WO2010104301A2

WO2010104301A2 - Cosmetic composition for skin moisturizing

Info

Publication number: WO2010104301A2
Application number: PCT/KR2010/001432
Authority: WO
Inventors: Sun Kyung Choi; Chan Woo Lee; Chan Ki Lee; Young Jin Choi; Han Sung Kim; Jin Wong Kim
Original assignee: Amorepacific Corporation
Priority date: 2009-03-09
Filing date: 2010-03-08
Publication date: 2010-09-16
Also published as: WO2010104301A3; CN102316848A; KR20100101328A; TWI444200B; TW201036641A; CN102316848B; KR101096393B1

Abstract

Disclosed is a cosmetic composition for skin moisturizing comprising chia seed gel as an effective ingredient. The cosmetic composition for skin moisturizing exhibits superior moisturizing effect with little stickiness, and is widely applicable in the fields of beauty care and cosmetics.

Description

COSMETIC COMPOSITION FOR SKIN MOISTURIZING

This disclosure relates to a cosmetic composition for skin moisturizing.

As human skin ages, it becomes dry gradually. Recently, various skin dryness conditions, skin-itching atopy, or the like occur even in young ages. Skin dryness and damage may also be caused by temperature, humidity, UV or various pollutants.

To solve the problem, various cosmetic products are released in the market. However, the products providing superior moisturizing effect tend to be sticky, which may cause discomfort or unpleasantness. Therefore, there is a need for a product capable of providing neat feeling with little stickiness while providing superior moisturizing effect.

This disclosure directs to providing a cosmetic composition for skin moisturizing.

In an aspect, there is provided a cosmetic composition containing chia seed gel as an effective ingredient.

The disclosed cosmetic composition exhibits superior moisturizing effect and little stickiness, and thus is widely applicable in the fields of beauty care and cosmetics.

The above and other aspects, features and advantages of the disclosed exemplary embodiments will be more apparent from the following detailed description taken in conjunction with the accompanying drawings in which:

Fig. 1 is a graph comparing moisturizing effect of chia seed gel and hyaluronic acid; and

Fig. 2 shows moisturizing effect measurement results for various samples.

Exemplary embodiments now will be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments are shown. This disclosure may, however, be embodied in many different forms and should not be construed as limited to the exemplary embodiments set forth therein. Rather, these exemplary embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of this disclosure to those skilled in the art. In the description, details of well-known features and techniques may be omitted to avoid unnecessarily obscuring the presented embodiments.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of this disclosure. As used herein, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise. Furthermore, the use of the terms a, an, etc. does not denote a limitation of quantity, but rather denotes the presence of at least one of the referenced item. The use of the terms “first”, “second”, and the like does not imply any particular order, but they are included to identify individual elements. Moreover, the use of the terms first, second, etc. does not denote any order or importance, but rather the terms first, second, etc. are used to distinguish one element from another. It will be further understood that the terms “comprises” and/or “comprising”, or “includes” and/or “including” when used in this specification, specify the presence of stated features, regions, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, regions, integers, steps, operations, elements, components, and/or groups thereof.

Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and the present disclosure, and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

A cosmetic composition according to an embodiment is a cosmetic composition for skin moisturizing comprising chia seed gel as an effective ingredient. In an embodiment, the cosmetic composition for skin moisturizing may further comprise agave syrup as an effective ingredient. In another embodiment, the cosmetic composition for skin moisturizing may further comprise one or more selected from poly-γ-glutamic acid, glucan and hyaluronic acid as an effective ingredient. The cosmetic composition for skin moisturizing provides superior moisturizing effect and little stickiness.

In an embodiment, the chia seed gel may be comprised in an amount of 0.001 to 20 wt%, specifically 0.5 to 3.0 wt%, more specifically 1.0 to 1.5 wt%, based on the total weight of the composition. The aforesaid chia seed gel content range is one capable of minimizing stickiness while providing superior moisturizing effect.

In another embodiment, the agave syrup may be comprised in an amount of 0.001 to 20 wt%, specifically 1 to 10 wt%, more specifically 5 wt%, based on the total weight of the composition. The addition of the agave syrup to the chia seed gel may reduce stickiness and provide neat feeling.

In addition to the chia seed gel and the agave syrup, the composition may further comprise one or more selected from poly-γ-glutamic acid, glucan and hyaluronic acid. In an embodiment, a combined content of the chia seed gel, the agave syrup, the poly-γ-glutamic acid and the hyaluronic acid may be 0.1 to 30 wt% based on the total weight of the composition, but is not particularly limited thereto.

The chia seed gel is produced by separating water-soluble polymers from Aztec chia seed native to Mexico. Upon contact with water, chia seed absorbs water as much as 12 times its weight and swells. Thus, it makes one feel stuffed and eat less food. The transparent viscous substance around the seed is effective in removing feces contained long in the intestines. Further, it contains about 60% omega-3 fatty acid and is excellent in body weight loss since it promotes metabolism and fat burning. Besides, chia seed oil is also used as a skin emollient and chia seed gel is often used for fever treatment or wound healing. A composition according to an embodiment comprises low-molecular-weight chia seed gel, which has moisturizing effect, as an effective ingredient. The chia seed gel may have an average molecular weight of, for example, 500,000 daltons (Da) or smaller, specifically 1,000 to 500,000 Da, more specifically 150,000 to 250,000 Da.

The agave syrup refers to a syrup obtained from extraction of agave cactus, a kind of agave found in Mexico. Agave cactus is sweeter than sugar by about 30% but its glycemic index is only about 1/3. Thus, it is often used as a natural sweetener replacing sugar. In addition to fructose, it contains minerals such as iron, calcium, potassium and magnesium. It facilitates proliferation of bifidobacteria and aids in treating constipation. Further, it contains inulins which remove bacterial toxins, thereby aiding in detoxification of the stomach and the liver and refreshing bloodstream. In particular, agave syrup exhibits excellent moisturizing effect because it contains 74 to 86% of high-quality fructose. The agave syrup may have an average molecular weight of, for example, 50,000 Da or smaller, specifically 100 to 50,000 Da, more specifically 1,000 to 20,000 Da.

The poly-γ-glutamic acid (γ-PGA) refers to an anionic amino acid polymer in which the γ-carboxyl group of glutamic acid is bound with the α-amino group of glutamic acid by an amide bonding. Poly-γ-glutamic acid is produced by strains of Bacillus, which are isolated from, for example, cheonggukjang, a traditional Korean fermented soybean paste made using the jip, or dried rice plants, natto, a traditional Japanese fermented soybean food, or kinema, a traditional Nepalese fermented soybean food. The poly-γ-glutamic acid produced by the strains of Bacillus is edible, water-soluble, anionic and biodegradable. Also, poly-γ-glutamic acid inhibits the action of collagenase, removes the skin's horny layer, and makes the skin smooth and moisturized.

The glucan is a polysaccharide of D-glucose monomers linked by glycosidic bonds, and is classified into α-glucan and β-glucan depending on the position of glucose bonding. Glucan activates natural killer cells and thus has an anticancer effect. Also, it is reported to effective in reducing total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels in the blood.

β-Glucan is effective in reducing the level of LDL-C. This is because β-glucan binds with bile acid, thereby increasing viscosity in the intestines and decreasing reuptake of the bile acid. Consequently, it increases synthesis and excretion of bile acid in the intestines and, at the same time, increases synthesis of cholesterol in the liver. α-Glucan can be obtained from plant starches and β-glucan is available from the cell wall of mushrooms, grains and yeast. α-Glucan and β-glucan play the role of strengthening the skin's immune cells, which lose their functions with aging, and thereby maintains the skin elastic and moisturized.

The hyaluronic acid is a mucopolysaccharide existing in the dermis and is found in body fluids, cow's eyeballs, rooster combs, animal tissues or placenta. Especially, it exists in high concentrations in connective tissue and skin. Because of excellent tissue healing and moisturizing effect, hyaluronic acid is widely used in the fields of medicine and cosmetics. For example, in orthopedic surgery, it is injected to connect bones. In plastic surgery, it is injected to remove wrinkles. Also, hyaluronic acid has a very superior water retaining capacity it is capable of absorbing water about 6,000 times of its weight. A newborn baby has soft and moist skin because of high hyaluronic acid content. As hyaluronic acid in the dermis decreases with aging, the skin becomes dry and develops fine wrinkles. Moisturizers containing hyaluronic acid are frequently used to reduce the skin dryness and fine wrinkles.

Fig. 1 is a graph comparing moisturizing effect of chia seed gel and hyaluronic acid. Skin moisturizing effect was measured after applying nothing, 2.0 mg/cm²of hyaluronic acid or 2.0 mg/cm²of chia seed gel on inside the left forearm. Moisturizing effect was measured using WSK-P500U (Inforward Inc.) in a room maintained at 25℃ and relative humidity 45% for 3.5 seconds. The result reveals that the application of chia seed gel or hyaluronic acid leads to remarkably increased moisturizing effect as compared to the control with nothing applied. The moisturizing effect was maintained until 70 minutes.

A cosmetic composition according to an embodiment comprises low-molecular-weight chia seed gel and agave syrup, which provide superior moisturizing effect, as well as poly-γ-glutamic acid, glucan and hyaluronic acid, and thus has improved moisturizing effect with less stickiness. It may be prepared into various cosmetic formulations, without particular limitations. For example, it may be prepared into cosmetic compositions such as softening lotion, astringent lotion, nourishing lotion, nourishing essence, nourishing cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, gel, powder, makeup base, body lotion, body cream, body oil, body essence, or the like. Further, it may be prepared into transdermal formulations such as lotion, ointment, gel, cream, patch or spray. In an embodiment, the cosmetic composition may be used for moisturizing the skin.

Those skilled in the art may combine different ingredients for each formulation without difficulty, depending on application type or purpose of use.

The examples and experiments will now be described. The following examples and experiments are for illustrative purposes only and not intended to limit the scope of this disclosure.

Test Example: Comparison of feeling after use

1. Preparation of chia seed gel

Chia seed was added to a mixture of 1,3-butylene glycol and purified water and stirred until the fibrous component comes out. Then, the gel portion was separated by centrifugation and filtered to obtain chia seed gel. Thus prepared chia seed gel had an average molecular weight of 150,000 to 250,000 Da.

2. Preparation of agave syrup

Agave was crushed, heated, extracted and then cooled to prepare agave syrup. Thus prepared agave syrup had an average molecular weight of 1,000 to 20,000 Da.

3. Preparation of cosmetic composition

Chia seed gel and agave syrup, which have moisturizing effect and a relatively low molecular weight, were used together with poly-γ-glutamic acid, glucan and hyaluronic acid to accomplish moisturization without stickiness. Moisturizers were prepared with various contents as shown in Table 1.

Each ingredient (chia seed gel, poly-γ-glutamic acid, glucan and hyaluronic acid) was diluted with purified water. Specifically, chia seed gel was diluted to 3 wt%, poly-γ-glutamic acid to 5 wt%, glucan to 0.4 wt%, and hyaluronic acid to 1 wt%.

The average molecular weights of the ingredients are as follows: poly-γ-glutamic acid = 1,500,000 to 2,500,000 Da; hyaluronic acid = 800,000 to 1,500,000 Da; glucan = 700,000 to 1,300,000 Da; chia seed gel = 150,000 to 250,000 Da; and agave syrup = 1,000 to 10,000 Da. The molecular weight was measured using 120C Series HPLC/GPC (Agilent Technologies), using Alltech 3300 ELSD as a detector and using a pL-aquagel OH-30 8 ㎛ column. Gas flow rate was 1.4 L/min and purified water was flown at 0.7 mL/min. Sample injection volume was 20 ㎕.

4. Comparison of feeling after use

After use of the compositions given in Table 1, feeling after use and moisturizing effect were evaluated.

Feeling after use was evaluated by a panel of 30 trainees. Evaluation was made from ‘-’(none at all) to ‘+++’(a great deal). Between the two extremes were ‘+’(slightly) and ‘++’(to some extent). Preference for each composition was evaluated as overall rating.

Table 1

Ingredients	Sample No.
Ingredients	1	2	3	4	5
γ-PGA, 5%	35%	30%	30%	30%	35%
Chia seed gel, 3%	45%	45%	35%	25%	35%
SC-glucan, 0.4%	10%	10%	20%	20%	15%
Hyaluronic acid, 1%	10%	10%	20%	25%	15%
Agave syrup	-	5%	5%	-	-
Test result
pH	6.6	6.9	6.7	6.9	6.6
Stickiness	+	-	++	+++	++
Neatness	++	+++	++	-	+
Overall rating(feeling after use)	27%(n = 8)	60%(n = 18)	-	-	13 %(n = 4)

As seen in Table 1, Samples 1 and 2, which contained 45% of 3% chia seed gel, showed less stickiness than

Samples

3, 4 and 5. Of Samples 1 and 2, Sample 2 containing 5% of agave syrup showed better preference with neat feeling. Sample 3, which contained 5% of agave syrup, 35% of 3% chia seed gel, 20% of 0.4% glucan and 20% of 1% hyaluronic acid, were sticker and less neat than Sample 2. Sample 4, which contained 10% less 3% chia seed gel and 5% less agave syrup than Sample 3, were sticker and less neat than Sample 3. And, Sample 5, which contained the same amount of 3% chia seed gel but 5% less agave syrup than Sample 3, showed similar stickiness but less neatness.

Concluding the test result, the composition of Sample 2, which contained 45% of 3% chia seed gel, 30% of 5% poly-γ-glutamic acid, 10% of 0.4% glucan, 10% of 1% hyaluronic acid and 5% of agave syrup, exhibited the best neatness and less stickiness.

5. Comparison of moisturizing effect

Moisturizing effect was tested for the samples. 2.0 mg/cm²of each sample was applied on inside the left forearm and moisturizing effect was measured. Measurement was made using WSK-P500U (Inforward Inc.) in a room maintained at 25℃ and relative humidity 45% for 3.5 seconds. The result is shown in Fig. 2.

As seen in Fig. 2, Sample 2 again showed the best result.

Various cosmetic formulations were prepared as follows.

Preparation Example 1: Nourishing lotion (milk lotion)

Nourishing lotion containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 2

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	2.0
Squalane	5.0
Beeswax	4.0
Polysorbate 60	1.5
Sorbitan sesquioleate	1.5
Liquid paraffin	0.5
Caprylic/capric triglyceride	5.0
Glycerine	3.0
Butylene glycol	3.0
Propylene glycol	3.0
Carboxyvinyl polymer	0.1
Triethanolamine	0.2
Antiseptic, pigment and perfume	adequate
Purified water	to 100

Preparation Example 2: Softening lotion (skin lotion)

Softening lotion containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 3

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	2.0
Glycerine	3.0
Butylene glycol	2.0
Propylene glycol	2.0
Carboxyvinyl polymer	0.1
PEG 12 nonyl phenyl ether	0.2
Polysorbate 80	0.4
Ethanol	10.0
Triethanolamine	0.1
Antiseptic, pigment and perfume	adequate
Purified water	to 100

Preparation Example 3: Nourishing cream

Nourishing cream containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 4

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	2.0
Polysorbate 60	1.5
Sorbitan sesquioleate	0.5
PEG60 hydrogenated castor oil	2.0
Liquid paraffin	10
Squalane	5.0
Caprylic/capric triglyceride	5.0
Glycerine	5.0
Butylene glycol	3.0
Propylene glycol	3.0
Triethanolamine	0.2
Antiseptic	adequate
Pigment	adequate
Perfume	adequate
Purified water	to 100

Preparation Example 4: Massage cream

Massage cream containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 5

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	1.0
Beeswax	10.0
Polysorbate 60	1.5
PEG 60 hydrogenated castor oil	2.0
Sorbitan sesquioleate	0.8
Liquid paraffin	40.0
Squalane	5.0
Caprylic/capric triglyceride	4.0
Glycerine	5.0
Butylene glycol	3.0
Propylene glycol	3.0
Triethanolamine	0.2
Antiseptic, pigment and perfume	adequate
Purified water	to 100

Preparation Example 5: Pack

Pack containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 6

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	1.0
Polyvinyl alcohol	13.0
Sodium carboxymethylcellulose	0.2
Glycerine	5.0
Allantoin	0.1
Ethanol	6.0
PEG 12 nonyl phenyl ether	0.3
Polysorbate 60	0.3
Antiseptic, pigment and perfume	adequate
Purified water	to 100

Preparation Example 6: Gel

Gel containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 7

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	2.0
Sodium ethylenediamineacetate	0.05
Glycerine	5.0
Carboxyvinyl polymer	0.3
Ethanol	5.0
PEG 60 hydrogenated castor oil	0.5
Triethanolamine	0.3
Antiseptic, pigment and perfume	adequate
Purified water	to 100

Preparation Example 7: Water-in-oil emulsion

Water-in-oil emulsion containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 8

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	3.0
Butylene glycol	10
Salt	1.5
Ozokerite	2.0
Dicaprylyl carbonate	20
Sorbitan isostearate	2.5
Cetyl dimethicone copolyol	2.0
Poly(methyl methacrylate)	3.0
Iron oxide	1.5
Titanium oxide	12.0
Talc (size: 3.06 m)	5.0
Antiseptic, pigment and perfume	adequate
Purified water	to 100

Preparation Example 8: Twin cake powder

Twin cake powder containing chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup was prepared as follows according to a common method.

Table 9

Ingredients	wt%
Chia seed gel, poly-γ-glutamic acid, glucan, hyaluronic acid and agave syrup	1.0
Nylon powder	5.0
Modified starch	3.0
Titanium dioxide	3.0
Mica	25.0
Squalene	0.5
Dimethicone	0.8
Antiseptic, pigment and perfume	adequate
Silicone-treated talc	to 100

While the exemplary embodiments have been shown and described, it will be understood by those skilled in the art that various changes in form and details may be made thereto without departing from the spirit and scope of this disclosure as defined by the appended claims.

In addition, many modifications can be made to adapt a particular situation or material to the teachings of this disclosure without departing from the essential scope thereof. Therefore, it is intended that this disclosure not be limited to the particular exemplary embodiments disclosed as the best mode contemplated for carrying out this disclosure, but that this disclosure will include all embodiments falling within the scope of the appended claims.

Claims

A cosmetic composition for skin moisturizing comprising chia seed gel as an effective ingredient.
The cosmetic composition for skin moisturizing according to claim 1, which further comprises agave syrup as an effective ingredient.
The cosmetic composition for skin moisturizing according to claim 1 or 2, which further comprises one or more selected from poly-γ-glutamic acid, glucan and hyaluronic acid as an effective ingredient.
The cosmetic composition for skin moisturizing according to claim 1 or 2, wherein the chia seed gel has an average molecular weight of 1,000 to 500,000 Da and the agave syrup has an average molecular weight of 100 to 50,000 Da.
The cosmetic composition for skin moisturizing according to claim 4, wherein the chia seed gel has an average molecular weight of 150,000 to 250,000 Da and the agave syrup has an average molecular weight of 1,000 to 20,000 Da.
The cosmetic composition for skin moisturizing according to claim 1 or 2, wherein the chia seed gel is comprised in an amount of 0.001 to 20 wt% based on the total weight of the composition.
The cosmetic composition for skin moisturizing according to claim 6, wherein the chia seed gel is comprised in an amount of 0.5 to 3.0 wt% based on the total weight of the composition.
The cosmetic composition for skin moisturizing according to claim 2, wherein the agave syrup is comprised in an amount of 0.001 to 20 wt% based on the total weight of the composition.
The cosmetic composition for skin moisturizing according to claim 3, wherein the chia seed gel, the agave syrup, the poly-γ-glutamic acid, the glucan and the hyaluronic acid are comprised in a combined amount of 0.1 to 30 wt% based on the total weight of the composition.