WO2010038579A8 - マイクロビーズ作製方法及びマイクロビーズ - Google Patents

マイクロビーズ作製方法及びマイクロビーズ Download PDF

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Publication number
WO2010038579A8
WO2010038579A8 PCT/JP2009/065508 JP2009065508W WO2010038579A8 WO 2010038579 A8 WO2010038579 A8 WO 2010038579A8 JP 2009065508 W JP2009065508 W JP 2009065508W WO 2010038579 A8 WO2010038579 A8 WO 2010038579A8
Authority
WO
WIPO (PCT)
Prior art keywords
microbeads
thin film
producing
hydrophilic layer
shaped
Prior art date
Application number
PCT/JP2009/065508
Other languages
English (en)
French (fr)
Other versions
WO2010038579A1 (ja
Inventor
市村　真理
賢三 町田
岸井　典之
田中　正信
Original Assignee
ソニー株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ソニー株式会社 filed Critical ソニー株式会社
Priority to RU2011111081/15A priority Critical patent/RU2492487C2/ru
Priority to US13/120,967 priority patent/US8546068B2/en
Priority to EP09817616.7A priority patent/EP2333547B1/en
Priority to CN200980137315.8A priority patent/CN102165317B/zh
Priority to BRPI0919402A priority patent/BRPI0919402A2/pt
Publication of WO2010038579A1 publication Critical patent/WO2010038579A1/ja
Publication of WO2010038579A8 publication Critical patent/WO2010038579A8/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00502—Particles of irregular geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Laminated Bodies (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

　多種類のマイクロビーズを含むビーズセットであって、各マイクロビーズのポピュレーションが明確なビーズセットを供給できるマイクロビーズ作製方法の提供。基板上に親水性有機材料からなる親水層を製膜する工程S1と、この親水層にマイクロビーズとして剥離され得る薄膜を積層する工程S2と、製膜された薄膜をフォトリソグラフィーによって所定の形状に成形する成形工程S3と、成形後の薄膜上に所定の物質を固相化する固相化工程S6と、前記物質が固相化された成形後の薄膜を、前記親水層の少なくとも一部とともに基板から剥離してマイクロビーズを得る剥離工程S7と、を含むマイクロビーズ作製方法を提供する。
PCT/JP2009/065508 2008-09-30 2009-09-04 マイクロビーズ作製方法及びマイクロビーズ WO2010038579A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
RU2011111081/15A RU2492487C2 (ru) 2008-09-30 2009-09-04 Способ получения микробусин и микробусины
US13/120,967 US8546068B2 (en) 2008-09-30 2009-09-04 Method for fabricating microbeads and microbeads
EP09817616.7A EP2333547B1 (en) 2008-09-30 2009-09-04 Process for producing microbeads
CN200980137315.8A CN102165317B (zh) 2008-09-30 2009-09-04 制作微珠的方法和微珠
BRPI0919402A BRPI0919402A2 (pt) 2008-09-30 2009-09-04 método para fabricar microcontas, e, microcontas

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008252329A JP5375005B2 (ja) 2008-09-30 2008-09-30 マイクロビーズ作製方法
JP2008-252329 2008-09-30

Publications (2)

Publication Number Publication Date
WO2010038579A1 WO2010038579A1 (ja) 2010-04-08
WO2010038579A8 true WO2010038579A8 (ja) 2011-12-29

Family

ID=42073352

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/065508 WO2010038579A1 (ja) 2008-09-30 2009-09-04 マイクロビーズ作製方法及びマイクロビーズ

Country Status (8)

Country Link
US (1) US8546068B2 (ja)
EP (1) EP2333547B1 (ja)
JP (1) JP5375005B2 (ja)
KR (1) KR20110076889A (ja)
CN (1) CN102165317B (ja)
BR (1) BRPI0919402A2 (ja)
RU (1) RU2492487C2 (ja)
WO (1) WO2010038579A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5569122B2 (ja) * 2010-04-23 2014-08-13 三菱レイヨン株式会社 生体分子検出用デバイス
JP5707909B2 (ja) * 2010-12-06 2015-04-30 大日本印刷株式会社 微粒子の製造方法
WO2012165193A1 (ja) * 2011-05-31 2012-12-06 大日本印刷株式会社 偽造防止用粒子及びその製造方法、偽造防止用インク、偽造防止用シート、有価証券、カード
KR101364261B1 (ko) * 2013-02-01 2014-02-17 서강대학교산학협력단 마이크로 비드 기판 자동 형성 장치
CN106215821B (zh) * 2016-08-12 2018-08-17 江苏泽成生物技术有限公司 一种磁微粒化学发光免疫分析试剂用羧基磁珠的制备方法
CN114107889A (zh) * 2021-11-11 2022-03-01 杭州四马化工科技有限公司 一种金属箔脱模方法
CN114086120A (zh) * 2021-11-11 2022-02-25 杭州四马化工科技有限公司 一种超薄金属箔的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04173841A (ja) * 1990-11-05 1992-06-22 Nec Corp 機能性基を有する高分子膜の部分的形成方法
US5583162A (en) * 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
DE69907630T2 (de) * 1998-01-22 2004-02-26 Luminex Corp., Austin Mikropartikel mit multiplen fluoreszenz-signalen
US6365189B1 (en) * 1999-10-22 2002-04-02 3M Innovative Properties Company Method of delivering and releasing a pheromone
CA2406635A1 (en) * 2000-04-19 2001-10-25 3D Molecular Sciences Limited A method of fabricating coded particles
GB0009719D0 (en) * 2000-04-19 2000-06-07 Scient Generics Ltd A method of fabricating coded particles
JP3923856B2 (ja) * 2002-06-13 2007-06-06 大日本印刷株式会社 マイクロアレイチップの製造方法
JP4173841B2 (ja) * 2004-06-22 2008-10-29 平河ヒューテック株式会社 化学検査装置
GB2422686A (en) * 2004-12-07 2006-08-02 Univ Southampton Preparation of solid support particles for chemical reactions
US8357616B2 (en) * 2005-04-14 2013-01-22 President And Fellows Of Harvard College Adjustable solubility in sacrificial layers for microfabrication
JP5224228B2 (ja) * 2006-09-15 2013-07-03 Ｎｌｔテクノロジー株式会社 薬液を用いた基板処理方法
WO2008115550A1 (en) * 2007-03-20 2008-09-25 The Regents Of The University Of California Mechanical process for creating particles in a fluid
CN101149364A (zh) * 2007-11-10 2008-03-26 大连理工大学 水溶性牺牲层微流控芯片制备方法
JP4582224B2 (ja) * 2008-05-02 2010-11-17 ソニー株式会社 マイクロビーズ作製方法及びマイクロビーズ

Also Published As

Publication number Publication date
WO2010038579A1 (ja) 2010-04-08
BRPI0919402A2 (pt) 2015-12-15
EP2333547B1 (en) 2017-05-10
US20110183272A1 (en) 2011-07-28
RU2011111081A (ru) 2012-09-27
RU2492487C2 (ru) 2013-09-10
US8546068B2 (en) 2013-10-01
EP2333547A1 (en) 2011-06-15
JP2010085149A (ja) 2010-04-15
KR20110076889A (ko) 2011-07-06
CN102165317B (zh) 2014-03-12
CN102165317A (zh) 2011-08-24
EP2333547A4 (en) 2013-05-01
JP5375005B2 (ja) 2013-12-25

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