WO2010075824A1 - Uso de peptido tipo apl para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i - Google Patents
Uso de peptido tipo apl para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i Download PDFInfo
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- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000003614 tolerogenic effect Effects 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Definitions
- the present invention is related to the branch of medicine, particularly with the use of a modified APL-like peptide (from the English Altered Peptide Ligand, abbreviated APL) or its analogues in the treatment of inflammatory bowel diseases (such as Crohn's disease and Ia ulcerative colitis) and type I diabetes mellitus.
- APL modified Altered Peptide Ligand
- Infliximab is a chimeric monoclonal antibody (AcM) that contains the murine variable region and the constant region of a human IgGI molecule, which binds with great affinity and specificity to circulating TNF ⁇ and to that produced in membranes (Knight DM et al. . (1993) Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 30: 1443-1453).
- AcM monoclonal antibody
- APLs are analogs of immunogenic peptides with one or several substitutions in the essential positions of contact with the T-cell receptor or with the Major Histocompatibility Complex, which interferes with or modifies the cascade of events necessary for the complete activation of T cells.
- Bielekova B and Martin R (2001) Antigen-specific immunomodulation via altered peptide ligands. J Mol Med 79: 552-65).
- the ability to experimentally manipulate the intrinsic properties of known peptide ligands allows appropriately altering the nature, course and potency of the cellular immune response.
- WO 2006/032216 APL-type peptides are claimed, derived from the human 60 kDa thermal stress protein (abbreviated Hsp60, from the English 6OkDa heat shock protein), as well as the use of a pharmaceutical preparation that comprises these peptides in the treatment of AR.
- Type I diabetes mellitus is a specific autoimmune disease mediated by T cells that destroy the ⁇ cells of the pancreas that produce insulin, which leads to a deregulation of glucose metabolism (Brown L and Eisenbarth GS (1990) Type- I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 8: 647-79).
- This peptide promotes the induction of activated T-cell apoptosis of the intestinal own lamina and peripheral blood of patients with Crohn's disease, which results in the inhibition of T-cell clones. involved in the pathogenesis of this disease, without causing inesp immunosuppression Ecological as with the use of drugs that block TNF ⁇ .
- the use of the APL-type immunomodulatory peptide, or its analogues, in the treatment of inflammatory bowel diseases, is aimed at neutralizing clones of T cells that participate in the inflammatory process characteristic of this type of disease.
- the pharmaceutical preparation of the invention is characterized by its high specificity, since it is directed to the neutralization of pathogenic T cells, when they are in a state of activation.
- immunomodulatory peptide in the manufacture of a medicament for the treatment of inflammatory bowel diseases also has the advantage that regardless of whether the parenteral administration route (intradermal, subcutaneous or intravenous, for example) is used, its active ingredient is Biodistributes primarily to the gastrointestinal tract: stomach, small intestine and colon. In addition, the peptide remains in these organs for the time necessary to exert its biological mechanisms. As discussed, in inflammatory bowel diseases the uncontrolled activation of effector T cells, directed against the commensal flora, occurs precisely in the gastrointestinal tract.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Marine Sciences & Fisheries (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK09804226.0T DK2374468T3 (da) | 2008-12-29 | 2009-12-29 | Anvendelse af peptid af APL-typen til behandling af inflammatoriske tarmsygdomme og type 1-diabetes |
AU2009335405A AU2009335405B2 (en) | 2008-12-29 | 2009-12-29 | Use of an APL peptide for the treatment of inflammatory bowel disease and type 1 diabetes |
CA2748493A CA2748493C (en) | 2008-12-29 | 2009-12-29 | Use of apl-type peptide for treating intestinal inflammatory diseases and type 1 diabetes |
RU2011131872/15A RU2524630C2 (ru) | 2008-12-29 | 2009-12-29 | Применение apl пептида для лечения воспалительной болезни кишечника и диабета типа 1 |
EP09804226.0A EP2374468B1 (en) | 2008-12-29 | 2009-12-29 | Use of apl-type peptide for treating intestinal inflammatory diseases and type 1 diabetes |
MX2011007033A MX2011007033A (es) | 2008-12-29 | 2009-12-29 | Uso de peptido tipo apl para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i. |
US13/142,471 US8410057B2 (en) | 2008-12-29 | 2009-12-29 | Method of inducing T cell apoptosis by administering Altered Peptide Ligand |
BRPI0923832-8A BRPI0923832B1 (pt) | 2008-12-29 | 2009-12-29 | Uso de um peptídeo tipo apl para o tratamento de doenças inflamatórias intestinais e diabetes tipo 1. |
JP2011543973A JP5646506B2 (ja) | 2008-12-29 | 2009-12-29 | 腸の炎症性疾患及び1型糖尿病を治療するためのapl型ペプチドの使用 |
CN200980156252.0A CN102307587B (zh) | 2008-12-29 | 2009-12-29 | Apl肽用于治疗炎症性肠病和1型糖尿病的用途 |
ES09804226.0T ES2438096T3 (es) | 2008-12-29 | 2009-12-29 | Utilización de péptidos tipo LPA para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo 1 |
ZA2011/05320A ZA201105320B (en) | 2008-12-29 | 2011-07-19 | Use of apl-type peptide for treating intestinal inflammatory diseases and type 1 diabetes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20080254A CU23701A1 (es) | 2008-12-29 | 2008-12-29 | Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
CU2008-0254 | 2008-12-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010075824A1 true WO2010075824A1 (es) | 2010-07-08 |
Family
ID=41820665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CU2009/000009 WO2010075824A1 (es) | 2008-12-29 | 2009-12-29 | Uso de peptido tipo apl para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
Country Status (15)
Country | Link |
---|---|
US (1) | US8410057B2 (es) |
EP (1) | EP2374468B1 (es) |
JP (1) | JP5646506B2 (es) |
KR (1) | KR101620341B1 (es) |
CN (1) | CN102307587B (es) |
AU (1) | AU2009335405B2 (es) |
BR (1) | BRPI0923832B1 (es) |
CA (1) | CA2748493C (es) |
CU (1) | CU23701A1 (es) |
DK (1) | DK2374468T3 (es) |
ES (1) | ES2438096T3 (es) |
MX (1) | MX2011007033A (es) |
RU (1) | RU2524630C2 (es) |
WO (1) | WO2010075824A1 (es) |
ZA (1) | ZA201105320B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024017423A1 (es) * | 2022-07-22 | 2024-01-25 | Centro De Ingenieria Genética Y Biotecnología | Péptido para el tratamiento de enfermedades relacionadas con afectaciones en la apolipoproteina ai o la transtirretina |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018002586A (es) | 2015-09-01 | 2020-11-24 | First Wave Bio Inc | Composiciones para usarse en el tratamiento de afecciones asociadas a una repsuesta inflamatoria anómala. |
CU24508B1 (es) | 2017-12-29 | 2021-04-07 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición farmacéutica que comprende péptido tipo apl |
US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
CU20200026A7 (es) * | 2020-04-13 | 2021-11-04 | Ct Ingenieria Genetica Biotecnologia | Péptido para el tratamiento del síndrome de la tormenta de citocinas |
CN117883547A (zh) * | 2021-07-30 | 2024-04-16 | 河北菲尼斯生物技术有限公司 | Se-dr亲和肽在制备治疗风湿疾病的药物中的用途 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997001959A1 (en) * | 1995-06-30 | 1997-01-23 | Yeda Research And Development Co. Ltd. | Novel peptides derived from human heat shock protein 60 for treatment of diabetes, compositions, methods and kits |
WO2001043691A2 (en) * | 1999-12-15 | 2001-06-21 | Peptor Ltd. | Fragments and antagonists of heat shock protein 60 |
WO2006032216A2 (es) | 2004-09-24 | 2006-03-30 | Centro De Ingenieria Genetica Y Biotecnologia | Peptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8003A (en) * | 1851-03-25 | Improvement in scythe-tastenings | ||
CZ293784B6 (cs) * | 1994-12-21 | 2004-07-14 | Yeda Research And Development Co. Ltd. | Analog peptidu p277, farmaceutický přípravek, který ho obsahuje pro léčení nebo diagnózu diabetu |
US6180103B1 (en) * | 1994-12-21 | 2001-01-30 | Yeda Research And Development Co., Ltd. | Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes |
US6110746A (en) * | 1995-06-30 | 2000-08-29 | Yeda Research And Development Co. Ltd. | Peptides derived from human heat shock protein 60 for treatment of diabetes, compositions, methods and kits |
EP1687423A4 (en) * | 2003-11-24 | 2007-04-18 | Yeda Res & Dev | HSP60 PEPTIDE FRAGMENT-ENCODING DNA VACCINES FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
-
2008
- 2008-12-29 CU CU20080254A patent/CU23701A1/es unknown
-
2009
- 2009-12-29 KR KR1020117017870A patent/KR101620341B1/ko active IP Right Grant
- 2009-12-29 DK DK09804226.0T patent/DK2374468T3/da active
- 2009-12-29 CN CN200980156252.0A patent/CN102307587B/zh active Active
- 2009-12-29 JP JP2011543973A patent/JP5646506B2/ja active Active
- 2009-12-29 US US13/142,471 patent/US8410057B2/en active Active
- 2009-12-29 CA CA2748493A patent/CA2748493C/en active Active
- 2009-12-29 RU RU2011131872/15A patent/RU2524630C2/ru active
- 2009-12-29 ES ES09804226.0T patent/ES2438096T3/es active Active
- 2009-12-29 EP EP09804226.0A patent/EP2374468B1/en active Active
- 2009-12-29 WO PCT/CU2009/000009 patent/WO2010075824A1/es active Application Filing
- 2009-12-29 MX MX2011007033A patent/MX2011007033A/es active IP Right Grant
- 2009-12-29 BR BRPI0923832-8A patent/BRPI0923832B1/pt active Search and Examination
- 2009-12-29 AU AU2009335405A patent/AU2009335405B2/en not_active Ceased
-
2011
- 2011-07-19 ZA ZA2011/05320A patent/ZA201105320B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997001959A1 (en) * | 1995-06-30 | 1997-01-23 | Yeda Research And Development Co. Ltd. | Novel peptides derived from human heat shock protein 60 for treatment of diabetes, compositions, methods and kits |
US6682897B1 (en) | 1995-06-30 | 2004-01-27 | Yeda Research And Development Co. Ltd. | Peptides derived from human heat protein 60 for treatment of diabetes, compositions, methods and kits |
WO2001043691A2 (en) * | 1999-12-15 | 2001-06-21 | Peptor Ltd. | Fragments and antagonists of heat shock protein 60 |
WO2006032216A2 (es) | 2004-09-24 | 2006-03-30 | Centro De Ingenieria Genetica Y Biotecnologia | Peptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
EP1803732A2 (en) * | 2004-09-24 | 2007-07-04 | Centro De Ingenieria Genetica Y Biotecnologia (Cigb) | Peptides and apl-type derivatives of hsp60 and pharmaceutical compositions |
Non-Patent Citations (30)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2024017423A1 (es) * | 2022-07-22 | 2024-01-25 | Centro De Ingenieria Genética Y Biotecnología | Péptido para el tratamiento de enfermedades relacionadas con afectaciones en la apolipoproteina ai o la transtirretina |
Also Published As
Publication number | Publication date |
---|---|
RU2524630C2 (ru) | 2014-07-27 |
DK2374468T3 (da) | 2013-12-09 |
ES2438096T3 (es) | 2014-01-15 |
KR20110119677A (ko) | 2011-11-02 |
CA2748493C (en) | 2017-08-22 |
BRPI0923832B1 (pt) | 2019-09-24 |
EP2374468B1 (en) | 2013-09-11 |
US20120035106A1 (en) | 2012-02-09 |
CU23701A1 (es) | 2011-09-21 |
JP5646506B2 (ja) | 2014-12-24 |
RU2011131872A (ru) | 2013-02-10 |
CN102307587B (zh) | 2014-04-30 |
AU2009335405A1 (en) | 2011-08-25 |
BRPI0923832A2 (pt) | 2015-07-21 |
AU2009335405B2 (en) | 2013-07-18 |
MX2011007033A (es) | 2011-07-20 |
US8410057B2 (en) | 2013-04-02 |
KR101620341B1 (ko) | 2016-05-12 |
EP2374468A1 (en) | 2011-10-12 |
JP2012514013A (ja) | 2012-06-21 |
CN102307587A (zh) | 2012-01-04 |
ZA201105320B (en) | 2012-04-25 |
CA2748493A1 (en) | 2010-07-08 |
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