WO2016071483A1 - Dispositif médicamenteux - Google Patents

Dispositif médicamenteux Download PDF

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Publication number
WO2016071483A1
WO2016071483A1 PCT/EP2015/075884 EP2015075884W WO2016071483A1 WO 2016071483 A1 WO2016071483 A1 WO 2016071483A1 EP 2015075884 W EP2015075884 W EP 2015075884W WO 2016071483 A1 WO2016071483 A1 WO 2016071483A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
thread
carpule
drive
drive element
Prior art date
Application number
PCT/EP2015/075884
Other languages
German (de)
English (en)
Inventor
Tobias Kistler
Roland Limbeck
Sarah Kühnle
Tilman Roedle
Original Assignee
Vetter Pharma-Fertigung GmbH & Co. KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vetter Pharma-Fertigung GmbH & Co. KG filed Critical Vetter Pharma-Fertigung GmbH & Co. KG
Publication of WO2016071483A1 publication Critical patent/WO2016071483A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe

Definitions

  • the invention relates to a medicament device according to the preamble of claim 1.
  • Medication facilities of the type discussed here are known. They are used to administer a drug to a patient, which is housed for example in a carpule, which is received by a housing.
  • medicine devices of this kind are designed as a pen, which is provided with a drive. This serves to displace a plunger in the longitudinal direction of the carpule and engage in this to move a plug there existing. As a result, the existing in the carpule drug is discharged.
  • the drive element and the plunger are formed with a thread which serves to move the plunger with a rotation of the drive element in the direction of the longitudinal extension of the housing and the carpule therein.
  • gearboxes are coupled to the drive, which make space within the medicament device necessary, and also increase the costs for the production of this device.
  • the object of the invention is therefore to provide a medicament device of the type mentioned here, which avoids the disadvantages mentioned here.
  • a medicament device with the features of claim 1 which comprise a carpule, a housing, a plunger, a cooperating with this drive and a drive element, wherein the drive element and the plunger cooperate with each other such that this is a displacement of the Stopping within the carpule causes.
  • Drive element and plunger act together via a thread.
  • the medicament device is characterized in that the thread of the drive element over its longitudinal extent has a changing pitch. In this way it is possible to realize at a constant rotation of the drive element different fast displacement movements of the plunger and thus a plug within a carpule, without the need for a gear would be required.
  • the drug device created here is therefore characterized by a compact and simpler structure and comparatively low production costs.
  • the plunger which the displacement of the plug within the Carpule serves, is hollow and has an internal thread on its inner surface.
  • the Ant ebselement engages in the interior of the plunger and has an external thread, which cooperates with the internal thread of the plunger.
  • the plunger is moved in the direction of its longitudinal extension.
  • selected configuration is characterized by a small footprint, also by lower frictional forces.
  • a further preferred embodiment of the medicament device is characterized in that the internal thread of the plunger has a threaded portion which cooperates with the external thread of the drive element designed as a threaded rod. It is therefore not necessary to provide a thread on the entire inner surface of the plunger. This allows a very simple construction of the thread drive. As a threaded portion of the internal thread, such a region of the internal thread is referred to, which cooperates with the external thread of the threaded rod.
  • an embodiment which is characterized in that from the inner surface of the interior of the plunger, a projection springs, is provided at the free end of the threaded portion.
  • a projection springs is provided at the free end of the threaded portion.
  • the threaded portion measured in the longitudinal extension of the housing or the plunger, has a height which is smaller or equal is like the distance between two sets of threads in the area of minimum pitch of the effective external thread of the threaded rod.
  • the term "effective external thread” refers to the area of the external thread which cooperates with the threaded section, ie the threaded section of the plunger does not engage the entire length of the external thread of the threaded rod measured in the direction of the longitudinal extent of the housing, but only in the area It is also not intended that the internal thread of the plunger over the entire height of the interior of the plunger with the external thread of the threaded rod cooperates
  • the threaded section has a height which is less than or equal to the minimum pitch of the effective external thread tt is also realized by a single web, which engages in the external thread.
  • FIG. 2 shows a bottom view of a first exemplary embodiment of an element of the medicament device, namely the plunger
  • Figure 3 shows a cross section of a second embodiment of an element of the medicament device, namely the plunger
  • FIG. 4 shows a perspective side view of a drive with a drive element arranged in a tappet.
  • FIG. 1 shows a medicament device 1 with a carpule 3 containing a medicament with a longitudinal axis 5.
  • the carpule 3 has a cavity 7, which serves to receive a medicament.
  • Within the carpule at least one displaceable in the direction of its longitudinal axis 5 stopper 9 is provided.
  • the medicament device 1 also has a housing 1 1 accommodating the carpule 3 with a central axis 13 which runs coaxially to the longitudinal axis 5.
  • the housing 1 1 comprises a drive 15 with a drive element 19 which can be set in rotation.
  • the drive 15 is provided with a power supply integrated in the medicament device 1. It is also conceivable, however, to supply the drive 15 with power wirelessly or via a cable.
  • the drive element 19 is designed here as a threaded rod 20 with a thread.
  • the housing 1 1 also includes a plunger 21, which cooperates with the at least one plug 9 such that the plug 9 within the carpule 3 in the direction of its longitudinal axis 5 is displaced.
  • the plunger 21 in turn is formed with a thread, which cooperates with the thread of the drive element 19. It is provided that the threads of both the drive element and the plunger interact in such a way that the plunger is displaced in the direction of the central axis 13 and the longitudinal axis 5 by the drive element 19 upon activation of the drive 15, in FIG. 1 upwards in order to move the at least one plug 9 upwardly within the cavity 7 of the carpule 3. gladly.
  • the drive element 19 or the plunger 21 has an external thread and vice versa the plunger or the drive element has an internal thread, wherein the two threads cooperate with each other such that during a rotation of the drive element 19 or the plunger 21 an axial Displacement in the direction of the longitudinal extension of the drug device 1 takes place.
  • the drive element 19 has a thread, the slope of which - seen over the longitudinal extent of the drive element 19 - changes.
  • the plunger 21 is hollow, and the drive element 19 protrudes into the cavity of the plunger 21 inside.
  • the drive member 19 may be formed as a hollow cylinder, in which a plunger 21 engages, wherein the hollow member has an internal thread and engaging in this hollow member, in this case the plunger 21, an external thread.
  • the axial displacement of the plunger 21 is effected by the interaction of external and internal threads, so that also the at least one plug 9. It is crucial that the medicament device 1 is formed so that the two cooperating means of a threaded elements, the drive element 19th and the plunger 21 can cooperate so that the displacement of the plunger 21 in Rieh- tion of the longitudinal extension of the civilneinnchtung 1 and this can engage in the cavity 7 of the carpule, there to move the at least one plug 9. Therefore, here also the drive element 19 and the plunger 21 are arranged coaxially to one another and to the central axis 13 and the longitudinal axis 5.
  • FIG. 1 shows that in the exemplary embodiment illustrated here, the medicament device 1 is designed as a pen, which serves to administer a medicament present in the cavity 7 of the carpule 3 to a patient by activating the drive 15.
  • the carpule 3 is closed off at its end 23 facing away from the at least one plug 9 with a closure part 25, so that the medicament present in the cavity 7 is reliably protected from contamination.
  • a conventional cannula may also be attached to administer a drug to a patient.
  • the carpule 3 is designed as a so-called Doppelcrokarpule.
  • the cavity 7 thus has a first partial cavity 27 and a second partial cavity 29, which are separated from each other by a second plug 30.
  • the two partial cavities 27 and 29 have, on the one hand, a powder and, on the other hand, a solvent, it being possible for the powder to be a lyophilizate. It is also conceivable, however, to accommodate a liquid in both partial cavities 27 and 29.
  • the powder and the solvent or the two liquids must be mixed with each other, in the first case, the powder is dissolved.
  • the first stopper 9 by means of the plunger 21 - in Figure 1 - upwards in the direction of the end 23 so far displaced until it is arranged in the region of a bypass, not shown here, so that the powder and the liquid or in the two partial cavities 27 and 29 existing fluids can mix with each other. Structure and mode of operation, including the initiation process of the mixture or solution of substances present in the partial cavities 27 and 29 is known, so that it will not be discussed further here.
  • the medicament device 1 is still provided with a surrounding the carpule 3 sleeve 31, which serves to protect the carpule 3.
  • the housing 1 1 of the drug device 1 is formed so that it can be firmly connected at its end facing away from the drive 15 with the carpule 3 and, if present, with the sleeve 31.
  • the carpule 3 is fixedly held inside the sleeve 31. Once it is attached to the housing 1 1.
  • the plunger 21 is provided with preferably provided at the lower end end of the central axis 13 facing away projections 33 which engage in a provided in the inner surface of the housing 1 1 groove 35.
  • at least two opposing projections 33 are provided which cooperate with two grooves 35 accordingly.
  • the projections and the grooves serve to realize a rotationally fixed housing of the plunger 21 in the interior of the housing 1 1. It is readily apparent that at least one projecting from the inside of the housing 1 1 projection can engage in at least one provided on the outside of the plunger 21 groove, so far a function reversal is realized.
  • Figure 2 shows a bottom view of the plunger 21, namely an embodiment of the plunger, in which no wings are provided on the outer surface 37, as Figure 1 shows, but at least one channel, here two opposing grooves 35 ', in which from the inside of the housing 1 1 springing, not shown here engage projections.
  • the same and functionally identical elements are provided with the same reference numerals, so that reference is made to the preceding description.
  • the plunger 21 engages the drive element 19, not shown here, which is designed as a threaded rod 20 with an external thread.
  • the plunger 21 has an internal thread, which engages with a threaded portion 41 in the external thread of the threaded rod 20.
  • the threaded portion 41 is preferably provided on the central axis 13 of the housing 1 1 and thus the plunger 21 facing the end of at least one here as 40 projecting from the inner surface 40 web projection formed so that this threaded portion 41 cooperate with the external thread of the drive element 19, not shown here can.
  • the interior 39 of the plunger 21 can also be oval, wherein in the region of the inner surface 40 of the inner space 39 with the smallest inner diameter, a threaded portion can be provided, which engages in the external thread of the drive element 19. It is therefore not absolutely necessary to provide a web for realizing a threaded portion 41 which engages in the external thread.
  • a triangular or polygonal inner contour of the plunger 21 can be formed so that at least a portion of the inner surface of the plunger 21 has a threaded portion 41 which engages in the external thread of the drive element 19.
  • the web 43 is preferably provided on the lower, the drive 15 facing the end of the plunger 21. It moves in a rotation of the drive member 19 in its external thread upwards and thus moves away from the drive 15. Since the threaded member 20 formed as drive element 19 has a variable thread pitch with variable pitch, the axial, taking place in the direction of the central axis 13 movement of Projection 23 and thus that of the plunger 21 depending on the rotational speed of the drive element 19, but here also of the thread pitch.
  • the web 43 with the engaging in the external thread of the drive 19 threaded portion 41 does not necessarily have to be part of the plunger 21. It is also possible to provide an annular nut element which has the web 43 on its inner side or has an oval or polygonal inner cross section with a threaded portion.
  • the nut member is rotatably housed in the housing 1 1, as already explained with reference to the plunger 21.
  • the drive element 19 selected as a threaded rod 20 the nut element is moved in the longitudinal direction of the medicament device 1 with the threaded section 41 which cooperates with the external thread and pushes upwards a plunger 21 formed in this case separately from the nut element in the direction of the carpule 3.
  • the at least one plug 9 is displaced upward within the carpule 3, as has already been explained in connection with the plunger 21.
  • FIG. 3 shows a cross-section through a plunger 21 in the region in which a threaded section 41 is realized on the inner surface 40 circumscribing the inner space 39, as was mentioned with reference to FIG. 2 in connection with the web 43 present there.
  • the same and functionally identical elements are provided with the same reference numerals, so that reference is made to the preceding description.
  • a rolling body 42 is provided here, which is mounted on the plunger 21 such that it can rotate at least about an axis of rotation which is arranged substantially parallel to the central axis 13 of the housing 11.
  • the roller body 42 projects beyond the inner surface 40 of the plunger 21 to realize the threaded portion 41. It is arranged on the wall 38, in the embodiment illustrated here embedded in the wall 38, which here has a recess A for accommodating the rolling body 42.
  • the rolling body 42 may be formed as a ball or as a disc which is cylindrical or lens-shaped. It is crucial that the roller body 42 has a projecting into the interior 39 surface portion which engages between two thread rests of the external thread of the drive element 19, not shown here.
  • the thread section 41 realized here by a surface section of the rolling body 42, by the way, the thread section designed for the web 43 applies correspondingly.
  • the web 43 and the rolling body 42 may be formed on the inner surface 40 of a plunger 21, the inner surface, as shown in Figures 2 and 3, is cylindrical or elliptical.
  • the web 43 and the rolling body 42 are arranged in a region of the inner surface 40 which has an inner diameter which is smaller than in a direction perpendicularly measured to ensure that the web 43 and the rolling body 42, respectively formed threaded portion 41 engages in the external thread of the drive element 19.
  • the rolling body 42 does not have to be provided directly in the wall 38 of a plunger 21. Rather, it is also possible to provide an annular nut member with a rolling body 42 described here, which is rotatably mounted, here by grooves 35 ', in which engage projections which extend from the inside of the housing 1 1.
  • the threaded portion 41 moves with the nut element in the direction of the central axis 13 and pushes the plunger 21 upward in FIG. 1, as has already been explained.
  • the nut member can be replaced if necessary, if the threaded portion 41 is worn, or if Antriebssele- elements 19 are used with different thread pitches, which are to cooperate with the threaded portion 41.
  • the surface portion of the rolling body 42 is formed such that it engages between two adjacent thread ridges of the external thread on the drive element 19.
  • a thread with a large pitch is provided on the drive 15 facing the region of the threaded rod 20 formed as driving element 19, while provided at the opposite end a low pitch is.
  • the thread pitch can decrease continuously or decrease over the longitudinal axis of the Ant ebselements 15, ie in the direction of the central axis 13 in a desired ratio. It is also possible, by the way, for the threaded rod 20, viewed over its longitudinal extent, to have different areas with different thread pitches, wherein several areas with a large thread pitch and also several areas with a small thread pitch can be provided.
  • the web 43 or the rolling body 42 moves at a constant rotational speed at a relatively high speed in the direction of its longitudinal extent, while the displacement speed is slower in the region of a small thread pitch.
  • the at least one plug 9 is initially displaced at a slow speed.
  • an overpressure is built up in the lower part cavity 29, as a result of which the second stopper 30 is likewise moved upward in the direction of the end 23 of the carpule 3, into the region of a not shown here. set bypasses. It is predeterminable, if necessary, by attempts to determine how long the anti-element must rotate at a given thread pitch around the second plug 30 in the area of the bypass. Once this is done, the drive 15 is deactivated.
  • the mixture or reconstitution of the substances present in the partial cavities 27 and 29 can also be carried out by dissolving a lyophilisate.
  • the drive 15 can be reactivated to expel air from the cavity 7 of the carpule 3.
  • the way to expel the air can be predetermined, so that here too a relatively high feed rate of the first and second stopper 9, 30 can be realized. Once the air is expelled, the drive 15 is again deactivated.
  • the medicament device 1 in this case the pen, is now ready to administer a ready-mixed medicament in the cavity 7 of the carpule 3.
  • a drug is now caused to have the desired dose predetermined by the time of activation of the drive 15.
  • the plug 9 is advanced relatively slowly.
  • the thread pitch of the external thread of the threaded rod 20 is therefore small in the region in which the threaded portion 41 engages during the administration of a medicament.
  • FIG. 4 shows the drive 15 of a medicament device 1 with a drive element 19, which is designed as a threaded rod 20. This is located within a ram 21 shown cut here, the at least one, in this example two wings 33 which engage in the apparent from Figure 1 groove 35 in the wall of the housing 1 1, which is not shown here.
  • Figure 4 serves to illustrate how the external thread of the threaded rod 20 may be formed. It can be clearly seen that the thread pitch of the external thread in the lower, here near the drive 15 located region has a large pitch, while it is formed at its opposite end with a small pitch.
  • different thread pitches can be provided on the outside of the drive 19 realized as a threaded rod.
  • the drive 15 may cause rotation of the drive member 19 for predetermined periods of time to discharge defined volumes of a drug from the cavity 7 of the carpule 3.
  • the drive member 19 By provided in the upper portion of the drive member 19 low pitches the drug is administered slowly, so that no adverse effects on a patient are to be feared. Due to the relatively slow feed rate of the plug or moreover, a very accurate dosage of a drug can be realized.
  • the advantages described here arise not only when the medicament device 1, as shown formed as a pen, but also when the medicament device 1 is coupled to any infusion device.
  • the activation of the drive 15 can be controlled and / or regulated to administer different drug doses in one and the same medicament device 1.
  • the drive element 19 may be separable from the drive 15 so that drive elements 19 with different thread pitches and over the length of the drive element 19 can also be used over different ranges of thread pitches and coupled to a drive 15. It is thus possible in a simple manner to provide different displacement speeds of the at least one plug of the medicament device 1 and thus to design the medicament device for different administration situations.
  • a further advantage of the medicament device 1 described here results from the following circumstance: A translatory movement or displacement of the plunger 21 and thus of the at least one plug 9 can be detected directly by suitable sensors. However, it is also possible to detect the rotation of the drive element 19 by means of a suitable sensor and to calculate the translatory movement of the plunger 21 or of the at least one plug 9 as a function of the thread pitch of the drive element. For example, it is possible with manageable effort to detect the rotation of the drive element 19 every 10 °. In a region with a large thread pitch, for example, a feed of x mm, during a certain number of revolutions, results. in an area with a low pitch a feed of x / 10 mm is given.
  • a low pitch area of the thread cooperates with the threaded portion 41 so that a lesser amount of feed (for example, x 10 mm) is given for a given number of revolutions of the drive member 19. This can therefore be detected with a relatively simple sensor.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif médicamenteux (1), comprenant une ampoule (3) renfermant un médicament et présentant un axe longitudinal (5), ladite ampoule comprenant au moins un bouchon (9) pouvant être déplacé en son sein dans le sens de l'axe longitudinal (5), un logement (11) abritant l'ampoule (3) et présentant un axe médian (13) disposé de manière concentrique par rapport à l'axe longitudinal (5) de l'ampoule (3), un poussoir (21) disposé de manière solidaire en rotation dans le logement (11), pouvant être déplacé dans le sens de son axe médian (13), présentant un taraudage et agissant sur au moins un bouchon (9), et comprenant un entraînement (15) coopérant avec le poussoir (21) et présentant un élément d'entraînement (19) qui peut être mis en rotation par l'entraînement (15) et qui comporte un filetage, le filetage de l'élément d'entraînement (19) coopérant avec le taraudage du poussoir (21) de telle sorte que le poussoir (21) peut être décalé dans le sens de l'axe médian (13) du logement (11) lors d'une rotation de l'élément d'entraînement (19). L'invention se caractérise en ce que le filetage de l'élément d'entraînement (19) a une pente variable sur son extension longitudinale.
PCT/EP2015/075884 2014-11-06 2015-11-06 Dispositif médicamenteux WO2016071483A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014222736.4A DE102014222736A1 (de) 2014-11-06 2014-11-06 Medikamenteneinrichtung
DE102014222736.4 2014-11-06

Publications (1)

Publication Number Publication Date
WO2016071483A1 true WO2016071483A1 (fr) 2016-05-12

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PCT/EP2015/075884 WO2016071483A1 (fr) 2014-11-06 2015-11-06 Dispositif médicamenteux

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DE (1) DE102014222736A1 (fr)
WO (1) WO2016071483A1 (fr)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
WO2016205961A1 (fr) * 2015-06-23 2016-12-29 Techpharma Licensing Ag Dispositif d'injection pourvu d'un filetage à pas variable
US11185629B2 (en) 2016-06-08 2021-11-30 Shl Medical Ag Dosing apparatus and injection device
US11253652B2 (en) 2016-11-28 2022-02-22 Shl Medical Ag Device for dispensing a substance

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DE102006038103A1 (de) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit variabler Gewindeführung
WO2014166914A1 (fr) * 2013-04-10 2014-10-16 Sanofi Ensemble d'entraînement pour dispositif d'administration de médicament

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GB0304824D0 (en) * 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
DE102006038101A1 (de) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit Klauensicherung
US8647309B2 (en) * 2008-05-02 2014-02-11 Sanofi-Aventis Deutschland Gmbh Medication delivery device

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Publication number Priority date Publication date Assignee Title
EP1090610A2 (fr) * 1999-10-06 2001-04-11 Ngk Spark Plug Co., Ltd Instrument facilitant l'extrusion d'un agent chimique, malaxeur pour préparer et extruder un agent chimique, et procédés pour les utiliser
DE102006038103A1 (de) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit variabler Gewindeführung
WO2014166914A1 (fr) * 2013-04-10 2014-10-16 Sanofi Ensemble d'entraînement pour dispositif d'administration de médicament

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016205961A1 (fr) * 2015-06-23 2016-12-29 Techpharma Licensing Ag Dispositif d'injection pourvu d'un filetage à pas variable
US10561799B2 (en) 2015-06-23 2020-02-18 Tecpharma Licensing Ag Drive unit and injection device
US10799647B2 (en) 2015-06-23 2020-10-13 Ypsomed Ag Injection device having a thread having a variable pitch
US11883637B2 (en) 2015-06-23 2024-01-30 Ypsomed Ag Injection device having a thread having a variable pitch
US11185629B2 (en) 2016-06-08 2021-11-30 Shl Medical Ag Dosing apparatus and injection device
US11253652B2 (en) 2016-11-28 2022-02-22 Shl Medical Ag Device for dispensing a substance

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