WO2010022568A1

WO2010022568A1 - A medication for use in abstinence of drugs and preparation thereof

Info

Publication number: WO2010022568A1
Application number: PCT/CN2008/072427
Authority: WO
Inventors: 钟厚禄
Original assignee: Zhong Houlu
Priority date: 2008-08-30
Filing date: 2008-09-19
Publication date: 2010-03-04
Also published as: CN101342345A

Abstract

A medication for use in abstinence of drugs and preparation thereof. The said medication is a capsule made from the following 28 kinds of traditional Chinese medicinal materials by extraction of ethanol, alkali liquor, distillation, acid liquor, and water in turn, addition into Powder Cordyceps, and then mixture. The said traditional Chinese medicinal materials include Herba Solani Nigri, Radix Angelicae Sinensis, Rhizoma Corydalis, Concha Haliotidis, Radix Stephaniae Cepharanthae, Rhizoma Curcumae, Ramulus Uncariae, Herba Asperulae Maximowiczii, Radix Hedysari, Radix Dipsaci, Rhizoma Gastrodiae, Semen Trigonellae, Radix Codonopsis, Flos Daturae Metelis, Tremella, Radix Rehmanniae, Radix Astragali, Herba Cistanches, Semen Ziziphi Spinosae, Semen Alpiniae, Juice Cucurbitae moschatae, Radix Polygalae, Fructus Piperis Longi, Cortex Mori, Herba Moslae, Radix Stephaniae Japonicae, Radix Acanthopanacis Senticosi, and Radix Salviae Miltiorrhizae. The medication has the effect on reinforcing immunity, antivirus, and antiinfectious, without drug dependence and side effect.

Description

Detoxification drug and preparation process thereof

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a Chinese herbal medicine detoxification capsule and a preparation process thereof.

Background technique

Major drugs such as heroin and opium seriously endanger human physical and mental health. Seeking a drug that can completely eliminate drugs remains a global problem. At present, there are many methods used in domestic and foreign drug rehabilitation, mainly including the reduction method, the substitution method, and the hibernation method. Although these treatments have certain curative effects, they cannot completely cure their toxicities. Many detoxification drugs themselves contain certain toxins. After use, patients will have new dependence on drugs, which will cause certain side effects and deepen patients' pain.

Summary of the invention

The object of the present invention is to provide a Chinese herbal medicine detoxification capsule which can completely eradicate, does not rebound, and has no toxic or side effects, and a preparation process thereof, in view of the above problems existing in the prior art.

The Chinese herbal medicine detoxification capsule of the invention and the preparation process thereof are carried out by the following steps:

a, take 50 ~ 150g of Solanum nigrum, 50 ~ 150g of Angelica, 60 ~ 180g of Corydalis, 60 - 180g of stone cassia, 60 ~ 180g of white medicine, 40 ~ 120g of sputum, 40 ~ 120g of hook 40~120g of chlorophyll, 30~90g of red peony, 30~90g of continuation, 40~120g of gastrodia, 40~120g of fenugreek, 50~150g of Codonopsis, 50~150g of mandala Flowers, 60-180 g of white fungus, 50-150 g of raw land, 50-150 g of scutellaria, 70-210 g of Cistanche, 70-210 g of jujube kernel, 60-180 g of cardamom, 50-150 g of pumpkin juice, 50-150 g Polygala, 40 ~ 120g 荜茇, 40 ~ 120g of mulberry white, 40 ~ 120g of vanilla, 50 ~ 150g of golden vine, 60 ~ 180g of acanthopanax and 60 ~ 180g of Salvia, washed, baked After smashing, immersing in 60 ~ 95% concentration, 3 ~ 6 liters of ethanol for 10 ~ 60 minutes, filtering, filtering out the dregs, and using the conventional technique of seepage for 6 ~ 18 hours (drug The slag is to be used. The obtained percolate is allowed to stand for 6 to 18 hours, and the concentrate obtained after recovering the ethanol from the supernatant is added to the weight percentage of 70 to 80%. , Freeze-dried, pulverized powder of dried, the dried powder was added again Cordyceps powder 50 ~ 80g, upon mixing, pulverization, prepared as a dry 100 mesh sieve.

b. Soak the dregs filtered in a in 1 ~ 10% concentration, 3 ~ 6 liters of alkali solution 4 ~ 12 In the hour, filter and filter out the dregs (resistance of filter residue), concentrate the filtrate to a paste and soak in 60 ~

95% concentration, 3 ~ 6 liters of ethanol for 6 ~ 18 hours, take the supernatant to recover the ethanol to obtain a concentrate, freeze-dried, pulverized to obtain a dry powder, and then add 30 ~ 100g of Cordyceps powder to the dry powder , mixed, pulverized, 100 mesh sieved to make a dry powder.

C. The dregs filtered out in b are steam distilled to obtain a mixed oil, and the remaining dregs (to be used). d. Soak the remaining dregs in c to 5 ~ 10 liters of water, and boil for at least 1 hour. After filtering, filter out the dregs (drugs are used), add hydrochloric acid to the filtrate to make the pH reach 2 ~ 5, heat Stop heating at 60 ~ 100 °C, and let stand for 6 ~ 18 hours, filter, vacuum concentration, freeze-drying, pulverize to obtain dry powder, then add 30 ~ 50g of Cordyceps powder to the dry powder, mix, Crush, 100 mesh sieved to make a dry powder.

e. Dip the dregs filtered out in d to boil in 1 ~ 2 liters of water, and filter and filter the dregs by the conventional technique. The seepage solution obtained by percolating for 6 ~ 18 hours is allowed to stand 6 ~ After 18 hours, the concentrate obtained from the supernatant was concentrated to a paste, and then added to 60-95% concentration, 3-6 liters of ethanol, and allowed to stand for 6-18 hours, and the supernatant was taken to recover ethanol. Add 70~80% by weight of water to the liquid, freeze-dried and pulverize to obtain dry powder, then add 50-80g of Cordyceps powder to the dry powder, mix, smash and 100 mesh to make dry powder. .

f. The semi-finished products prepared in the above a, b, c, d, e are mixed, 100 mesh sieved, and bagged to prepare the Chinese herbal medicine detoxification capsule of the invention.

detailed description

Hereinafter, the Chinese herbal medicine detoxification capsule of the present invention and a preparation process thereof will be further described in detail in conjunction with the above invention.

Take Solanum nigrum L., Angelica, Corydalis, Stone Cassia, White Pharmacy, Rhizoma Curcumae, Hook, Campanula, Rhododendron, Dipsacus, Gastrodia elata, Fenugreek, Codonopsis, Mandala, Tremella, Radix, Radix, Cistanche , Suanzaoren, Myrtle, Pumpkin Juice, Polygala, Poria, Mulberry White, Herb, Calendula, Acanthopanax and Salvia: 28 Chinese herbal medicines, after washing, drying, pulverizing to powder, according to the following examples The Chinese herbal medicine detoxification capsule of the invention is prepared.

Example:

a, 150g of Solanum nigrum L., 150g of Angelica, 180g of Corydalis, 180g of Cassia, 180g of white medicinal herbs, 120g of zedoary, 120g of hook, 120g of chlorophyll, 90g of red peony, 90g of Dips, 120g of gastrodia, 120g of fenugreek, 150g of Codonopsis, 150g Mandala flower, 180g of white fungus, 150g of raw land, 150g of sassafras, 210g of Cistanche, 210g of jujube kernel, 180g of cardamom, 150g of pumpkin juice, 150g of Polygala, 120g of sorghum, 120g of mulberry 120g of vanilla, 150g of golden vine, 180g of acanthopanax senticosus and 180g of salvia miltiorrhiza powder were soaked in 80% concentration and 6 liters of ethanol for 40 minutes. After filtration, the dregs were filtered off, and the dregs were infiltrated by conventional techniques. The osmosis solution was allowed to percolate for 10 hours (the slag was used for use). The obtained osmosis solution was allowed to stand for 12 hours, and 80% by weight of water was added to the concentrate obtained after taking the ethanol recovered from the supernatant, and lyophilized. The pulverized dry powder was prepared by pulverizing, and 80 g of cordyceps powder was added to the dry powder, and the mixture was mixed, pulverized, and sieved through 100 mesh to prepare a dry powder.

b. Soak the dregs filtered in a in a 10% concentration, 6 liters of alkali solution for 10 hours, filter and filter out the dregs (drugs are used), concentrate the filtrate to a paste and soak in 80 % concentration, 6 liters of ethanol for 12 hours, the supernatant obtained by recovering ethanol from the supernatant, lyophilized, pulverized to obtain a dry powder, and then added 100 g of cordyceps powder to the dry powder, which was mixed and pulverized. 100 mesh sieved to make a dry powder.

c. The dregs filtered out in b are steam distilled to obtain the mixed oil, and the remaining dregs (to be used). d. Soak the remaining dregs in c to 10 liters of water, and boil for at least 1 hour. After filtering and filtering out the dregs, add hydrochloric acid to the filtrate to make the PH value reach 2, stop heating when heated to 80 ° C, and let stand. After 12 hours, the dried powder was filtered, vacuum concentrated, freeze-dried, and pulverized, and then 50 g of cordyceps powder was added to the dried powder, which was mixed, pulverized, and sieved through 100 mesh to prepare a dry powder.

e. Dip the dregs filtered out in d to boil in 2 liters of water, and filter and filter the dregs by using the conventional technique for seeping for 10 hours to allow the percolate to stand for 12 hours. The concentrate obtained from the supernatant is concentrated to a paste, added to 80% strength, 6 liters of ethanol, and allowed to stand for 12 hours, and the supernatant obtained by recovering the supernatant from the supernatant is added with 80% by weight of water. The dried powder is obtained by freeze-drying and pulverization, and 50 g of cordyceps powder is added to the dry powder, and the mixture is mixed, pulverized, and sieved through 100 mesh to prepare a dry powder.

The Chinese herbal medicine detoxification capsule prepared by the embodiment of the present invention is sent to the Guizhou Provincial Center for Disease Control and Prevention for toxicity test. The results of the toxicity test conducted by the animal using the animal mouse indicate that: using the Chinese herbal medicine detoxification capsule of the present invention, "No experimental animal was found. The poisoning performance appeared. ", "There was no death of any experimental animals.", confirming that the "Chinese herbal medicine detoxification capsules of the present invention are actually non-toxic." Scope. ".

The Chinese herbal medicine detoxification capsule prepared by the embodiment of the present invention is sent to the clinical application of the compulsory detoxification department of the Lanzhou Public Security Bureau of Gansu Province, and the specific curative effect of the clinical use of the institute is as follows:

The Compulsory Drug Rehabilitation Institute of Lanzhou City Public Security Bureau of Gansu Province, with the Chinese herbal medicine detoxification capsules of the present invention and the internationally renowned brand western medicine Luofeixiding detoxification drugs, selected 12 drug users with no history of drug abuse and no difference in drug use for clinical control. Among them, 6 cases were a group of Chinese herbal detoxification capsules of the present invention, and each case was taken orally once a day, each time, and the dose was 0.3 g/particle. At the same time, another 6 cases were another group of oral lofexidine detoxification drugs. The control used by the two groups of drug users after 10 days of clinical use showed that the Chinese herbal medicine detoxification capsule of the present invention was significantly more effective than the lofecilidine group (P < 0.001); the response rate to anxiety and craving There was also a significant difference from the lofexidine group (P < 0.001). The Chinese herbal medicine detoxification capsule of the invention has no dependence on clinical use, especially the detoxification effect of heroin dependence, less adverse reactions, safe use, and no dependence.

The clinical use observation of the Chinese herbal medicine detoxification capsule of the invention shows that it can effectively control tearing, salivation, sweating, vomiting, diarrhea, tremor, convulsion, irritability for heroin withdrawal symptoms. Stop vomiting and create conditions for oral medication. It also relieves pain better, and its analgesic effect is similar to that of aminophenol. Vital signs are stable.

The Chinese herbal medicine detoxification capsule of the present invention was stopped for 5 days, and the symptoms of the drug-using patients were not rebounded, and the symptoms still remaining during the withdrawal period tend to be alleviated, effectively demonstrating that it has no dependence.

Effect of the invention

The Chinese herbal medicine detoxification capsule of the invention takes the first two hours to quit the drug addiction, takes one month continuously, radically cures, and is verified by many clinical use, the cure rate and the cure rate of the detoxification are up to 100%. It has the functions of enhancing immunity, anti-virus, anti-infection, non-rebound, no dependence, no toxic and side effects, and can achieve complete rehabilitation. The preparation process is simple and the cost is low.

Claims

Rights request

1. A Chinese herbal medicine detoxification capsule and a preparation process thereof, characterized in that:

a, take 50 ~ 150g of Solanum nigrum, 50 ~ 150g of Angelica, 60 ~ 180g of Corydalis, 60 - 180g of stone cassia, 60 ~ 180g of white medicine, 40 ~ 120g of sputum, 40 ~ 120g of hook 40~120g of chlorophyll, 30~90g of red peony, 30~90g of continuation, 40~120g of gastrodia, 40~120g of fenugreek, 50~150g of Codonopsis, 50~150g of mandala Flowers, 60-180 g of white fungus, 50-150 g of raw land, 50-150 g of scutellaria, 70-210 g of Cistanche, 70-210 g of jujube kernel, 60-180 g of cardamom, 50-150 g of pumpkin juice, 50-150 g Polygala, 40 ~ 120g 荜茇, 40 ~ 120g of mulberry white, 40 ~ 120g of vanilla, 50 ~ 150g of golden vine, 60 ~ 180g of acanthopanax and 60 ~ 180g of Salvia, washed, baked After smashing, immersing in 60 ~ 95% concentration, 3 ~ 6 liters of ethanol for 10 ~ 60 minutes, filtering, filtering out the dregs, and using the osmosis method to percolate for 6 ~ 18 hours. After standing for 6 to 18 hours, 70% to 80% by weight of water is added to the concentrate obtained after recovering the ethanol from the supernatant, and freeze-dried and pulverized. The dried powder was again dried Cordyceps powder was added in 50 ~ 80g powder, by mixing, grinding, sieving mesh 100 made of a dry powder,

b. Soak the dregs filtered in a in 1 ~ 10% concentration, 3 ~ 6 liters of alkali solution for 4 ~ 12 hours, filter and filter out the dregs, concentrate the filtrate to a paste and soak in 60 ~ 95% concentration, 3 ~ 6 liters of ethanol for 6 ~ 18 hours, take the supernatant to recover the ethanol to obtain the concentrate, freeze-dried, pulverized to obtain a dry powder, and then add 30 ~ 100g of Cordyceps to the dry powder Powder, mixed, pulverized, 100 mesh sieved to make dry powder,

c. The dregs filtered out in b are steam distilled to obtain the mixed oil, and the remaining dregs are d, so that the remaining dregs in c are soaked in 5-10 liters of water, and boiled for at least 1 hour, filtered and filtered. The slag, the filtrate is added with hydrochloric acid to make the pH value of 2 ~ 5, when heated to 60 ~ 100 ° C, the heating is stopped, and allowed to stand for 6 ~ 18 hours, filtered, vacuum concentrated, freeze-dried, pulverized to obtain dry powder, and then Add 30 ~ 50g of Cordyceps powder to the dry powder, mix it, crush it, and sieve it through 100 mesh to make dry powder.

e, dipping the dregs filtered out in d to boil in 1 ~ 2 liters of water, and filtering and filtering the dregs for 6 to 18 hours by percolation for 6-18 hours. The concentrate obtained from the supernatant is concentrated to a paste, and then added to a concentration of 60 to 95%, 3 to 6 liters of ethanol, and allowed to stand for 6~. After 18 hours, the concentrate obtained by recovering the ethanol from the supernatant is added with water of 70-80% by weight, freeze-dried, pulverized to obtain a dry powder, and then 50-80 g of cordyceps powder is added to the dry powder. After mixing, pulverizing, 100 mesh sifting to make a dry powder,

f. The semi-finished products prepared in the above a, b, c, d, e are mixed, 100 mesh sieved, and filled into capsules to prepare capsules.