WO2008119691A2 - Stylo-injecteur pour liquide à injecter - Google Patents

Stylo-injecteur pour liquide à injecter Download PDF

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Publication number
WO2008119691A2
WO2008119691A2 PCT/EP2008/053467 EP2008053467W WO2008119691A2 WO 2008119691 A2 WO2008119691 A2 WO 2008119691A2 EP 2008053467 W EP2008053467 W EP 2008053467W WO 2008119691 A2 WO2008119691 A2 WO 2008119691A2
Authority
WO
WIPO (PCT)
Prior art keywords
rod
piston
container
pen injector
injection
Prior art date
Application number
PCT/EP2008/053467
Other languages
German (de)
English (en)
Other versions
WO2008119691A3 (fr
Inventor
Jürgen Schmidt-Evers
Bernd Ruhland
Clemens Micheler
Original Assignee
Schmidt-Evers Juergen
Bernd Ruhland
Clemens Micheler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07108190A external-priority patent/EP1974759A1/fr
Application filed by Schmidt-Evers Juergen, Bernd Ruhland, Clemens Micheler filed Critical Schmidt-Evers Juergen
Publication of WO2008119691A2 publication Critical patent/WO2008119691A2/fr
Publication of WO2008119691A3 publication Critical patent/WO2008119691A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Definitions

  • Pen injectors for liquid injectables, especially insulin, are in use millions of times.
  • the individual types have largely approximated.
  • the pens have the shape of an oversized and oversized fountain pen with a length of about 15cm without injection cannula or about 17cm with such a.
  • Your housing usually consists of at least two housing parts. The first housing part is used for
  • the second housing part contains a piston rod as well as a mechanical gearbox for driving the same and a metering device
  • the cartridges are standardized and consist of transparent material, preferably glass.
  • the cylinder chamber is closed at one end with a piston.
  • the other end of the cartridge is tapered and also closed, with a membrane, but can be easily pierced by the injection cannula, so that the injection cannula then has connection to the cylinder chamber.
  • the liquid injection agent In the cylinder chamber is the liquid injection agent. If on the piston rod in
  • the piston rod is stiff and has a length which is at least equal to the maximum total displacement of
  • Piston in the cartridge between the filling and empty state or greater than this Alterverschiebeweg is.
  • the theoretical minimum length of the pen injectors considered here is therefore essentially determined by the length of the insulin cartridge plus the length of the piston rod.
  • the standardized cartridges have a length of about 6.5 cm, and the maximum displacement of the piston element in the insulin cartridge is about 4.5 cm. This means that the total length of a pen injector of the construction described above can not be less than 11 cm (without injection cannula). Since the metering device needs additional space in the second housing part, one arrives at the above-mentioned overall length of approximately 17 cm (with injection cannula).
  • Pen injectors of the type considered here are just over twenty years on the market. There are a large number of IPR publications, some of which are to be cited below:
  • an injection device which serves to mix a powdery substance, for example a vitamin powder, with a solvent only immediately before the injection.
  • the solvent is in a container with a piston slidably disposed therein.
  • the piston is provided with a threaded hole through which a piston rod provided with a mating male thread extends into the solvent-filled portion of the container.
  • the piston rod is rotatable and axially displaceable. It closes in the non-use state, the outlet opening of the container.
  • the outlet opening is made free and the solvent can enter into a mixing chamber located in front of the outlet opening of a housing surrounding the container, in which the powdery substance is located.
  • the piston is then transported forward and ejects the powder-solvent mixture from the mixing chamber.
  • a donor device for pasty masses which is known from US 2, 349, 726 also works.
  • an apparatus for infusion of liquid therapeutic substances is known in which the piston located in a container is also penetrated by a threaded piston rod, wherein the piston rod in the liquid therapeutic substance contained with the part of the container extends.
  • the piston rod is fixed a priori against axial displacement. It is powered by a motor.
  • Injection material is located in a container which is closed by a piston.
  • the piston consists of a rubber stopper with a central hole through which extends a drive guide member.
  • the drive guide member is connected at its one end to a drive mechanism and carries at its other end a mixing element in the form of a screw conveyor, which projects into the filled with the injection material part of the container.
  • a linear force is exerted on the mixing element either manually, mechanically or by the drive mechanism so that the mixing element acts like a piston and forces the injection material into an injection pre-chamber.
  • the invention addresses the above-described known proposal to relocate the piston rod into the container in order to take into account the need for a shortened pen injector identified by the survey.
  • special problems that occur during the development of a practicable product must be solved.
  • Container is sucked.
  • most injectables, especially insulin should not come into contact with the supply of air.
  • there is air in the container there is a risk that air will also be injected with the injection medium, which can result in a fatal embolism. It would therefore be necessary to remove the air from the container before each injection
  • Injection means comprising a housing with a container for the injection means, with an outlet opening on the container, with a piston displaceable in the container, and with a displacer element (for example the piston rod) extending into the part of the container filled with the injection means, whose
  • Displacement volume is changeable.
  • the invention is based on the special object of improving such a pen injector in that displacements of the displacer element or changes to the displacer element lead neither to a negative pressure (intake of air) nor to an overpressure (ejection of injection medium), unless the latter is desired.
  • Compensation means that control the movements of the piston and the displacer element at least in selected operating phases so that - when the displacer element releases a certain volume space or or displaces a certain injection medium volume - the piston at the same time an equal Injector volume displaces or releases an equal volume of space, and vice versa.
  • the displacer element may be a first piston penetrating rod which extends into the part of the container filled with the injectant. It may be provided with an external thread corresponding to the internal thread of a threaded hole located in the piston.
  • a further development may consist in that the first rod is axially displaceable and forms the displacer element, that the first rod has a second external thread which corresponds to a second internal thread of a compensating element connected to the housing, that the second thread has a smaller pitch than the first thread has, and that the pitch ratio of the two threads is dimensioned so that a reverse rotation of the first rod simultaneously leads to an axial backward movement of the first rod and to a forward movement of the piston, such that the volume released from the first rod at the same time the forward moving piston is taken.
  • first rod is hollow
  • displacer element is formed by a second rod, which is arranged axially displaceably in the first rod.
  • the second rod should be locked against rotation with respect to the housing.
  • the second rod may be provided with an external thread which corresponds to an internal thread of a compensation element connected to the first rod, this thread having a greater pitch than the thread of the first rod and the threaded hole in the piston and wherein the ratio of the pitches is such that reverse rotation of the second bar results in axial protrusion of the second bar from the first bar and, at the same time, advancement of the piston, the volume of space released by the second bar being equal to an injection means - Volume is, which displaces the piston due to a forward movement.
  • the compensation element can be designed so that its internal thread at least a certain angular position of the corresponding external thread bearing rod or under pressure of the same allows a passage of the first rod in the axial forward direction, but does not allow an axial backward movement of this rod. This is possible, for example, when the compensation element consists of at least two parts which are moved apart for decoupling transversely to the axis of the first rod and can be moved towards each other again for coupling.
  • Another embodiment of the variant described above may consist in that the first rod at its end located in the container has a closure body, which is able to close the outlet opening of the container when advancing the first rod, and that the first Rod next to the closure body has wall openings that allow passage of the injection, so that when the outlet opening of the container and when advancing the piston displaced by the piston Injetationsstoff- volume is pressed into the cavity of the first rod and pushes back the second rod accordingly.
  • Another aspect of the invention relates to the special task that a pen injector of the type considered here is actuated only by forward and backward rotation of the Kobenstange, so - as will be explained in more detail later - works on the rotation-rotation principle.
  • a pen injector having the following known features: a housing, a container for receiving the injection means, an outlet opening on the container, a displaceable in the container piston, a threaded rod, at least over part of its length with a
  • Container protrudes, and a rotating element for rotating the threaded rod.
  • the object is achieved according to claim 20, characterized in that the threaded rod is fixed against axial displacement, and that the threaded rod via a
  • One-way clutch is connected to the rotary member, which couples in the forward direction and decoupled in the reverse direction, so that can be done by turning back the rotary member by a certain angle of rotation metering of the next injection stroke and by forward rotation by the predetermined rotation angle of the injection stroke can be performed.
  • An emphasized embodiment of the pen-injector according to the invention may consist in that between the rotary member and the threaded rod in addition a transmission gear is turned on.
  • a transmission gear is turned on.
  • the one-way clutch may have a plurality of detent positions according to an embodiment of the invention. This makes it possible for the user of the pen injector to acoustically record and count the number of units to be set during dosing.
  • the transmission gear is a planetary gear, wherein the planetary ring forms the rotary element, and that the central wheel is connected to the threaded rod via the one-way clutch.
  • rotation limiting means are provided for the rotary member, which allow a rotation of the rotary member by a maximum of 360 degrees.
  • the piston consists of a threaded core containing a solid core and a sheathing consisting of resilient material. In this way, a good seal between the threaded rod and the piston should be ensured.
  • a development relating to the housing may consist in that it consists of a cup-like lower part and a likewise cup-like upper part, wherein the upper part and the lower part are directed with their openings against each other and connectable to each other.
  • the lower part serves to receive the container for the injection means, while the upper part serves to receive the one-way clutch and the transmission gear.
  • the housing - to form a twin-pen - have a lower part, which has at least two receiving spaces for each container.
  • a separate upper part are provided for each container, which serves for receiving in each case an overrunning clutch and a transmission gear.
  • the lower part is then connected to an Anastomo seteil, which brings together the outputs of the container and can open into a common injection channel.
  • twin-pen is already described in principle in WO 01/02039 A1.
  • the twin-pen according to the invention is characterized in that the elements of the single device described above are particularly well suited to its realization.
  • the pen-type injector of the present invention may further be provided with an energy storing and driving mechanism which is charged with rotation of the rotary member in the metering rotational direction and which rotates the rotary member to perform the injection in the other rotational direction. If such a pen injector designed in this way can be dispensed with the transmission gear if necessary.
  • the invention further relates to a finished cartridge for a pen-injector, which is designed as described above.
  • "Fertigkarpule” is a term for a container designed according to an EU standard for insulin.
  • the finished carpule is characterized according to claim 40, characterized in that it contains a threaded rod guided by the piston.A useful further development is the subject of claim 41.
  • a method of operating the pen injector described above, which operates on the rotation-rotation principle, is the subject of claim 42.
  • the adjustment can be rotated and / or displaced by pressing.
  • the mechanical gear is a relatively complicated construction and consists of mutually running and telescopically nested threaded spindle.
  • the invention has for its object to look for a simple alternative to the last-mentioned mechanical transmission.
  • a pen injector with which this object is to be achieved has the following known
  • Features include: a housing, a container for the injection means, a displaceable in the container piston, and an adjusting element for the piston.
  • Figure 1 shows a section through a schematic pen-injector, which operates on the so-called.
  • Rotary-pressure principle but here is associated with a vacuum-forming problem, in four successive operating phases (a) - (d);
  • FIG. 2 shows a schematic section through a schematized pen injector, such as the compensation element indicated schematically in FIG. 1 for remedying the vacuum problem, likewise in four successive operating phases (a) - (d); 3 shows a section through a schematized pen-type injector, such as that shown in FIG. 2, here with a first concrete solution for the compensation element, in three successive operating phases (a) - (c) as well as several sections;
  • FIG. 4 shows a section through a schematized pen injector, such as that shown in FIG. 2, here with a second concrete solution for the compensation element and additionally a planetary gear and a plurality of cuts, in three successive operating phases (a) - (c);
  • FIG. 5 shows a section through a schematized pen injector, which operates in a first variant according to the so-called displacement principle I, in four successive operating phases (a) - (d);
  • FIG. 6 shows several illustrations of a specific embodiment of the pen injector shown in FIG. 5;
  • FIG. 7 shows a section through a schematic pen-type injector which operates according to the so-called displacement principle II in four successive operating phases (a) - (d);
  • FIG. 8 shows a concrete embodiment of the pen injector shown in FIG. 7 with illustrations (a) - (1) of the individual parts;
  • FIG. 9 shows a section through a schematized pen injector with a schematically indicated one-way clutch, which operates according to the so-called. Turn-spin principle, in four successive operating phases (a) - (d);
  • FIG. 10 shows a section through a schematic pen-type injector, such as in FIG. 9, here with a concrete solution for the one-way clutch and with one
  • Planetary gear in four consecutive phases of operation (a) - (d) as well as several sections and views; 11 shows a twin-pen injector in section with a finished carpule, which is designed and prefabricated according to the invention;
  • FIG. 12 shows a section through a schematized pen injector, as in FIG. 4 (but without planetary gear mechanism), which is additionally provided with a hydraulic injector
  • Reduction gear is provided, in three consecutive phases of operation (a) - (c) and with two cuts.
  • the pen injector shown in Figure 1 which operates on the spin-push principle, has a housing 1, in which there is a container 2 for the injection liquid 3, which is for example insulin.
  • a displaceable piston 6 through which extends a (first) rod 5, which extends into the portion of the container 2 containing the injection liquid 3.
  • the first rod 5 is provided with a (first) external thread 5a.
  • the piston 6 is provided with a central threaded hole, the internal thread of which corresponds to the external thread 5a of the first rod 5.
  • At the end of the rod 5 sits a rotationally and / or axially displaceable actuating element 9.
  • the piston 6 consists of a fixed core 6a with the threaded hole and an elastic coating 6b.
  • the preferably made of hard plastic core 6a ensured with the appropriate precision of the threaded hole and the external thread 5a of the rod 5, the necessary
  • Figure l (a) shows the pen-injector in the home position.
  • Figure l (b) shows that the actuator 4 is rotated in the reverse direction, such that the rod 4 turns out of the container.
  • Backward direction is to be understood here in general as the direction of rotation, in which the rod 4 is turned out of the container, so that the next injection stroke is metered in.
  • the backwards moving rod retracts Volume 11 free, which leads to the intake of air that settles under the piston 6 as unwanted air cushion 12.
  • FIG. 1 (c) shows the injection phase.
  • manual pressure is exerted on the actuating element 4 with the thumb or a finger, with the result that the rod 5 is displaced into the container 2 while the piston 6 is entrained.
  • the piston 6 presses injection means through an outlet opening of the container 2 and an injection needle 10 to the outside.
  • FIG. 1 (d) corresponds again to FIG. 1 (b) with regard to its operating phase (metering). It can be seen, however, that the air cushion 12a has doubled in the figure l (d), and this continues.
  • the pen-injector of Figure 2 differs from that of Figure 1 by an additional compensation element 8, which is connected to the housing 1. Further, the rod 5 is provided in addition to the - provided in a lower portion - first thread 5a in an upper portion with a second thread 5b.
  • the compensation element 8 has a threaded hole 7 with an internal thread, which corresponds to the second thread 5b of the rod 5.
  • the second thread 5b has a smaller pitch than the first thread 5a.
  • the compensation element 8 is designed so that its internal thread under certain conditions allows a piercing of the rod 5 in the direction of the container 2, so that the piston 6 pushed further into the container 2 into it can be, with the result that, as desired injection liquid 3 exits the injection needle 10.
  • the latter is shown in FIG. 2 (c).
  • FIG. 2 (d) corresponds again to FIG. 2 (b) with regard to its operating phase (metering).
  • FIG. 3 shows a first concrete realization of the compensation element 8 of FIG. 2, which is designated here by the reference numeral 18.
  • the housing 1 consists of a lower part Ia and an upper part Ib. Between the cover plate Ic of the upper part Ib and another plate 18a, which are interconnected by connecting bolts 18c, a keyhole plate 18b is embedded.
  • the threaded hole 17 which corresponds to a provided on the rod 5 second thread 15b. This corresponds to the second thread 5b in Figure 2.
  • the threaded hole 17 has - seen in the circumferential direction - four recessed portions 18d and between these four projecting portions 18e. Only the four projecting portions 18e carry the second internal thread.
  • FIG 4 shows a second concrete realization of the compensation element 8 of Figure 2 in the form of an expandable threaded portion 28.
  • the pen injector shown here is provided with a planetary gear 24 and a resilient pressure device 26, which will be explained in more detail.
  • the expandable threaded portion 28 consists of a block of elastic plastic, such as Teflon or nylon, which has the shape of a truncated cone. From the truncated cone point forth four axial cuts 28a have been introduced into the block in the present example, whereby four elastically deflectable segments 28b are formed, each with its free end a - seen in the circumferential direction - forming part of a threaded hole 27, with a second Thread 25b of the rod 5 corresponds.
  • the second thread 25b corresponds to the second thread 5b in Figure 2.
  • the degree of deflectability of the segments 28b may be influenced by notches 28c at the root of the segments. It can be seen that by the oblique arrangement of the segments 28b with respect to the longitudinal axis of the rod 5, a push-through of the rod 5 through the threaded hole 27 from top to bottom (towards the container 2) is possible if the rod 5 is a corresponding axial pressure is applied. In contrast, the threaded portion 28 does not allow a pushing of the rod 5 in the opposite direction, ie from bottom to top (away from the container 2). This function will be explained later in more detail in connection with FIG. 6f.
  • the above-mentioned planetary gear 24 is provided to reduce the number of rotations necessary for dosing, for example by a factor of 4. It is not possible to increase the slopes of the first 5a and the second thread 25b of the rod 5 arbitrarily (even with it is in principle a reduction of the revolutions of the actuating element 4 in Figure 2 possible), since then the piston 6 would rotate in the container 2 in a no longer negligible extent with the rod 5.
  • the planetary gear 24 is arranged between the cover plate Ic of the upper housing part Ib and the bottom plate 25d of a receiving pot 25b for the printing device 25. It consists of a planetary ring 24a with internal teeth, three intermediate wheels 24d, the axle pin 24c connect the bottom plate 25d and the cover plate Ic together and keep at a distance. In the center of the planetary gear is a central gear pin 24c with external teeth, which is connected to the rod 5 or a part thereof. All elements 24a, 24b and 24c mesh with each other with their teeth. If the planetary ring is turned by hand once around itself, the central gear pin 24c is rotated several times, for example four times, according to the dimensions of the elements of the planetary gear 24.
  • the gear pin 24c is axially displaceable because of its teeth extending in the axial direction when a corresponding pressure is exerted on it.
  • the pressure is in the present case is not exerted directly on the gear pin 24c, but on the printing device 26.
  • This consists of the above-mentioned pot 26b and also a cup-shaped running lid portion 26a, which can dip with its opening down into the pot 25b.
  • a compression spring 26c which is designed both as a helix and as a spiral. It tapers from top to bottom and lies with its lower end on the bottom plate 26d of the receiving pot 26b.
  • the special shape of the compression spring 26c ensures the least possible friction when the rod 5 rotates with respect to the pressure device 26 connected to the housing 1.
  • the pressure device 26 allows that a pressure force exerted by hand on the lid part 26 a is not immediately fully transmitted to the piston 6 but is stretched in its effect in time. This takes into account the fact that the tissue into which the injection agent is to be injected can not immediately absorb the entire quantity of the injection medium to be administered with an injection stroke, but that this is possible only over a certain period of time.
  • the compression spring 26c acts as energy storage, which can deliver the energy once supplied to him over a corresponding period of time.
  • FIGS. 4 (d) -4 (f) are self-explanatory, so that additional explanations are omitted.
  • the pen injector shown in Figure 5 operates on the displacement principle I.
  • a first rod 35 is hollow here and provided with a first external thread 35a, which corresponds to a corresponding internal thread of a located in the piston 6 threaded hole.
  • a second rod 36 extends inside the first hollow rod 35.
  • the second rod 36 is slidably disposed in the first hollow rod 35 in the axial direction.
  • a rotary member 34 which is only rotatable, but not axially displaceable. This is indicated by the four black triangles.
  • the rotary element 34 contains a compensation element 38, which corresponds to the compensation element 8 in FIG.
  • the second rod 36 has at its upper end portion a second thread 36b, which is provided with a corresponding internal thread 37 of the
  • Compensation element 38 corresponds.
  • the second rod 36 is secured against rotation. More details will be in connection with the concrete Embodiment described in accordance with Figure 6. At the end of the second rod 36 is a pressure element 36a.
  • Figure 5 (a) shows the pen-injector in home position.
  • Figure 5 (b) shows the dosing phase.
  • the rotary member 34 is rotated in the reverse direction, with the result that the second rod 36 emerges from the first hollow rod 35 upwards.
  • the pitch of the second thread 37 of the second rod 36 is greater than the pitch of the thread 35a of the first hollow rod 35.
  • the ratio of the pitches of the two said threads is selected so that when the second rod 36 emerges from the first hollow rod 35 released volume 31 is occupied by a forward movement of the piston 6 immediately at the same time.
  • the corresponding volume occupied by the piston 6 is designated 33.
  • Figure 5 (c) shows the subsequent injection phase.
  • pressure is exerted on the pressure element 36a of the second rod 36, with the result that the internal thread 37 of the compensating element 38 opens and the second rod 36 is displaced in the first hollow rod 35 in the direction of the container interior.
  • the predosed volume 33 is displaced by the second rod 36, but not compensated by a movement of the piston 6.
  • injection agent exits through the outlet opening 10 of the container, resulting in injection.
  • Figure 5 (d) again shows the dosing phase corresponding to that in Figure 5 (b).
  • Figure 5 (e) again shows the injection phase corresponding to Figure 5 (c).
  • FIG. 6 shows a practical realization of the scheme shown diagrammatically in FIG.
  • FIG. 5 shows the pen injector in side view.
  • the housing 1 here consists of a lower part l (a) and an upper part l (b).
  • the upper part l (b) is designed so that it identifies openings on both sides, through which the Drehkelement 34 is accessible.
  • Figure 6 (b) shows the pen-injector rotated 90 degrees. It can be seen how the rotary member 34 is accessible from the outside.
  • Figure 6 (c) shows a section B-B through the pen injector shown in Figure 6 (b).
  • the lower portion of the second rod 36 is threadless and has two O-rings 36d in annular grooves for sealing.
  • the upper portion of the second rod 36 is provided adjacent the second thread 36b with a longitudinal groove 36c.
  • a lug 19 which is provided on the upper part 1b of the housing 1, engages in the longitudinal groove 36c, namely on a housing bridge located there id.
  • the rotating element 9 is hollow on the inside and contains the compensating element 38. This agrees with the compensating element 28 shown in FIGS. 4 (d) and 4 (e) and already described. In addition, it should be added at this point that oblique angle of the segments 38b (denoted by the reference numerals 28b in FIGS. 4 (a) and 4 (b)) with respect to the axis of the rod 5 is selected so that the segments 38b coincide with the upper surfaces of the threads of the second thread 36b of the second rod 36 form a right angle.
  • FIG. 6 (f) two forces K1 and K2 are shown, which can act on the second rod 5.
  • the force Kl is directed downward while the force K2 is directed upward.
  • the upward force Kl can be decomposed into two components.
  • the one component acts in the direction of the arms and therefore can not exert any torque on segments 38b.
  • the second component applies a torque Mz to the segments 38b. This torque Mz attempts to rotate the segments 38b inward and keep the internal thread of the compensating element 38 closed.
  • the one force component of the downward force Kl exerts on the segments 38b a torque Ma, which leads to an opening of the internal thread of the compensating element 38.
  • the other component of the downward force Kl acts in the direction of the segments 38b and therefore does not exert any torque on the arms.
  • the downwardly acting force K l has a component capable of opening the internal thread 38 a of the compensating element 38, while the upward force K 2 has a component which ensures that the internal thread 38 b of the Compensation element 38 remains closed.
  • Fig. 6 (d) shows a view C from above of the pressing member 36a of the second rod 36 in Fig. 6 (a).
  • Figures 6 (f) - 6 (g) show a section through the piston 6, the first rod 36 and the second rod 35 in exploded view.
  • Figure 7 shows another variant of the displacement principle II, which differs from the displacement principle I ( Figures 5 and 6) in that no second thread and therefore no compensation element is required, and that the second rod 46 is no longer against Rotary movements and the first hollow rod 45 no longer need to be fixed against axial displacements.
  • the first rod 45 is again formed hollow and firmly connected to a provided at its upper end actuator 44. It is connected to an external thread 45a, which corresponds to a corresponding internal thread of a threaded hole in the piston 6.
  • a closure body 45b At the lower end of the first hollow rod 45 is a closure body 45b, which closes the outlet opening 2a of the container 2 when the first hollow rod 45 is driven axially downwards.
  • first hollow rod 45 in its lower end portion through openings for the injection means, so that it can flow into the interior of the first hollow rod 45 and also can flow out again.
  • a second rod 46 is also arranged here again, namely freely displaceable.
  • Fig. 7 (a) the actuator 44 and the first hollow rod 45 connected thereto are in a lower stop position, in which the shutter body 45b closes the outlet port 2a of the container 2. In this position, the first hollow rod 45 and the actuator 44 are initially fixed against axial displacement upwards.
  • FIG. 7 (b) shows, as a next step, the metering of the next injection stroke by reverse rotation of the actuating element 44.
  • the piston 6 is displaced downwards and displaces injection means with the volume 43. Since the exit opening 2a of the container 2 is closed, the displaced injection means 3 flows through the passage openings 45c in the interior of the first hollow rod 45 and pushes the second rod 46 upwards. In this case, the second rod 46, the space volume 41 free, which is equal to the displaced by the piston 6 injection agent volume 43.
  • the length at which the second rod 46 exits the top of the actuator 44 is a measure of the dosage of the next injection stroke.
  • Figure 7 (c) shows the injection as the next step.
  • the second hollow rod 45 with the closure body 45b and the actuator 44 is moved a little bit axially upwards. Then this will be in the interior of the first hollow rod 45 injection means 3 are pressed out by pressing on the pressure element 46, and it flows - since the piston 6 is fixed against axial displacements - through the outlet opening 2a and the injection needle 10 to the outside.
  • FIG. 7 (d) again corresponds to the metering step according to FIG. 7 (b).
  • Figure 8 shows the displacement principle II in a practically realized embodiment.
  • the same reference numerals are used here as in FIG. 7.
  • Figure 8 (a) shows the upper part of the pen-injector with the lower part Ia and the
  • the upper part Ib of the housing 1 contains on the opposite sides each have a window Ie, through which the actuating element 49 is accessible.
  • the second rod 46 with the pressure element 46a located thereon emerges. It is essential here that the upper part Ib of the housing 1 with respect to the lower part Ia to a
  • Angle according to the indicated arrow can be rotated in the reverse direction, with the result that the upper part Ib relative to the lower part Ia raises. This is also indicated by an arrow.
  • the angle by which the two housing parts Ia and 2b can be rotated against each other, is determined by a provided in the wall, the housing base Ib scenery Ig, in which a provided on the wall of the housing upper part Ib inwardly directed pin If engages. This is shown in FIG. 1 (g).
  • the pitch of the thread 45a is made larger than that of the gate Ig, it is even possible that the piston 6 during a rotational movement of the housing upper part Ib relative to the lower housing part Ia a small piece is pushed into the container 2 and thus one -wenn even if practically negligible - compensates for the formation of vacuum by lifting the closure body.
  • FIG. 8 (k) shows the special design of the closure body 45b. This is connected to the reduction of Drehreibung via a ball joint 45e with the first hollow rod 45.
  • Figure 8 (i) shows the second rod 46 with the pressure element 46a. It has a circular cross-section.
  • the housing upper part can be composed of two parts.
  • a vertical parting line Ij is provided.
  • the pressure element 46a can be separable from the second rod 46 or can be subsequently connected thereto.
  • FIG. 9 shows a schematized pen injector in five successive operating phases, which operates according to the rotation-rotation principle.
  • the individual elements are the same as in FIG. 1, so that the same reference numerals have been used there as well and reference is made to the description there.
  • rotation-push principle is here that the rod 5 is fixed against axial displacements.
  • a freewheel gear between the rod and the actuating element 54, which rotatably couples the actuating element 54 only in one direction of rotation with each other and decoupled in the other direction.
  • the direction of rotation in which a coupling is to take place is that in which the piston 6 is driven into the container 2. This direction of rotation is called the forward direction. In the reverse direction accordingly takes place a decoupling, which has the consequence that the piston 6 is not moved, but remains in its position.
  • Figure 9 (a) shows a home position or standby position.
  • Figure 9 (b) shows, as a first step, the injection by pre-turning the actuator 54, with the result that injection means is ejected.
  • FIG. 9 (c) shows, as a next step, the metering of the next injection stroke by turning back a certain angle of rotation.
  • FIG. 9 (d) again shows, as a next step, the injection by pre-turning the actuating element 54 by the same rotational angle with which the injection stroke was dosed in the previous dosing phase.
  • the essential difference to the rotational-push principle according to FIG. 1 is therefore that the user of the pen injector no longer needs to press the turning / rotating principle to execute the injection, but must turn it.
  • This may be advantageous from the point of view that a more powerful injection is possible with a rotary motion than with a pushing movement in which there is a risk that the injection needle will penetrate deeper into the tissue during the injection as a result of the pressure exerted on the actuating element.
  • two hands are required for the rotation-rotation principle, while u for the rotational-push principle.
  • This may be a matter of individual choice.
  • FIG. 10 shows a more concrete embodiment of the pen injector shown schematically in FIG. 9 and operating according to the rotation / rotation principle. Therefore, the same reference numerals have been used here as in FIG. 9.
  • Actuator can be reduced to only one. This is possible with appropriate dimensioning of the pitch of the thread 5a of the rod 5 and the piston 6.
  • the planetary gear 54 is disposed between the cover plate Ic of the housing upper part Ib and another plate Ih which is connected to the cover plate Ic by the axle bolts 54e of the three intermediate gears 54d.
  • the three intermediate gears 54d mesh on the one hand with the internal toothing of the planetary ring 54a and on the other hand with a central wheel 50a.
  • the planetary ring 54a assumes the function of the actuating element 54 from FIG. 9.
  • the central gear 50 a is integrally formed with a bell-shaped part 50 b, which belongs to the one-way clutch 50.
  • the bell-shaped part forms inside a kind of wheel ring from which spoke-like spring elements 50b extend against the upper end portion of the rod 5, which forms a type of wheel hub.
  • the upper end portion of the rod 5 is provided for this purpose with latching recesses and / or projections 5b.
  • the spoke-like spring elements 50b extend at an acute angle radial direction, with the result that they slide in the reverse direction of rotation of the bell-shaped part 50b over the latching recesses 5c and in
  • a brake 53 is still installed, which works like the overrunning clutch 50, only in the reverse manner. It consists of a wheel ring 53a fastened to the lower housing part 1b, from which also spoke-like spring elements 53b extend inwards against the latching recesses and / or projections on the upper end portion of the rod 5, also at an acute angle to the radial direction, however so that they prevent in the reverse direction of rotation of the bell-shaped part 50b rotational drive of the rod 5 in any case. In a forward rotational direction of the bell-shaped part 50b, the brake 53 does not hinder the rotary driving of the rod 5, since the spoke-like spring elements 53b then slide over the latching recesses and / or projections.
  • FIGS. 9 (e) -9 (h) are self-explanatory, so that further explanations are omitted.
  • FIG. 11 shows the construction of a so-called twin pen.
  • the housing 1 is here provided with two receiving openings If for each injection medium container 3.
  • the grout container may be a finished carpule as shown in Fig. 11 (b).
  • the twin pen contains permanently installed container 2 and thus is designed as a disposable device. Since the pen injector according to the invention is characterized by a small number of components, it is particularly suitable for the disposable version.
  • the twin pen in FIG. 11 (a) differs from the single device according to FIG. 10 in that it has an anastomosis part 60.
  • This is attached to the lower part of the container 1. It has two recesses 60a, 60b which serve to receive the end regions of the containers 2 provided with the outlets 2b.
  • the anastomosis part is provided with two needles which project into the outlet openings 2b of the containers 2 and puncture the septum 2c provided there.
  • the needles are connected via merging channels 60c, 60d to a central channel 6Of.
  • the latter is located in a threaded projection 6Oe on Anastomoseteil 60.
  • On the threaded extension 6Oe a needle cap 60g is screwed, in which a sealing ring 60a is located.
  • the needle cap 60g has an injection needle 10, which protrudes with its upper end portion in the central channel 6Of to the point where the two merge skanäle 60c, 6Od open into the central channel 6Of. In this way, it is ensured that the dead volume remaining after an injection from a container in the anastomosis part is negligibly small.
  • twin-pen On the lower housing part Ia of the twin-pen two housing tops Ib are placed, which are formed in the same manner, as shown in the figure 10 and described above. This means that all the essential elements that can be used for a single pen can also be applied to a twin pen.
  • FIG. 11 (d) shows the double pen according to FIG. 11 (a) from above.
  • twin-Pen two different injectables can be injected simultaneously or consecutively injected through the same cannula. The user therefore only needs to sting once.
  • a twin-pen for diabetics if these two insulins, for example, a fast and a Delayed acting insulin, want to inject in each new to be selected mixture with a injection act.
  • FIG. 11 (c) shows how the pen injector or the twin pen according to the invention can be provided with an energy storage and drive mechanism 67.
  • This consists of a wound on a winding body 67e in a stretched form helical spring 67c. This engages with its one end to the housing belonging to the cover plate Id and with the other end to the planetary ring 54a.
  • the planetary ring 54a By rotating the planetary ring 54a in the direction of rotation causing the metering, ie clockwise, the helical spring is further tensioned.
  • a triggering element 67f By actuating a triggering element 67f, the injection can then be carried out, wherein the helical spring shortens to its original length and advances the piston.
  • a rubber band can be used.
  • FIG. 11 (c) Also shown in Figure 11 (c) is how a dosage indicator can be designed.
  • four colored sectors 67b are marked on the planetary ring 54a, each of which represents the range of 10 units, that is, 0, 10, 11, 20, 21, 30, and 31. ... 40th
  • the portion of the housing top Ib which is located below the planetary ring 54a contains a window through which numbers of 1 to 10 are visible, which are on the outside of the bell-shaped part 50b
  • Freewheel coupling 50 (see Figure 10 (g)) - distributed over the circumference - are mounted and appear in turn when turning this part. With a quarter turn, ie a rotation angle of 90 degrees (corresponding to a colored segment 67b) of the planetary ring 54a, the bell-shaped part 50b is rotated once by 360 degrees. In this way, the 40 units can be set individually.
  • FIG. 12 shows an embodiment corresponding in principle to the embodiment shown in FIG. 1, which represents the rotational pressure principle.
  • a hydraulic reduction gear 70 is provided in order to convert the relatively short displacement of the piston and the relatively high pressure force, which is necessary for the displacement of the piston, in the manner described.
  • this embodiment will be described in more detail.
  • the pen injector according to FIG. 12 has a housing 1 which consists of a plurality of housing sections, namely the lower housing section 1a, the middle housing section 1b, the connecting housing section 11c and the housing housing section 1b.
  • Section Ik which serves to receive the hydraulic reduction gear 70.
  • a container 2 which contains the injection means 3.
  • a first rod 5 which carries on its outer side a first thread 5a, which corresponds to a corresponding internal thread of a provided in the piston 6 threaded hole.
  • an outlet opening 2b At the lower end of the container 2 is an outlet opening 2b, which opens into an injection needle 10.
  • the rod 5 is connected at its upper end by a plug-in coupling with a plug-in pin 4 b, which sits on an actuating element 4.
  • Actuator 4 is both rotatable and axially displaceable.
  • the spigot 4b carries a second thread 5b which corresponds to the internal thread of a compensating element 28 which has already been described in connection with FIGS. 4 (d) and 4 (e).
  • the hydraulic reduction gear 70 is housed in a block 7Oi which includes a first hydraulic chamber 70a and a second hydraulic chamber 70b.
  • the first chamber 70a has a small cross-section than the second chamber 70b.
  • an adjusting piston 70c is displaceably mounted in the first chamber 70b.
  • the second chamber 70b has a cross section that matches the cross section of the container 2.
  • the two chambers 70a and 70b are interconnected by a channel 7Od.
  • In the two chambers 70a and 70b is hydraulic fluid 7Oe.
  • a working piston 7Of is slidably disposed, which is provided with a tip having a transmission element 70g. The tip has the purpose of keeping the friction between the working piston 7Of and the actuator 4 as low as possible.
  • the adjusting piston 70c is surrounded by a cylindrical jacket 70g at a distance, which is guided in an annular channel 70h of the block 7Oi and projects deeper into the block than the adjusting piston 70c. In this way, the adjusting piston 70c even then has sufficient guidance when it is in its upper end position.
  • first chamber 70a is also a coil spring 7Oj, which is acted upon depression of the adjusting piston 70c with pressure and always has the tendency to urge the adjusting piston 70c in its upper end position.
  • Figure 12 (a) shows the injector pen in the home position.
  • Figure 12 (c) shows that for metering the actuator 4 is rotated backwards so that it moves upwards. If the dosage should be less than the maximum, remains between the top of the transmission element 70g and the actuator 4, a distance which is equalized but at the next stroke by pressing on the adjusting element 31. In this way, a problem-free correction of a previously made incorrect dosage is possible.
  • FIGS. 12 (d) and 12 (e) are self-explanatory, so that further explanations are omitted.

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Abstract

Stylo-injecteur pour liquide à injecter (3), notamment de l'insuline, comportant un contenant (2) pour le liquide à injecter (3) et un piston (6) mobile dans ce contenant, ainsi qu'un élément de compression (5) s'étendant dans la partie du contenant (2) où se trouve le liquide à injecter (3), le volume de compression étant variable. Le stylo-injecteur comprend en outre des moyens de compensation (8) qui commandent le déplacement du piston (6) au moins dans des phases de fonctionnement sélectionnées de manière à ce que, lorsque l'élément de compression (5) libère un certain espace (11) ou comprime un certain volume de liquide à injecter (3), le piston (6) comprime simultanément le même volume de liquide à injecter (3) ou libère simultanément le même espace et inversement. L'élément de compression (5) peut être une tige filetée traversant un trou taraudé associé dans le piston (6), son volume de compression dans la partie du contenant (2) où se trouve le liquide à injecter (3) variant par rotation et/ou poussée axiale. Ce dispositif doit permettre d'éviter que l'air ne pénètre dans le contenant (2) lors de la libération d'un espace (11) par l'élément de compression (5).
PCT/EP2008/053467 2007-03-29 2008-03-25 Stylo-injecteur pour liquide à injecter WO2008119691A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP07105279.9 2007-03-29
EP07105279 2007-03-29
EP07108190A EP1974759A1 (fr) 2007-03-29 2007-05-14 Injection appareil, specialement insulin-pen
EP07108190.5 2007-05-14
EP07118207A EP1974760A1 (fr) 2007-03-29 2007-10-10 Pen-Injecteur par un injection liquide, particulier insulin
EP07118207.5 2007-10-10
EP08101190.0 2008-01-31
EP08101190 2008-01-31

Publications (2)

Publication Number Publication Date
WO2008119691A2 true WO2008119691A2 (fr) 2008-10-09
WO2008119691A3 WO2008119691A3 (fr) 2009-01-15

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PCT/EP2008/053467 WO2008119691A2 (fr) 2007-03-29 2008-03-25 Stylo-injecteur pour liquide à injecter

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Cited By (5)

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DE102007058659A1 (de) * 2007-12-06 2009-09-24 Tecpharma Licensing Ag Dosisanzeige für eine Vorrichtung zur dosierten Verabreichung eines fluiden Produkts
WO2010139668A1 (fr) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Administration d'au moins de deux medicaments par une interface de selection et de distribution a dose unique
WO2011045385A1 (fr) * 2009-10-16 2011-04-21 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicaments
WO2013026850A1 (fr) 2011-08-22 2013-02-28 Ruhland, Bernd Stylo-injecteur avec piston magnétique sans tige
JP2018537209A (ja) * 2015-12-14 2018-12-20 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 医薬送達装置

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US3082914A (en) * 1958-11-06 1963-03-26 Gill Wilbur Dispensing device
WO1994015660A1 (fr) * 1993-01-05 1994-07-21 Berney Jean Claude Dispositif de perfusion a piston motorise
EP0980687A1 (fr) * 1998-08-20 2000-02-23 Sooil Development Co., Ltd. Pousse seringue portatif
DE102004055870A1 (de) * 2004-11-19 2006-05-24 Robert Bosch Gmbh Spritze mit Entlüftungsvorrichtung

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Publication number Priority date Publication date Assignee Title
US3082914A (en) * 1958-11-06 1963-03-26 Gill Wilbur Dispensing device
WO1994015660A1 (fr) * 1993-01-05 1994-07-21 Berney Jean Claude Dispositif de perfusion a piston motorise
EP0980687A1 (fr) * 1998-08-20 2000-02-23 Sooil Development Co., Ltd. Pousse seringue portatif
DE102004055870A1 (de) * 2004-11-19 2006-05-24 Robert Bosch Gmbh Spritze mit Entlüftungsvorrichtung

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DE102007058659B4 (de) * 2007-12-06 2009-12-10 Tecpharma Licensing Ag Dosisanzeige für eine Vorrichtung zur dosierten Verabreichung eines fluiden Produkts
DE102007058659A1 (de) * 2007-12-06 2009-09-24 Tecpharma Licensing Ag Dosisanzeige für eine Vorrichtung zur dosierten Verabreichung eines fluiden Produkts
WO2010139668A1 (fr) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Administration d'au moins de deux medicaments par une interface de selection et de distribution a dose unique
CN102458513A (zh) * 2009-06-02 2012-05-16 赛诺菲-安万特德国有限公司 两种或更多种药物通过单一剂量选择和单一分配接口的输送
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US9108003B2 (en) 2009-10-16 2015-08-18 Sanofi-Aventis Deutschland Gmbh Drug delivery device
WO2011045385A1 (fr) * 2009-10-16 2011-04-21 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicaments
WO2013026850A1 (fr) 2011-08-22 2013-02-28 Ruhland, Bernd Stylo-injecteur avec piston magnétique sans tige
JP2018537209A (ja) * 2015-12-14 2018-12-20 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 医薬送達装置
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US10918794B2 (en) 2015-12-14 2021-02-16 Hoffmann-La Roche Inc. Medical delivery device
US10918795B2 (en) 2015-12-14 2021-02-16 Hoffmann-La Roche Inc Medical delivery device
US10918793B2 (en) 2015-12-14 2021-02-16 Hoffmann-La Roche Inc. Medical delivery device

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