TWI444200B - Cosmetic composition for skin moisturizing - Google Patents

Cosmetic composition for skin moisturizing Download PDF

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TWI444200B
TWI444200B TW099106682A TW99106682A TWI444200B TW I444200 B TWI444200 B TW I444200B TW 099106682 A TW099106682 A TW 099106682A TW 99106682 A TW99106682 A TW 99106682A TW I444200 B TWI444200 B TW I444200B
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gel
agave syrup
hyaluronic acid
cosmetic composition
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TW201036641A (en
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Sun Kyung Choi
Chan Woo Lee
Chan Ki Lee
Young Jin Choi
Han Sung Kim
Jin Wong Kim
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Amorepacific Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88Polyamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)

Description

皮膚保濕用化妝品組成物 Cosmetic composition for skin moisturizing

本發明係有關一種皮膚保濕用化妝品組成物。 The present invention relates to a cosmetic composition for skin moisturizing.

隨著人類皮膚老化,逐漸變得乾燥。最近,即使年輕人在各種皮膚乾燥條件下,也會發生皮膚瘙癢過敏,或類似的症候。皮膚乾燥和受損也可能是由於溫度,濕度,紫外線或各種污染物所造成。 As human skin ages, it gradually becomes dry. Recently, even if young people are exposed to various dry conditions, skin itching allergy, or similar symptoms may occur. Dry and damaged skin can also be caused by temperature, humidity, UV rays or various contaminants.

為了解決這個問題,各種化妝產品在市場上推出。然而,提供優質的保濕效果之產品往往是黏黏的,這可能會導致不舒服或不愉快。因此,有必要一種產品能夠提供幾乎沒有黏黏的清爽感覺,同時提供卓越的保濕效果。 In order to solve this problem, various cosmetic products have been introduced on the market. However, products that provide a good moisturizing effect are often sticky, which can cause discomfort or unpleasantness. Therefore, it is necessary for a product to provide a refreshing feeling with almost no stickiness while providing excellent moisturizing effects.

本發明提供一種皮膚保濕用化妝品組成物。 The present invention provides a cosmetic composition for skin moisturizing.

一方面,本發明提供一種皮膚保濕用化妝品組成物,其中含有「稼籽凝膠」(chia seed gel;譯者加註:依據維基百科,“稼”chia係墨西哥那瓦特人語,意味獲得油膩,是一種開花植物,學名Salvia hispanica;其種子(略"籽")被研磨為滋補飲料和作為食物來源)作為有效成分。 In one aspect, the present invention provides a cosmetic composition for skin moisturization, which comprises a "chia seed gel"(translator's note: according to Wikipedia, "garden" chia is a Mexican Navat language, meaning greasy , is a flowering plant, the scientific name Salvia hispanica; its seeds (slightly "seed") are ground to a nourishing drink and as a food source) as an active ingredient.

所揭露的化妝品組成物具有優異的保濕效果,粘感小,因此是廣泛地適用於美容和化妝品領域。 The disclosed cosmetic composition has an excellent moisturizing effect and a small stickiness, and thus is widely used in the fields of beauty and cosmetics.

最佳模式:Best mode:

兹以具體內涵並參照附圖,將作更為周全面的描述,其中包含實例。 A more comprehensive description will be made with specific meanings and with reference to the accompanying drawings, including examples.

但是此揭露,可以有許多不同的形式,故本發明之範圍不應該局限於實例中所述。更確切地講,這些具體實例提供使本發明徹底和完整的說明,並對此領域之熟悉技藝者充分表達本發明的範圍。在本說明書中,熟知的特點和技術 之細節可以省略,以避免不必要地模糊本發明的具體內涵。 However, the disclosure may be in many different forms, and the scope of the invention should not be limited to the examples. Rather, these specific examples are provided to provide a thorough and complete description of the invention, and the scope of the invention is fully described by those skilled in the art. In this specification, well-known features and techniques The details may be omitted to avoid unnecessarily obscuring the specific meaning of the invention.

此處所使用的術語只為特定具體內涵之描述,並非用來限制本發明之範圍。若無特別清楚地註明,則本文提到的單數形式的冠詞,亦可包括其複數形式。此外,使用單數形式的冠詞等不表示一個限制數量,而是指存在至少一個被引用的物項。在使用術語“第一”、“第二”等等,並不意味著任何特定的順序,而是包括單個元件之識別。此外,使用術語“第一”、“第二”等不表示任何順序或重要性,而是第一、第二等是用來區分一個元件不同於另一個。將進一步了解的是在本說明書中使用術語“包括”和/或“包含”或“涵蓋”和/或“含有”時,係意含特徵、區域、整數、步驟、操作、元件及/或組件的存在;但並不排除一個或多個其他特徵、區域、整數、步驟、操作、元件、組件及/或其群組之存在或增加。 The terminology used herein is for the purpose of description and description The singular forms of the articles, as used herein, may also include the plural. In addition, the use of a singular article or the like does not denote a limitation. The use of the terms "first", "second", etc., does not imply any particular order, but includes the identification of a single element. Moreover, the use of the terms "first", "second", etc. does not denote any order or importance, but the first, second, etc. are used to distinguish one element from another. It will be further understood that the term "comprising" and / or "comprising" or "comprising" and / or &quot The existence or addition of one or more other features, regions, integers, steps, operations, components, components and/or groups thereof.

除非另有註明,此處使用的所有術語(包括技術和科學術語)相同於普通熟習技藝者一般理解的含義。將進一步理解的是,例如字典常用定義之術語,應解釋為其含義 是符合相關技藝和本發明之文脈;除非另有定義,否則並不會理想化或超過其正式意涵。 Unless otherwise stated, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art. It will be further understood that, for example, the terminology commonly used in a dictionary should be interpreted as its meaning. It is in accordance with the relevant art and the context of the present invention; unless otherwise defined, it does not idealize or exceed its formal meaning.

依據一具體實例,化妝品組成物係包括稼籽凝膠作為有效成分之皮膚保濕用化妝品組成物。在另一具體實例中,皮膚保濕用化妝品組成物可進一步包括「龍舌蘭糖漿」(agave syrup)作為有效成分。在另一具體實例中,皮膚保濕用化妝品組成物可進一步包括一個或多個選自聚-γ-谷氨酸(poly-γ-glutamic acid)、葡聚糖(glucan)和透明質酸(hyaluronic acid)等化合物作為有效成分。本皮膚保濕用化妝品組成物提供優越的保濕效果,且黏感小。 According to a specific example, the cosmetic composition is a skin moisturizing cosmetic composition comprising a seed gel as an active ingredient. In another embodiment, the skin moisturizing cosmetic composition may further include "agave syrup" as an active ingredient. In another embodiment, the skin moisturizing cosmetic composition may further comprise one or more selected from the group consisting of poly-gamma-glutamic acid, glucan, and hyaluronic acid. A compound such as acid) is used as an active ingredient. The skin moisturizing cosmetic composition provides superior moisturizing effect and a small stickiness.

在一個具體實例中,稼籽凝膠可佔組成物總重量的0.001至20重量%,特別是0.5至3.0重量%,更具體而言是1.0至1.5重量%。上述稼籽凝膠含量範圍是能最大限度地減少黏感,同時提供卓越的保濕效果。 In a specific example, the seed gel may comprise from 0.001 to 20% by weight, particularly from 0.5 to 3.0% by weight, more specifically from 1.0 to 1.5% by weight, based on the total weight of the composition. The range of gel content of the above-mentioned crops is to minimize stickiness while providing excellent moisturizing effect.

在另一具體實例中,龍舌蘭糖漿可佔組成物總重量的0.001至20重量%,特別是1至10重量%,更具體而言 是5重量%。在稼籽凝膠中添加龍舌蘭糖漿可以減少黏感,並提供清爽的感覺。 In another embodiment, the agave syrup may comprise from 0.001 to 20% by weight, in particular from 1 to 10% by weight, based on the total weight of the composition, more specifically It is 5% by weight. Adding agave syrup to the seed gel reduces stickiness and provides a refreshing sensation.

除了稼籽凝膠和龍舌蘭糖漿外,組成物尚可進一步包括一種或多種選自聚-γ-谷氨酸、葡聚糖和透明質酸等化合物。在一個具體實例中,稼籽凝膠、龍舌蘭糖漿、聚-γ-谷氨酸和透明質酸加起來可佔組成物總重量的0.1到30重量%;但並不特別局限於此範圍。 In addition to the crop gel and the agave syrup, the composition may further include one or more compounds selected from the group consisting of poly-γ-glutamic acid, dextran, and hyaluronic acid. In a specific example, the crop gel, agave syrup, poly-γ-glutamic acid, and hyaluronic acid may add up to 0.1 to 30% by weight based on the total weight of the composition; but are not particularly limited to this range. .

稼籽凝膠是由原產於墨西哥“阿茲台克“(Aztec)稼種子分離出水溶性聚合物而得。稼種子與水接觸後,可吸收多達12倍本身重量的水而膨脹。因此,令人感到塞滿及減少進食。種子周圍的透明粘性物質能有效地消除中長期留在腸道糞便。此外,它含有約60% ω-3-脂肪酸,是優秀的瘦身劑;因為它促進新陳代謝和燃燒脂肪。再者,嘉籽油也被用作潤膚霜,而稼籽凝膠通常用於治療發燒或傷口癒合。依據一個具體實例之組成物包含具保濕作用之低分子量稼籽凝膠作為一種有效成分。此稼籽凝膠之平均分子量例如是500,000道爾頓或更小、特別是1000至500,000道爾頓、更具體而言,150,000至250,000道爾頓。 The seed gel is obtained by separating water-soluble polymers from the seeds of the Aztec crops originating in Mexico. After contact with water, the seeds can absorb up to 12 times their own weight and expand. Therefore, it feels full and reduces eating. The transparent viscous material around the seeds can effectively eliminate the feces in the intestines in the medium and long term. In addition, it contains about 60% omega-3-fatty acids and is an excellent slimming agent; it promotes metabolism and burns fat. In addition, Jiayou oil is also used as a moisturizer, and the seed gel is usually used to treat fever or wound healing. The composition according to a specific example contains a moisturizing low molecular weight seed gel as an active ingredient. The average molecular weight of the seed gel is, for example, 500,000 Daltons or less, especially 1000 to 500,000 Daltons, more specifically 150,000 to 250,000 Daltons.

龍舌蘭糖漿是萃取自墨西哥龍舌蘭仙人掌。龍舌蘭仙人掌比蔗糖甜約30%,但其血糖指數只有約1/3。因此,它經常被用來作為代替蔗糖之天然甜味劑。龍舌蘭糖漿除了含有果糖外,還含有礦物質,如鐵、鈣、鉀和鎂。它促進雙歧桿菌增殖和輔助治療便秘。此外,它含有能消除細菌毒素的「菊粉」(inulins),從而幫助胃和肝臟之排毒,及血液之更新。特別是龍舌蘭糖漿具有優良的保濕效果,因為它包含74至86%的高品質果糖。龍舌蘭糖漿之平均分子量例如是50,000道爾頓或以下、特別是100至50,000道爾頓、最好是1,000至20,000道爾頓。 Agave syrup is extracted from the Mexican agave cactus. Agave cactus is about 30% sweeter than sucrose, but its glycemic index is only about 1/3. Therefore, it is often used as a natural sweetener in place of sucrose. In addition to fructose, agave syrup also contains minerals such as iron, calcium, potassium and magnesium. It promotes the proliferation of bifidobacteria and adjuvant treatment of constipation. In addition, it contains "inulins" that eliminate bacterial toxins, helping the stomach and liver to detoxify and renew blood. In particular, agave syrup has an excellent moisturizing effect because it contains 74 to 86% of high quality fructose. The average molecular weight of the agave syrup is, for example, 50,000 Daltons or less, particularly 100 to 50,000 Daltons, preferably 1,000 to 20,000 Daltons.

聚-γ-谷氨酸(γ-PGA)是指陰離子氨基酸聚合物,其中谷氨酸之γ-羧基與谷氨酸之α-氨基酸係以醯胺鍵連結。聚-γ-谷氨酸是由「芽孢桿菌」菌株(strains of Bacillus)製得,而芽孢桿菌係由例如清麴分離出來;清麴乃由吉彼(jip)所製的傳統韓國醱酵豆醬、或乾稻、納豆(傳統日本大豆醱酵食品)或吉納嗎(kinema-傳統的尼泊爾大豆醱酵食品)製成。由芽孢桿菌所製之聚-γ-谷氨酸是可食用、溶於水、陰離子性和可生物降解的。此外,聚-γ-谷氨酸可抑制膠原酶的活動,去除皮膚的角質層,並使得皮膚光滑潤澤。 Poly-γ-glutamic acid (γ-PGA) refers to an anionic amino acid polymer in which the γ-carboxyl group of glutamic acid and the α-amino acid of glutamic acid are linked by a guanamine bond. Poly-γ-glutamic acid is produced from strains of Bacillus , and Bacillus is isolated from, for example, Qingyan; Qingyu is a traditional Korean yeast bean paste made by Jip. Or dry rice, natto (traditional Japanese soybean yeast food) or Gina (kinema - traditional Nepalese soy yeast food). The poly-gamma-glutamic acid produced by Bacillus is edible, water soluble, anionic and biodegradable. In addition, poly-gamma-glutamic acid inhibits the activity of collagenase, removes the stratum corneum of the skin, and makes the skin smooth and moist.

葡聚糖是一種由D-葡萄糖單體藉由糖苷鍵連結所得之多醣;視葡萄糖結合之位置可分為α-葡聚糖和β-葡聚糖。葡聚糖可激活自然殺傷細胞,因而具有抗癌作用。此外,據報導其可有效降低血液中總膽固醇和低密度脂蛋白膽固醇(LDL-C)之濃度。 Glucan is a polysaccharide obtained by linking D-glucose monomers by glycosidic bonds; and depending on the position of glucose binding, it can be classified into α-glucan and β-glucan. Glucan activates natural killer cells and thus has an anti-cancer effect. In addition, it has been reported to be effective in reducing the concentration of total cholesterol and low density lipoprotein cholesterol (LDL-C) in the blood.

β-葡聚糖能有效地減少LDL-C之濃度。這是因為β-葡聚糖與膽汁酸結合,從而增加在腸道中之粘度,並減少膽汁酸之再攝取。因此,它增加膽汁酸在腸道內的合成和分泌,在同時增加膽固醇在肝臟中之合成。α-葡聚糖可從植物澱粉中獲得,而β-葡聚糖可從蘑菇、穀物和酵母之細胞壁取得。α-葡聚糖和β-葡聚糖可發揮強化皮膚免疫細胞(該免疫細胞老化會失去功能)的作用,從而保持皮膚彈性和滋潤。 Β-glucan can effectively reduce the concentration of LDL-C. This is because β-glucan binds to bile acids, thereby increasing the viscosity in the intestine and reducing the reuptake of bile acids. Therefore, it increases the synthesis and secretion of bile acids in the intestine, while at the same time increasing the synthesis of cholesterol in the liver. Alpha-glucans are available from plant starch, while beta-glucans are available from the cell walls of mushrooms, grains and yeast. Α-glucan and β-glucan act to strengthen skin immune cells, which lose their function when aging, thereby maintaining skin elasticity and moisture.

在透明質酸是一種存在於真皮中之粘多醣(mucopolysaccharide),並發現於體液、牛的眼球、公雞雞冠、動物組織或胎盤中。特別是,它高濃度存在於結締組織和皮膚中。由於出色的組織癒合和滋潤的效果,透明質酸是廣泛應用於醫學領域和化妝品。例如,在整形外 科,將它注入連接骨頭中。在整容手術,注射它可消除皺紋。此外,透明質酸具有十分優越持水能力-它能夠吸收本身重量約6,000倍的水。新生嬰兒皮膚柔軟滋潤,因為透明質酸含量高。老化使得透明質酸在真皮中減少,皮膚變得乾燥和形成細小皺紋。含有透明質酸之保濕劑經常用來減少皮膚乾燥和細紋。 Hyaluronic acid is a mucopolysaccharide found in the dermis and found in body fluids, bovine eyeballs, rooster cockscombs, animal tissues or placenta. In particular, it is present in high concentrations in connective tissue and skin. Hyaluronic acid is widely used in the medical field and cosmetics due to excellent tissue healing and moisturizing effects. For example, outside the plastic surgery Branch, inject it into the connecting bone. In cosmetic surgery, it is injected to eliminate wrinkles. In addition, hyaluronic acid has a very good water holding capacity - it can absorb about 6,000 times its own weight of water. Newborn babies have soft, moisturized skin due to high hyaluronic acid content. Aging causes hyaluronic acid to decrease in the dermis, and the skin becomes dry and forms fine wrinkles. Hyaluronic acid containing hyaluronic acid is often used to reduce dryness and fine lines.

第1圖是稼籽凝膠和透明質酸的保濕作用比較圖。皮膚保濕效果是在左前臂內側塗用2.0毫克/厘米2的透明質酸或2.0毫克/厘米2的稼籽凝膠來衡量。保濕效果測定採用WSK-P500U儀器(Inforward公司製),包含在25℃,相對濕度45%的房間裡保持3.5秒。結果表明,和未採用任何保濕劑之對照者比較起來,使用稼籽凝膠或透明質酸顯著地提高保濕效果。保濕效果一直維持到70分鐘。 Figure 1 is a comparison of the moisturizing effects of the grape seed gel and hyaluronic acid. The skin moisturizing effect is measured by applying 2.0 mg/cm 2 of hyaluronic acid or 2.0 mg/cm 2 of the seed gel on the inside of the left forearm. The moisturizing effect was measured using a WSK-P500U instrument (manufactured by Inforward Co., Ltd.), and it was kept in a room at 25 ° C and a relative humidity of 45% for 3.5 seconds. The results showed that the use of crop gel or hyaluronic acid significantly improved the moisturizing effect compared to the control without any moisturizer. The moisturizing effect is maintained for up to 70 minutes.

依據一具體實例之化妝品組成物包括能提供優越保濕效果的低分子量稼籽凝膠和龍舌蘭糖漿,以及聚-γ-谷氨酸,葡聚糖和透明質酸,從而改善保濕效果並减少黏感。其可配製成各種化妝品配方,而沒有特別的限制。例如,它可配製成化妝品組成物,如柔膚化妝水、收斂化妝水、滋潤乳液、滋養精華、營養霜、按摩膏、精華素、眼霜、 眼部精華、清潔霜、清潔泡沫、潔淨水、化妝包、凝膠、化妝粉、粉底,身體乳液、身體霜、按摩油、身體精華,或類似組成物。此外,它可配製成透皮配方,如化妝水,藥膏,凝膠,乳液,貼片或噴霧劑。依據一具體實例,化妝品組成物可用於滋潤皮膚。 The cosmetic composition according to a specific example includes a low molecular weight seed gel and agave syrup which provide superior moisturizing effects, and poly-γ-glutamic acid, dextran and hyaluronic acid, thereby improving moisturizing effect and reducing Sticky. It can be formulated into various cosmetic formulations without particular limitation. For example, it can be formulated into cosmetic compositions such as softening lotion, astringent lotion, moisturizing lotion, nourishing essence, nutrient cream, massage cream, serum, eye cream, Eye essence, cleansing cream, cleansing foam, cleansing water, cosmetic bag, gel, make-up powder, foundation, body lotion, body cream, massage oil, body essence, or the like. In addition, it can be formulated into transdermal formulations such as lotions, ointments, gels, lotions, patches or sprays. According to a specific example, the cosmetic composition can be used to moisturize the skin.

對此領域之熟悉技藝者可根據應用類型或使用目的,毫無困難地結合不同成分製備各種配方。 Those skilled in the art can prepare various formulations in combination with different ingredients without difficulty depending on the type of application or the purpose of use.

現在描述實例及實驗。下面的實例及實驗只用於說明之目的,並非用來限制本發明範圍。 Examples and experiments are now described. The following examples and experiments are for illustrative purposes only and are not intended to limit the scope of the invention.

測試實例:使用後的感受比較Test example: Comparison of feelings after use 1.稼籽凝膠之製備1. Preparation of crop seed gel

將稼籽添加到1,3-丁二醇和純淨水混合物中,攪拌直到纖維成分析出。然後,藉由離心分離取出凝膠部分,並過濾獲得稼籽凝膠。如此所製稼籽凝膠之平均分子量為150,000至250,000道爾頓。 The seeds were added to the 1,3-butanediol and purified water mixture and stirred until the fibers were analyzed. Then, the gel fraction was taken out by centrifugation, and filtered to obtain a seed gel. The wheat seed gel thus prepared has an average molecular weight of from 150,000 to 250,000 Daltons.

2.龍舌蘭糖漿的製備2. Preparation of agave syrup

將龍舌蘭粉碎、加熱、萃取、然後冷卻以製備龍舌蘭糖漿。如此所得龍舌蘭糖漿之平均分子量達1,000至20,000道爾頓。 The agave is pulverized, heated, extracted, and then cooled to prepare agave syrup. The agave syrup thus obtained has an average molecular weight of 1,000 to 20,000 Daltons.

3.化妝品組成物的製備3. Preparation of cosmetic composition

使具有保濕效果和相對低分子量之稼籽凝膠及龍舌蘭糖漿,與聚-γ-谷氨酸、葡聚糖和透明質酸配製成無黏感之保濕劑。表1列出具各種配方之保濕劑。 A moisturizing effect and a relatively low molecular weight of the seed gel and agave syrup are combined with poly-γ-glutamic acid, dextran and hyaluronic acid to form a non-stick moisturizer. Table 1 lists the humectants with various formulations.

每個成分(稼籽凝膠、聚-γ-谷氨酸、葡聚糖和透明質酸)均以純淨水稀釋。具體來說,稼籽凝膠稀釋至3重量%,聚-γ-谷氨酸至5重量%,葡聚糖至0.4重量%,而透明質酸至1重量%。 Each ingredient (garlic gel, poly-gamma-glutamic acid, dextran, and hyaluronic acid) was diluted with purified water. Specifically, the seed gel is diluted to 3% by weight, poly-γ-glutamic acid to 5% by weight, dextran to 0.4% by weight, and hyaluronic acid to 1% by weight.

諸成分之平均分子量如下:聚-γ-谷氨酸=1,500,000至2,500,000道爾頓;透明質酸=800,000至1,500,000道爾頓;葡聚醣=700,000至1,300,000道爾頓;稼籽凝膠=150,000至250,000道爾頓;而龍舌蘭糖漿=1,000至10,000道爾頓。分子量測定係採用120C系列高性能液相層析法/膠體滲透 層析法(安捷倫科技公司出品),使用奧特奇3300 ELSD(揮發性光散射偵測器)作為偵測器和採用一支30.8微米圓柱(PL-aquagel OH)。氣體流量為1.4升/分鐘,純淨水流量是0.7毫升/分鐘。樣品注入量為20微升。 The average molecular weight of the ingredients is as follows: poly-γ-glutamic acid = 1,500,000 to 2,500,000 Daltons; hyaluronic acid = 800,000 to 1,500,000 Daltons; dextran = 700,000 to 1,300,000 Daltons; crop gel = 150,000 Up to 250,000 Daltons; and agave syrup = 1,000 to 10,000 Daltons. Molecular weight determination using 120C series of high performance liquid chromatography / colloidal penetration Chromatography (Agilent Technologies) uses the Alltech 3300 ELSD (Volatile Light Scattering Detector) as a detector and a 30.8 micron cylinder (PL-aquagel OH). The gas flow rate was 1.4 L/min and the purified water flow rate was 0.7 ml/min. The sample injection amount was 20 μl.

4.使用後的感覺之比較4. Comparison of feeling after use

組成物使用後的評估見表1,包含使用後的感覺和保濕效果之評價。 The evaluation of the composition after use is shown in Table 1, and includes the evaluation of the feeling and moisturizing effect after use.

由評估小組的30名學員評估使用後感覺。評價是從’-’(完全沒有)的’+++’(大量有)。兩個極端之間是’+’(略有)和’++’(在某種程度上有)。每個組成物之偏好率被評估為總體評價。 The 30 participants of the assessment team assessed the post-use sensation. The evaluation is '+++' (a lot) from '-' (not at all). Between the two extremes are '+' (slightly) and '++' (to some extent). The preference rate of each composition was evaluated as an overall evaluation.

如表1所示,含有45重量%的3%稼籽凝膠之樣品1和2,比樣品3,4和5,表現出了較少的黏感。在樣品1和2中,含有5重量%的龍舌蘭糖漿之樣品2,具清爽的感覺而顯得較優越。含有5重量%的龍舌蘭糖漿、35重量%的3%稼籽凝膠、20重量%的0.4%葡聚醣和20重量%的1%透明質酸之樣品3,比樣品2更具黏感而較不清爽。和樣品3比較起來,含有少10重量%的3%稼籽凝膠及少5重量%的龍舌蘭糖漿之樣品4顯得更具黏感而較不清爽。而且,和樣品3比較起來, 含有同量的3%稼籽凝膠及少5重量%的龍舌蘭糖漿之樣品5,顯示類似的黏感,但較不清爽。 As shown in Table 1, Samples 1 and 2 containing 45% by weight of 3% of the seed gel showed less stickiness than Samples 3, 4 and 5. In Samples 1 and 2, Sample 2 containing 5% by weight of agave syrup was superior to a refreshing feeling. Sample 3 containing 5% by weight of agave syrup, 35% by weight of 3% seed gel, 20% by weight of 0.4% dextran and 20% by weight of 1% hyaluronic acid, more viscous than sample 2 Feeling is less refreshing. Compared to Sample 3, Sample 4 containing less than 10% by weight of 3% of the seed gel and 5% by weight of agave syrup appeared to be more viscous and less refreshing. Moreover, compared with sample 3, Sample 5, containing the same amount of 3% crop gel and 5% less agave syrup, showed a similar stickiness but was less refreshing.

總結測試結果,含有45重量%的3%稼籽凝膠、30重量%的5%聚-γ-谷氨酸、10重量%的0.4%葡聚醣和10重量%的1%透明質酸及5重量%的龍舌蘭糖漿之樣品2組成物表現最清爽,且黏感小。 Summarizing the test results, containing 45% by weight of 3% seed gel, 30% by weight of 5% poly-γ-glutamic acid, 10% by weight of 0.4% dextran and 10% by weight of 1% hyaluronic acid and The composition of the sample 2 of 5% by weight of agave syrup showed the freshest appearance and the stickiness was small.

5.保濕效果之比較5. Comparison of moisturizing effects

測試諸樣本之保濕效果。每個樣品塗2.0毫克/厘米2於左前臂內側,測定保濕效果。在一個保持在25℃,相對濕度45%之房間裡,使用WSK-P500U儀(Inforward公司製)測量3.5秒。結果如圖2所示。 Test the moisturizing effect of the samples. Each sample was coated with 2.0 mg/cm 2 on the inside of the left forearm to measure the moisturizing effect. In a room maintained at 25 ° C and a relative humidity of 45%, a WSK-P500U instrument (manufactured by Inforward Co., Ltd.) was used for 3.5 seconds. The result is shown in Figure 2.

如第2圖所示,樣品2再次表現出最好的結果。 As shown in Figure 2, Sample 2 again showed the best results.

各種化妝品配方之製法如下:The preparation of various cosmetic formulations is as follows:

製備例1:滋養乳液(乳液)Preparation Example 1: Nourishing emulsion (emulsion)

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚糖、透明質酸和龍舌蘭糖漿之滋養乳液如下。 The nourishing emulsion containing the seed gel, poly-γ-glutamic acid, dextran, hyaluronic acid and agave syrup was prepared according to the usual method as follows.

製備例2:軟化乳液(潤膚露)Preparation Example 2: Softening Emulsion (Moisturizing Lotion)

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚糖、透明質酸和龍舌蘭糖漿之軟化乳液如下。 A softening emulsion containing a seed gel, poly-γ-glutamic acid, dextran, hyaluronic acid and agave syrup was prepared according to the usual method as follows.

製備例3:滋養霜Preparation Example 3: Nourishing Cream

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚糖、透明質酸和龍舌蘭糖漿之滋養霜如下。 The nourishing cream containing the seed gel, poly-γ-glutamic acid, dextran, hyaluronic acid and agave syrup was prepared according to the usual method as follows.

製備例4:按摩霜Preparation Example 4: Massage Cream

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚糖、透明質酸和龍舌蘭糖漿之按摩霜如下。 The massage cream containing the crop gel, poly-γ-glutamic acid, dextran, hyaluronic acid and agave syrup was prepared according to the usual method as follows.

製備例5:化妝包Preparation Example 5: Cosmetic bag

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚醣、透明質酸和龍舌蘭糖漿之化妝包如下。 A cosmetic bag containing a seed gel, poly-γ-glutamic acid, dextran, hyaluronic acid, and agave syrup was prepared according to the usual method as follows.

製備例6:凝膠Preparation Example 6: Gel

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚糖、透明質酸和龍舌蘭糖漿之凝膠如下。 The gel containing the seed gel, poly-γ-glutamic acid, dextran, hyaluronic acid and agave syrup was prepared according to the usual method as follows.

製備例7:水-在-油中型乳液Preparation Example 7: Water-in-oil medium emulsion

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚糖、透明質酸和龍舌蘭糖漿之水-在-油中型乳液如下。 A water-in-oil medium emulsion containing a seed gel, poly-γ-glutamic acid, dextran, hyaluronic acid and agave syrup was prepared according to the usual method as follows.

製備例8:雙刷粉餅Preparation Example 8: Double Brush Powder

依據常法製備含有稼籽凝膠、聚-γ-谷氨酸、葡聚糖、透明質酸和龍舌蘭糖漿之雙刷粉餅如下。 A double brush powder containing a seed gel, poly-γ-glutamic acid, dextran, hyaluronic acid and agave syrup was prepared according to the usual method as follows.

雖然具體實例已說明和描述,但是對此領域之熟悉技藝者即可在形式和細節上做各種變化而不偏離本發明所附申請專利範圍的精義。 While the invention has been shown and described with reference to the embodiments of the invention

此外,為適應特殊情況或材料而做許多修改,均不偏離本發明之基本範圍。因此,本發明之範圍並不局限於特定實例所顯現的最佳模式,事實上所有的實例均包括在所附申請專利範圍內。 In addition, many modifications may be made to adapt a particular situation or material without departing from the basic scope of the invention. Therefore, the scope of the invention is not limited to the preferred embodiment of the invention, and all of the examples are included in the scope of the appended claims.

從最後的附圖配合先前詳細描述將使上述具體實例之特點和好處及其他方面優勢更加明顯,其中:第1圖是比較稼籽凝膠和透明質酸的保濕作用圖示;而第2圖顯示各種樣品的保濕效果測量結果。 The features and advantages of the above specific examples and other advantages will be more apparent from the final drawings in conjunction with the prior detailed description, wherein: Figure 1 is a graphical representation of the moisturizing effect of the comparison of the crop gel and hyaluronic acid; Shows the moisturizing effect measurement results of various samples.

Claims (4)

一種皮膚保濕用化妝品組成物,包含有稼籽凝膠、龍舌蘭糖漿、聚-γ-谷氨酸、葡聚糖和透明質酸作為有效成分;其中稼籽凝膠佔組成物總重量的0.001至20重量%且龍舌蘭糖漿佔組成物總重量的0.001至20重量%;其中稼籽凝膠、龍舌蘭糖漿、聚-γ-谷氨酸、葡聚糖和透明質酸一共佔組成物總重量的0.1至30重量%。 A skin moisturizing cosmetic composition comprising a seed gel, agave syrup, poly-γ-glutamic acid, dextran and hyaluronic acid as active ingredients; wherein the seed gel accounts for the total weight of the composition 0.001 to 20% by weight and agave syrup 0.001 to 20% by weight based on the total weight of the composition; wherein the seed gel, agave syrup, poly-γ-glutamic acid, dextran and hyaluronic acid account for 0.1 to 30% by weight based on the total weight of the composition. 如申請專利範圍第1項所述之皮膚保濕用化妝品組成物,其中稼籽凝膠之平均分子量為1,000至500,000道爾頓,而龍舌蘭糖漿之平均分子量為100至50,000道爾頓。 The cosmetic composition for skin moisturizing according to claim 1, wherein the wheat seed gel has an average molecular weight of 1,000 to 500,000 Daltons, and the agave syrup has an average molecular weight of 100 to 50,000 Daltons. 如申請專利範圍第2項所述之皮膚保濕用化妝品組成物,其中稼籽凝膠之平均分子量為150,000至250,000道爾頓,而龍舌蘭糖漿之平均分子量為1,000至20,000道爾頓。 The skin moisturizing cosmetic composition according to claim 2, wherein the wheat seed gel has an average molecular weight of 150,000 to 250,000 Daltons, and the agave syrup has an average molecular weight of 1,000 to 20,000 Daltons. 如申請專利範圍第1項所述之皮膚保濕用化妝品組成物,其中稼籽凝膠佔組成物總重量的0.5至3.0重量%。 The cosmetic composition for skin moisturizing according to claim 1, wherein the seed gel accounts for 0.5 to 3.0% by weight based on the total weight of the composition.
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CN102316848B (en) 2014-02-12
CN102316848A (en) 2012-01-11

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