WO2010042228A3 - Méthodes de prédiction d'évolution de maladie chez des patients souffrant d'un cancer du côlon - Google Patents

Méthodes de prédiction d'évolution de maladie chez des patients souffrant d'un cancer du côlon Download PDF

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Publication number
WO2010042228A3
WO2010042228A3 PCT/US2009/005573 US2009005573W WO2010042228A3 WO 2010042228 A3 WO2010042228 A3 WO 2010042228A3 US 2009005573 W US2009005573 W US 2009005573W WO 2010042228 A3 WO2010042228 A3 WO 2010042228A3
Authority
WO
WIPO (PCT)
Prior art keywords
projection
closure
methods
membrane
patients
Prior art date
Application number
PCT/US2009/005573
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English (en)
Other versions
WO2010042228A2 (fr
Inventor
Francis Barany
Owen Parker
Manny D. Bacolod
Sarah F. Giardina
Yu-Wei Cheng
Daniel A. Notterman
Gunter S. Schemmann
Philip B. Paty
Monib Zirvi
Original Assignee
Cornell University
University Of Medicine And Dentistry Of New Jersey
The Trustees Of Princeton University
Sloan-Kettering Institute For Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University, University Of Medicine And Dentistry Of New Jersey, The Trustees Of Princeton University, Sloan-Kettering Institute For Cancer Research filed Critical Cornell University
Priority to US13/123,689 priority Critical patent/US20110257034A1/en
Publication of WO2010042228A2 publication Critical patent/WO2010042228A2/fr
Publication of WO2010042228A3 publication Critical patent/WO2010042228A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne une méthode pour identifier des gènes qui donnent des informations relatives à un pronostic de cancer du côlon ainsi que des méthodes pour déterminer le pronostic d'un patient atteint d'un cancer du côlon en fonction des niveaux d'expression des gènes identifiés comme donnant des informations relatives à un pronostic de cancer du côlon. L'invention concerne également un groupe de 176, 71, et 101 gènes, dont le niveau d'expression donnent des informations relatives à un pronostic de cancer du côlon.
PCT/US2009/005573 2008-10-10 2009-10-13 Méthodes de prédiction d'évolution de maladie chez des patients souffrant d'un cancer du côlon WO2010042228A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/123,689 US20110257034A1 (en) 2008-10-10 2009-10-13 Methods for identifying genes which predict disease outcome for patients with colon cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10457408P 2008-10-10 2008-10-10
US61/104,574 2008-10-10

Publications (2)

Publication Number Publication Date
WO2010042228A2 WO2010042228A2 (fr) 2010-04-15
WO2010042228A3 true WO2010042228A3 (fr) 2010-05-27

Family

ID=42101142

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/005573 WO2010042228A2 (fr) 2008-10-10 2009-10-13 Méthodes de prédiction d'évolution de maladie chez des patients souffrant d'un cancer du côlon

Country Status (2)

Country Link
US (1) US20110257034A1 (fr)
WO (1) WO2010042228A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8440395B2 (en) * 2001-04-02 2013-05-14 University Of South Florida Methods of detecting and treating colon disorders
GB2494741B (en) * 2011-06-27 2013-11-06 Ambergen Inc A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery
CA2857073A1 (fr) 2011-11-28 2013-06-06 Institucio Catalana De Recerca I Estudis Avancats Methodes et trousses pour le pronostic du cancer colorectal
US20160122825A1 (en) * 2012-06-26 2016-05-05 Board Of Regents, The University Of Texas System Efficient functional genomics platform
EP2970978A4 (fr) * 2013-03-11 2016-11-02 Univ North Carolina Compositions et méthodes de ciblage de la n-acétylglucosamine transférase à liaison o et d'accélération de la cicatrisation des plaies
US10087487B2 (en) * 2014-09-09 2018-10-02 Kuwait University Method for determining risk of metastatic relapse in a patient diagnosed with colorectal cancer
JP2017538938A (ja) 2014-12-11 2017-12-28 ウイスコンシン・アルムニ・リサーチ・ファンデーション 大腸癌の検出及び処置方法
JP6551656B2 (ja) 2015-04-08 2019-07-31 シスメックス株式会社 卵巣癌に関する情報の取得方法、ならびに卵巣癌に関する情報を取得するためのマーカーおよび卵巣癌検出用キット
CN107771285A (zh) 2015-06-08 2018-03-06 阿奎尔诊断有限公司 方法
US11391744B2 (en) 2015-06-08 2022-07-19 Arquer Diagnostic Limited Methods and kits
CN105400865B (zh) * 2015-07-06 2018-10-23 中国人民解放军总医院 Tmem176a基因启动子区dna甲基化检测
CA2991868A1 (fr) * 2015-07-31 2017-02-09 Vascular Biogenics Ltd. Proteine 2 contenant le domaine de sperme motile et cancer
KR101889764B1 (ko) * 2016-07-29 2018-08-20 충남대학교 산학협력단 알비폭스 2 단백질 항체를 유효성분으로 함유하는 소화기계 암 진단용 조성물 및 키트
CN106947818B (zh) * 2017-04-11 2020-03-13 成都望路医药技术有限公司 一种诊治结肠腺癌的分子标志物
CN108562746A (zh) * 2018-04-08 2018-09-21 深圳市盛波尔生命科学技术有限责任公司 Cnpy2异构体2在结直肠癌诊断、预后、复发转移及放化疗疗效预测中的应用
CN109022257B (zh) * 2018-08-16 2021-12-31 新疆农业大学 Numb基因用于筛选哈萨克马泌乳性能的试剂盒及其应用
CA3122378A1 (fr) * 2018-11-01 2020-05-07 The Broad Institute, Inc. Identification de cancers sensibles au modulateur de pde3
US20220025465A1 (en) * 2018-11-14 2022-01-27 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing and treating cancer
CN110055330B (zh) * 2019-04-30 2022-10-11 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物stamp-ep9及其应用
WO2022053985A1 (fr) 2020-09-10 2022-03-17 Vascular Biogenics Ltd. Anticorps de protéine 2 contenant un domaine du sperme motile et leurs méthodes d'utilisation
CN114672554A (zh) * 2020-12-24 2022-06-28 复旦大学附属华山医院 一种检测肿瘤相关基因谱表达量的方法及其用途
WO2022235482A1 (fr) * 2021-05-03 2022-11-10 Rutgers, The State University Of New Jersey Immunothérapie pour une maladie intestinale inflammatoire et/ou un cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050118606A1 (en) * 2002-11-25 2005-06-02 Roth Richard B. Methods for identifying risk of breast cancer and treatments thereof
US20050287544A1 (en) * 2003-12-01 2005-12-29 Francois Bertucci Gene expression profiling of colon cancer with DNA arrays
US20070087365A1 (en) * 2005-10-07 2007-04-19 Wim Van Criekinge Methylation markers for diagnosis and treatment of ovarian cancer
US20080026415A1 (en) * 2006-07-13 2008-01-31 Rimm David L Methods for making cancer prognoses based on subcellular localization of biomarkers
US20080145313A1 (en) * 2006-08-30 2008-06-19 Genesis Research & Development Corporation Limited Compositions and Methods for the Treatment and Prevention of Neoplastic Disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT211753Z2 (it) * 1987-06-03 1989-04-07 Mira Lanza Spa Dispositivo di chiusura per flaconi per liquidi
US5188628A (en) * 1990-11-06 1993-02-23 Sandoz Ltd. Closure device for enteral fluid containers
US5782383A (en) * 1996-09-04 1998-07-21 Rexan Closures Inc. Dispensing closure for sealed enteral fluid containers
US6012596A (en) * 1998-03-19 2000-01-11 Abbott Laboratories Adaptor cap
ES1043166Y (es) * 1999-03-10 2000-12-16 Embalaplas Sa Disposicion perfeccionada de antiviolabilidad autoincorporada a tapones estructurados en vaiven.
EP1639090A4 (fr) * 2003-06-09 2008-04-16 Univ Michigan Compositions et methodes de traitement et de diagnostic du cancer
MX2007008980A (es) * 2005-01-25 2008-01-14 Sky Genetics Inc Acidos nucleicos para apoptosis de celulas cancerigenas.
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20080133141A1 (en) * 2005-12-22 2008-06-05 Frost Stephen J Weighted Scoring Methods and Use Thereof in Screening
ES2491222T3 (es) * 2006-01-11 2014-09-05 Genomic Health, Inc. Marcadores de expresión génica para el pronóstico de cáncer colorrectal
US8211634B2 (en) * 2006-02-14 2012-07-03 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
WO2007106425A2 (fr) * 2006-03-10 2007-09-20 Northeastern University Procédés protéomiques pour identifier et utiliser des biomarqueurs putatifs associés à un état dysplasique des cellules cervicales ou d'autres types de cellules
CA2671194A1 (fr) * 2006-12-08 2008-06-19 Asuragen, Inc. Genes et voies genetiques regules par le mir-20 en tant que cibles en vue d'une intervention therapeutique
EP2559771A3 (fr) * 2007-05-17 2013-06-12 Bristol-Myers Squibb Company Bio-marqueurs et méthodes pour déterminer la sensibilité aux modulateurs du recepteur du facteur de croissance de l'insuline (IGF1R).

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050118606A1 (en) * 2002-11-25 2005-06-02 Roth Richard B. Methods for identifying risk of breast cancer and treatments thereof
US20050287544A1 (en) * 2003-12-01 2005-12-29 Francois Bertucci Gene expression profiling of colon cancer with DNA arrays
US20070087365A1 (en) * 2005-10-07 2007-04-19 Wim Van Criekinge Methylation markers for diagnosis and treatment of ovarian cancer
US20080026415A1 (en) * 2006-07-13 2008-01-31 Rimm David L Methods for making cancer prognoses based on subcellular localization of biomarkers
US20080145313A1 (en) * 2006-08-30 2008-06-19 Genesis Research & Development Corporation Limited Compositions and Methods for the Treatment and Prevention of Neoplastic Disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DE ANGELIS: "MOLECULAR CHARACTERIZATIONS OF DERIVATIVES OF HCTL 16 COLORECTAL CANCER CELLS THAT ARE RESISTANT TO THE CHEMOTHERAPEUTIC AGENT 5-FLUROURACIL.", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 24, no. 5, 1 May 2004 (2004-05-01), pages 1279 - 1288, XP009109882 *
NASH: "AUTOMATED, MULTIPLEX ASSAY FOR HIGH-FREQUENCY MICROSATELLITE INSTABILITY IN COLORECTAL CANCER.", JOURNAL CLINICAL ONCOLOGY, vol. 21, no. 16, 15 August 2003 (2003-08-15), pages 3105 - 3112, XP008181697 *
SEGDITSAS: "PUTATIVE DIRECT AND INDIRECT WNT TARGETS IDENTIFIED THROUGH CONSISTENT GENE EXPRESSION CHANGES IN APC-MUTANT INTESTINAL ADENOMAS FRROM HUMANS AND MICE.", HUMAN MOLECULAR GENETICS, vol. 17, no. 24, 15 December 2008 (2008-12-15), pages 3864 - 3875, XP055303404, DOI: 10.1093/HMG/DDN286 *
TOUMA: "RETINOIC ACID AND THE HISTONE DEACETYLASE INHIBITOR TRICHOSTATIN A INHIBIT THE PROLIFERATION OF HUMAN RENAL CELL CARCINOMA IN A XENOGRAFT TUMOR MODEL.", CLINICAL CANCER RESEARCH, vol. 11, no. 9, 1 May 2005 (2005-05-01), pages 3558 - 3566, XP055303411 *

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US20110257034A1 (en) 2011-10-20
WO2010042228A2 (fr) 2010-04-15

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