WO2010093593A1 - Automated intraocular lens injector device - Google Patents

Automated intraocular lens injector device Download PDF

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Publication number
WO2010093593A1
WO2010093593A1 PCT/US2010/023544 US2010023544W WO2010093593A1 WO 2010093593 A1 WO2010093593 A1 WO 2010093593A1 US 2010023544 W US2010023544 W US 2010023544W WO 2010093593 A1 WO2010093593 A1 WO 2010093593A1
Authority
WO
WIPO (PCT)
Prior art keywords
lens
tubular body
injector
cartridge assembly
intraocular lens
Prior art date
Application number
PCT/US2010/023544
Other languages
French (fr)
Inventor
Kyle Brown
David A. Downer
Sushant Muchhala
Marshall K. Proulx
Stephen J. Van Noy
Dengzhu Yan (Dan)
Original Assignee
Alcon Research, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2011008381A priority Critical patent/MX2011008381A/en
Priority to BRPI1008638A priority patent/BRPI1008638B8/en
Application filed by Alcon Research, Ltd. filed Critical Alcon Research, Ltd.
Priority to SG2011056322A priority patent/SG173546A1/en
Priority to CA2751461A priority patent/CA2751461C/en
Priority to EP10705223.5A priority patent/EP2395943B1/en
Priority to ES10705223.5T priority patent/ES2525534T3/en
Priority to CN201080007320.XA priority patent/CN102316824B/en
Priority to AU2010213941A priority patent/AU2010213941B2/en
Priority to RU2011137436/14A priority patent/RU2494704C2/en
Priority to NZ594436A priority patent/NZ594436A/en
Priority to JP2011550178A priority patent/JP5543495B2/en
Priority to KR1020117020298A priority patent/KR101339069B1/en
Publication of WO2010093593A1 publication Critical patent/WO2010093593A1/en
Priority to IL214384A priority patent/IL214384A/en
Priority to ZA2011/05661A priority patent/ZA201105661B/en
Priority to HK12106145.7A priority patent/HK1165256A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A61F2/1678—Instruments for inserting intraocular lenses into the eye with a separate cartridge or other lens setting part for storage of a lens, e.g. preloadable for shipping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details

Definitions

  • the present invention relates generally to devices and techniques for delivering an intraocular lens (IOL) into an eye and more particularly to cartridges used for shipping and for injection of the lOLs.
  • IOL intraocular lens
  • the human eye functions to provide vision by transmitting light through a clear outer portion called the cornea, and focusing the image by way of a crystalline lens onto a retina.
  • the quality of the focused image depends on many factors including the size and shape of the eye, and the transparency of the cornea and the lens.
  • age or disease causes the lens to become less transparent, vision deteriorates because of the diminished light which can be transmitted to the retina.
  • This deficiency in the lens of the eye is medically known as a cataract.
  • An accepted treatment for this condition is surgical removal of the lens and replacement of the lens function by an artificial intraocular lens (IOL).
  • IOL intraocular lens
  • phacoemulsification In the United States, the majority of cataractous lenses are removed by a surgical technique called phacoemulsification. During this procedure, an opening is made in the anterior capsule and a thin phacoemulsification cutting tip is inserted into the diseased lens and vibrated ultrasonically. The vibrating cutting tip liquefies or emulsifies the lens so that the lens may be aspirated out of the eye. The diseased lens, once removed, is then replaced by the IOL.
  • the IOL is injected into the eye through the same small incision used to remove the diseased lens.
  • An insertion cartridge of an IOL injector is loaded with the IOL, the tip of the insertion cartridge is inserted into the incision, and the lens is delivered into the eye.
  • Many IOLs manufactured today are made from a polymer with specific characteristics. These characteristics allow the lens to be folded for insertion through a very small incision; the lens unfolds into its proper shape after delivery into the eye.
  • Injector cartridges that fold the lens and provide a relatively small diameter lumen through which the lens may be pushed into the eye, usually by a soft tip plunger, are commonly used. Some of these cartridges are described in U.S. Patent No.
  • An intraocular lens injector cartridge assembly containing a pre-loaded lens and an integral lens-contacting plunger rod is disclosed.
  • the cartridge assembly is configured for removably mating with an injector handpiece, and is thus suitable for use with either manual or automated injector systems.
  • An exemplary embodiment of an intraocular lens injector cartridge assembly includes a tubular body having a longitudinal bore extending between a distal end and a proximal end, an intraocular lens disposed within said longitudinal bore, and a lens-contacting plunger rod retained substantially within said bore, between the intraocular lens and the proximal end of the tubular body.
  • the lens-contacting plunger rod is configured for translation along the longitudinal bore upon engagement by an injector rod introduced by the injector handpiece into the proximal end of the tubular body, so that the intraocular lens is folded and ejected from the distal end of the tubular body by the translation of the lens-contacting plunger rod.
  • the cartridge assembly comprises a plunger guide disposed within the longitudinal bore and at least partially surrounding the circumference of the lens-contacting plunger rod.
  • the cartridge assembly may further include one or more grips protruding from the tubular body, for engagement with the injector handpiece.
  • the tubular body comprises an opening disposed on a first face of the tubular body for installing at least one of the intraocular lens and the lens-contacting plunger rod, and a cover installed over said opening.
  • the cover is connected to the tubular body by a hinge at one end of the cover, in some of these embodiments; in these and other embodiments the tubular body may comprise one or more retaining features proximate to the opening, so that the cover can be configured to snap fit into the one or more retaining features.
  • Figure 1 is a plan view of an exemplary disposable, pre-loaded, intraocular lens injector cartridge assembly.
  • Figure 2 is an elevation view of the cartridge assembly of Figure 1.
  • Figure 3 is a cross-sectional view of the cartridge assembly of Figure 1.
  • Figures 4A and 4B illustrate another exemplary IOL injector cartridge assembly.
  • Figures 5A and 5B illustrate the delivery of a lens from the injector cartridge according to some embodiments of the invention.
  • IOL intraocular lens
  • the handpiece which may be manually or electrically powered, includes a lens contacting plunger that is forced into and through the injector cartridge, folding the lens and ejecting the lens into the eye from the tip, or "distal" end, of the injector cartridge.
  • a lens contacting plunger that is forced into and through the injector cartridge, folding the lens and ejecting the lens into the eye from the tip, or "distal" end, of the injector cartridge.
  • Embodiments of the present invention include an intraocular lens injector cartridge assembly configured for removably mating with an injector handpiece.
  • the cartridge assembly is pre-loaded with an intraocular lens, and has the flexibility to be attached to a manual or automated injector.
  • the cartridge assembly includes a lens- contacting plunger rod built into the cartridge, so that a moveable rod from the handheld-injector device engages the lens-contacting plunger rod, which in turn advances and ejects the lens. Because the cartridge and lens contacting plunger are provided as a single, disposable unit, and because the rod of the re-usable injector device never makes contact with the IOL, the likelihood of contamination is reduced over that which might occur with reusable lens-contacting plungers.
  • a disposable, pre-loaded, intraocular lens injector cartridge 10 includes a tubular body 11 with a longitudinal bore 18 therein.
  • An intraocular lens 20 is pre-installed so that it is disposed within the longitudinal bore 18, along with a lens-contacting plunger 30.
  • the lens-contacting plunger 30 is retained at least substantially within the longitudinal bore 18, between the intraocular lens and the proximal end 16 of the cartridge 10, and may include, in some embodiments, a socket 32 for mating with an injector rod 40 of the injector handpiece (not shown).
  • lens- contacting plunger 30 When engaged by injector rod 40, which is introduced by the injector handpiece into the proximal end 16 of the cartridge, lens- contacting plunger 30 translates along the longitudinal bore 18, folding the intraocular lens 20 as it passes through the tapering portion 12 of the cartridge, and ejecting intraocular lens 20 into a patient's eye from the distal end 15 of the cartridge.
  • the interior of the tubular body 1 1 may include a plunger guide feature 35 (which may be integrally formed with the tubular body, in some embodiments, or a separately installed feature in others) to keep the lens-contacting plunger rod 30 properly oriented; the plunger guide feature 35 may also serve to retain the lens-contacting plunger rod 30 within the cartridge 10, such as by "trapping" the innermost end of the plunger rod 30 within the cartridge 10, or simply by providing sufficient friction to keep the plunger rod 30 from easily falling out of the cartridge 10.
  • a plunger guide feature 35 which may be integrally formed with the tubular body, in some embodiments, or a separately installed feature in others
  • the tubular body 11 is generally formed from any material suitable for use in eye surgery, and in some embodiments may be molded, in one or several pieces, from a suitable thermoplastic such as polypropylene.
  • the thermoplastic may contain a lubricity-enhancing agent such as those disclosed in U.S. Pat. No. 5,716,364.
  • Nozzle 14 may be rounded, oval or elliptical in cross- section, in various embodiments, and may have a cross-sectional area as small as about one square millimeter at distal tip 15, so that the distal tip 15 may be inserted into a very small incision in the eye.
  • cartridge 10 includes a pair of grips 17 protruding from the tubular body 11 ; these grips allow easier manipulation of cartridge 10 and provide a mechanism for engaging the injector handpiece so that the cartridge 10 may be locked into place.
  • narrowing injector portion 11 may be specially shaped to fold the intraocular lens 20 as it is pushed along the longitudinal bore 18 by lens-contacting plunger rod 30.
  • suitable designs for the injector portion 11 are possible, including but not limited to those illustrated in U.S. Patent No. 5,947,976 (Van Noy et al.) and U.S. Patent No. 6,143,001 (Brown et a/.); the entire contents of both of these patent documents are incorporated herein by reference.
  • the tubular body 11 of the pre-loaded cartridge 10 may be formed in a single piece, in some embodiments.
  • the intraocular lens 20 and lens-contacting plunger rod 30 may be pre-installed in the cartridge 10, from the cartridge's proximal end 16, by the rgrtridge's manufacturer prior to shipping the device.
  • other embodiments such as the embodiment of cartridge 10 pictured in Figures 4A and 4B, may include an opening 42 disposed on one face of the cartridge body 11 , so that the intraocular lens 20 and lens- contacting plunger rod 30 may be more easily installed. After these components are installed, the opening 42 may be closed by installing a cover 44 over the opening 42.
  • the cover 44 and tubular body 42 may be formed so that the cover 44 snaps into place; the cover 44 may form a hinged connection to the tubular body 11 at one end, in some embodiments. In other embodiments the cover 44 may be glued or otherwise fused into place after the lens-contacting plunger rod 30 and/or intraocular lens 20 are installed.
  • FIGs 5A and 5B illustrate the basic operation of some embodiments of the present operation.
  • an injector rod 40 has been introduced by the injector handpiece into the proximal end 16 of the tubular body 11 , so that it has mated with the socket 32 of the lens-contacting plunger rod 30. Further movement of the injector rod 40 causes the lens-contacting plunger rod 30 to engage the intraocular lens 20, which in some embodiments may be pre-installed in a slightly pre-folded condition. In any case, additional folding occurs as lens 20 travels through the tapering portion 12 of the cartridge body, through the nozzle 14. Finally, the intraocular lens 20 is expressed into the eye from the distal tip 15 of nozzle 14, as shown in Figure 5B, where it unfolds into its natural shape.
  • IOL injector cartridge assemblies described above are suitable for use with handpieces that include a manually activated injector rod, or with handpieces that include an electrically driven injector rod.
  • IOL injector cartridge assemblies designed according to the concepts disclosed herein may, in some embodiments, be compatible with both sorts of handpiece.
  • a further advantage of providing the cartridge, lens, and lens- contacting plunger as a single unit is the ability to dispose of the plunger after a single use, thereby reducing the likelihood of contamination that might be seen on reusable lens plungers.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Prostheses (AREA)

Abstract

An intraocular lens injector cartridge assembly contains a pre-loaded lens and an integral lens-contacting plunger rod. Configured for removably mating with an injector handpiece, the cartridge assembly is suitable for use with either manual or automated injector systems. The injector cartridge assembly includes a tubular body (11) having a longitudinal bore (18) extending between a distal end and a proximal end, an IOL disposed within said longitudinal bore (30), and a lens-contacting plunger rod retained within said bore, between the IOL and the proximal end of the tubular body. The lens-contacting plunger rod is configured for translation along the longitudinal bore upon engagement by an injector rod introduced by the injector handpiece into the proximal end of the tubular body, so that the IOL is folded and ejected from the distal end of the tubular body by the translation of the lens-contacting plunger rod.

Description

AUTOMATED INTRAOCULAR LENS INJECTOR DEVICE
CROSS REFERENCE TO RELATED APPLICATIONS
This application claims priority to U.S. Provisional Application Serial No. 61/151 ,712, filed February 1 1 , 2009.
TECHNICAL FIELD
The present invention relates generally to devices and techniques for delivering an intraocular lens (IOL) into an eye and more particularly to cartridges used for shipping and for injection of the lOLs.
BACKGROUND
The human eye functions to provide vision by transmitting light through a clear outer portion called the cornea, and focusing the image by way of a crystalline lens onto a retina. The quality of the focused image depends on many factors including the size and shape of the eye, and the transparency of the cornea and the lens. When age or disease causes the lens to become less transparent, vision deteriorates because of the diminished light which can be transmitted to the retina. This deficiency in the lens of the eye is medically known as a cataract. An accepted treatment for this condition is surgical removal of the lens and replacement of the lens function by an artificial intraocular lens (IOL).
In the United States, the majority of cataractous lenses are removed by a surgical technique called phacoemulsification. During this procedure, an opening is made in the anterior capsule and a thin phacoemulsification cutting tip is inserted into the diseased lens and vibrated ultrasonically. The vibrating cutting tip liquefies or emulsifies the lens so that the lens may be aspirated out of the eye. The diseased lens, once removed, is then replaced by the IOL.
The IOL is injected into the eye through the same small incision used to remove the diseased lens. An insertion cartridge of an IOL injector is loaded with the IOL, the tip of the insertion cartridge is inserted into the incision, and the lens is delivered into the eye. Many IOLs manufactured today are made from a polymer with specific characteristics. These characteristics allow the lens to be folded for insertion through a very small incision; the lens unfolds into its proper shape after delivery into the eye. Injector cartridges that fold the lens and provide a relatively small diameter lumen through which the lens may be pushed into the eye, usually by a soft tip plunger, are commonly used. Some of these cartridges are described in U.S. Patent No. 5,947,976, issued September 7, 1999 to Van Noy et al., and in U.S. Patent No. 6,537,283, issued March 25, 2003 to Van Noy; the entire contents of each of these patents is incorporated herein by reference. Other cartridges and injector devices are illustrated in U.S. Patent No. 4,681 ,102 (Bartell), U.S. Patent Nos. 5,494,484 and 5,499,987 (Feingold), U.S. Patent Nos. 5,616,148 and 5,620,450 (Eagles, et al.), U.S. Patent No. 5,275,604 (Rheinish, et al.), and U.S. Patent No. 5,653,715 (Reich, et al.) the entire contents of each of these documents are also incorporated herein by reference to provide context and technical background for the disclosure that follows. Notwithstanding the various designs disclosed in these references, improvements in IOL injector cartridges and IOL injection techniques are still needed.
SUMMARY
An intraocular lens injector cartridge assembly containing a pre-loaded lens and an integral lens-contacting plunger rod is disclosed. The cartridge assembly is configured for removably mating with an injector handpiece, and is thus suitable for use with either manual or automated injector systems. An exemplary embodiment of an intraocular lens injector cartridge assembly includes a tubular body having a longitudinal bore extending between a distal end and a proximal end, an intraocular lens disposed within said longitudinal bore, and a lens-contacting plunger rod retained substantially within said bore, between the intraocular lens and the proximal end of the tubular body. The lens-contacting plunger rod is configured for translation along the longitudinal bore upon engagement by an injector rod introduced by the injector handpiece into the proximal end of the tubular body, so that the intraocular lens is folded and ejected from the distal end of the tubular body by the translation of the lens-contacting plunger rod. In some embodiments, the cartridge assembly comprises a plunger guide disposed within the longitudinal bore and at least partially surrounding the circumference of the lens-contacting plunger rod.
Various embodiments of the cartridge assembly may further include one or more grips protruding from the tubular body, for engagement with the injector handpiece. In some embodiments, the tubular body comprises an opening disposed on a first face of the tubular body for installing at least one of the intraocular lens and the lens-contacting plunger rod, and a cover installed over said opening. The cover is connected to the tubular body by a hinge at one end of the cover, in some of these embodiments; in these and other embodiments the tubular body may comprise one or more retaining features proximate to the opening, so that the cover can be configured to snap fit into the one or more retaining features.
Of course, those skilled in the art will appreciate that the present invention is not limited to the above features, advantages, contexts or examples, and will recognize additional features and advantages upon reading the following detailed description and upon viewing the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is a plan view of an exemplary disposable, pre-loaded, intraocular lens injector cartridge assembly.
Figure 2 is an elevation view of the cartridge assembly of Figure 1.
Figure 3 is a cross-sectional view of the cartridge assembly of Figure 1.
Figures 4A and 4B illustrate another exemplary IOL injector cartridge assembly.
Figures 5A and 5B illustrate the delivery of a lens from the injector cartridge according to some embodiments of the invention.
DETAILED DESCRIPTION
Many conventional intraocular lens (IOL) injector cartridges, including several of those described in the U.S. patents discussed above, are manually loaded with an IOL shortly before the injection procedure, and attached to an injector handpiece.
The handpiece, which may be manually or electrically powered, includes a lens contacting plunger that is forced into and through the injector cartridge, folding the lens and ejecting the lens into the eye from the tip, or "distal" end, of the injector cartridge. In addition to the inconvenience and potential complications associated with loading the IOL, those skilled in the art will appreciate that another concern with these systems is that the lens contacting plunger must be carefully cleaned before reuse, to avoid contamination of the IOL.
Embodiments of the present invention include an intraocular lens injector cartridge assembly configured for removably mating with an injector handpiece. The cartridge assembly is pre-loaded with an intraocular lens, and has the flexibility to be attached to a manual or automated injector. The cartridge assembly includes a lens- contacting plunger rod built into the cartridge, so that a moveable rod from the handheld-injector device engages the lens-contacting plunger rod, which in turn advances and ejects the lens. Because the cartridge and lens contacting plunger are provided as a single, disposable unit, and because the rod of the re-usable injector device never makes contact with the IOL, the likelihood of contamination is reduced over that which might occur with reusable lens-contacting plungers.
As seen in the exemplary embodiment pictured in Figures 1-3, a disposable, pre-loaded, intraocular lens injector cartridge 10 includes a tubular body 11 with a longitudinal bore 18 therein. An intraocular lens 20 is pre-installed so that it is disposed within the longitudinal bore 18, along with a lens-contacting plunger 30. The lens-contacting plunger 30 is retained at least substantially within the longitudinal bore 18, between the intraocular lens and the proximal end 16 of the cartridge 10, and may include, in some embodiments, a socket 32 for mating with an injector rod 40 of the injector handpiece (not shown). When engaged by injector rod 40, which is introduced by the injector handpiece into the proximal end 16 of the cartridge, lens- contacting plunger 30 translates along the longitudinal bore 18, folding the intraocular lens 20 as it passes through the tapering portion 12 of the cartridge, and ejecting intraocular lens 20 into a patient's eye from the distal end 15 of the cartridge. As seen in Figure 3, the interior of the tubular body 1 1 may include a plunger guide feature 35 (which may be integrally formed with the tubular body, in some embodiments, or a separately installed feature in others) to keep the lens-contacting plunger rod 30 properly oriented; the plunger guide feature 35 may also serve to retain the lens-contacting plunger rod 30 within the cartridge 10, such as by "trapping" the innermost end of the plunger rod 30 within the cartridge 10, or simply by providing sufficient friction to keep the plunger rod 30 from easily falling out of the cartridge 10.
The tubular body 11 is generally formed from any material suitable for use in eye surgery, and in some embodiments may be molded, in one or several pieces, from a suitable thermoplastic such as polypropylene. In some embodiments, the thermoplastic may contain a lubricity-enhancing agent such as those disclosed in U.S. Pat. No. 5,716,364. Nozzle 14 may be rounded, oval or elliptical in cross- section, in various embodiments, and may have a cross-sectional area as small as about one square millimeter at distal tip 15, so that the distal tip 15 may be inserted into a very small incision in the eye. In the embodiment shown in Figures 1-3, cartridge 10 includes a pair of grips 17 protruding from the tubular body 11 ; these grips allow easier manipulation of cartridge 10 and provide a mechanism for engaging the injector handpiece so that the cartridge 10 may be locked into place. Those skilled in the art will appreciate that narrowing injector portion 11 may be specially shaped to fold the intraocular lens 20 as it is pushed along the longitudinal bore 18 by lens-contacting plunger rod 30. A variety of suitable designs for the injector portion 11 are possible, including but not limited to those illustrated in U.S. Patent No. 5,947,976 (Van Noy et al.) and U.S. Patent No. 6,143,001 (Brown et a/.); the entire contents of both of these patent documents are incorporated herein by reference.
As noted above, the tubular body 11 of the pre-loaded cartridge 10 may be formed in a single piece, in some embodiments. In such embodiments, the intraocular lens 20 and lens-contacting plunger rod 30 may be pre-installed in the cartridge 10, from the cartridge's proximal end 16, by the rgrtridge's manufacturer prior to shipping the device. However, other embodiments, such as the embodiment of cartridge 10 pictured in Figures 4A and 4B, may include an opening 42 disposed on one face of the cartridge body 11 , so that the intraocular lens 20 and lens- contacting plunger rod 30 may be more easily installed. After these components are installed, the opening 42 may be closed by installing a cover 44 over the opening 42. In some embodiments, the cover 44 and tubular body 42 may be formed so that the cover 44 snaps into place; the cover 44 may form a hinged connection to the tubular body 11 at one end, in some embodiments. In other embodiments the cover 44 may be glued or otherwise fused into place after the lens-contacting plunger rod 30 and/or intraocular lens 20 are installed.
Figures 5A and 5B illustrate the basic operation of some embodiments of the present operation. In Figure 5A, an injector rod 40 has been introduced by the injector handpiece into the proximal end 16 of the tubular body 11 , so that it has mated with the socket 32 of the lens-contacting plunger rod 30. Further movement of the injector rod 40 causes the lens-contacting plunger rod 30 to engage the intraocular lens 20, which in some embodiments may be pre-installed in a slightly pre-folded condition. In any case, additional folding occurs as lens 20 travels through the tapering portion 12 of the cartridge body, through the nozzle 14. Finally, the intraocular lens 20 is expressed into the eye from the distal tip 15 of nozzle 14, as shown in Figure 5B, where it unfolds into its natural shape.
Although details of the handpiece are not necessary for a full understanding of the present invention and are therefore not discussed in detail herein, those skilled in the art will appreciate that the cartridge assemblies described above are suitable for use with handpieces that include a manually activated injector rod, or with handpieces that include an electrically driven injector rod. Thus, IOL injector cartridge assemblies designed according to the concepts disclosed herein may, in some embodiments, be compatible with both sorts of handpiece. Those skilled in the art will appreciate that a further advantage of providing the cartridge, lens, and lens- contacting plunger as a single unit is the ability to dispose of the plunger after a single use, thereby reducing the likelihood of contamination that might be seen on reusable lens plungers.
The preceding description of various embodiments of an intraocular lens injection cartridge assembly and methods for using such a device was given for purposes of illustration and example. Those skilled in the art will appreciate, of course, that the present invention may be carried out in other ways than those specifically set forth herein without departing from essential characteristics of the invention. The present embodiments are thus to be considered in all respects as illustrative and not restrictive, and all changes coming within the meaning and equivalency range of the appended claims are intended to be embraced therein.

Claims

CLAIMSWhat is claimed is:
1. An intraocular lens injector cartridge assembly configured for removably 5 mating with an injector handpiece, the cartridge assembly comprising: a tubular body having a longitudinal bore extending between a distal end and a proximal end; an intraocular lens disposed within said longitudinal bore; and a lens-contacting plunger rod retained substantially within said bore, between0 the intraocular lens and the proximal end of the tubular body, and configured for translation along the longitudinal bore upon engagement by an injector rod introduced by the injector handpiece into the proximal end of the tubular body, so that the intraocular lens is folded and ejected from the distal end of the tubular body by the translation of the lens-contacting plunger rod. 5
2. The cartridge assembly of claim 1 , further comprising one or more grips protruding from the tubular body, for engagement with the injector handpiece.
3. The cartridge assembly of claim 1 , wherein the tubular body comprises an0 opening disposed on a first face of the tubular body for installing at least one of the intraocular lens and the lens-contacting plunger rod, and a cover installed over said opening.
4. The cartridge assembly of claim 3, wherein the cover is connected to the5 tubular body by a hinge at one end of the cover.
5. The cartridge assembly of claim 3, wherein the tubular body comprises one or more retaining features proximate to the opening, and wherein the cover is configured to snap fit into the one or more retaining features. n
6. The cartridge assembly of claim 1 , further comprising a plunger guide disposed within the longitudinal bore and at least partially surrounding the circumference of the lens-contacting plunger rod. 5
PCT/US2010/023544 2009-02-11 2010-02-09 Automated intraocular lens injector device WO2010093593A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
RU2011137436/14A RU2494704C2 (en) 2009-02-11 2010-02-09 Automatic injecting device for intraocular lens introduction
AU2010213941A AU2010213941B2 (en) 2009-02-11 2010-02-09 Automated intraocular lens injector device
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BRPI1008638A BRPI1008638B8 (en) 2009-02-11 2010-02-09 intraocular lens injector cartridge assembly
EP10705223.5A EP2395943B1 (en) 2009-02-11 2010-02-09 Automated intraocular lens injector device
ES10705223.5T ES2525534T3 (en) 2009-02-11 2010-02-09 Automated intraocular lens injector device
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CN102316824A (en) 2012-01-11
BRPI1008638B1 (en) 2020-03-10
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US9421092B2 (en) 2016-08-23
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ES2525534T3 (en) 2014-12-26
SG173546A1 (en) 2011-09-29

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