WO2010084921A1 - 分析システム、分析装置、容器、分析方法、プログラムおよび記録媒体 - Google Patents
分析システム、分析装置、容器、分析方法、プログラムおよび記録媒体 Download PDFInfo
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- WO2010084921A1 WO2010084921A1 PCT/JP2010/050725 JP2010050725W WO2010084921A1 WO 2010084921 A1 WO2010084921 A1 WO 2010084921A1 JP 2010050725 W JP2010050725 W JP 2010050725W WO 2010084921 A1 WO2010084921 A1 WO 2010084921A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/54—Labware with identification means
- B01L3/545—Labware with identification means for laboratory containers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
- B01L2300/022—Transponder chips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/023—Sending and receiving of information, e.g. using bluetooth
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/024—Storing results with means integrated into the container
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
Definitions
- the present invention relates to an analysis system, an analysis apparatus, a container, an analysis method, a program, and a recording medium.
- analyzers for analyzing specific components in samples have been widely used.
- an analyzer that reacts a sample (specimen) such as blood or urine with a specific reagent, detects the reaction by an optical method or an electrochemical method, and outputs a detection result.
- Such analyzers can be broadly classified into dedicated machines in which the analysis target is specified and general-purpose machines in which the user freely sets the analysis target (analysis item).
- a cartridge-type container pre-filled with necessary reagents is prepared, and preset analysis conditions are input to the apparatus, and if the cartridge-type container and the sample are set in the dedicated machine, A series of steps such as sampling of a sample, reaction between a sample and a reagent, detection of a reaction, and output of a detection result can be automatically performed.
- the user needs to set necessary reagents in the apparatus and input analysis conditions to the apparatus according to the analysis item. That is, the dedicated machine has an advantage that the analysis can be automatically performed, but there is a problem that the analysis items are limited and the analysis items cannot be expanded.
- a general-purpose machine has a problem in terms of analysis efficiency because analysis is manual, but it has an advantage that analysis items can be set freely. Therefore, conventionally, in order to achieve both analysis efficiency and expansion of analysis items, it is necessary to have both a dedicated machine and a general-purpose machine. However, possessing both a dedicated machine and a general-purpose machine is costly and requires a wide analysis space.
- Patent Document 1 An analyzer having a function of a dedicated machine and a function of a general-purpose machine has been proposed (Patent Document 1).
- this analyzer it is possible to distinguish and use a dedicated cartridge type container that is filled with a specific reagent in advance and a general purpose cartridge type container that is empty in the container and that can be freely filled by the user.
- the dedicated cartridge type container is sealed with a container, and a bar code including analysis conditions is printed on the seal.
- the general-purpose cartridge type container is not sealed.
- the analyzer determines whether it is a dedicated cartridge type container or a general-purpose cartridge type container depending on whether or not the container is sealed.
- the analysis is automatically performed in the analyzer according to preset conditions.
- the container is a general-purpose cartridge type container, the user selects an analysis item, reads the analysis condition of the selected analysis item from the storage device, and performs the analysis according to the read analysis condition.
- the analyzer has an advantage of having both functions of a dedicated machine and a general-purpose machine. However, there is a demand for analyzers to further expand analysis items and automate analysis.
- an object of the present invention is to provide an analysis system, an analysis apparatus, a container, an analysis method, a program, and a recording medium that can further expand analysis items and automate analysis.
- the analysis system of the present invention comprises: An analysis system for performing an analysis using a container and an analysis device,
- the container includes a dedicated container preliminarily provided with a reagent for a specific analysis item, and an expansion container in which a user can freely set the analysis item,
- the dedicated container and the expansion container include information signs,
- the information indicator includes analysis condition information,
- the analysis condition information is information that can be determined whether the dedicated container or the expansion container,
- the analyzer is A sign reading means for reading information of the information sign; Control means for controlling the analysis conditions, The sign reading means reads information on the information sign, The control means determines whether the container is the dedicated container or the expansion container based on the analysis condition information of the read information sign.
- the analyzer of the present invention is an analyzer used in the analysis system of the present invention, A sign reading means for reading the information sign information of the container; Control means for controlling the analysis conditions, The sign reading means reads information on the information sign, The control means determines whether the container is the dedicated container or the expansion container based on the analysis condition information of the read information sign.
- the container of the present invention is a container used in the analysis system of the present invention, and includes a dedicated container preliminarily equipped with a reagent for a specific analysis item, and an expansion container in which a user can freely set the analysis item.
- the dedicated container and the expansion container include an information label, the information label includes analysis condition information, and the analysis condition information is information capable of determining whether the dedicated container or the expansion container. It is characterized by.
- the analysis method of the present invention is an analysis method for analyzing using a container and an analyzer
- the container includes a dedicated container preliminarily equipped with a reagent for a specific analysis item, and an expansion container in which a user can freely set the analysis item
- the dedicated container and the expansion container include information signs
- the information indicator includes analysis condition information
- the analysis condition information is information that can be determined whether the dedicated container and the expansion container
- the analyzer is A sign reading means for reading information of the information sign; Control means for controlling the analysis conditions, In the analyzer, Read the information sign information by the sign reading means, The control means judges whether the container is the dedicated container or the expansion container based on the analysis condition information of the read information sign.
- the program of the present invention is a program that can execute the analysis method of the present invention in the analyzer.
- the recording medium of the present invention is a recording medium that records the program of the present invention.
- the container is the dedicated container or the expansion container based on the analysis condition information of the information sign of the container. Therefore, since the expansion container also has the analysis condition information in the information label, the analysis items can be expanded and the analysis can be automated.
- FIG. 1 is a perspective view showing an example of the configuration of a container used in the analysis system of the present invention.
- FIG. 2 is a cross-sectional view of the container shown in FIG. 1 as viewed in the II direction.
- FIG. 3 is a perspective view showing another example of the configuration of the container used in the analysis system of the present invention.
- 4 is a cross-sectional view of the container shown in FIG. 3 as seen in the II-II direction.
- FIG. 5 is a block diagram showing an example of the configuration of an analyzer used in the analysis system of the present invention.
- FIG. 6 is a block diagram showing another example of the configuration of the analyzer used in the analysis system of the present invention.
- FIG. 7 is a schematic diagram showing an example of the analysis system of the present invention.
- FIG. 1 is a perspective view showing an example of the configuration of a container used in the analysis system of the present invention.
- FIG. 2 is a cross-sectional view of the container shown in FIG. 1 as viewed in the II
- FIG. 8 is a flowchart in an example of the analysis system of the present invention.
- FIG. 9 is a flowchart in another example of the analysis system of the present invention.
- FIG. 10 is a flowchart in still another example of the analysis system of the present invention.
- FIG. 11 is a diagram for explaining the operation of the analyzer used in the analysis system of the present invention.
- FIG. 12 is a table showing an example of the configuration of the analysis condition information according to the present invention.
- the analysis condition information includes an analysis condition number and an analysis condition associated with the analysis condition number, and each of the dedicated container and the extended container is assigned with the individual analysis condition number.
- the control means determines whether the dedicated container or the expansion container is based on the analysis condition number. According to this aspect, the dedicated container and the expansion container can be discriminated quickly and easily.
- the analysis apparatus further includes analysis condition information storage means for storing analysis condition information for each analysis item, and is stored in advance when the control means determines that the dedicated container is used.
- analysis condition information is acquired from the analysis condition information storage means
- the control information is output according to the acquired analysis condition information, and the expansion container is determined, the analysis item set by the user is the first analysis. If it is determined whether or not the item is an analysis item for the first time, the analysis condition input request information is output, and the analysis condition information input according to the output information is stored in the analysis condition information storage means.
- the analysis device further includes an input unit for inputting information from outside the device, and the analysis condition information is input by the input unit.
- the analysis device further includes an information acquisition unit, and the information acquisition unit exists outside the analysis device via a communication line network outside the system according to the analysis condition input request information.
- the analysis condition information to be acquired is acquired, and the acquired analysis condition information is input.
- the server further includes a server, and the analysis condition information existing outside the analyzer is stored in the server.
- the analysis apparatus further includes an information transmission unit, and analysis condition information regarding an analysis item set by a user can be stored in the server via the communication line network by the information transmission unit. It is preferable that According to this aspect, the analysis condition information set by one user can be used by other users, and the analysis can be further automated when viewed from the whole system.
- the expansion container is filled with a common reagent tank filled with a common reagent that can be used in common and a special reagent that needs to be specially prepared according to the analysis item set by the user. It is preferable to have a special reagent tank possible. With such an embodiment, the user can save the trouble of preparing the common reagent, and as a result, the analysis efficiency is improved.
- the special reagent tank of the expansion container is filled with a special reagent in advance.
- the container provider fills the special reagent tank with the special reagent according to the user's request, it is possible to further save the user's trouble, and as a result, the analysis efficiency is improved. It will be further improved.
- the common reagent preferably includes DNA polymerase and dNTP
- the special reagent preferably includes a primer.
- the special reagent may further include a probe, an intercalator, and the like.
- the dedicated container and the expansion container are cartridge-type containers.
- the analysis system according to the present invention further includes a special reagent container for filling a special reagent that needs to be specially prepared according to an analysis item set by a user, and the analysis apparatus includes the cartridge-type container set. And a special reagent container set part. According to this aspect, it becomes possible to reduce the dead volume of the reagent as will be described later.
- the extended cartridge type container is set in the cartridge type container setting unit
- the special reagent container is set in the special reagent container setting unit
- the extended cartridge type container is common. It is preferable to have a common reagent tank filled with a common reagent that can be used, and the special reagent container is filled with the special reagent.
- the information sign is a barcode or a two-dimensional code.
- the analysis condition information includes an analysis condition number and an analysis condition associated with the analysis condition number, and the individual analysis condition number is assigned to each of the dedicated container and the extended container.
- the control means determines whether the dedicated container or the expansion container is based on the analysis condition number.
- the analysis apparatus of the present invention further includes analysis condition information storage means for storing analysis condition information for each analysis item, and when the control means determines that the dedicated container, the analysis condition information stored in advance is stored. Whether or not the analysis item set by the user is the first analysis item when the analysis item is acquired from the analysis condition information storage means, outputs control information according to the acquired analysis condition information, and is determined as the expansion container If it is determined that the analysis item is the first analysis item, the analysis condition input request information is output, and the analysis condition information input according to the output information is stored in the analysis condition information storage unit, A mode in which control information is output according to the analysis condition information stored in the analysis condition information storage means when it is determined that it is not an analysis item.
- the analysis apparatus of the present invention further includes an input unit for inputting information from outside the apparatus, and the analysis condition information is input by the input unit.
- the analysis apparatus further includes information acquisition means, and the analysis condition information existing outside the analysis apparatus via the communication line network outside the system by the information acquisition means according to the analysis condition input request information. It is preferable to input the acquired analysis condition information.
- the analysis condition information existing outside the analysis apparatus is stored in a server outside the analysis apparatus.
- the apparatus further includes an information transmission unit, and the analysis condition information regarding the analysis item set by the user can be stored in the server by the information transmission unit via the communication line network. .
- the analysis target is, for example, a gene.
- the analyzer of the present invention is preferably, for example, a cartridge type container compatible type.
- the analyzer of the present invention it is possible to use a special reagent container for filling a special reagent that needs to be specially prepared according to the analysis item set by the user. It is preferable to have a special reagent container setting part.
- the extended cartridge type container is set in the cartridge type container set part
- the special reagent container is set in the special reagent container set part
- the extended cartridge type container can be used in common. It is preferable to have a common reagent tank filled with a common reagent, and the special reagent container is filled with the special reagent.
- the label reading means is a bar code reader.
- the analysis condition information includes an analysis condition number and an analysis condition associated with the analysis condition number, and the individual analysis condition number is assigned to each of the dedicated container and the extended container. In addition, it is preferable that whether the dedicated container or the expansion container can be determined based on the analysis condition number.
- the expansion container can be filled with a common reagent tank filled with a common reagent that can be used in common and a special reagent that needs to be specially prepared according to the analysis item set by the user. It is preferable to have a special reagent tank.
- the special reagent tank of the expansion container may be prefilled with a special reagent.
- the analysis target may be a gene
- the common reagent may include DNA polymerase and dNTP
- the special reagent may include a primer
- the dedicated container and the expansion container are cartridge containers.
- the container of the present invention preferably further includes a special reagent container for filling a special reagent that needs to be specially prepared according to the analysis item set by the user.
- the expansion cartridge type container has a common reagent tank filled with a common reagent that can be used in common, and the special reagent container is filled with the special reagent. There may be.
- the information sign is a barcode or a two-dimensional code.
- the analysis condition information includes an analysis condition number and an analysis condition associated with the analysis condition number, and the individual analysis condition number is assigned to each of the dedicated container and the extended container.
- the control means determines whether the container is the dedicated container or the expansion container based on the analysis condition number.
- the analysis apparatus further includes analysis condition information storage means for storing analysis condition information for each analysis item, and when it is determined that the dedicated container is stored in advance by the control means.
- analysis condition information is acquired from the analysis condition information storage means, the control information is output according to the acquired analysis condition information, and the expansion container is determined, the analysis item set by the user is the first analysis. If it is determined whether or not the item is an analysis item for the first time, the analysis condition input request information is output, and the analysis condition information input according to the output information is stored in the analysis condition information storage means. When it is determined that the analysis item is not the first analysis item, it is preferable to output control information according to the analysis condition information stored in the analysis condition information storage means.
- the analysis device further includes an input unit for inputting information from outside the device, and the analysis condition information is input by the input unit.
- the analysis apparatus further includes an information acquisition unit, and the information acquisition unit exists outside the analysis apparatus via a communication line network outside the system according to the analysis condition input request information.
- the analysis condition information to be acquired is acquired, and the acquired analysis condition information is input.
- a server is used and the analysis condition information existing outside the analysis apparatus is stored in the server.
- the analysis apparatus further includes an information transmission unit, and the analysis condition information regarding the analysis item set by the user is stored in the server via the communication line network by the information transmission unit. It is preferable.
- the expansion container is filled with a common reagent tank filled with a common reagent that can be used in common and a special reagent that needs to be specially prepared according to the analysis item set by the user. It is preferable to have a special reagent tank possible.
- the special reagent tank of the expansion container may be prefilled with a special reagent.
- the analysis target may be a gene
- the common reagent may include DNA polymerase and dNTP
- the special reagent may include a primer
- the dedicated container and the expansion container are preferably cartridge type containers.
- a special reagent container for filling a special reagent that needs to be specially prepared according to an analysis item set by a user is used, and the analysis device includes the cartridge-type container set.
- the aspect which has a part and the said special reagent container setting part may be sufficient.
- the expansion cartridge type container has a common reagent tank filled with a common reagent that can be used in common, and the special reagent container is filled with the special reagent.
- the extended cartridge type container is set in the cartridge type container set part, the special reagent container is set in the special reagent container set part, the common reagent of the cartridge type container, and the special reagent of the special reagent container Is preferably used for analysis.
- the information sign is a barcode or a two-dimensional code.
- FIGS. 1 to 4 show an example of a container used in the analysis system of the present invention.
- FIG. 1 is a perspective view of the container of the present embodiment
- FIG. 2 is a cross-sectional view taken along the II direction of FIG. 1
- FIG. 3 is a perspective view of the container of FIG.
- FIG. 4 is a cross-sectional view seen in the II-II direction of FIG. 1 to 4, the same parts are denoted by the same reference numerals.
- FIG. 1 and FIG. 2 show the container of the present example without a seal.
- the container 1 is a cartridge-type container, the common reagent tank 11 filled with the common reagent 111, the operation tank 12 used for operations such as reaction and dilution, and the special reagent 113 filled with the special reagent 113.
- a tank 13 and a sample tank 14 filled with a sample (specimen) are provided.
- the common reagent tank 11 is divided into three tanks 11a, 11b, and 11c, and each of them is filled with three common reagents 111a, 111b, and 111c.
- the special reagent tank 13 is divided into three tanks 13a, 13b, and 13c.
- Each of the three tanks is filled with three special reagents 113a, 113b, and 113c.
- the special reagent is prefilled by the container provider and supplied to the user.
- the user fills the special reagent at the time of analysis.
- the extended cartridge type container is filled with the special reagent. Will be offered to.
- the special reagent tank of the expansion cartridge type container is not filled with the special reagent, and the special reagent is filled into the special reagent container.
- the filling of the special reagent into the special reagent container may be performed by the user at the time of analysis, or may be performed in advance by the container provider according to the user's request.
- FIG. 3 and 4 show the container of this example in a sealed state.
- the container is sealed by a seal 15 so that the upper openings of the common reagent tank 11, the operation tank 12 and the special reagent tank 13 are sealed, while the sample tank 14 is in an upper opening state. It has become.
- An information sign (barcode) 16 is printed on a part of the surface of the seal 15.
- the bar code 16 describes analysis condition information. Examples of the analysis condition information include an analysis condition number and an analysis condition associated with the analysis condition number. As described above, if an analysis condition number is assigned to each of the dedicated container and the expansion container, it is possible to determine the dedicated container or the expansion container and specify the analysis condition information only by recognizing the analysis condition number. Can be acquired.
- the information described in the barcode 16 is not limited to the analysis condition information, and other information may be described. Other information includes, for example, analysis items, reagent manufacturing date, reagent expiration date, lot number, product number, customer information, and the like.
- the material of the container is not particularly limited, and examples thereof include ordinary plastic.
- the measurement site for example, the operation tank
- FIG. 5 is a block diagram illustrating the configuration of the analyzer according to the present embodiment.
- the analyzer 2 of this embodiment includes a central processing unit (CPU) 21, a sampling pump unit 22, a nozzle drive unit 23, a measurement unit 24, a storage device 25, an input device 26, and an output device 27. It is provided as a main component.
- the CPU 21 controls the movement of the sampling pump unit 22, the nozzle drive unit 23 and the measurement unit 24.
- the sampling pump unit 22 drives a pump for sampling a sample, a reagent, and the like.
- the nozzle drive unit 23 moves the nozzle to each tank of the cartridge type container and moves the nozzle up and down.
- the nozzle drive unit 23 is equipped with a barcode reader.
- the measurement unit 24 measures the reaction between the sample and the reagent. Examples of the reaction measurement method include an optical method and an electrochemical method. In the case of an optical method, the measurement unit 24 includes, for example, a light source and a light receiving unit. In the case of an electrochemical method, for example, an electrode is included.
- the storage device 25 stores analysis condition information, other information, various programs, and the like, and is configured by appropriately combining flash memory, RAM, ROM, and the like.
- the input device 26 is for inputting information to the analysis device, and includes a keyboard, a key sheet, a terminal such as a USB, a drive such as a CD and a CD-R, and the like.
- the output device 27 is for outputting analysis results and other information, and examples thereof include a printer and a display.
- each of the above-described constituent elements may be integrated or may be divided into a plurality of devices.
- PC personal computer
- the analysis apparatus of the present embodiment in the case of analysis using an expansion container in the CPU, if the analysis item is the first time, information requesting input of analysis condition information is output from the output means.
- the analysis condition information input by the input means is automatically stored in the storage device by the CPU and used for the subsequent analysis.
- the common reagent tank 11 is filled with dNTP, polymerase and other reagents, and the special reagent tank 13 is filled with primers and probes.
- the user injects a sample (specimen) into the sample (specimen) tank 14 of the cartridge type container.
- the nozzle automatically moves, samples the sample in the sample tank 14, breaks the seal 15, and injects it into the operation tank 12.
- the nozzle automatically moves, the seal 15 is broken, dNTP, polymerase and primer are sampled, injected into the operation tank 12, and reacted with the sample.
- the temperature cycle is controlled by the measurement unit 24. After a certain number of cycles of reaction, the probe in the reaction is detected by optical techniques.
- the analyte of the present invention includes, in addition to genes, biomolecules such as proteins (for example, enzymes, antigens, antibodies, etc.) and lipids, organic molecules other than biomolecules, and inorganic molecules.
- biomolecules such as proteins (for example, enzymes, antigens, antibodies, etc.) and lipids, organic molecules other than biomolecules, and inorganic molecules.
- the cartridge type container is set in the analyzer. Then, the barcode of the container is read by the barcode reader (S1), and the analysis condition number is recognized (S2). Next, the analysis condition number is referred to the analysis condition information stored in the storage device, and it is determined whether or not the container is a dedicated cartridge type container (S3).
- An example of the analysis condition information stored in the storage device is shown in the table of FIG. As illustrated, in this table, the container type, the analysis condition number, and the analysis condition are stored in association with each other. As shown in the figure, for example, the analysis condition numbers 1, 2 and 3 are numbers assigned to the dedicated containers. Therefore, if the analysis condition number of the barcode (see FIG.
- the analyzer determines that the container is a dedicated container (Yes), and the condition of the analysis condition No. 1 (for example, the temperature is X 1 ° C.) is acquired (S4), and the analysis is performed by the CPU according to this condition. It is executed (S5).
- the analyzer determines that the container is a dedicated container, and the analysis condition number 2 (for example, the temperature is X 2 ° C, etc.) is designated.
- the analysis condition number is 3
- the analysis condition of analysis condition number 3 for example, the temperature is X 3 ° C, etc.
- the analyzer when the analysis condition number is E1, the analyzer is not a dedicated container ( No) is determined (S3), in other words, it is determined as an expansion container (S3).
- S3 In the case of an expansion container, it is determined whether or not the designated analysis item is the first time (S31). If it is not the first time (No, if there is a previous analysis with the analyzer), the analysis condition information is acquired from the storage device (S4), and the analysis is executed by the CPU according to this condition (S5).
- the analysis item is the first time (Yes)
- the CPU outputs information requesting input of analysis condition information to the output device.
- the user inputs analysis condition information from the input device in accordance with the request.
- the analysis condition number E1 of the expansion container stores three analysis conditions E1a, E1b, and E1c, these analysis conditions are output to the output device.
- the user can input the analysis condition information by designating the analysis condition from the input device using the input device. For example, if the analysis condition E1a is designated, the analysis condition such as the temperature Y 1 ° C. is automatically input.
- the input analysis condition information is automatically stored in the storage device by the CPU for subsequent analysis. And after execution of an analysis, an analysis result is output from an output device (S6).
- the user inputs the analysis condition information, but the present invention is not limited to this.
- the analysis device or the container provider may record the analysis condition information on a recording medium (CD, USB memory, etc.) and provide the recording medium to the user.
- FIG. 6 the same parts as those in FIG.
- the analyzer of this embodiment includes a communication interface 28, and the storage device 25 stores information acquisition means (search program).
- the analysis apparatus 2 of this embodiment can be connected to a server 3 outside the apparatus via a communication network 4.
- the other configuration of the analyzer of the present embodiment is the same as that of the analyzer of the first embodiment.
- the analysis procedure of this embodiment is to automatically search and acquire analysis condition information when the analysis apparatus determines that the container is an expansion container and the analysis item is the first time, and performs analysis according to the acquired analysis condition information.
- the process is the same as that of Example 1 except that That is, when it is determined from the barcode that the container is an expansion container (S3), it is subsequently determined whether or not the analysis item is the first time (S31). If the analysis item is not the first time (No), the analysis condition information is acquired from the storage device (S4), the analysis is executed (S5), and the analysis result is output (S6).
- the communication interface is activated by the CPU, and the information acquisition means (search program) of the storage device is read and executed by the CPU (S321).
- the information acquisition means automatically accesses and searches a server outside the apparatus via the communication network (Internet) (S322), and acquires analysis condition information in the server (S323). Subsequently, according to the acquired analysis condition information, an analysis is executed (S5), and an analysis result is output (S6).
- the server is not particularly limited, and may be a server where research information is uploaded by a public research institution such as a university, or may be a server managed by an analyzer or a container provider. According to the present embodiment, even when the user newly sets an analysis item, the analysis condition information can be automatically acquired, so that the analysis apparatus can be further automated.
- Example 3 an example of an analysis apparatus in which analysis condition information input by a user is uploaded to a server outside the apparatus will be described based on the flowchart of FIG.
- the analyzer of the present embodiment has the same configuration as that of the analyzer of Embodiment 2 (see FIG. 6).
- the procedure up to the output of the analysis result is the same as that of the analyzer of the first embodiment (see FIG. 8). Accordingly, in FIG. 10, the same parts as those in FIG. In the flow of FIG. 10, after the analysis result is output (S6), the output device outputs information for allowing the user to determine whether or not the input analysis condition information is to be uploaded (S7).
- the measurement is finished as it is.
- the communication interface is activated by the CPU (S71), the analysis conditions are uploaded to the server outside the apparatus (S72), and the analysis is completed.
- a server (site) for uploading analysis condition information is specified, a lot of analysis condition information will be gathered, and as described in the example of the analysis apparatus of the second embodiment, the user sets it for the first time. In the case of the analyzed item, it is easy to download the analysis condition information.
- whether or not to upload the analysis condition information is selected after the output of the analysis result (S6).
- the present invention is not limited to this. For example, the execution of the analysis (S5) Thereafter, it may be determined whether to upload the analysis conditions.
- Example 4 Next, based on FIG. 11, the Example of the analysis system using an expansion cartridge type container and a special reagent container is described.
- the same parts as those in FIGS. 1 to 4 are denoted by the same reference numerals.
- the extended cartridge type container 1 and the special reagent container 31 are used, and the analyzer 2 is provided with an extended cartridge type container setting unit 29 and a special reagent container setting unit 30.
- the common reagent tanks 11a, 11b, and 11c of the expansion cartridge type container are filled with the common reagents 111a, 111b, and 111c, respectively, but the special reagent tanks 13a, 13b, and 13c are empty.
- the special reagent container 31 is filled with the special reagent 113.
- the common reagent tank 11 is filled with dNTP, polymerase and other reagents, and the special reagent container 31 is filled with primers and probes.
- the user injects a sample (specimen) into the sample (specimen) tank 14 of the cartridge type container.
- the nozzle automatically moves to sample the sample in the sample tank 14 and inject it into the operation tank 12.
- the nozzle automatically moves, samples common reagents such as dNTP and polymerase, and injects them into the operation tank 12.
- the nozzle automatically moves to move the primer and probe from the special reagent container 31. Is sampled and injected into the operation tank 12 to react with the sample.
- the reaction is PCR
- the temperature cycle is controlled by the measurement unit. After a certain number of cycles of reaction, the probe in the reaction is detected by optical techniques. In this way, the use amount of the special reagent can be saved by using the special reagent container without using the special reagent tank of the cartridge type container. That is, in order to perform sampling at the nozzle, in addition to the amount necessary for the reaction, an extra amount (dead volume) for enabling sampling is required.
- the amount required for the reaction is 20 ⁇ L, and an extra volume (dead volume) to enable sampling ) Is 20 ⁇ L
- the total dead volume is 80 ⁇ L in a 20 ⁇ L ⁇ 4 reagent tank.
- the amount of reagent necessary for four measurements is 80 ⁇ L (20 ⁇ L ⁇ 4 measurement) and an extra amount (dead volume) 20 ⁇ L to enable sampling, so the total dead volume Can be 20 ⁇ L.
- the analysis system and the like of the present invention are preferably used in the field of clinical examinations, but the present invention is not limited or limited to this and can be widely applied to other fields.
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Abstract
Description
容器および分析装置を用いて分析を実施する分析システムであって、
前記容器は、特定の分析項目の試薬を予め備える専用容器と、使用者が自由に分析項目を設定可能な拡張容器とを含み、
前記専用容器および前記拡張容器は、情報標識を含み、
前記情報標識は、分析条件情報を含み、
前記分析条件情報は、前記専用容器または前記拡張容器であるかを判断可能な情報であり、
前記分析装置は、
前記情報標識の情報を読み取る標識読み取り手段と、
分析条件を制御する制御手段とを有し、
前記標識読み取り手段は、前記情報標識の情報を読み取り、
前記制御手段は、前記読み取られた情報標識の分析条件情報に基づき、前記専用容器または前記拡張容器であるかを判断することを特徴とする。
前記容器が有する前記情報標識の情報を読み取る標識読み取り手段と、
分析条件を制御する制御手段とを有し、
前記標識読み取り手段は、前記情報標識の情報を読み取り、
前記制御手段は、前記読み取られた情報標識の分析条件情報に基づき、前記専用容器または前記拡張容器であるかを判断することを特徴とする。
前記容器は、特定の分析項目の試薬を予め備える専用容器と、使用者が自由に分析項目を設定可能な拡張容器とを含み、
前記専用容器および前記拡張容器は、情報標識を含み、
前記情報標識は、分析条件情報を含み、
前記分析条件情報は、前記専用容器および前記拡張容器であるかを判断可能な情報であり、
前記分析装置は、
前記情報標識の情報を読み取る標識読み取り手段と、
分析条件を制御する制御手段とを有し、
前記分析装置において、
前記標識読み取り手段により、前記情報標識の情報を読み取り、
前記制御手段により、前記読み取られた情報標識の分析条件情報に基づき、前記専用容器または前記拡張容器であるかを判断することを特徴とする。
Claims (19)
- 容器および分析装置を用いて分析を実施する分析システムであって、
前記容器は、特定の分析項目の試薬を予め備える専用容器と、使用者が自由に分析項目を設定可能な拡張容器とを含み、
前記専用容器および前記拡張容器は、情報標識を含み、
前記情報標識は、分析条件情報を含み、
前記分析条件情報は、前記専用容器または前記拡張容器であるかを判断可能な情報であり、
前記分析装置は、
前記情報標識の情報を読み取る標識読み取り手段と、
分析条件を制御する制御手段とを有し、
前記標識読み取り手段は、前記情報標識の情報を読み取り、
前記制御手段は、前記読み取られた情報標識の分析条件情報に基づき、前記専用容器または前記拡張容器であるかを判断することを特徴とする分析システム。 - 前記分析条件情報が、分析条件番号と、前記分析条件番号に関連づけられた分析条件を含み、前記専用容器および拡張容器のそれぞれに、個別の前記分析条件番号が付与されており、前記制御手段が、前記分析条件番号によって、前記専用容器か前記拡張容器かを判断する請求の範囲1記載の分析システム。
- 前記分析装置が、さらに、分析項目毎に分析条件情報を記憶する分析条件情報記憶手段を有し、
前記制御手段において、前記専用容器と判断した場合、予め記憶されていた分析条件情報を前記分析条件情報記憶手段から取得し、前記取得された分析条件情報に従って制御情報を出力し、
前記拡張容器と判断した場合、前記使用者が設定した分析項目が、初回の分析項目であるか否かを判断し、
初回の分析項目であると判断した場合、分析条件入力要求情報を出力し、かつ前記出力情報に従って入力された分析条件情報を、前記分析条件情報記憶手段に記憶させ、
初回の分析項目でないと判断した場合、前記分析条件情報記憶手段に記憶された分析条件情報に従って制御情報を出力する請求の範囲1記載の分析システム。 - 前記分析装置は、さらに、装置外部から情報を入力する入力手段を有し、前記入力手段により、前記分析条件情報を入力する請求の範囲1記載の分析システム。
- 前記分析装置は、さらに、情報取得手段を有し、前記分析条件入力要求情報に従い、前記情報取得手段により、システム外の通信回線網を介し、前記分析装置外に存在する前記分析条件情報を取得し、前記取得された分析条件情報を入力する請求の範囲1記載の分析システム。
- さらに、サーバーを有し、前記分析装置外に存在する前記分析条件情報が、前記サーバー内に格納されている請求の範囲5記載の分析システム。
- 前記分析装置は、さらに、情報送信手段を有し、使用者が設定した分析項目に関する分析条件情報が、前記情報送信手段により、前記通信回線網を介し、前記サーバー内に格納可能である請求の範囲6記載の分析システム。
- 前記拡張容器は、共通して使用可能な共通試薬が充填された共通試薬槽と、使用者が設定した分析項目に応じて特別に用意する必要がある特別試薬を充填可能な特別試薬槽とを有する請求の範囲1記載の分析システム。
- 前記拡張容器の特別試薬槽に、予め、特別試薬が充填されている請求の範囲8記載の分析システム。
- 分析対象が、遺伝子であり、前記共通試薬が、DNAポリメラーゼおよびdNTPを含み、前記特別試薬が、プライマーを含む請求の範囲8記載の分析システム。
- 前記専用容器および前記拡張容器が、カートリッジ式容器である請求の範囲1記載の分析システム。
- さらに、使用者が設定した分析項目に応じて特別に用意する必要がある特別試薬を充填するための特別試薬容器を有し、前記分析装置は、前記カートリッジ式容器セット部および前記特別試薬容器セット部を有する請求の範囲11記載の分析システム。
- 前記分析装置において、前記カートリッジ式容器セット部に、前記拡張カートリッジ式容器がセットされ、前記特別試薬容器セット部に、前記特別試薬容器がセットされ、前記拡張カートリッジ式容器は、共通して使用可能な共通試薬が充填された共通試薬槽を有し、前記特別試薬容器には、前記特別試薬が充填されている請求の範囲12記載の分析システム。
- 前記情報標識が、バーコードまたは二次元コードである請求の範囲1記載の分析システム。
- 請求の範囲1記載の分析システムに使用する分析装置であって、
前記容器が有する前記情報標識の情報を読み取る標識読み取り手段と、
分析条件を制御する制御手段とを有し、
前記標識読み取り手段は、前記情報標識の情報を読み取り、
前記制御手段は、前記読み取られた情報標識の分析条件情報に基づき、前記専用容器または前記拡張容器であるかを判断することを特徴とする分析装置。 - 請求の範囲1記載の分析システムに使用される容器であって、特定の分析項目の試薬を予め備える専用容器と、使用者が自由に分析項目を設定可能な拡張容器とを含み、前記専用容器および前記拡張容器は、情報標識を含み、前記情報標識は、分析条件情報を含み、前記分析条件情報は、前記専用容器または前記拡張容器であるかを判断可能な情報であることを特徴とする容器。
- 容器および分析装置を用いて分析する分析方法であって、
前記容器は、特定の分析項目の試薬を予め備える専用容器と、使用者が自由に分析項目を設定可能な拡張容器とを含み、
前記専用容器および前記拡張容器は、情報標識を含み、
前記情報標識は、分析条件情報を含み、
前記分析条件情報は、前記専用容器および前記拡張容器であるかを判断可能な情報であり、
前記分析装置は、
前記情報標識の情報を読み取る標識読み取り手段と、
分析条件を制御する制御手段とを有し、
前記分析装置において、
前記標識読み取り手段により、前記情報標識の情報を読み取り、
前記制御手段により、前記読み取られた情報標識の分析条件情報に基づき、前記専用容器または前記拡張容器であるかを判断することを特徴とする分析方法。 - 請求の範囲17記載の分析方法を、前記分析装置において実行可能なプログラム。
- 請求の範囲18記載のプログラムを記録した記録媒体。
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JP2019078765A (ja) * | 2013-04-05 | 2019-05-23 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 生体試料のための分析システム |
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US20120021419A1 (en) | 2012-01-26 |
JPWO2010084921A1 (ja) | 2012-07-19 |
EP2392928A1 (en) | 2011-12-07 |
KR101312156B1 (ko) | 2013-09-26 |
CN102282469A (zh) | 2011-12-14 |
US9121839B2 (en) | 2015-09-01 |
EP2392928A4 (en) | 2017-09-27 |
KR20110086763A (ko) | 2011-07-29 |
JP5498944B2 (ja) | 2014-05-21 |
CN102282469B (zh) | 2014-12-10 |
EP2392928B1 (en) | 2019-12-11 |
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