the first blood flow velocity measuring means 118.
- the blood shear rate SR is calculated by real-time processing based on the average blood flow velocity SPD AVG measured in the SC1.
- the blood viscosity ⁇ is the viscosity shear rate relationship VCSR (for example, the blood viscosity ⁇ and the blood shear rate SR calculated in advance at SA4 in FIG. From the relational expression), real-time processing is performed based on the blood shear rate SR calculated in SC2.
- VCSR viscosity shear rate relationship
- the blood shear stress SS is calculated from the Newtonian viscosity law expressed by the equation (10) and the blood shear rate SR calculated in the SC2 and the SC3. It is calculated by real-time processing based on the calculated blood viscosity ⁇ .
- the blood shear stress SS calculated in SC4 is recorded in a storage device or the like, and immediately displayed on the monitor screen display device 30 if calculated.
- the blood shear stress SS calculated in SC4 is calculated based on the average blood flow velocity SPD AVG measured as the average value of the blood flow velocity SPD for each heartbeat. It can be said that the shear stress is SS AVG .
- SB4 it is determined whether or not the ischemic release for FMD evaluation has been performed, as in SB2.
- SB5 is executed.
- FIG. 15 shows the main part of the control operation executed in SB5 of FIG. 13, that is, the diameter change rate R of the blood vessel 20 after the release of the ischemia and the blood flow velocity distribution DS2 after the release of the ischemia.
- 7 is a flowchart for explaining a control operation for calculating blood shear stress SS by real-time processing based on DS2.
- the flowchart of FIG. 15 is repeatedly executed with an extremely short cycle time of, for example, about several milliseconds to several tens of milliseconds.
- SD1 in FIG. 15 the measurement of the vessel lumen diameter d 1 (Measurement of diameter change ratio R) is performed. This is the same as SC1 in FIG. In parallel with the measurement of the diameter change rate R of the blood vessel 20, the post-ischemic blood flow velocity distribution DS2 in the blood vessel 20 is measured and recorded. SD1 corresponds to the blood vessel diameter measuring means 110 and the second blood flow velocity measuring means 126.
- the maximum value SR2 MAX of the blood shear rate SR is calculated by real-time processing based on the post-ischemic blood flow velocity distribution DS2 measured in SD1. Specifically, the maximum value SR2 MAX of the blood shear rate SR is calculated from the blood shear rate distribution DSR calculated based on the post-ischemic blood flow velocity distribution DS2. For example, the blood shear rate SR in the blood shear rate distribution DSR is considered to be a maximum value near the wall of the blood vessel 20.
- the blood viscosity ⁇ is the viscosity shear rate relationship VCSR (for example, blood viscosity ⁇ and blood shear rate SR calculated in advance in SA4 in FIG. From the relational expression), a real-time process is performed based on the maximum value SR2 MAX of the blood shear rate SR calculated in SD2.
- VCSR viscosity shear rate relationship
- the blood shear stress SS is calculated from the Newtonian viscosity law expressed by the above equation (10), the maximum value SR2 MAX of the blood shear rate SR calculated in SD2 and the blood viscosity ⁇ calculated in SD3. Based on the above, it is calculated by real-time processing.
- blood shear stress SS calculated in SD4 is temporally averaged for each heartbeat, and the average value for each heartbeat is calculated as one heartbeat average shear stress SS AVG .
- the blood shear stress SS calculated in SD4 is continuously drawn according to the elapsed time within the time of one heartbeat, integrated with the time, and the value obtained by dividing the integrated value by the time of the one heartbeat is the above.
- One heart rate average shear stress SS AVG One heart rate average shear stress SS AVG .
- the blood shear stress SS calculated in SD4 and the one heart rate average shear stress SS AVG calculated in SD5 are recorded in a storage device or the like, and are displayed on the monitor screen display device 30 as soon as they are calculated. .
- SD4, SD5, and SD6 correspond to the second blood shear stress calculating means 132.
- an index value related to the vasodilator function is calculated from the measurement result or calculation result in SB3 or SB5.
- the maximum value R MAX is calculated from the diameter change rate R of the blood vessel 20 measured in SB3 or SB5.
- the calculated ratio of the maximum value R MAX of the diameter change rate of the blood shear stress related value SS X and ischemia after opening of the vessel 20 which is derived from the calculation results for SB3 or SB5, it monitor screen display Displayed on the device 30.
- the blood vessel diameter measurement means 110 uses ultrasonic waves radiated toward the blood vessel 20 in the living body 14 within a predetermined blood vessel diameter measurement period TIME1 after the release of ischemia.
- the diameter change rate R luminal diameter expansion rate R
- the blood flow velocity distribution measuring means 102 non-invasively by ultrasound before releasing the ischemia.
- Blood flow velocity distribution DS resting blood flow velocity distribution DS RT
- viscosity shear rate relationship calculating means 104 calculates the relationship between blood viscosity ⁇ and blood shear rate SR before the ischemia is released.
- the viscosity shear rate relationship VCSR Prior to the measurement of the diameter change rate R of the blood vessel 20 after ischemia release, the viscosity shear rate relationship VCSR, which is the relationship, is based on the resting blood flow velocity distribution DS RT measured by the blood flow velocity distribution measuring means 102.
- the blood shear stress calculation means 112 is calculated after the release of the ischemia.
- TIME1 the blood vessel diameter measurement period
- the blood flow velocity in the blood vessel 20 is measured in parallel with the measurement of the diameter change rate R of the blood vessel 20, and based on the measured blood flow velocity SPD using the viscosity shear rate relationship VCSR. Blood shear stress SS is calculated.
- the blood shear stress SS calculated using this viscosity shear rate relationship VCSR can be accurately calculated.
- the blood viscosity ⁇ and the blood shear stress SS can be evaluated in a spatio-temporal manner.
- the blood shear stress SS can be calculated with a light calculation load thereafter.
- the reaction is caused by the expansion shear stress of the blood vessel diameter after the release of ischemia as a stimulus
- a plurality of FMD test results can be compared and evaluated based on the blood shear stress SS indicating the stimulus amount. It is also possible to correct the FMD test result with the blood shear stress SS indicating the amount of stimulation, and it is possible to improve the repeatability of the FMD test by calculating the blood shear stress SS.
- the blood flow velocity distribution measuring means 102 measures a resting blood flow velocity distribution DS RT before releasing the ischemia, and the viscosity shear velocity relationship calculating means 104 calculates the viscosity shear velocity relationship VCSR before releasing the ischemia. Therefore, when the ischemia is released (time t1 in FIG. 4), the viscosity shear rate relationship VCSR is determined. Therefore, it is not necessary to perform a calculation with a large calculation load in the process from the measurement of the blood flow velocity SPD to the calculation of the blood viscosity ⁇ after the release of ischemia, for example, in accordance with the Navier-Stokes equation.
- the blood shear stress SS can be calculated by real-time processing with a light calculation load. Further, if the blood shear stress SS is calculated by real-time processing in this way, the blood shear stress SS can be obtained immediately even during measurement, and an index value in the FMD test can be obtained quickly.
- the blood shear stress calculating means 112 includes the first blood flow rate measuring means 118, the first blood shear rate calculating means 120, the first blood viscosity calculating means 122, and the first blood shear. Stress calculating means 124. Then, (a) the first blood flow velocity measuring means 118 performs the blood vessel 20 in parallel with the measurement of the diameter change rate R of the blood vessel 20 by the blood vessel diameter measuring means 110 within the blood vessel diameter measuring period TIME1 after the release of the ischemia.
- the first blood viscosity calculating means 122 is calculated by the first blood shear speed calculating means 120 from the viscosity shear speed relation VCSR calculated in advance by the viscosity shear speed relation calculating means 104 before the release of ischemia.
- the blood viscosity ⁇ is calculated based on the calculated blood shear rate SR, and (d) the first blood shear stress calculating unit 124 calculates the blood shear rate SR calculated by the first blood shear rate calculating unit 120 and the first blood.
- the blood shear stress SS is calculated based on the calculated blood viscosity ⁇ . Therefore, by measuring the average blood flow velocity SPD AVG , it is not necessary to calculate, for example, the blood shear rate distribution DSR in the process from the measurement until the blood viscosity ⁇ is calculated and the blood shear stress SS is calculated. It is possible to reduce the calculation load. Therefore, the blood shear stress SS can be calculated by real-time processing in parallel with the measurement of the diameter change rate R of the blood vessel 20 after the release of the ischemia and the measurement of the average blood flow velocity SPD AVG without requiring high computing ability. .
- the first blood shear rate calculation means 120 calculates the average blood flow velocity SPD AVG as the blood vessel diameter (for example, the blood vessel lumen diameter d 1 ), as shown in the equation (9).
- the blood shear rate SR is obtained by dividing the value by), so that the blood shear rate SR can be immediately calculated from the average blood flow rate SPD AVG , and the calculation load can be reduced.
- the electronic control unit 28 can calculate the blood shear stress SS by real-time processing in parallel with the measurement of the average blood flow velocity SPD AVG with a light calculation load.
- the first blood shear stress calculation means 124 sets the blood shear stress SS to 1. The calculation is performed for each heartbeat, and the calculation load can be reduced compared to the case where blood shear stress SS is calculated a plurality of times during one heartbeat.
- the first blood shear stress calculation means 124 calculates the blood shear stress SS for each heartbeat within the blood vessel diameter measurement period TIME1, so that the above-mentioned in real time with a light computation load.
- the blood shear stress SS is calculated, and thereafter it is possible to quickly obtain an index value in the FMD test using the blood shear stress SS.
- the viscosity shear rate relationship calculating means 104 is measured by the blood flow velocity distribution measuring means 102 by the blood viscosity distribution calculating means 106 and the blood shear rate distribution calculating means 108 provided therein.
- Blood viscosity distribution DV resting blood viscosity distribution DV RT
- blood shear rate distribution DSR resting blood shear rate distribution DSR RT
- the viscosity shear rate relationship VCSR is calculated based on the blood viscosity ⁇ and the blood shear rate SR extracted at a plurality of points preset in the blood vessel 20 in the viscosity distribution DV RT and the resting blood shear rate distribution DSR RT . . Therefore, it is possible to more accurately calculate the viscosity shear rate relationship VCSR that is individually adjusted to the blood vessel 20 to be examined and the blood flowing in the blood vessel 20. Therefore, the blood shear stress SS calculated using this viscosity shear rate relationship VCSR can be accurately calculated.
- the blood viscosity distribution calculating means 106 calculates blood flow velocity distribution measuring means from the Navier-Stokes equations stored in advance by the equations (2) and (3).
- a resting blood viscosity distribution DV RT in the blood vessel 20 to be measured is calculated based on the resting blood flow velocity distribution DS RT measured by 102. Therefore, it is possible to calculate the rest time of blood viscosity distribution DV RT based in a practical vascular function testing apparatus in the resting blood flow velocity distribution DS RT.
- the second blood flow velocity measuring means 126 changes the diameter of the blood vessel 20 by the blood vessel diameter measuring means 110 within the blood vessel diameter measuring period TIME1 after the release of the ischemia.
- the blood flow velocity distribution DS blood flow velocity distribution DS2 after ischemia release
- the second blood shear rate calculating means 128 measures the second blood flow velocity.
- the maximum value SR2 MAX of the blood shear rate SR is calculated based on the post-ischemic blood flow velocity distribution DS2 measured by the means 126
- the second blood viscosity calculating means 130 is calculated by the viscosity shear rate relation calculating means 104.
- a blood viscosity ⁇ is calculated based on the maximum value SR2 MAX of the blood shear rate SR calculated by the second blood shear rate calculation means 128 from the viscosity shear rate relationship VCSR calculated in advance before release of ischemia, (d )
- the second blood shear stress calculating means 132 is the second blood Based on the maximum value SR2 MAX of the blood shear rate SR calculated by the shear rate calculation means 128 and the blood viscosity ⁇ calculated by the second blood viscosity calculation means 130, the blood shear stress SS is calculated within the blood vessel diameter measurement period TIME1. calculate.
- the first blood flow velocity measuring means 118 measures the average blood flow velocity SPD AVG.
- the second blood flow velocity measuring means 126 measures the post-ischemic blood flow velocity distribution DS2. Therefore, the blood shear stress SS calculated by the second blood shear stress calculating means 132 is more accurate than the case calculated by the first blood shear stress calculating means 124, but the calculation load until the calculation is large. It is possible to switch how the blood shear stress SS is calculated according to the above-described predetermined calculation method switching conditions, for example, depending on the calculation load predicted after the release of ischemia. is there.
- the index value calculation means 114 calculates the maximum value from the diameter change rate R of the blood vessel 20 measured by the blood vessel diameter measurement means 110 after the blood vessel diameter measurement period TIME1.
- R MAX blood vessel diameter change rate maximum value R MAX
- the ratio with the vascular diameter change rate maximum value R MAX is calculated. Therefore, the measurement result of the diameter change rate R of the blood vessel 20 after the release of the ischemia can be evaluated based on the blood shear stress SS. For example, a plurality of FMD test results can be compared and evaluated based on blood shear stress SS.
- the ultrasonic probe 24 that emits ultrasonic waves toward the blood vessel 20 has a plurality of ultrasonic oscillators linearly extending in the longitudinal direction of the blood vessel 20. direction (x 0 axis direction) and the ultrasonic array probe C for long axis arranged in a first short in which a plurality of ultrasonic oscillators are arranged perpendicular to the longitudinal direction of the linearly vessel 20
- An ultrasonic array probe for axis A and an ultrasonic array probe for second short axis B are provided.
- the blood flow velocity SPD in the blood vessel 20 is measured by ultrasonic waves from the long-axis ultrasonic array probe C, and the blood vessel diameter is measured by ultrasonic waves from the first short-axis ultrasonic array probe A. Is done. Therefore, measurement of the blood flow velocity SPD (for example, average blood flow velocity SPD AVG , blood flow velocity distribution DS, etc.) and measurement of the blood vessel diameter are performed in parallel using the ultrasonic probe 24 that has been put to practical use. be able to. Further, in this embodiment, the first short axis ultrasonic array probe A is not used, and the long axis ultrasonic array probe C is operated for measuring the blood flow velocity SPD and the blood vessel lumen diameter. The operation for measuring d 1 (blood vessel diameter) may be alternately performed in a very short cycle, and the same applies to such a case.
- the blood shear stress SS is measured for the mean blood flow velocity SPD AVG or the blood flow velocity distribution DS2 after the ischemia release within the blood vessel diameter measurement period TIME1 after the ischemia is released.
- the blood shear stress SS is not calculated by the real-time process, but is calculated by the batch process after all the measurement of the average blood flow velocity SPD AVG is completed.
- FIG. 16 is a functional block diagram for explaining a main part of the control function provided in the vascular function testing device 22 (vascular function evaluation unit 100), and corresponds to FIG. 5 of the first embodiment.
- the viscosity shear rate relationship calculating means 204 in FIG. 16 is basically the same as the viscosity shear rate relationship calculating means 104 of the first embodiment, but unlike the viscosity shear rate relationship calculating means 104, the above-mentioned after release of ischemia. after a blood vessel diameter measuring time period TIME1, i.e., calculates the viscosity-shear rate relationship VCSR after completion of the measurement vessel lumen diameter d 1 by vascular diameter measuring unit 110 after the ischemia open.
- TIME1 blood vessel diameter measuring time period
- the viscosity shear rate relationship VCSR does not have to be calculated in advance prior to the measurement of the diameter change rate R of the blood vessel 20 after the release of ischemia. .
- the blood viscosity distribution calculation unit 206 provided in the viscosity shear rate relationship calculation unit 204 is basically the blood viscosity distribution calculation unit of the first embodiment. 106.
- the resting blood viscosity distribution DV RT is calculated after the blood vessel diameter measurement period TIME1 after the release of ischemia.
- the blood shear rate distribution calculating unit 208 provided in the viscosity shear rate relationship calculating unit 204 is basically the same as the blood shear rate distribution calculating unit 108 of the first embodiment, but its blood shear rate distribution calculating unit. Unlike the means 108, the resting blood shear rate distribution DSR RT is calculated after the passage of the blood vessel diameter measurement period TIME1 after the release of ischemia.
- the blood shear stress calculation means 212 is basically the same as the blood shear stress calculation means 112 of the first embodiment, but unlike the blood shear stress calculation means 112, the blood shear stress calculation period TIME1 after the release of the ischemia is different. After the elapse of time, the blood shear stress SS is calculated by batch processing. Therefore, as shown in FIG. 16, the blood shear stress calculating means 212 includes the first blood flow velocity measuring means 118 in the same manner as the blood shear stress calculating means 112, but the first blood shear rate of the first embodiment.
- the blood shear stress calculating means 212 includes a blood flow velocity measurement execution determining means 116, a second blood flow velocity measuring means 126, a second blood shear velocity calculating means 128, a second blood viscosity calculating means 130 of the first embodiment, The second blood shear stress calculating means 132 and the equivalent are not provided.
- the calculation method switching condition it is not determined whether or not the calculation method switching condition is satisfied, that is, it is not determined whether or not the pulse rate PR at the time of release of the ischemic is greater than or equal to the pulse rate determination value PR1.
- the first blood flow velocity measuring means 118 in the example does not depend on the pulse rate PR at the time of release of the ischemia, but the change rate R of the diameter of the blood vessel 20 by the blood vessel diameter measurement means 110 within the blood vessel diameter measurement period TIME1 after the release of ischemia. In parallel with the measurement, the average blood flow velocity SPD AVG in the blood vessel 20 is measured noninvasively.
- the first blood shear rate calculating means 220 is basically the same as the first blood shear rate calculating means 120 of the first embodiment, but unlike the first blood shear rate calculating means 120, the first blood shear rate calculating means 120 after the release of ischemia.
- the blood vessel diameter measurement period TIME1 e.g., after the measurement of the average blood flow velocity SPD AVG by the first blood flow velocity measuring means 118 after the release of ischemia is completed
- batch processing is performed based on the average blood flow velocity SPD AVG.
- the first blood viscosity calculating means 222 is basically the same as the first blood viscosity calculating means 122 of the first embodiment, but unlike the first blood viscosity calculating means 122, the blood vessel diameter measurement after release of ischemia.
- the viscosity shear rate relationship calculating unit 204 calculates the viscosity shear rate relationship VCSR after the lapse of the period TIME1
- the blood viscosity ⁇ is determined by batch processing based on the blood shear rate SR calculated by the first blood shear rate calculating unit 220. Is calculated.
- the first blood shear stress calculation means 224 is basically the same as the first blood shear stress calculation means 124 of the first embodiment, but unlike the first blood shear stress calculation means 124, the first blood shear stress calculation means 224 after the release of ischemia.
- the blood shear stress is determined by batch processing based on the blood shear rate SR calculated by the first blood shear rate calculating means 220 and the blood viscosity ⁇ calculated by the first blood viscosity calculating means 222. Calculate SS.
- FIG. 17 shows the main part of the control operation of the blood vessel function testing device 22 (electronic control device 28) of the present embodiment, that is, the blood shear by batch processing together with the measurement of the diameter change rate R of the blood vessel 20 after ischemia release in FMD evaluation. It is a flowchart for demonstrating the control action
- SE1 corresponding to the blood flow velocity distribution measuring means 102 and the blood vessel diameter measuring means 110, like the SA1 of FIG. 12, at rest before ischemia open, and the rest diameter d a and rest-time blood flow velocity distribution DS RT Measured.
- the resting blood viscosity distribution DV RT is calculated based on the resting blood flow velocity distribution DS RT measured in SE1. This resting blood viscosity distribution DV RT is calculated after the passage of the blood vessel diameter measurement period TIME1 after release of ischemia.
- resting blood shear rate distribution DSR RT is calculated based on resting blood flow rate distribution DS RT measured in SE1. This resting blood shear rate distribution DSR RT is calculated after elapse of the blood vessel diameter measurement period TIME1 after release of ischemia.
- the viscosity shear rate relationship VCSR is set to the resting blood viscosity distribution DV RT calculated in SE3 and the resting blood shear rate distribution DSR RT calculated in SE4.
- Calculated based on SE5 differs from SA4 in FIG. 12 in that the viscosity shear rate relationship VCSR is calculated after the lapse of the blood vessel diameter measurement period TIME1, but is otherwise the same as SA4 in FIG.
- the blood shear rate SR is calculated based on the average blood flow velocity SPD AVG measured in SE2.
- SE6 differs from SC2 in FIG. 14 in that the blood shear rate SR is calculated by batch processing after the blood vessel diameter measurement period TIME1 has elapsed, but otherwise is the same as SC2 in FIG.
- the blood viscosity ⁇ is calculated in SE6 from the viscosity shear rate relationship VCSR calculated in SE5 (for example, a relational expression between blood viscosity ⁇ and blood shear rate SR). It is calculated based on the obtained blood shear rate SR.
- SE7 differs from SC3 in FIG. 14 in that the blood viscosity ⁇ is calculated by batch processing after the blood vessel diameter measurement period TIME1 has elapsed, but otherwise is the same as SC3 in FIG.
- the blood shear stress SS is calculated based on the blood shear rate SR calculated in SE6 and the blood viscosity ⁇ calculated in SE7.
- SE8 differs from SC4 in FIG. 14 in that the blood shear stress SS is calculated by batch processing after the vascular diameter measurement period TIME1 has elapsed, but otherwise is the same as SC4 in FIG.
- the blood shear stress SS (1 heartbeat average shear stress SS AVG ) calculated in SE8 is recorded in a storage device or the like and displayed on the monitor screen display device 30. .
- SE10 corresponding to the index value calculation means 114 is the same as SB6 in FIG.
- the blood shear stress SS is calculated by batch processing, so that the index value in the FMD test can be obtained quickly by calculating the blood shear stress SS by real-time processing. Except for, the same effects as in the first embodiment can be obtained.
- the calculation method switching condition determined by the blood flow velocity measurement execution determination means 116 is satisfied, and the case where the pulse rate PR at the time of ischemia release is equal to or higher than the pulse rate determination value PR1.
- the calculation method switching condition may be defined by a measurement amount other than the pulse rate.
- the blood vessel diameter measurement period TIME1 starts from the time of release of the ischemia (time point t1) as shown in FIG. 4, but instead, starts from a certain time after the release of the ischemia. It may be a thing.
- blood vessel diameter measuring time period TIME1 is set so as to include the time at which the vessel lumen diameter d 1 at least the blood vessel diameter measuring the periodic inter TIME1 has reached its maximum value d MAX. Even when the blood vessel diameter measurement period TIME1 is set to start after a certain time from the release of the ischemia, the blood shear stress calculation means 112 immediately enters the blood vessel 20 from the release of the ischemia. It is desirable to measure the blood flow velocity SPD.
- the first blood flow velocity measuring means 118 calculates and measures the average blood flow velocity SPD AVG from the blood flow velocity distribution DS, but the blood flow velocity distribution DS is obtained by ultrasonic Doppler measurement.
- the average blood flow velocity SPD AVG can be measured without measurement.
- the average blood flow velocity SPD AVG measured by the first blood flow velocity measuring means 118 is described as an average value of the blood flow velocity SPD for each heartbeat.
- measurement cycle flow velocity SPD AVG is also variously considered in addition to one heartbeat, for example, the average blood flow velocity SPD AVG is set to the average value of the blood flow velocity SPD per heart rate predetermined for several beats Alternatively, it may be the average value of the blood flow velocity SPD for each time shorter than one heartbeat. In addition, it may be averaged based on a standard other than the heart rate.
- FIG. 13 of the above-described embodiment a flowchart without SB1, SB4, and SB5 can be considered. In such a case, the flowchart of FIG. 13 starts from SB2, and the flowchart of FIG. 15 becomes unnecessary.
- the upper arm 16 in FIG. 1 is, for example, the upper arm of a human body.
- the blood vessel diameter measuring unit 110 synthesizes an image using the ultrasonic waves emitted from the first short-axis ultrasonic array probe A of the ultrasonic probe 24 and uses the image to vascular lumen. Although the diameter d 1 is measured, it is possible to synthesize an image with the ultrasonic waves emitted from the long-axis ultrasonic array probe C and measure the vessel lumen diameter d 1 from the image.
- the viscosity shear rate relationship calculating means 104 and 204 calculates the viscosity shear rate relationship VCSR from the resting blood viscosity distribution DV RT and the resting blood shear rate distribution DSR RT.
- the blood viscosity ⁇ and the blood shear rate SR at a plurality of sampling points are extracted.
- the resting blood viscosity distribution DV RT and the resting blood shear rate distribution DSR RT that are the basis of the extraction are, for example, specified in one heartbeat. It is desirable to adopt the time phase (time). As an example, it is a phase in which the blood flow velocity SPD is maximized or minimized during one heartbeat.
- the viscosity shear rate relationship calculating means 104 and 204 may calculate the viscosity shear rate relationship based on the resting blood viscosity distribution DV RT and the resting blood shear rate distribution DSR RT in a plurality of time phases during one heartbeat.
- VCSR is calculated for each of the plurality of calculated viscosity shear rate relations VCSR, and the first blood viscosity calculating means 122, 222 and the second blood viscosity calculating means 130 are used for calculating the blood viscosity ⁇ .
- the viscosity shear rate relationship VCSR may be used.
- the index value calculating means 114 is to calculate the ratio of the blood vessel diameter change rate maximum value R MAX after blood shear stress related value SS X and ischemia opened blood vessel after the ischemia open
- An index value (ratio) may be calculated by replacing the maximum diameter change rate value R MAX with another parameter.
- the other parameters include (i) the maximum value of the diameter change amount of the blood vessel 20 after the release of the ischemia (the unit is “mm”, for example), and (ii) the ischemia release from the time t1 to the time t2 in FIG.
- Diameter change amount, ratio of diameter change, or time constant of diameter change, and blood flow velocity SPD, blood flow rate, blood shear A transfer function when one of the speed SR and the blood shear stress SS is input and the other is output can be considered.
- the blood flow velocity distribution measuring means 102 measures the resting blood flow velocity distribution DS RT before releasing the ischemia.
- the viscosity shear rate relationship calculating means 204 measures the ischemia release. Since the viscosity shear rate relationship VCSR is calculated after elapse of the subsequent blood vessel diameter measurement period TIME1, the blood flow velocity distribution measurement unit 102 has the viscosity shear rate relationship calculation unit 204 before calculating the viscosity shear rate relationship VCSR. Then, the resting blood flow velocity distribution DS RT may be measured after the vascular diameter measurement period TIME1.
- the viscosity shear rate relationship calculating means 204 calculates the viscosity shear rate relationship VCSR after the blood vessel diameter measurement period TIME1 after the release of ischemia, and the viscosity shear rate relationship VCSR is calculated. It can be calculated before the release of the ischemia.
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Abstract
Description
20:血管
22:血管機能検査装置
24:超音波プローブ
102:血流速度分布測定手段
104:粘度ずり速度関係算出手段
110:血管径測定手段
112:血液ずり応力算出手段
114:指標値算出手段
118:第1血流速度測定手段
120:第1血液ずり速度算出手段
122:第1血液粘度算出手段
124:第1血液ずり応力算出手段
126:第2血流速度測定手段
128:第2血液ずり速度算出手段
130:第2血液粘度算出手段
132:第2血液ずり応力算出手段
A:第1短軸用超音波アレイ探触子(直交方向超音波アレイ探触子)
C:長軸用超音波アレイ探触子(長手方向超音波アレイ探触子)
Claims (12)
- 阻血開放後の予め定められた血管径測定期間内に生体内の血管に向けて放射された超音波により非侵襲的に該血管の径変化割合を測定する血管径測定手段を備えた血管機能検査装置であって、
前記阻血開放前または前記血管径測定期間の経過後に前記超音波により非侵襲的に前記血管内の血流速度分布を測定する血流速度分布測定手段と、
血液粘度と血液ずり速度との関係である粘度ずり速度関係を、前記血流速度分布測定手段により測定された前記血流速度分布に基づいて算出する粘度ずり速度関係算出手段と、
前記阻血開放後の前記予め定められた血管径測定期間内に前記血管の径変化割合の測定と並行して前記血管内の血流速度を測定し、前記粘度ずり速度関係を用いて該測定した血流速度に基づき血液ずり応力を算出する血液ずり応力算出手段と
を、含むことを特徴とする血管機能検査装置。 - 前記血流速度分布測定手段は、前記阻血開放前に前記血流速度分布を測定し、
前記粘度ずり速度関係算出手段は、前記阻血開放前に前記粘度ずり速度関係を算出する
ことを特徴とする請求項1に記載の血管機能検査装置。 - 前記血液ずり応力算出手段は、
前記阻血開放後の前記予め定められた血管径測定期間内に前記血管の径変化割合の測定と並行して前記血管内の平均血流速度を測定する第1血流速度測定手段と、
該第1血流速度測定手段に測定された該平均血流速度に基づいて血液ずり速度を算出する第1血液ずり速度算出手段と、
前記粘度ずり速度関係算出手段により算出された前記粘度ずり速度関係から、前記第1血液ずり速度算出手段により算出された前記血液ずり速度に基づいて血液粘度を算出する第1血液粘度算出手段と、
前記第1血液ずり速度算出手段により算出された前記血液ずり速度と前記第1血液粘度算出手段により算出された前記血液粘度とに基づいて血液ずり応力を算出する第1血液ずり応力算出手段とを、備えている
ことを特徴とする請求項2に記載の血管機能検査装置。 - 前記第1血液ずり速度算出手段は、前記平均血流速度を前記血管径で割ったものを前記血液ずり速度とする
ことを特徴とする請求項3に記載の血管機能検査装置。 - 前記平均血流速度は、前記血管内における1心拍毎の血流速度の平均値である
ことを特徴とする請求項4に記載の血管機能検査装置。 - 前記第1血液ずり応力算出手段は、前記予め定められた血管径測定期間内に1心拍毎に前記血液ずり応力を算出する
ことを特徴とする請求項5に記載の血管機能検査装置。 - 前記粘度ずり速度関係算出手段は、前記血流速度分布測定手段により測定された前記血流速度分布に基づいて血液粘度分布と血液ずり速度分布とを算出し、該血液粘度分布と該血液ずり速度分布内の前記血管内に予め設定された複数点における抽出された血液粘度と血液ずり速度とに基づいて前記粘度ずり速度関係を算出する
ことを特徴とする請求項3乃至6の何れか1項に記載の血管機能検査装置。 - 前記粘度ずり速度関係算出手段は、予め記憶されたナビエ-ストークス方程式から、前記血流速度分布測定手段により測定された前記血流速度分布に基づいて前記血液粘度分布を算出する
ことを特徴とする請求項7に記載の血管機能検査装置。 - 前記血液ずり応力算出手段は、
前記阻血開放後の前記予め定められた血管径測定期間内に前記血管径の測定と並行して前記血管内の血流速度分布を測定する第2血流速度測定手段と、
該第2血流速度測定手段に測定された該血流速度分布に基づいて血液ずり速度の最大値を算出する第2血液ずり速度算出手段と、
前記粘度ずり速度関係算出手段により算出された前記粘度ずり速度関係から、前記第2血液ずり速度算出手段により算出された前記血液ずり速度の最大値に基づいて血液粘度を算出する第2血液粘度算出手段と、
前記第2血液ずり速度算出手段により算出された前記血液ずり速度の最大値と前記第2血液粘度算出手段により算出された前記血液粘度とに基づいて前記予め定められた血管径測定期間内に血液ずり応力を算出する第2血液ずり応力算出手段とを、備えており、
予め定められた演算方式切換条件が満たされた場合には前記第1血流速度測定手段が前記平均血流速度を測定する一方で、前記予め定められた演算方式切換条件が満たされなかった場合には前記第2血流速度測定手段が前記血流速度分布を測定する
ことを特徴とする請求項3乃至8の何れか1項に記載の血管機能検査装置。 - 前記第1血液ずり応力算出手段または前記第2血液ずり応力算出手段により算出された前記血液ずり応力に関連する値と前記血管径測定手段により測定された前記阻血開放後の前記血管の径変化割合の最大値との比を算出する指標値算出手段
を含むことを特徴とする請求項9に記載の血管機能検査装置。 - 前記超音波を前記血管に向けて放射する超音波プローブは、複数個の超音波発振子が直線的に前記血管の長手方向に配列された長手方向超音波アレイ探触子と、複数個の超音波発振子が直線的に前記血管の長手方向とは直交して配列された直交方向超音波アレイ探触子とを備えており、
前記長手方向超音波アレイ探触子からの超音波により前記血管内の血流速度を測定し、前記直交方向超音波アレイ探触子からの超音波により前記血管径を測定する
ことを特徴とする請求項1乃至10の何れか1項に記載の血管機能検査装置。 - 前記超音波を前記血管に向けて放射する超音波プローブは、複数個の超音波発振子が直線的に前記血管の長手方向に配列された長手方向超音波アレイ探触子を備えており、
前記長手方向超音波アレイ探触子に、前記血管内の血流速度を測定するための作動と前記血管径を測定するための作動とを時間経過に従って交互に行わせる
ことを特徴とする請求項1乃至10の何れか1項に記載の血管機能検査装置。
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JP2011518167A JP5219228B2 (ja) | 2009-06-09 | 2009-06-09 | 血管機能検査装置 |
EP09845796.3A EP2441390B1 (en) | 2009-06-09 | 2009-06-09 | Device for examining vascular function |
PCT/JP2009/060562 WO2010143271A1 (ja) | 2009-06-09 | 2009-06-09 | 血管機能検査装置 |
US13/377,357 US8500640B2 (en) | 2009-06-09 | 2009-06-09 | Blood vessel function inspecting apparatus |
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US20080015569A1 (en) | 2005-02-02 | 2008-01-17 | Voyage Medical, Inc. | Methods and apparatus for treatment of atrial fibrillation |
US9055906B2 (en) | 2006-06-14 | 2015-06-16 | Intuitive Surgical Operations, Inc. | In-vivo visualization systems |
US10004388B2 (en) * | 2006-09-01 | 2018-06-26 | Intuitive Surgical Operations, Inc. | Coronary sinus cannulation |
US20080097476A1 (en) | 2006-09-01 | 2008-04-24 | Voyage Medical, Inc. | Precision control systems for tissue visualization and manipulation assemblies |
US9226648B2 (en) | 2006-12-21 | 2016-01-05 | Intuitive Surgical Operations, Inc. | Off-axis visualization systems |
CN102113900B (zh) | 2010-01-05 | 2015-07-15 | 深圳迈瑞生物医疗电子股份有限公司 | 彩色血流动态帧相关方法和装置 |
WO2012107050A1 (en) * | 2011-02-08 | 2012-08-16 | Region Nordjylland, Aalborg Sygehus | A system for determining flow properties of a blood vessel |
WO2016119247A1 (zh) * | 2015-01-30 | 2016-08-04 | 深圳迈瑞生物医疗电子股份有限公司 | 超声成像方法和系统 |
CN105852910A (zh) * | 2016-04-18 | 2016-08-17 | 何宗彦 | 一种通过多普勒超声检测血管内皮功能的方法及其设备 |
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EP2441390A4 (en) | 2014-05-21 |
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