WO2010083645A1 - Pyrimido[5,4-e][1,2,4]triazines et leurs utilisations - Google Patents

Pyrimido[5,4-e][1,2,4]triazines et leurs utilisations Download PDF

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Publication number
WO2010083645A1
WO2010083645A1 PCT/CN2009/070252 CN2009070252W WO2010083645A1 WO 2010083645 A1 WO2010083645 A1 WO 2010083645A1 CN 2009070252 W CN2009070252 W CN 2009070252W WO 2010083645 A1 WO2010083645 A1 WO 2010083645A1
Authority
WO
WIPO (PCT)
Prior art keywords
pyrimido
triazin
phenyl
fluoro
amine
Prior art date
Application number
PCT/CN2009/070252
Other languages
English (en)
Inventor
Ben Li
Li Chen
Renhai Chen
Peibin Zhai
Dean Cameron Baylis
Jonathan Coates
John Deadman
Eric Jones
David Rhodes
Original Assignee
Shanghai Targetdrug Co., Ltd
Avexa Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Targetdrug Co., Ltd, Avexa Limited filed Critical Shanghai Targetdrug Co., Ltd
Priority to PCT/CN2009/070252 priority Critical patent/WO2010083645A1/fr
Publication of WO2010083645A1 publication Critical patent/WO2010083645A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention porte sur un composé de la formule (I) ou sur un dérivé, un sel ou un promédicament de qualité pharmaceutique de celui-ci : formule (I). La présente invention porte en outre sur des compositions pharmaceutiques comportant un composé de la formule (I) et sur des procédés de traitement ou de prévention d'infections virales, en particulier d'infections au VHC, par l'administration d'un composé de la formule (I).
PCT/CN2009/070252 2009-01-21 2009-01-21 Pyrimido[5,4-e][1,2,4]triazines et leurs utilisations WO2010083645A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2009/070252 WO2010083645A1 (fr) 2009-01-21 2009-01-21 Pyrimido[5,4-e][1,2,4]triazines et leurs utilisations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2009/070252 WO2010083645A1 (fr) 2009-01-21 2009-01-21 Pyrimido[5,4-e][1,2,4]triazines et leurs utilisations

Publications (1)

Publication Number Publication Date
WO2010083645A1 true WO2010083645A1 (fr) 2010-07-29

Family

ID=42355487

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2009/070252 WO2010083645A1 (fr) 2009-01-21 2009-01-21 Pyrimido[5,4-e][1,2,4]triazines et leurs utilisations

Country Status (1)

Country Link
WO (1) WO2010083645A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102060782A (zh) * 2010-11-18 2011-05-18 孙智华 制备氯代嘧啶或其类似物的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813393A (en) * 1971-07-13 1974-05-28 Hoffmann La Roche Pyrimidotriazines
CN1610683A (zh) * 2001-12-27 2005-04-27 霍夫曼-拉罗奇有限公司 作为磷酸酶抑制剂的嘧啶并三嗪

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813393A (en) * 1971-07-13 1974-05-28 Hoffmann La Roche Pyrimidotriazines
CN1610683A (zh) * 2001-12-27 2005-04-27 霍夫曼-拉罗奇有限公司 作为磷酸酶抑制剂的嘧啶并三嗪

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
D. J. BROWN ET AL.: "Aza-analogues of pteridine. Part VI. some 3-alkyl-5(and 7)-aminopyrimido[5,4-e]-as-triazines and related compounds.", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999), vol. 18, 1972, pages 2316 - 19 *
FRANCO GATTA ET AL.: "Synthesis of 2,8-disubstituted 1,2,4-triazolo[5,1-i]purines.", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, no. 5, 1994, pages 1171 - 6 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102060782A (zh) * 2010-11-18 2011-05-18 孙智华 制备氯代嘧啶或其类似物的方法

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