WO2010009589A1

WO2010009589A1 - Use of hydrochloric acid for the manufacture of a medicament for treatment of gastritis, enteritis and angiitis

Info

Publication number: WO2010009589A1
Application number: PCT/CN2008/071708
Authority: WO
Inventors: 刘智仁
Original assignee: Liu Zhiren
Priority date: 2008-07-21
Filing date: 2008-07-21
Publication date: 2010-01-28

Abstract

Use of hydrochloric acid for the manufacture of a medicament for the treatment of gastritis, enteritis and angiitis. Said medicament is usually an aqueous solution comprising hydrochloric acid. The pH of the solution is controlled in the range of 1.5-6.9.

Description

Application of hydrochloric acid in the preparation of medicaments for treating gastritis, enteritis and vasculitis

[1] The present invention relates to the use of hydrochloric acid in the preparation of a medicament for the treatment of gastritis, enteritis and vasculitis.

Background technique

[2] The formation mechanism of gastritis, enteritis, and vasculitis has not yet been determined in the medical community. For example, modern medicine believes that the onset of acute and chronic gastroenteritis may be related to the following factors:

[3] First, the infectious factors

Eat food contaminated with bacteria or their toxins. Common pathogenic bacteria are Salmonella parahaemolyticus (halophilic bacteria) Helicobacter pylori, and certain influenza viruses and enteroviruses. Among the toxins, the golden staphylococcal toxin is the most common. Salmonella is often grown in meat and eggs. Vibrio parahaemolyticus is mainly used in crab, fish, snails, sea bream and other seafood pickles. The food is long-lasting, milk and meat are suitable for staphylococcal reproduction and enterotoxin production.

[4] Second, physical and chemical factors

Physical factors such as eating overheated, cold and rough food, X-ray irradiation, etc. Chemical factors such as spirits, strong tea, spices and certain drugs can damage the gastric mucosa and cause inflammatory changes.

[5] Third, other

Overeating, excessive fatigue, cold, etc., reduce the body's resistance or damage the gastric mucosal barrier, and are prone to attack by the above factors.

[6] It is common to use hunger therapy for gastrointestinal diseases, reduce gastric acid method, anti-inflammatory bactericidal method, etc. It is difficult to cure intestinal and stomach diseases regardless of the method used.

[7] Thromboangiitis obliterans, referred to as vasculitis, is a slow-moving, mainly vascular lesion involving the small arteries and veins of the extremities. Pathological changes are staged, non-suppurative inflammation of the vessel wall with intraluminal thrombosis

The lumen is blocked, causing limb ischemia, causing pain and gangrene of the extremities. The course of the disease is periodic, and the lesions are mostly in the lower limbs. Occurs in men aged 20-40. It belongs to the category of "dislocation" of Chinese medicine. At present, the cause of vascular inflammation is still unclear. Medicine believes that it is mainly related to the following factors:

[8] 1, smoking: Comprehensive domestic data, thromboangiitis obliterans have a history of smoking accounted for 60% -95%. Tobacco Nicotine can cause small blood vessels to sputum and cause vascular damage. Erb et al. have used tobacco extracts for animal experiments to cause vascular lesions. Harkary other tobacco leachate skin test, the positive rate was found thromboangiitis obliterans patients ⁽⁷ 8% ^--87%), significantly higher than normal (16% ^--46%).

2, sex hormones: The disease occurs mostly in young men, domestic and foreign reports accounted for 97.5% _ 98.2%. It has been reported that prostaglandin E has the effects of relaxing blood vessels and inhibiting platelet aggregation. Such as prostate dysfunction or during the young adult, frequent sexual life causes prostaglandins to be lost with semen, resulting in a corresponding decrease in prostaglandins, which may cause peripheral vasomotor dysfunction, thrombosis, secondary inflammation.

3. Cold and humid: According to domestic statistics, there are 57.9% of those with a history of cold. Long-term cold stimulates vasospasm, causing degeneration of vascular inflammation, thickening of intimal hyperplasia, and thrombosis.

4, trauma: trauma caused by vascular injury, or stimulation of nerve receptors due to trauma, which in turn causes central nervous system dysfunction, which gradually loses its regulation of blood vessels, causing vasospasm, long-term paralysis and thrombosis.

5 factors of blood coagulation increase: thrombus occlusive vasculitis patients with increased blood viscosity and plasma viscosity, red blood cell electrophoresis, sputum slowing, increased platelet aggregation, but in the pathogenesis, the causal relationship between blood and blood vessels, still To be studied.

6, immunology: In recent years, studies have shown that patients with thromboangiitis obliterans have special antibodies. Some scholars believe that this disease is an autoimmune disease under the repeated action of tobacco allergy and other factors.

At present, the treatment of vasculitis often uses vasodilator drugs and anti-inflammatory drugs. Because the medical community's formation mechanism of vasculitis is not clear, the medication can only relieve symptoms to a certain extent and cannot be cured.

Disclosure of invention

technical problem

The technical problem to be solved by the invention is to provide a use of hydrochloric acid in the preparation of a medicament for treating gastritis. The technical problem to be solved by the present invention is to provide a use of hydrochloric acid in the preparation of a medicament for treating gastritis. The technical problem to be solved by the present invention is to provide a use of hydrochloric acid in the preparation of a medicament for treating enteritis. The technical problem to be solved by the present invention is to provide a use of hydrochloric acid in the preparation of a medicament for treating vasculitis. [19] Without being bound by a particular theory, the inventors have discovered that the formation of gastritis, enteritis, and vasculitis is based on the following mechanisms: Food is digested in the stomach, producing large amounts of organic acids, carbonic acid, and hydrogen ions (H+), collectively referred to as gastric acid. . Mucus and lipid membrane surface of the gastric parietal cells of the stomach carbonate adsorption (H ₂ C0 _3), an inorganic acid forming the protective layer, the protective layer protects the stomach from gastric digestion of food organic acids produced inch erosion. Similarly, the mucus and lipids on the intestinal wall absorb the carbonic acid (H ₂ C0 ₃ ) in the intestine to form a protective layer of inorganic acid; the mucus and lipids on the blood vessel wall adsorb carbonic acid (H ₂ C0 ₃ ) in the blood vessel. , forming a protective layer of inorganic acid.

[20] There are individual differences in the ability of mucus and lipids to adsorb inorganic acids in the body, and this adsorption capacity also declines as the body functions decline. When the body's adsorption capacity to the inorganic acid protective layer is reduced, the inorganic acid protective layer is easily replaced by organic acids in the gastrointestinal and intravascular blood, so that the organic acid directly contacts the stomach wall, the intestinal wall, and the blood vessel wall, thus causing Erosion of the stomach, intestines, and blood vessel walls. The corroded stomach wall is inflamed and forms gastritis. Light is superficial gastritis, when the stomach wall is severely corroded,

Atrophic gastritis is formed by erosion. In the same way, the erosion of the intestinal wall by organic acids causes enteritis, and the erosion of the blood vessel wall by organic acids causes vasculitis.

[21] Based on the above mechanism, the inventors have found through enthusiasm that hydrochloric acid is the most ideal material for forming a protective layer of inorganic acid.

[22] Therefore, in a first aspect of the invention, there is provided a use of hydrochloric acid for the preparation of a medicament for treating gastritis.

[23] In a second aspect of the invention, there is provided a use of hydrochloric acid for the preparation of a medicament for the treatment of enteritis.

[24] In a third aspect of the invention, there is provided a use of hydrochloric acid for the manufacture of a medicament for treating vasculitis.

[25] The mechanism of the hydrochloric acid of the present invention for treating gastritis, enteritis and vasculitis is as follows: Hydrochloric acid is a strong inorganic acid, and the ability of mucus and lipid substances on the stomach wall, intestinal wall and blood vessel wall to adsorb hydrochloric acid is much better than adsorption of carbonic acid. The ability to treat sputum with hydrochloric acid, hydrochloric acid on the stomach wall, intestinal wall and blood vessel wall to form a strong adsorption of inorganic acid protective layer, the inorganic acid protective layer is not easily replaced by organic acid, the same hydrochloric acid also played a role in the damage The role of sterilization and anti-inflammatory. The inorganic acid can protect the body, and the conclusion that the organic acid erodes the body can be explained from the following: An aqueous solution containing a mineral acid (hydrochloric acid) and an aqueous solution containing an organic acid (such as acetic acid) (the pH of the aqueous solution is equal) The skin is scrubbed separately, and the aqueous solution of inorganic acid moisturizes the skin to protect the skin. After scrubbing several times with an aqueous solution of organic acid, the skin is roughened. This can explain to some extent that when the organic acid directly contacts the human body surface, the inner wall of the organ and the inner wall of the blood vessel, it will be eroded and destroyed, while the inorganic acid can protect it. [26] The hydrochloric acid of the present invention is used for preparing a drug for treating gastritis, enteritis, and vasculitis. Generally, the drug is an aqueous solution containing hydrochloric acid. Preferably, the pH of the aqueous solution is controlled at 1.5 to 6.9, and more preferably The pH of the aqueous solution is controlled to be 4 to 6.5.

[27] Further, the pH of the aqueous solution is controlled to be 6.5 to 6.9. According to the national drinking water standard, the pH of drinking water should be 6.5 to 8.5. Therefore, as long as the pH of the aqueous solution is controlled to be 6.5 to 6.9, the aqueous solution containing hydrochloric acid can be directly consumed as edible hydrochloric acid water.

[28] The drugs can be used for the preparation of oral liquid or injection and other dosage forms, as a therapeutic aqueous solution of hydrochloric acid in the treatment of gastritis, enteritis, vasculitis, daily drinking is generally controlled at 1000~3000ml, divided into 3 ~6 times to drink, 3 to 6 months for a course of treatment. In the treatment of gastritis, enteritis, vasculitis, the recommended daily dose is 500ml, divided into two injections, intravenous drip, for 2 to 3 months for a course of treatment. According to the above usage and dosage, gastroenteritis, enteritis and vasculitis can be treated. After one year, the general dose can be halved, and after two years, basic rehabilitation.

[29] The oral solution can be artificially prepared as follows: Hydrochloric acid is added to the drinking water and stirred evenly. The pH value is accurately detected before filling and sterilizing, and the pH is controlled at 1.5 to 6.9; the pH of the edible hydrochloric acid is controlled at 6.5 to 6.9.

[30] In the industrial process, a pH control device can be used to continuously, stably and in large quantities prepare the above aqueous solution containing hydrochloric acid.

[31] An injection can be prepared from hydrochloric acid in a pharmaceutically usual manner as long as the pH of the injection is controlled to be 1.5 to 6.9.

[32] 自 Hydrochloric acid hydrazine is made from tap water. Generally, a purification device should be installed at the front end to meet the national sanitary standard for drinking water.

[33] In order to achieve the purpose of treating gastritis, enteritis, vasculitis, the hydrochloric acid of the present invention can also be applied to other solutions, such as physiological saline, glucose solution, beverage, etc., and the method for preparing hydrochloric acid water is the same as above, as long as control The pH of the oral solution or the injection can be used.

[34] The edible hydrochloric acid water according to the present invention generally does not allow heating to be consumed, because heating causes the hydrochloric acid to volatilize and loses its therapeutic effect. Do not drink beverages, tea and alkaline health products that are prone to scaling. Theophylline and alkaline substances are easily neutralized with hydrochloric acid to disable the aqueous hydrochloric acid solution.

[35] In order to illustrate the therapeutic effect of the hydrochloric acid of the present invention on gastritis, enteritis, vasculitis, the present invention has clinically observed 1060 patients with gastritis and enteritis drinking drinking hydrochloric acid, wherein 500 patients with gastritis, enteritis 400 patients, 160 patients with vasculitis, 560 males and 500 females, with an average age of 59 years, age range 28~7

2 years old.

[36] The results of the use showed that: After taking the two years, 370 cases of patients with gastritis treated with hydrochloric acid water and drugs and completely treated with hydrochloric acid water have been cured.

90 cases were converted from atrophic gastritis to superficial gastritis, 40 cases of gastric medicine stopped taking, and abdominal pain disappeared. 350 cases of 50 cases, 50 cases of patients with enteritis treated with hydrochloric acid and drugs and completely drinking hydrochloric acid Symptoms were alleviated; 130 patients with vasculitis treated with hydrochloric acid combined with drugs and completely treated with hydrochloric acid for the treatment of vasculitis were cured, and 30 symptoms were alleviated. The total effective rate is 100%.

[37] The medicament prepared by the hydrochloric acid preparation of the invention is safe and reliable for treating gastritis, enteritis and vasculitis, and has a certain and obvious effect.

Embodiments of the invention

[38] The present invention will be further described below in conjunction with the embodiments, but the scope of protection of the present invention is not limited thereto.

[39] Example 1

[40] Add high-purity dilute hydrochloric acid to drinking water and mix well. Precisely control the pH value of 6.5~6.9, which can be used directly.

[41] Example 2

[42] Add high-purity hydrochloric acid to a hydrochloric acid solution diluted to 2% in drinking water and fill it in a hydrochloric acid solution with a flow controller. The hydrochloric acid solution and the drinking water are mixed at a certain flow ratio through a pipe, and a pH detector is disposed at the end of the pipe. The hydrochloric acid aqueous solution was controlled to have a pH of 6.5 to 6.9 to prepare edible hydrochloric acid water.

[43] Application example 1

[44] 16 Treating 16 patients with gastritis with the edible hydrochloric acid prepared above, the patient was given 2000ml daily.

In the morning, before the Chinese food, drink 500ml each, and drink a little 1000ml before dinner.

[45] Table 1 shows the improvement of gastritis in cases after drinking the edible hydrochloric acid water of the present invention.

[46] Table 1 consumption of hydrochloric acid water for the treatment of gastritis Patient number of the original symptoms of age gastritis

1 superficial gastritis 28 10 months cured

2 superficial gastritis 34 one year healed

3 superficial gastritis 56 one and a half year healed

4 superficial gastritis 56 one and a half year healed

5 superficial gastritis 38 one year healed

6 superficial gastritis 57 one and a half year healed

7 superficial gastritis 67 recovered in two years

8 superficial gastritis 55 one and a half year healed

9 superficial gastritis 57 one and a half year healed

10 Atrophic gastritis 68 After two and a half years, it turned into superficial gastritis

11 Atrophic gastritis 69 After two years, it turned into superficial gastritis

12 atrophic gastritis 56 two years of recovery

13 atrophic gastritis 58 three years of recovery

14 Atrophic gastritis 67 After two years, it turned into superficial gastritis

15 Atrophic gastritis 66 After two years, it turned into superficial gastritis

16 Atrophic gastritis 76 After two years, it turned into superficial gastritis

[47]

[48] Application example 2

[49] 16 Treatment of 16 cases of enteritis with the edible hydrochloric acid prepared above, the patient consumed 2000ml daily

[2] Table 2 shows the improvement of enteritis in cases after drinking the edible hydrochloric acid water of the present invention.

[51] Table 2 consumption of hydrochloric acid water for the treatment of enteritis

[52] Therapeutic effect of patients with original symptoms of age-induced enteritis

number

1 Enteritis 30 Healed after one year

2 Enteritis 34 Healed after one year

3 Enteritis 54 Healed after two years

4 Enteritis 55 Healed after two years

5 Enteritis 38 Healed after one year

6 enteritis 60 recovered after two years

7 Enteritis 67 Healed after two years

8 Enteritis 55 Healed after one year

9 Enteritis 58 Healed after one year

10 enteritis 68 symptoms are significantly reduced after two years

11 enteritis 69 symptoms are significantly reduced after two years

12 Enteritis 55 Healed after one year

13 Enteritis 57 Healed after one year

14 enteritis 67 symptoms are significantly reduced after two years

15 enteritis 66 symptoms are significantly reduced after two years

16 enteritis 74 symptoms are significantly reduced after two years

[53] Application example 3

[54] 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16

[55] Table 3 shows the improvement of vasculitis in cases after drinking the edible hydrochloric acid water of the present invention.

[56] Table 3 consumption of hydrochloric acid water treatment of vasculitis Patient number original symptom age treatment effect

1 vasculitis 30 recovered after one year

2 vasculitis 34 recovered after one year

3 vasculitis 54 recovered after two years

4 vasculitis 55 recovered after two years

5 vasculitis 38 recovered after one year

6 vasculitis 60 recovered after two years

7 vasculitis 67 recovered after two years

8 vasculitis 55 recovered after one year

9 vasculitis 58 recovered after one year

10 vasculitis 68 symptoms are significantly reduced after two years

11 vasculitis 69 symptoms are significantly reduced after two years

12 vasculitis 55 recovered after one year

13 vasculitis 57 recovered after one year

14 vasculitis 67 symptoms are significantly reduced after two years

15 vasculitis 66 symptoms are significantly reduced after two years

16 vasculitis 74 Significant relief after two years From Table 1, Table 2, Table 3, it can be seen that the aqueous solution of hydrochloric acid is effective in the treatment of gastritis, enteritis and vasculitis, and the total effective rate is 100%.

Claims

Claim

1. The application of hydrochloric acid in the preparation of a medicament for treating gastritis.

The use of hydrochloric acid according to claim 1 for the preparation of a medicament for treating gastritis, characterized in that the medicament is an aqueous solution containing hydrochloric acid, and the pH of the aqueous solution is controlled to be 1.5 to 6.9.

The use of hydrochloric acid according to claim 2 for the preparation of a medicament for treating gastritis, characterized in that the pH of the aqueous solution is controlled at 4 to 6.5.

The use of hydrochloric acid according to claim 2 for the preparation of a medicament for treating gastritis, characterized in that the pH of the aqueous solution is controlled at 6.5 to 6.9.

5. The application of hydrochloric acid in the preparation of a medicament for treating enteritis.

The use of hydrochloric acid according to claim 5 for the preparation of a medicament for treating enteritis, characterized in that the medicament is an aqueous solution containing hydrochloric acid, and the pH of the aqueous solution is controlled to be 1.5 to 6.9.

7. Use of hydrochloric acid according to claim 6 for the preparation of a medicament for the treatment of enteritis, characterized in that the pH of the aqueous solution is controlled between 4 and 6.5.

The use of hydrochloric acid according to claim 6 for the preparation of a medicament for the treatment of enteritis, characterized in that the pH of the aqueous solution is controlled at 6.5 to 6.9.

9. The application of hydrochloric acid in the preparation of a medicament for treating vasculitis.

The use of hydrochloric acid according to claim 9 for the preparation of a medicament for treating vasculitis, characterized in that the medicament is an aqueous solution containing hydrochloric acid, and the pH of the aqueous solution is controlled to be 1.5 to 6.9.