WO2010038081A3 - Dérivés hétérocycliques et procédés d’utilisation associés - Google Patents
Dérivés hétérocycliques et procédés d’utilisation associés Download PDFInfo
- Publication number
- WO2010038081A3 WO2010038081A3 PCT/GB2009/051299 GB2009051299W WO2010038081A3 WO 2010038081 A3 WO2010038081 A3 WO 2010038081A3 GB 2009051299 W GB2009051299 W GB 2009051299W WO 2010038081 A3 WO2010038081 A3 WO 2010038081A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- topoisomerase
- phenylamino
- hetero
- pyrimidine
- pyridine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
L’invention porte sur les composés de la formule (I) ainsi que sur les sels pharmaceutiquement acceptables associés. L’invention concerne également des procédés de préparation associés, des compositions pharmaceutiques contenant lesdits dérivés et leurs utilisations en tant que médicaments, ainsi que dans le traitement des infections bactériennes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10258308P | 2008-10-03 | 2008-10-03 | |
US61/102,583 | 2008-10-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010038081A2 WO2010038081A2 (fr) | 2010-04-08 |
WO2010038081A3 true WO2010038081A3 (fr) | 2010-05-27 |
Family
ID=41698441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2009/051299 WO2010038081A2 (fr) | 2008-10-03 | 2009-10-02 | Dérivés hétérocycliques et procédés d’utilisation associés |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100137313A1 (fr) |
AR (1) | AR073760A1 (fr) |
TW (1) | TW201016676A (fr) |
UY (1) | UY32158A (fr) |
WO (1) | WO2010038081A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011146313A1 (fr) | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Composés de pyrazolopyrimidine pour le traitement du cancer |
CA2797947C (fr) | 2010-06-04 | 2019-07-09 | Charles Baker-Glenn | Derives d'aminopyrimidine au titre de modulateurs de lrrk2 |
CA2801781C (fr) * | 2010-07-21 | 2018-02-27 | Rigel Pharmaceuticals, Inc. | Inhibiteurs de proteine kinase c et leurs utilisations |
DE102010050558A1 (de) * | 2010-11-05 | 2012-05-10 | Merck Patent Gmbh | 1H-Pyrrolo[2,3-b]pyridinderivate |
HUE037844T2 (hu) | 2010-11-10 | 2018-09-28 | Genentech Inc | Pirazol-aminopirimidin-származékok mint LRRK2 modulátorok |
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
TWI548621B (zh) | 2011-04-22 | 2016-09-11 | 標誌製藥公司 | 經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法 |
US9345793B2 (en) | 2011-08-17 | 2016-05-24 | Piramal Imaging Sa | Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi |
EP2748166B1 (fr) | 2011-08-23 | 2018-07-11 | Asana BioSciences, LLC | Composés de pyrimido-pyridazinone et leurs procédés d'utilisation |
CA2850617A1 (fr) | 2011-10-03 | 2013-04-11 | The University Of North Carolina At Chapel Hill | Composes pyrrolopyrimidines pour le traitement du cancer |
PL2804861T3 (pl) * | 2012-01-20 | 2018-08-31 | Genosco | Podstawione związki pirymidyny i ich zastosowanie jako inhibitory SYK |
EP2626356A1 (fr) * | 2012-02-08 | 2013-08-14 | Rheinische Friedrich-Wilhelms-Universität Bonn | Analogues de thiamine et leur utilisation en tant qu'antibiotiques |
KR102083041B1 (ko) | 2012-02-22 | 2020-05-27 | 샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트 | 술폰아미드 화합물 및 tnap 억제제로서 용도 |
WO2013177168A1 (fr) * | 2012-05-22 | 2013-11-28 | The University Of North Carolina At Chapel Hill | Composés pyrimidines pour le traitement du cancer |
ME03300B (fr) | 2012-06-13 | 2019-07-20 | Incyte Holdings Corp | Composés tricycliques substitués servant d'inhibiteurs des fgfr |
WO2014026125A1 (fr) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Dérivés de pyrazine en tant qu'inhibiteurs de fgfr |
CN102827058A (zh) * | 2012-09-18 | 2012-12-19 | 江苏德峰药业有限公司 | 一种n-叔丁氧羰基-l-焦谷氨酸酯的生产方法 |
CN102827059A (zh) * | 2012-09-18 | 2012-12-19 | 江苏德峰药业有限公司 | 一种n-叔丁氧羰基-l-焦谷氨酸乙酯的生产方法 |
CN103709172B (zh) * | 2012-09-28 | 2018-02-13 | 江苏先声药业有限公司 | 取代呋喃并哌啶衍生物及其应用 |
WO2014062774A1 (fr) | 2012-10-17 | 2014-04-24 | The University Of North Carolina At Chapel Hill | Composés pyrazolopyrimidines pour le traitement du cancer |
EP2925752A4 (fr) | 2012-11-27 | 2016-06-01 | Univ North Carolina | Composés à base de pyrimidine utilisables à des fins de traitement du cancer |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
JP6503338B2 (ja) | 2013-03-15 | 2019-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | Hdac阻害剤 |
DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
CA2917262A1 (fr) | 2013-07-02 | 2015-01-08 | Syngenta Participations Ag | Heterocycles bi- ou tricycliques a action pesticide avec substituants soufres |
WO2015021149A1 (fr) * | 2013-08-06 | 2015-02-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Inhibiteurs de la tyrosine kinase ack1/tnk2 |
NZ715903A (en) | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
WO2015157125A1 (fr) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Utilisations thérapeutiques de composés pyrazolopyrimidine sélectionnés présentant une activité anti-tyrosine kinase mer |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
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EA202092649A1 (ru) | 2018-05-04 | 2021-06-21 | Инсайт Корпорейшн | Соли ингибитора fgfr |
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US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
IL291901A (en) | 2019-10-14 | 2022-06-01 | Incyte Corp | Bicyclyl heterocycles as fgr suppressors |
WO2021076728A1 (fr) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
WO2021113479A1 (fr) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr |
KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
KR102621694B1 (ko) * | 2022-09-15 | 2024-01-08 | 주식회사 스탠다임 | 아데노신 a2a 수용체 길항제 및 이의 용도 |
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WO2000039101A1 (fr) * | 1998-12-24 | 2000-07-06 | Astrazeneca Ab | Composes de pyrimidine |
WO2001028561A1 (fr) * | 1999-10-21 | 2001-04-26 | Merck & Co., Inc. | Composes antibacteriens selectifs contre les bacteries gram positif, compositions contenant ces composes et techniques de traitement |
WO2003032994A2 (fr) * | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Nouvelles pyrimidines substituees, procede permettant de les produire et leur utilisation comme medicament |
WO2003063794A2 (fr) * | 2002-02-01 | 2003-08-07 | Rigel Pharmaceuticals, Inc. | Composes 2,4-pyrimidinediamine et leurs utilisations |
WO2004037814A1 (fr) * | 2002-10-25 | 2004-05-06 | Vertex Pharmaceuticals Incorporated | Compositions indazolinones utiles en tant qu'inhibiteurs des kinases |
WO2006035067A2 (fr) * | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | 5-heterocyclyl-pyrimidines inhibitrices du vih |
EP1749827A1 (fr) * | 2004-03-30 | 2007-02-07 | Kyowa Hakko Kogyo Co., Ltd. | Agent anti tumoral |
WO2008068470A1 (fr) * | 2006-12-04 | 2008-06-12 | Astrazeneca Ab | Composés d'urée polycycliques antibactériens |
WO2009131687A2 (fr) * | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibiteurs de protéines kinases |
-
2009
- 2009-10-02 WO PCT/GB2009/051299 patent/WO2010038081A2/fr active Application Filing
- 2009-10-02 AR ARP090103820A patent/AR073760A1/es unknown
- 2009-10-02 UY UY0001032158A patent/UY32158A/es unknown
- 2009-10-02 TW TW098133616A patent/TW201016676A/zh unknown
- 2009-10-02 US US12/572,436 patent/US20100137313A1/en not_active Abandoned
Patent Citations (10)
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WO2000027825A1 (fr) * | 1998-11-10 | 2000-05-18 | Janssen Pharmaceutica N.V. | Pyrimidines inhibant la replication du vih |
WO2000039101A1 (fr) * | 1998-12-24 | 2000-07-06 | Astrazeneca Ab | Composes de pyrimidine |
WO2001028561A1 (fr) * | 1999-10-21 | 2001-04-26 | Merck & Co., Inc. | Composes antibacteriens selectifs contre les bacteries gram positif, compositions contenant ces composes et techniques de traitement |
WO2003032994A2 (fr) * | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Nouvelles pyrimidines substituees, procede permettant de les produire et leur utilisation comme medicament |
WO2003063794A2 (fr) * | 2002-02-01 | 2003-08-07 | Rigel Pharmaceuticals, Inc. | Composes 2,4-pyrimidinediamine et leurs utilisations |
WO2004037814A1 (fr) * | 2002-10-25 | 2004-05-06 | Vertex Pharmaceuticals Incorporated | Compositions indazolinones utiles en tant qu'inhibiteurs des kinases |
EP1749827A1 (fr) * | 2004-03-30 | 2007-02-07 | Kyowa Hakko Kogyo Co., Ltd. | Agent anti tumoral |
WO2006035067A2 (fr) * | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | 5-heterocyclyl-pyrimidines inhibitrices du vih |
WO2008068470A1 (fr) * | 2006-12-04 | 2008-06-12 | Astrazeneca Ab | Composés d'urée polycycliques antibactériens |
WO2009131687A2 (fr) * | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibiteurs de protéines kinases |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2010038081A2 (fr) | 2010-04-08 |
US20100137313A1 (en) | 2010-06-03 |
UY32158A (es) | 2010-04-30 |
AR073760A1 (es) | 2010-12-01 |
TW201016676A (en) | 2010-05-01 |
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