WO2010059997A1 - Système commandé par ordinateur pour la fourniture d'énergie laser à la rétine - Google Patents

Système commandé par ordinateur pour la fourniture d'énergie laser à la rétine Download PDF

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Publication number
WO2010059997A1
WO2010059997A1 PCT/US2009/065421 US2009065421W WO2010059997A1 WO 2010059997 A1 WO2010059997 A1 WO 2010059997A1 US 2009065421 W US2009065421 W US 2009065421W WO 2010059997 A1 WO2010059997 A1 WO 2010059997A1
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WIPO (PCT)
Prior art keywords
image
retina
spots
laser
real
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PCT/US2009/065421
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English (en)
Inventor
Henry Hacker
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Government Of The United States Of America, As Represented By The Secretary Of The Army
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Priority to US13/130,380 priority Critical patent/US8433117B2/en
Publication of WO2010059997A1 publication Critical patent/WO2010059997A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00844—Feedback systems
    • A61F2009/00851—Optical coherence topography [OCT]

Definitions

  • the present invention is in the field of computer controlled systems for laser energy delivery to the retina.
  • Ness "Accidental bilateral Q-switched neodymium laser exposure: Treatment and recovery of visual function," SPIE 3254, pp. 80-89 (1998).
  • SPIE 3254 Treatment and recovery of visual function
  • SPIE 3254 pp. 80-89 (1998).
  • the development of subretinal neovascular membranes represents one of the most vision threatening complications of laser injury.
  • An embodiment of the invention provides a computer controlled system for laser energy delivery to the retina. More specifically, a method according to an embodiment of the invention captures a diagnostic image of a retina having at least one lesion, wherein the lesion includes a plurality of spots to be treated. Information is received from a user interface, wherein the information includes a duration, intensity, and/or wavelength of treatment for each of the spots. The position and/or size of the spots are determined automatically using an indicator dye locator and/or manually using the user interface. A real-time image of the retina is captured using eye tracking and/or image stabilization techniques. A composite image is created by linking the diagnostic image to the real-time image.
  • At least one updated real-time image of the retina is obtained using eye tracking and/or image stabilization software; and, an annotated image is created by modifying the composite image based on the updated real-time image.
  • a localized laser beam is delivered to each of the spots according to the information, the composite image, and the annotated image.
  • a device includes a retinal imager for capturing a diagnostic image of a retina having at least one lesion, wherein the lesion includes a plurality of spots to be treated.
  • the retinal imager also captures a real-time image and updated real-time images of the retina using eye tracking and/or image stabilization.
  • the indicator dye locator determines the position and/or size of each of the spots.
  • a user interface for receiving information.
  • the information includes a duration, intensity, and/or wavelength of treatment for each of the spots.
  • the information includes the position and/or size of each of the spots.
  • the device further includes a processor for creating a composite image by linking the diagnostic image to the real-time image.
  • the processor also creates an annotated image by modifying the composite image based on the updated real-time image.
  • a laser is provided for delivering a localized laser beam to each of the spots according to the information, the composite image, and the annotated image.
  • FIG. 1 illustrates a combination SLO/PDT (scanning laser ophthalmoscope/photodynamic therapy) laser therapy instrument
  • FIG. 2 illustrates a flow diagram illustrating operation of a computer controlled system for laser energy delivery to the retina
  • FIG. 3 illustrates an example of focal laser treatment
  • FIG. 4 illustrates an example of scatter laser sector treatment
  • FIG. 5 is a flow diagram illustrating a method according to an embodiment of the invention.
  • FIG. 6 is a schematic diagram illustrating a device according to an embodiment of the invention.
  • the basic science behind photodynamic therapy utilizes light to activate a photosensitizing parenterally administered dye that interacts with abnormal blood vessels through the formation and release of oxidizing free radicals. As a consequence of this reaction, neovascular membranes are shut down. This reduces the extension of the original laser eye injury into surrounding unaffected retinal tissue.
  • Clinical application of this device also extends to uncommon wartime cases of punctate inner choroidopathy (PIC) associated with ocular histoplasmosis syndrome, as well as conventional clinical treatment of age-related macular degeneration. From a basic research standpoint, one can compare the efficacy of hand delivery of light for dye activation to computer-assisted delivery of this therapy to improve treatment efficacy and visual outcomes.
  • PIC punctate inner choroidopathy
  • An embodiment of the invention provides a device (also referred to herein as the "system") having an interface with an existing scanning laser ophthalmoscope (also referred to herein as a "retinal imager”) to process and capture images of retinal neovascular membranes.
  • the device allows for shuttering-in of phototherapeutic laser energy to the affected tissue in real-time.
  • a user can define parameters for a specific therapeutic laser window size, intensity, and/or wavelength.
  • the device may be broadly applied to treatment of neovascular membranes that arise in the retina from a variety of other common medical conditions. For example, ocular histoplasmosis, retinal trauma, diabetic retinopathy, and age related macular degeneration may result in the formation of subretinal neovascular membranes.
  • the device uses advanced imaging modalities (optical coherence tomography (OCT) and in some embodiments wavefront corrected retinal imaging) to diagnose abnormalities, localizes neovascularization, and provides automated treatment with PDT.
  • OCT optical coherence tomography
  • the device assesses and treats choroidal neovascularization (CNV) from other causes (e.g., "wet" age related macular degeneration).
  • CNV choroidal neovascularization
  • the device in at least one embodiment manages laser-induced eye injuries and enhances ophthalmological diagnosis and treatment of other maladies at medical centers.
  • Ophthalmic imaging and an in-line PDT laser delivery system are integrated into a single device.
  • FIG. 1 illustrates a combination SLO/PDT (scanning laser ophthalmoscope/photodynamic therapy) laser therapy instrument 100.
  • Diagnostic images are captured utilizing conventional fluorescein and indocyanine green dyes. These dyes may be administered simultaneously to reduce image capture time and avoid an additional needle stick for the patient.
  • Image capture is performed by the instrument 100 (SLO) with excitation and detection wavelengths appropriate for the fluorescein and/or indocyanine green dyes.
  • the captured images are stored on a computer 1 10 for real-time review by the treating physician.
  • a processor 630 is located in the computer 110; and, a retinal imager 610 and laser 640 are located in the instrument 100.
  • Treatment images are selected on a display 112 by the medical professional and/or the system and digitally registered to the exact lesion on the stored image (CNV1 and CNV2). These lesions may include leaking microaneurysms, retinal pigment epithelial window defects, neoplasms such as capillary hemangiomas, or other tumors with the eye. If multiple treatment areas are required, each location is programmed for a specific energy level, exposure time, and treatment wavelength (in the case of a tunable treatment laser delivery system). For example, Table 1 illustrates a treatment plan for use with the instrument 100 for the lesions illustrated on the display 112.
  • the physician may initiate treatment by activation of a footpedal, joystick, or other control mechanism.
  • Each lesion will be treated according to a preprogrammed sequence, e.g., each location is programmed for a specific energy level, exposure time, and treatment wavelength as provided for in the treatment plan. Treatment may proceed smoothly from lesion to lesion as long as the control mechanism is activated. Alternatively, treatment may be activated with audio prompting from the computer 110 in stepwise fashion.
  • the physician may interrupt or resume treatment at any time during the therapeutic laser application.
  • the control mechanism may be programmed to permit shifting treatment to the next or prior lesion in the programmed sequence.
  • another series of retinal images may be captured as necessary with or without dye enhancement.
  • FIG. 2 illustrates a flow diagram of a method according to an embodiment of the invention.
  • a diagnostic image of a retina having at least one lesion is captured, where the lesion includes a plurality of spots to be treated (210).
  • diagnostic images are captured utilizing conventional fluorescein and indocyanine green dyes. These dyes may be administered simultaneously to reduce image capture time and avoid an additional needle stick for the patient.
  • Image capture is performed by the SLO device with excitation and detection wavelengths appropriate for the fluorescein and indocyanine green dyes.
  • Information is received from a user interface, wherein the information includes a duration, intensity, and/or wavelength of treatment for each of the spots (220).
  • each location is programmed for a specific energy level, exposure time, and treatment wavelength (in the case of a tunable treatment laser delivery system).
  • Table 1 illustrates a treatment plan for use with the instrument 100.
  • the position and/or size of the spots are determined automatically using an indicator dye locator and/or manually using the user interface.
  • the computer 1 10 includes indicator dye locator software for identifying abnormal vessels on the diagnostic image that are stained by indicator dye.
  • a treatment plan can be mapped out on the diagnostic image using a mouse or other suitable pointing device.
  • a real-time image of the retina is captured using an eye tracking and/or image stabilization system (230); and, a composite image is created by linking the diagnostic image to the real-time image (240).
  • the treatment plan that was mapped out on the diagnostic image is linked to an instrument that locks on to the retina using eye tracking and image stabilization so that the real-time view is aligned to the previously registered diagnostic image and treatment plan.
  • At least one updated real-time image of the retina is obtained using eye tracking and/or image stabilization (250).
  • an annotated image is created by modifying the composite image based on the updated real-time image (260).
  • a localized laser beam is delivered to each of the spots according to the information and the composite image (270).
  • the physician may interrupt or resume treatment at any time during therapeutic laser application.
  • the control mechansim may be programmed to permit shifting treatment to the next or prior lesion in the programmed sequence.
  • another series of retinal images may be captured as necessary with or without dye enhancement.
  • FIG. 3 is a flow diagram illustrating operation of a computer controlled system for laser energy delivery to the retina, wherein a diagnostic image is captured and stored in digital storage (310).
  • diagnostic images are captured utilizing conventional fluorescein and indocyanine green dyes.
  • Image capture is performed by the SLO device with excitation and detection wavelengths appropriate for the dyes.
  • a real-time image is also captured (320) and sent to a real-time image detector/comparator (330).
  • Lesion mapping with laser parameters is performed (340).
  • the user can specify laser parameters, such as position and size of spots to be treated on the retina, and duration, intensity, and wavelength of laser treatment.
  • a composite image with a laser tracking map is created (350) using the stored diagnostic image, the image from the real-time image detector/comparator, and the lesion mapping performed in 340.
  • the composite image remains static and does not change throughout diagnosis and laser delivery.
  • updated real-time images are captured and compared to the composite image to detect eye movement.
  • the composite image is sent to the real-time image detector/comparator, wherein the composite image is compared to updated real-time images of the retina.
  • a tracking signal is sent to a laser treatment driver from the real-time image detector/comparator (360).
  • the laser treatment driver is used by the system to administer PDT to the retina.
  • the laser treatment driver also obtains a laser positioning signal from the composite image.
  • an annotated image is created by modifying the composite image so that laser treatment is delivered according to parameters as shown on the annotated composite image.
  • a control interface is used to capture the real-time images (370).
  • the control interface receives input from the operator of the device (380) and the laser treatment driver.
  • the patient With the patient positioned at the diagnostic and therapeutic SLO 100, registration of the live (real-time) retinal image is obtained and correlated with the stored image data using image tracking and stabilization software. Once lock-on is achieved, the physician may initiate treatment by activation of the control mechanism.
  • FIG. 4 illustrates another example of focal laser treatment. Each spot 1-10 is planned on the diagnostic image. Treatment parameters are shown in the Table 2.
  • FIG. 5 illustrates an example of scatter laser sector treatment. Each spot is identified on the diagnostic image. Treatment parameters for blue spot group 510 (smaller spots in upper right of cluster) and green spot group 520 (larger spots on left side of cluster) are shown in Table 3.
  • the device is employed for computer assisted delivery of laser treatment for PDT.
  • PDT involves light activation of a photosensitizing dye that on laser exposure promotes the release of charged molecules that cause blood flow to stop in abnormal vascular beds (neovascular membranes).
  • a treatment plan is mapped out on a diagnostic image using a mouse or other suitable pointing device. This map is then linked to an instrument that locks on to the retina using eye tracking and image stabilization so that the realtime view is aligned to the previously registered diagnostic image and treatment plan.
  • eye tracking Many of the details of eye tracking are well-known and are not discussed herein in detail so as to focus the reader on the salient portions of the invention. Instead, reference is made to U.S. Patent Nos. 5, 106, 184 to Milbocker and 6,325,512 to Wei for the description of such details.
  • the Milbocker patent features a retinal blood flow velocimeter that projects an illumination beam through a steering system onto a retinal vessel, and forms a separate tracking image back through the steering system.
  • a fast tracking loop detects motion of the tracking image and moves the steering system to null image motion and keep the illumination beam centered on the vessel.
  • the beam is reflected from the vessel, picked up by detectors at two fixed angles, and processed by spectral analysis.
  • the illumination beam and the steering system follow entirely separate paths through the steering system.
  • Fiber optics translate the collected Doppler light without dispersion while preserving phase relationships, and absolute dimensions are determined from the image tracking electronics.
  • a processor then computes volumetric blood flow which it compares with normative data.
  • the Wei patent features an optical coherence tomography ("OCT") application apparatus that performs an OCT application on an object.
  • the OCT application apparatus includes an OCT scanning apparatus which outputs a beam of OCT scanning radiation and an active tracking system that generates and projects a beam of tracking radiation onto a region including a reference tracking feature, which active tracking system includes a tracking optical system that is disposed to intercept the beam of tracking radiation and the beam of OCT scanning radiation.
  • the active tracking system of Wei analyzes tracking radiation reflected from the region to detect movement of the object, and to generate a tracking signal which directs the tracking optical system to follow the movement of the object.
  • the OCT application comprises forming an OCT scan image of the object, for example and without limitation, a retina of an eye.
  • the physician may initiate treatment.
  • the application of treatment laser energy may be interrupted by the operator at will or by the instrument in the event of loss of eye tracking or loss of correspondence with the registered image (i.e., diagnostic image). Completion of treatment is resumed when the operator and/or instrument have realigned the patient.
  • the instrument retains a record of how much treatment has been applied to specific retinal locations to facilitate accurate resumption of therapy.
  • the computer guided application of light may be extended to the activation of retinal drugs delivered in an encapsulate such as a liposome or employment of other molecules which are light activated that have a therapeutic effect within the area of interest of laser illuminated tissue.
  • the device allows for rapid and precise placement of PDT.
  • High performance digital image processing and tracking coupled with computer controlled delivery of laser treatment is provided.
  • the use of treatment mapping on digital imagery allows for precise localization of treatment application to a specific area of the retina.
  • An embodiment of the invention uses computer guidance for the precise application of laser delivery to the retina in which the position, energy level, and duration of laser treatment are controlled spot by spot rather than a non-specific uniform energy level grid pattern.
  • the delivery of laser energy may also be performed in a continuous raster application, again with beam intensity and dwell time modified as necessary at any given place in the raster epoch.
  • FIG. 6 is a schematic diagram illustrating a system 600 according to an embodiment of the invention.
  • the system 600 includes a retinal imager 610 for capturing a diagnostic image of a retina having at least one lesion, wherein the lesion includes a plurality of spots to be treated.
  • the retinal imager 610 also captures a real-time image and updated real-time images of the retina using eye tracking and/or image stabilization.
  • the eye tracking determines the position and/or size of each of the spots.
  • a user interface 620 is provided for receiving information.
  • the information includes a duration, intensity, and/or wavelength of treatment for each of the spots.
  • the information includes the position and/or size of each of the spots.
  • computer guidance is used for the precise application of laser delivery to the retina in which the position, energy level, and duration of laser treatment are controlled spot by spot rather than a non-specific uniform energy level grid pattern.
  • the device further includes a processor 630 for creating a composite image by linking the diagnostic image to the real-time image.
  • a processor 630 for creating a composite image by linking the diagnostic image to the real-time image.
  • registration of the live (real-time) retinal image is obtained with the stored image data using image tracking and stabilization.
  • the processor 630 also creates an annotated image by modifying the composite image based on the updated real-time image.
  • the processor 630 is located in the computer 110.
  • a laser 640 is provided for delivering a localized laser beam to each of the spots according to the information, the composite image, and the annotated image.
  • the delivery of laser energy may be performed in a continuous raster application, with beam intensity and dwell time modified as necessary at any given place in the raster epoch.
  • an indicator dye locator is also provided for determining the position and/or size of the spots.
  • the retinal imager 610 and laser 640 are located in the instrument 100.
  • the invention can be utilized in a variety of settings to provide accurate imaging, diagnosis and treatment of lesions on a retina by accurately delivering laser energy to particular parts of the retina. For example, a physician wishing to image and treat lesions on a patient's retina would benefit by being able to compare a contemporaneous image of the lesions with previously taken images of the patient's retina prior to delivering laser energy. Also the invention can be used to diagnose and identify abnormal neovascular membranes in real-time, capture the precise location of the affected retinal tissue, and utilize the same optical pathway to precisely apply therapeutic photodynamic therapy.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)
  • Laser Surgery Devices (AREA)

Abstract

Un mode de réalisation de l'invention propose un procédé qui saisit une image de diagnostic d'une rétine qui présente au moins une lésion, la lésion comprenant plusieurs taches à traiter. L'information est reçue par une interface d'utilisateur, l'information incluant la durée, l'intensité et/ou la longueur d'onde du traitement pour chacune des taches. Une image en temps réel de la rétine est saisie et une image composite est créée en reliant l'image de diagnostic à l'image en temps réel. Au moins une image de la rétine mise à jour en temps réel est obtenue en utilisant un suivi de l'oeil et/ou une stabilisation d'image et une image annotée est créée en modifiant l'image composite sur la base de l'image mise à jour en temps réel. Un faisceau laser localisé est délivré sur chacune des taches en fonction de l'information, de l'image composite et de l'image annotée.
PCT/US2009/065421 2008-11-21 2009-11-21 Système commandé par ordinateur pour la fourniture d'énergie laser à la rétine WO2010059997A1 (fr)

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US11693108P 2008-11-21 2008-11-21
US61/116,931 2008-11-21

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US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics

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