WO2010142048A1 - Surveillance de l'engorgement dans un appareil d'administration - Google Patents

Surveillance de l'engorgement dans un appareil d'administration Download PDF

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Publication number
WO2010142048A1
WO2010142048A1 PCT/CH2010/000130 CH2010000130W WO2010142048A1 WO 2010142048 A1 WO2010142048 A1 WO 2010142048A1 CH 2010000130 W CH2010000130 W CH 2010000130W WO 2010142048 A1 WO2010142048 A1 WO 2010142048A1
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WO
WIPO (PCT)
Prior art keywords
drive
movement
return movement
return
elastic
Prior art date
Application number
PCT/CH2010/000130
Other languages
German (de)
English (en)
Inventor
Michael Rufer
Thomas Buri
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Publication of WO2010142048A1 publication Critical patent/WO2010142048A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M2005/16863—Occlusion detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir

Definitions

  • the present invention relates to an administration device for a fluid product, in particular a medicament in liquid form, as well as a method for monitoring an administration device.
  • a liquid-form medicament e.g. To administer an insulin preparation or a blood-thinning drug such as heparin over a longer period of time.
  • a blood-thinning drug such as heparin
  • the drug is often present in a container in which a plug is advanced so as to expel the drug from the container.
  • WO 2008/106805 describes a modular administration device for a liquid medicament which is designed as a "semi-disposable device"
  • Device comprises a reusable base unit and a replaceable
  • the base unit comprises a control device and one of them controllable
  • the cartridge includes a transfer sleeve, a hydraulic system, and a product reservoir with a slidable plug.
  • the transfer sleeve of the cartridge is in operation with the driver of the base unit in engagement such that the rotational movement of the
  • Carrier is transmitted to the transmission sleeve.
  • the transmission sleeve is in one
  • a occlusion detection is carried out by mechanical means by the guide nut against a spring force against the feed direction of the hydraulic stopper is slidably mounted and is moved when exceeding a certain pressure in the hydraulic reservoir in this direction. This shift is detected.
  • the occlusion detection takes place hydraulically in a device of basically similar construction in that a slide is displaced against a spring force when a certain pressure in the hydraulic reservoir is exceeded by the hydraulic fluid.
  • the occlusion detection takes place in a relatively simple manner mechanically, but due to the relatively complex mechanical structure of the cartridge a very precise and therefore relatively expensive production. In addition, the detection of the mechanical displacement by the controller in the base unit is difficult.
  • an apparatus for administering a fluid product comprising: drive means adapted to generate a drive movement in a drive direction and to act directly or indirectly on a product reservoir such that the drive movement exhausts the fluid product causes the product reservoir; and a control device, which is designed to control the drive device such that the drive device generates the drive movement during a drive period.
  • the device further comprises a detection device which is designed after the completion of the drive movement a measure for a return movement of the drive device in one of Drive direction opposite direction due to elastic forces to determine.
  • the distribution in such a delivery device is usually periodic: A distribution rindet only in discrete discharge operations at intervals of a certain time, usually of several minutes, instead of a relatively short period of time, which is usually only a few seconds. Only in this time a drive takes place.
  • forces and / or torques i.e., generally expressed generalized forces
  • a drive element e.g., a motor
  • These generalized forces are in balance with corresponding generalized counterforces.
  • these opposing forces also include in particular the force that opposes the product reservoir to the expulsion of the product.
  • the drive train consisting of the actual drive element and the entirety of the other mechanical components that serve to transmit motion from the actual drive element to the product reservoir, has a certain elasticity, which is due to design and choice of material.
  • the elasticity of the components of the drive train deform during a distribution elastic.
  • the deformation is greater, the greater the transmitted forces.
  • this relationship is linear (Hooke's law).
  • the greater the force that opposes the product reservoir to a discharge that is, the greater the pressure in the product reservoir, the greater will be the deformation. If the pressure in the product reservoir rises sharply due to an occlusion, this will also lead to a large increase in the elastic deformation of the powertrain.
  • the detection means may comprise means for outputting an error signal, wherein the output of the error signal takes place, provided that the measure for the return movement of the drive means satisfies at least a predetermined condition
  • the control means may then be adapted to receive this error signal and due to the error signal to take further action.
  • the error signal may e.g. a binary "flag", which is set at an output of the detector and which is monitored by the controller, so that the further administration is interrupted when setting the "flag”.
  • the device may comprise an alarm device for detecting, in the presence of the error signal, e.g. an audible alarm via a buzzer, a loudspeaker, etc., a vibration signal via a vibrator, and / or an optical signal, e.g. as a corresponding note in a display.
  • An error signal can be emitted, in particular, if one or more of the following conditions are met:
  • the speed of the drive device is controlled such that the Speed is lowered substantially continuously towards the end of a dispensing operation.
  • a speed control device outputs control signals to the drive device, which correspond to a target speed, which drops steadily, without jumps that go beyond design-related and / or control-related discontinuities, such as those caused by the resolution of the digital-analog converter used could be.
  • the target speed is continuously reduced to almost zero. It is advantageous if the final speed immediately before the shutdown of the drive at the end of the discharge period is not more than about 10% of the maximum speed during the discharge period.
  • the control device and the detection device can be embodied as analog, digital or mixed analog-digital electronic circuits.
  • these devices may jointly or individually comprise a digital signal processor in which the functionalities of these devices are implemented in hardware or in software.
  • the detection device can cooperate with a sensor device which is designed to detect movements made by the drive device. Such sensor devices for different types of movement are known per se.
  • the drive means may comprise an additional elastic element which is elastically deformable by the drive movement such that an elastic energy can be stored in the elastic element, and which is arranged that the elastic energy after completion of the drive movement in the return movement is convertible.
  • the elastic energy which can be stored in this element should be a significant part of the total energy storable in the drive train during normal operation, preferably at least 20%, better at least 50% of this energy.
  • the elastic element should cause the amount by which the drive is moved back to be significantly increased compared to a situation without an elastic element.
  • Suitable elastic elements are, for example, leaf or coil springs or elements made of an elastic plastic, for example, elastic plastic or rubber pads, etc. in the transmission of translational forces or torsion bars, torsion springs, etc. in the transmission of torques.
  • the drive device as the drive element on an electric motor, preferably a DC motor, with a motor shaft on which a drive rotational movement is generated.
  • the detection device is then preferably designed to determine directly or indirectly a measure of the angle of rotation by which the motor shaft rotates back in the opposite direction after completion of the drive movement.
  • a sensor device may be present, which may for example comprise an encoder which serves to detect the angle of rotation traveled by the motor shaft and as known from the prior art, and / or a device for Detekü ' on the of Motor may include back-induced voltage after switching off the drive voltage. The encoder count or the re-induced voltage after switching off the drive voltage directly represent a measure of the return movement.
  • such a device may in particular comprise a torsion element which is elastically deformable by the drive rotational movement by a torsion such that an elastic energy can be stored in the torsion element and which is arranged such that the elastic energy after completion of the drive rotational movement in the return movement is convertible to turn the engine back in the opposite direction.
  • the torsion element may e.g. comprise a rod made of elastic plastic or a torsion spring.
  • a rotatable transmission element for direct or indirect transmission of the drive rotary motion may be present on the product reservoir, for example in the form of a rotatable, but relative to a housing of the drive device axially displaceably arranged driver.
  • the torsion element is then preferably mounted between the motor and the transmission element. If the motor is followed by a transmission for reducing the drive rotary motion, the torsion element is preferably arranged between the transmission and the transmission element, for example on the output shaft of the transmission. This is advantageous because the acting at this point Torques due to the gear reduction are greater than directly on the motor shaft.
  • the device may additionally comprise the product reservoir with the fluid product.
  • the device can be modularly constructed as a semi-disposable device, as is basically described in the aforementioned WO 2008/106805.
  • the device preferably comprises a drive unit with the drive device, the detection device and the control device, as well as an exchangeable product unit detachably connectable to the drive unit with the product reservoir.
  • the transmission element is then preferably designed as a rotatable and non-displaceable driver in order to transmit a rotational movement from the drive device to the product unit.
  • the product reservoir may include a slidable plug.
  • the product unit then preferably comprises a conversion device, which is designed to convert a rotational movement of the driver into a feed movement of the plug.
  • This may comprise a rotationally fixed guide member which is in threaded engagement with a transmission member such that rotation of the transmission member in a predetermined rotational direction relative to the guide member results in advancement of the transmission member in a distal direction, the transmission member being configured to be direct or act indirectly on the product reservoir, that the advancing movement of the transfer member in the distal direction leads to an ejection of the fluid product from the product reservoir
  • the present invention also relates to a method according to claim 10.
  • the administering device comprises a drive means adapted to generate a drive movement in a drive direction and to act directly or indirectly on a product reservoir such that the drive movement produces an expulsion of the fluid product from the device Product reservoir effect
  • the precision of the amount of product released can be improved by adding a measure of the return movement of the drive device, due to elastic forces, to the discharge amount in the next discharge cycle in order to compensate for discharge errors due to elastic deformations.
  • the distribution of a predetermined discharge amount can be distributed over several discharge operations to obtain a plurality of mass for the return movement of the drive device.
  • Fig. 1 is a base unit of a delivery device according to a first
  • Fig. 2 shows an interchangeable cartridge of the administering device according to the first
  • FIG. 3 is a schematic diagram of the administration device according to the first
  • FIG. 4 shows a schematic diagram of an administration device according to another embodiment
  • Fig. 5 shows a diagram with a schematic velocity profile during a discharge cycle
  • Fig. 6 is a diagram in which the number of revolutions of a motor counter the drive direction are shown as a function of the pressure in the product reservoir.
  • FIG. 1 shows schematically a basic unit of a modular administration device ("semi-disposable device") for administration of a liquid medicament according to a first embodiment , to which reference is made for further details of the design of the base unit and the power transmission between the base unit and an associated cartridge.
  • a modular administration device for administration of a liquid medicament according to a first embodiment
  • the base unit 100 has a housing 110 in which a battery 120, an electronic control device 121, a drive device in the form of a drive motor 122, a gear 123, a driver 124, an encoder 125 for detecting the angle of rotation traveled by the shaft of the drive motor , as well as various other, unspecified and only partially shown components are housed.
  • controls 111 are arranged, which are indicated here only very schematically. Such controls may e.g. a display and one or more control buttons.
  • the control device 121 can be operated with regard to the individual needs of a patient.
  • the gear 123 and partially the motor 122 are parts of a finger-like structure 112 of substantially circular cylindrical basic shape, wherein the driver is arranged in the region of the free end of this finger-like structure.
  • the motor 122 drives the driver 124 via the gear 123 to a drive rotational movement.
  • the driver 124 essentially consists of a wheel, on the circumferential surface of which a plurality of driver ribs extending in the axial direction are arranged.
  • an interchangeable cartridge is shown, which with the base unit of FIG. 1 and with a needle adapter, not shown, to a complete Administration device is connectable.
  • the distal direction is to be understood in each case as the direction in which a respective movable element moves in the course of the administration of the product. In some of the embodiments described in more detail below, there is a deflection of an advancing movement through 180 ° in the interior of the administering device.
  • the distal direction is therefore defined only locally and may correspond to different absolute spatial directions for different parts of the administering device.
  • the proximal direction is defined as the direction opposite to the distal direction.
  • a lateral direction is a direction perpendicular thereto.
  • Cartridge 200 comprises a housing 210, in the region of which shown in FIG. 2 at the bottom a product container 220 in the form of a carpule with cylindrical side wall region and product plug 221 displaceable therein.
  • the product container 220 At its distal end (on the left in FIG. 2), the product container 220 is closed by a closure cap 222 with a septum and thus forms a product reservoir with volume Vi.
  • the product container At its proximal end, the product container is held in a sealing ring 242.
  • a hydraulic reservoir 230 is formed, which is delimited in the lateral direction by a cylindrical side wall region of the housing 210.
  • the hydraulic reservoir 230 is delimited by a hydraulic plug 231, which is axially movable and sealingly guided in the sidewall region.
  • the hydraulic reservoir 230 is arranged via a fluid channel 241, which is bounded by a closing element 240, with a bottom right in FIG Displacement reservoir 223 connected. This is limited in the distal direction by the product plug 221.
  • a suitable hydraulic fluid for example stained, deionized water, a suitable oil or another incompressible fluid, is filled in the hydraulic reservoir 230, in the displacement reservoir 223 and in the fluid passage 241.
  • the hydraulic fluid as a whole occupies a volume V 2 .
  • the hydraulic plug 231 comprises a rigid support 232 on which an annular Seal 233 is arranged, which seals the hydraulic plug 231 against the side wall of the housing.
  • the carrier 232 merges into a transmission sleeve 234.
  • the transmission sleeve 234 has, on the one hand, an external thread which engages with the internal thread of a guide nut 250 fixedly arranged in the housing.
  • On its inner circumferential surface, the transmission sleeve 234 on its inner circumferential surface, the transmission sleeve 234 on the other hand, a plurality of longitudinal grooves 236 which extend parallel to the longitudinal direction of the transmission sleeve and complementary to the corresponding longitudinal ribs on the driver 124 of the base unit 100 are formed. While here the transmission sleeve 234 is formed integrally with the hydraulic plug 231, these parts can also be formed separately and in particular against each other rotatable.
  • a needle adapter is first placed on the cartridge 200, to which a catheter of an infusion set adjoins.
  • the infusion set ends in and a cannula for piercing the skin of a patient.
  • the needle adapter includes a hollow needle that pierces the septum of the cap 222 of the product container 220 and thus connects the interior of the product container to the catheter.
  • the cartridge 200 is connected to the base unit 100.
  • the finger-like structure 112 is inserted into the interior of the transmission sleeve 234, wherein the longitudinal ribs on the outside of the driver 124 engage with the longitudinal grooves 236 in the inner circumferential surface of the transmission sleeve 234.
  • a sensor 113 detects in the control device whether the cartridge 200 is correctly connected to the base unit 100. If this is not the case, no commissioning can take place. While the sensor 113 is here designed as a mechanical switch, this can also be a non-contact sensor, e.g. a reflective photocell, a magnetic or capacitive sensor, or another type of proximity sensor.
  • the control device 121 controls the motor 122, so that the motor 122 via the gear 123, the driver 124 in a rotational movement.
  • This rotational movement is due to the engagement of the driver 124 transmitted to the longitudinal grooves of the transmission sleeve 234 on this.
  • the transmission sleeve 234 is engaged by a threaded connection with the guide sleeve 250, the rotational movement simultaneously causes a feed movement of the transmission sleeve 234 (in total a screw movement in the distal direction) and thus a feed of the entire hydraulic plug 231 in the distal direction.
  • the volume of the hydraulic reservoir 230 decreases so that the hydraulic fluid is forced through the fluid channel 241 into the displacement reservoir 223 and here leads to a feed of the product stopper 221 in the distal direction.
  • the base unit 100 comprises a first part of a drive train. This part includes the drive motor 122, the gear 123, and the cam 124.
  • the drive motor 122 generates a drive rotational movement of a motor shaft 126 with a drive torque
  • the gearbox 123 underpins the
  • the cartridge 200 includes a second part of the drive train.
  • This second part comprises the transmission sleeve 234, the hydraulic system and the product plug 221.
  • the transmission sleeve 234 converts the rotational movement of the driver 124 into a feed motion of the hydraulic plug 231; In this case, the torque MT is converted into a feed force acting in the distal direction. This leads to a pressure increase in the hydraulic reservoir.
  • the feed force is in equilibrium during the feed movement with a counterforce, which is formed by a pressure force F 2 in the hydraulic reservoir and loss forces, in particular frictional forces between the hydraulic plug and the wall of the hydraulic reservoir.
  • the product plug 221 is finally advanced and effected an expulsion of the product through the outlet 224, which is indicated in Figure 3 only highly schematic and is formed by the hollow needle of the needle adapter, through the infusion set and through the cannula.
  • the elasticity means that for a given number of revolutions of the engine, a smaller amount is expelled from the product reservoir than if the system were completely rigid.
  • there is a certain play in the drive train inevitably production-technical, which has a similar influence on the ejected amount as the elasticity.
  • Powertrain components are abutting each other. After the first start-up of the engine, the game then has a mostly negligible influence within a discharge operation, since all components are under load.
  • the hydraulic piston comes to a standstill and can not move due to the large static friction.
  • the elastic deformations in the drive train now lead to a torque that acts back on the drive motor and depends on the last transmitted by the drive train torque.
  • This torque causes the motor in the opposite direction to the Drive rotation is rotated back by a reverse angle until the torque is reduced so that it is in balance with corresponding counter torques (eg due to frictional forces and the self-locking of the engine).
  • the self-locking is usually low.
  • the number of revolutions by which the engine turns back, or the angle of return, correlates very well with the last torque applied by the engine before switching off. This torque in turn correlates very well with the pressure prevailing in the hydraulic reservoir. If this pressure exceeds a certain level or begins to rise sharply, this indicates an occlusion. In this way, the extent to which the engine is turned back after being turned off in the opposite direction can be used to draw conclusions about the pressure in the hydraulic reservoir and to detect occlusions.
  • the detection of the reverse rotation angle takes place in the present example by the encoder 125, which supplies signals over the angle of rotation traveled to a detection device 128 where they are detected. If these signals indicate an occlusion, the detector 128 sets a corresponding variable (eg, a binary occlusion "flag" or counter), sends it to the controller 121, and optionally takes further action, eg, issuing an alarm, turning off the device, etc.
  • the determination of the return angle can also be done in other ways, for example, by measuring the feedback induced in the motor, rotation angle-dependent voltage after switching off the motor.
  • the motor is switched off at the lowest possible speed, shortly before the standstill.
  • the end value of the speed at which the shutdown takes place depends on the design of the engine and is preferably chosen so that it is ensured that the engine generates a torque as constant as possible until switching off.
  • a corresponding velocity profile during a single dispensing operation is schematically illustrated in FIG. Such a discharge process usually takes a few seconds (period to). On the other hand, there are usually several minutes between successive dispensing operations, typically about 3-30 minutes.
  • the engine speed is continuously reduced (falling branch 501). As soon as the target speed of zero is reached, the engine is switched off immediately. After switching off the motor, the motor shaft rotates by a certain angle due to the elasticity in the drive train (reverse rotation area 502 in the speed profile). The amount by which the motor shaft turns back is detected during a monitoring period ts.
  • FIG. 6 illustrates how the number of revolutions in the opposite direction depends on the actual pressure in the hydraulic reservoir (as overpressure relative to the ambient pressure).
  • the diagram shows a family of characteristics measured for different delivery rates per dispensing operation (ie different time periods to) with an administration device of the type shown in FIGS. 1 and 2.
  • the curve 601 represents a typical characteristic as it would result from an averaging over a sufficiently large number of measured characteristic curves.
  • the engine always turns back at a certain angle even at low pressure in the hydraulic reservoir. This is mainly a consequence of the friction of the hydraulic stopper, which leads to a significant counterforce F 2 during its advance even at low pressure.
  • an elastic element in the drive train via which forces or torques are transmitted and which thereby is elastically deformable.
  • an elastic torsion element 127 may be provided between the gear 123 and the driver 124, which is mounted on the transmission shaft. The torsion element absorbs additional elastic energy depending on the transmitted torque, which is available after the end of the drive movement for turning back the motor.
  • the torsion element may be, for example, an elastic torsion bar or a torsion spring, as they are known in various designs.
  • FIG. 4 shows, by way of example, a schematic diagram of a second embodiment of an administering device that does not require any hydraulics. Like-acting parts are again provided with the same reference numerals as in FIG. 3. In this simpler embodiment, the transfer sleeve 234 immediately advances the product plug 221. The pressure thus generated in the product reservoir 220 leads to a counterforce Fi on the product plug 221. The further mode of operation is the same as in the embodiment of FIGS. 1 to 3.
  • the conversion of the rotary motion into a feed motion may be accomplished in ways other than those described above, for example, by a rotatable threaded nut running on a non-rotatable, longitudinally displaceable threaded rod which acts as a piston rod for the product or hydraulic plug.
  • the transmission of force between the base unit and the cartridge can also take place in other ways than shown here, for example translationally, as is well known from the prior art.
  • the structure of the device can also be fundamentally different; In particular, the device need not be designed as a semi-disposable device with base unit and cartridge, as is the case in the above examples, but may, for example, directly a replaceable cartridge with the product record, as is well known from the prior art.
  • controllable drive element e.g. an electrically inhibited spring or a gas generator, wherein in such cases advantageously after the discharge process, a decoupling between the actual drive element and the rest of the drive train to the elastic

Abstract

L'invention concerne un dispositif d'administration d'un produit fluide, qui comprend un dispositif d'entraînement (100). Ce dernier agit directement ou indirectement sur un réservoir (220) à produit pour entraîner une expulsion du produit fluide hors du réservoir (220) à produit. Un dispositif de commande (121) commande le dispositif d'entraînement (100) de telle sorte que le dispositif d'entraînement produise un mouvement d'entraînement pendant une durée d'entraînement. A la fin du mouvement d'entraînement, un dispositif de détection (128) détecte un recul du dispositif d'entraînement dans une direction opposée à la direction d'entraînement suite à l'action de forces élastiques exercées dans l'ensemble de l'entraînement. Ces forces dépendent entre autres de la pression qui règne dans le réservoir à produit, de sorte que l'amplitude du recul du dispositif d'entraînement peut être utilisée pour surveiller la pression qui règne dans le réservoir à produit et déceler des défauts de fonctionnement.
PCT/CH2010/000130 2009-06-10 2010-05-20 Surveillance de l'engorgement dans un appareil d'administration WO2010142048A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH897/2009 2009-06-10
CH00897/09A CH701270A1 (de) 2009-06-10 2009-06-10 Okklusionsüberwachung in einem Verabreichungsgerät.

Publications (1)

Publication Number Publication Date
WO2010142048A1 true WO2010142048A1 (fr) 2010-12-16

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PCT/CH2010/000130 WO2010142048A1 (fr) 2009-06-10 2010-05-20 Surveillance de l'engorgement dans un appareil d'administration

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CH (1) CH701270A1 (fr)
WO (1) WO2010142048A1 (fr)

Citations (5)

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US20050020980A1 (en) * 2003-06-09 2005-01-27 Yoshio Inoue Coupling system for an infusion pump
US20060184154A1 (en) * 1998-10-29 2006-08-17 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
WO2008106805A1 (fr) * 2007-03-02 2008-09-12 Tecpharma Licensing Ag Appareil d'administration à fonction de reconnaissance d'obstruction

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034004A (en) * 1987-06-19 1991-07-23 The University Of Melbourne Infusion pump and drive systems therefor
US20060184154A1 (en) * 1998-10-29 2006-08-17 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
US20040015124A1 (en) * 1999-11-24 2004-01-22 Sciulli Francis J. Fluid delivery system having a syringe interface module separate from but in communicaiton with a control unit
US20050020980A1 (en) * 2003-06-09 2005-01-27 Yoshio Inoue Coupling system for an infusion pump
WO2008106805A1 (fr) * 2007-03-02 2008-09-12 Tecpharma Licensing Ag Appareil d'administration à fonction de reconnaissance d'obstruction

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