WO2010058272A2 - Extraits de cosmétiques pouvant être obtenus de légumes de la famille des apiacées et notamment de racines pivotantes de carottes - Google Patents

Extraits de cosmétiques pouvant être obtenus de légumes de la famille des apiacées et notamment de racines pivotantes de carottes Download PDF

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Publication number
WO2010058272A2
WO2010058272A2 PCT/IB2009/007509 IB2009007509W WO2010058272A2 WO 2010058272 A2 WO2010058272 A2 WO 2010058272A2 IB 2009007509 W IB2009007509 W IB 2009007509W WO 2010058272 A2 WO2010058272 A2 WO 2010058272A2
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WO
WIPO (PCT)
Prior art keywords
dependent
sections
root
vegetables
carrot
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Application number
PCT/IB2009/007509
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English (en)
Other versions
WO2010058272A3 (fr
Inventor
Daniel Dizer
Rafael Alon
Yossef Kanner
Original Assignee
Yoffi Agshach Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoffi Agshach Ltd. filed Critical Yoffi Agshach Ltd.
Publication of WO2010058272A2 publication Critical patent/WO2010058272A2/fr
Publication of WO2010058272A3 publication Critical patent/WO2010058272A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/10—Apiaceae or Umbelliferae [Carrot family], e.g. parsley, caraway, dill, lovage, fennel or snakebed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Definitions

  • the family comprises various identified members, such as ((E,3R,8S)-Heptadeca-l,9-dien-4,6- diyne-3,8-diol) falcarindiol (FDOL); (l,9-heptadecadiene-4,6-diyn-3-ol) falcarinol (FOL); falcarindiol 3 -acetate, «-O-methylfalcarindiol, such as 3-O-methylfalcarindiol or 8-0- methylfalcarindiol etc, and derivatives thereof.
  • FDOL ((E,3R,8S)-Heptadeca-l,9-dien-4,6- diyne-3,8-diol) falcarindiol
  • FOL falcarinol
  • falcarindiol 3 -acetate «-O-methylfalcarindiol, such as 3-O-methylfalcarindiol or 8-0- methylfalcarindiol etc, and
  • US5455278 discloses food preservatives, pharmaceutical compositions and production method thereof, useful for inhibiting gram-positive bacteria, especially Listeria, Clostridium botulinum and Staphylococcus aureus in a food medium or other medium which comprises a chemical derivative of FDOL in an amount which is safe and effective to inhibit any such gram-positive bacteria which may be present in the medium.
  • the FDOL is obtained by a two- steps solvent extraction process, in which whole carrot roots are effectively contacted with solvents selected from hexane, petroleum ether, ethyl acetate, methylene chloride and ethanol.
  • Extracts obtained from shredded whole carrot taproot were demonstrated to have overall weak bactericide properties.
  • Hao et al. Food Microb., 1998, 15, 367-378
  • Glisic et al. Food Chem., 2007, 105, 346-352
  • MIC minimum inhibition concentration
  • super-critical carbon dioxide treatment of the extract provides selective biocidic properties, i.e., higher activity towards Gram-positive bacteria compared to Gram-negative bacteria.
  • the biocidic effect towards Bacillus subtilis was more than 15 times higher than towards E. coli.
  • US5455278 also teaches that FDOL-containing carrot extract are innocuous to Gram-negative bacteria such as Salmonella typhimurium and Escherichia coli.
  • Gram-negative bacteria such as Salmonella typhimurium and Escherichia coli.
  • Babic et al. (J. Appl. Bacter. 1994, 75, 135-141) found that purified whole carrot extract was 1,000 to 10,000 times more active biocide against Gram-positive bacteria (Leuconostoc mesenteroides, Staphylococcus aureus, and Listeria monocytogenes) than against Gram- negative bacteria (E. coli and Pseudomonas fluorescens).
  • Literature suggests well targeted use of polyacetylenes, especially FDOL and FOL in treating humans, especially in decreasing lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells (See Metzger et al., J. Agrc. Food Chem., 2008, 56, 3554-3560). Polyacetylenes have also found specific importance in inhibition of the mutagenicity of 2-nitrofluorene and 3-nitrofluoranthene (See Tang et al., Food Chem. Toxi., 1997, 35, 373-378), and antiproliferation activity of cancer cell (See Netzel et al., Inno., Food Sci. Emer.
  • deodorants are applied to the body, particularly the armpits, .
  • a subgroup of deodorants are "antiperspirants", which prevent odor and reduce sweat produced by parts of the body.
  • Aluminium chloride, aluminium chlorohydrate, and aluminium-zirconium compounds are the most widely used antiperspirants. Nevertheless, aluminum has been established as a neurotoxin, and an increased amount of aluminum was found in the brains of many Alzheimer's patients. Moreover, particular substances in deodorants, such as preservatives called parabens, or salts such as aluminum chloride used in antiperspirants, get into the bloodstream or accumulate in breast tissue, where they enhance or emulate the effects of estrogen, which stimulates the growth of cancerous breast cells. A connection between deodorants and renal dysfunction was also suggested. [13] A natural -bome non-toxic and non-irritant effective deodorant for eliminating or otherwise inhibiting fermenting bacteria is thus a long felt need.
  • the present invention relates to a cosmetic composition
  • a cosmetic composition comprising a cosmetically acceptable ingredient extractable from predetermined sections of Apiaceae vegetables' root, said ingredient is characterized by inhibiting effect towards pathogenic microorganisms located inside the body of a patient .
  • a ⁇ -carotene free cosmetic composition based on the cosmetically acceptable ingredient is disclosed.
  • the invention relates also to a use of a cosmetic composition based one the cosmetically acceptable ingredient in either human or animal
  • the cosmetic composition concerned may be adapted for applying dermally either in a continuous or non-continuous manner.
  • the cosmetic composition according the present invention comprise at least one additive selected from a group consisting of anti-infectives, antimicrobials, prebiotics, probiotics, acidif ⁇ ers, antivirals, antibiotics, markers, biomarkers, dyes, pigments, radio-labeled materials, glues, adhesives, lubricants, nutrients, peptides, amino acids, polysaccharides, enzymes, hormones, chelators, multivalent ions, emulsifying or de-emulsifying agents, binders, fillers, thickfiers, factors, co-factors, anticaries agents, anticellulites, antidandruff, antifungal, anti- inflammatories, anti-irritants, antimicrobials, antioxidants, astringents, antiperspirants, antiseptics, antistatic agents, binders, buffers, additional carriers, chelators, cell stimulants, cleansing agents, conditioners, deodorants, depilatories, detergents, dispersants
  • the predetermined sections of the root of Apiaceae vegetables from which the cosmetically acceptable ingredient is extractable are selected either from (i) the pericyclic parenchyma, or from (U) the phloem part, close to the secondary cambium, or a combination thereof.
  • the predetermined sections of the root of Apiaceae vegetables from which the cosmetically acceptable ingredient is extractable include the xylem.
  • the predetermined sections of the root of Apiaceae vegetables from which the cosmetically acceptable ingredient is extractable include either its fiber-containing sections or from its fibrous sections .
  • predetermined sections of the root of Apiaceae vegetables from which the cosmetically acceptable ingredient is extractable may include in its various embodiments colored sections, or pigment-containing sections selected in a non-limiting manner from a group consisting of carotenes, chlorophylls, carotenoids, flavonoids and phytochrome.
  • the Apiaceae vegetables from which the cosmetically acceptable ingredient can be obtained are selected from carrot, celery, fennel, parsley, parsnip
  • the Apiaceae vegetables are carrot (Daucus carota L) taproots.
  • an effective measure of at least one polyacetylene compound is included as a means for providing Gram-positive bacteria inhibition property, thereby adjusting the selectivity (S) of the composition to a desirable value, e.g. 1.1, or e.g. 8.
  • the polyacetylene is selected from a group consisting of ((E,3R,8S)- Heptadeca-l,9-dien-4,6-diyne-3,8-diol) falcarindiol; (l,9-heptadecadiene-4,6-diyn-3-ol 1,9- heptadecadiene-4,6-diyn-3-ol) falcarinol; falcarindiol 3-acetate, n-0-methylfalcarindiol, especially 3-O-methylfalcarindiol or 8-O-methylfalcarindiol, or any mixture thereof.
  • a method of providing skin, nails and/or hair care is also within the scope of the present invention, the method comprise inhibiting topical pathogenic contaminations of microorganisms in a patient, by (a) obtaining at least one composition comprising a cosmetically acceptable ingredient from predetermined sections of Apiaceae vegetables' root and, (b) topically introducing an effective dose of said cosmetic to the skin, nails or hair of either a human or animal patient.
  • topical introduction of the cosmetic may be provided by a means of an applicator or effecter,.
  • Said applicator or effecter may be for example either a rigid or a non-rigid brush, pad, spray of fluids.
  • the method according to the present invention further comprise in various of its embodiments admixing or otherwise adding the cosmetic at least one additive.
  • Such at least one additive may include anti-infectives, antimicrobials, prebiotics, probiotics, acidifiers, antivirals, antibiotics, markers, biomarkers, dyes, pigments, radio-labeled materials, glues, adhesives, lubricants, nutrients, peptides, amino acids, polysaccharides, enzymes, hormones, chelators, multivalent ions, emulsifying or de-emulsifying agents, binders, fillers, thickfiers, factors, co-factors, anticaries agents, anticellulites, antidandruff, antifungal, anti- inflammatories, anti-irritants, antimicrobials, antioxidants, astringents, antiperspirants, antiseptics, antistatic agents, binders, buffers, additional carriers, chelators, cell stimulants, cleansing agents, conditioners, deodorants, depilatories, detergents, dispersants, emollients, emulsifiers, enzymes, essential oils,
  • the predetermined sections of the root of Apiaceae vegetables from which the cosmetically acceptable ingredient is extracted are from either (i) the pericyclic parenchyma, (H) the phloem part, close to the secondary cambium, or a combination thereof.
  • the method comprise selecting predetermined sections of the root of Apiaceae vegetables from the xylem sections for extracting the cosmetically acceptable ingredient thereof.
  • the method comprise selecting the predetermined sections of the root of Apiaceae vegetables from its fiber-containing sections or from its fibrous sections for extracting the cosmetically acceptable ingredient thereof.
  • the method comprise selecting the predetermined sections of the root of Apiaceae vegetables from its colored sections or pigment-containing sections (e.g. sections comprising carotenes, chlorophylls, carotenoids, flavonoids and phytochrome).
  • sections or pigment-containing sections e.g. sections comprising carotenes, chlorophylls, carotenoids, flavonoids and phytochrome.
  • the Apiaceae vegetables are selected from a group consisting of carrot, celery, fennel, parsley, parsnip, or any combination of the same.
  • the Apiaceae vegetables are of one or more species and types of carrot (Daucus carota L) taproots.
  • the method according to the invention further provides for selectively inhibiting Gram- negative bacteria contaminating a medium while significantly less inhibiting Gram-positive bacteria in the medium.
  • the method may also comprise obtaining at least one polyacetylene compound from predetermined sections of the root of Apiaceae vegetables, useful for adjusting the selectivity ratio of the cosmetic composition, e.g. to a selectivity (S) between 1.1 and 10.
  • the invented method further concerns extracting outer sections of the root of Apiaceae vegetables by means of at least one first solvent until a final extract is obtained.
  • the method comprises a step of evaporating the extract in a manner that at least a portion of the at least one first solvent is eliminated from the final condensate product.
  • At least one step of re-extracting the obtained condensate by means of at least one second solvent may be a part of the method in yet further embodiments.
  • Re-evaporating the at least one second extract until a dry condensate final product is obtained may be included in the method as well.
  • the at least one first solvent is selected from a group of polar solvents, dipolar aprotic solvents, volatile solvents, water-miscible diluents, organic solvents with high dielectric constants (6.0-9.0), non-polar solvents (hexane, petroleum ether), extractants or any mixtures of the same.
  • Said at least one first solvent may comprise one or more of the following groups: Group A comprising at least one polar solvent; Group B comprising at least one dipolar solvent; and Group C comprising at least one non-polar solvent.
  • Group A comprises a first polar solvent and second polar solvent, the volume ratio between the first and second polar solvents ranging from 1 : 10 to 10: 1 (v/v).
  • B comprises a first bipolar solvent and second bipolar solvent, the volume ratio between the first and second bipolar solvents ranging from 1 :15 to 15:1 (v/v).
  • Group C comprises a first non-polar solvent and second non-polar solvent, the volume ratio between the first and second polar solvents ranging from 1 : 12 to 12: 1 (v/v).
  • the volume ratio between Group A to B is ranging from 1 :100 to 100:1 (v/v); wherein the volume ratio between Group B to C is ranging from 1 : 100 to 100:1 (v/v); and further wherein the volume ratio between Group A to C is ranging from 1 :100 to 100: 1 (v/v).
  • volume ratio between Group A to B is ranging from 1 :50 to 20:1 (v/v); wherein the volume ratio between Group B to C is ranging from 1:10 to 10:1 (v/v); and further wherein the volume ratio between Group A to C is ranging from 1 :50 to 15:1 (v/v).
  • the volume ratio between Group A, B and C is from 1 : 1 : 1 to 100: 10: 1 (v/v/v), respectively.
  • the invention further relates to cosmetics according to the description, characterized in both a proven inhibiting effect towards pathogenic microorganisms located inside the body of a patient and a therapeutic added value.
  • the cosmetic according to the invention may provide for treating acne by inhibiting Gram- positive Propionibacterium acnes bacteria.
  • a preparation of (i) oral rinse (ii) skin cleanser (iii) soap (e.g., toilet soap, laundry soap) (iv) shampoo (v) tooth brush paste comprising the cosmetic disclosed are also included in the scope of the present invention. .
  • the solvents were denoted by three different groups: Group A comprising at least one polar solvent; Group B comprising at least one dipolar solvent; and Group B comprising at least one non-polar solvent.
  • Group A comprising at least one polar solvent
  • Group B comprising at least one dipolar solvent
  • Group B comprising at least one non-polar solvent.
  • Various mixtures were tested, whereas combinations of volatile organic solvents with high dielectric constants (6.0-9.0) in acidic conditions and elevated temperature were found effective. Biocidal activity of the extract has been found unaffected (or at least nondestructively affected) by these conditions.
  • a zone inhibition assay was conducted to test the susceptibility of a species of microorganisms according to the diffusion agar assay (DAA) method.
  • DAA diffusion agar assay
  • Table 1 was obtained.
  • the term 'Body' refers to the carrot taproot inner section, whereas the term 'Peel' refers to the carrot taproot external sections as defined in the present invention.
  • solvents refers to extraction of either the body or peel sections by a solvent mixture, and the term water refers to similar systems whereat the sections were contacted with a water phase.
  • selectivity value (S) of the biocide defined as the ratio of
  • Gram-positive bacteria e.g., P. ph ⁇ seoli
  • the measure of its ability in inhibiting Gram-negative bacteria e.g., H. pylori
  • a deodorant simulating system made of carrot extract was produced according to the methods detailed in Example II.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

L'invention porte sur des produits cosmétiques qui s’utilisent à la fois pour les humains et les animaux et qui comportent des extraits pouvant être obtenus des sections interne et/ou externe de la racine de légumes de la famille des Apiacées, les sections externes étant choisies parmi (i) le parenchyme péricyclique et (ii) la partie de phloème, proche du cambium secondaire, de racines pivotantes de carottes. La présente invention concerne également des procédés qui produisent les produits cosmétiques et des procédés naturels pour traiter la peau, les cheveux, les poils et les ongles des humains et des animaux.
PCT/IB2009/007509 2008-11-19 2009-11-19 Extraits de cosmétiques pouvant être obtenus de légumes de la famille des apiacées et notamment de racines pivotantes de carottes WO2010058272A2 (fr)

Applications Claiming Priority (2)

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US11593708P 2008-11-19 2008-11-19
US61/115,937 2008-11-19

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WO2010058272A2 true WO2010058272A2 (fr) 2010-05-27
WO2010058272A3 WO2010058272A3 (fr) 2010-07-15

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9554978B2 (en) 2013-06-27 2017-01-31 The Procter & Gamble Company Personal care articles
KR101776073B1 (ko) * 2010-10-26 2017-09-19 (주)아모레퍼시픽 파이토크롬을 함유하는 메이크업 화장료 조성물
US10480851B2 (en) 2013-03-15 2019-11-19 Chart Energy & Chemicals, Inc. Mixed refrigerant system and method
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
US11110049B2 (en) 2017-06-23 2021-09-07 The Procter & Gamble Company Composition and method for improving the appearance of skin
US11583488B2 (en) 2020-06-01 2023-02-21 The Procter & Gamble Company Method of improving penetration of a vitamin B3 compound into skin
US11622963B2 (en) 2018-07-03 2023-04-11 The Procter & Gamble Company Method of treating a skin condition

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US5455278A (en) 1994-09-19 1995-10-03 Wisconsin Alumni Research Foundation Method of inhibiting pathogens and food spoilage bacteria
US20060193819A1 (en) 2001-11-09 2006-08-31 Michelle Lu Topical cosmetic composition with skin rejuvenation benefits

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IT1271342B (it) * 1994-12-28 1997-05-27 Indena Spa Proteine ricche in idrossiprolina e formulazioni farmaceutiche e cosmetiche che le contengono
GB0405545D0 (en) * 2004-03-12 2004-04-21 Univ Manchester Antimicrobial composition

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US5455278A (en) 1994-09-19 1995-10-03 Wisconsin Alumni Research Foundation Method of inhibiting pathogens and food spoilage bacteria
US20060193819A1 (en) 2001-11-09 2006-08-31 Michelle Lu Topical cosmetic composition with skin rejuvenation benefits

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BARANSKA ET AL., ANALYST, vol. 130, 2005, pages 855 - 859
BRANDT ET AL., TREN. FOOD SCI. TECH., vol. 15, 2004, pages 384 - 393
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101776073B1 (ko) * 2010-10-26 2017-09-19 (주)아모레퍼시픽 파이토크롬을 함유하는 메이크업 화장료 조성물
US10480851B2 (en) 2013-03-15 2019-11-19 Chart Energy & Chemicals, Inc. Mixed refrigerant system and method
US9554978B2 (en) 2013-06-27 2017-01-31 The Procter & Gamble Company Personal care articles
US9907738B2 (en) 2013-06-27 2018-03-06 The Procter & Gamble Company Personal care compositions and articles
US10357441B2 (en) 2013-06-27 2019-07-23 The Procter & Gamble Company Personal care articles
US11090244B2 (en) 2013-06-27 2021-08-17 The Procter & Gamble Company Personal care compositions and articles
US11110049B2 (en) 2017-06-23 2021-09-07 The Procter & Gamble Company Composition and method for improving the appearance of skin
US11622963B2 (en) 2018-07-03 2023-04-11 The Procter & Gamble Company Method of treating a skin condition
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
US11583488B2 (en) 2020-06-01 2023-02-21 The Procter & Gamble Company Method of improving penetration of a vitamin B3 compound into skin
US11911498B2 (en) 2020-06-01 2024-02-27 The Procter & Gamble Company Low pH skin care composition and methods of using the same

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