CN105748700B - Treat the externally used Mongolian medicine preparation of ulcerative colitis - Google Patents
Treat the externally used Mongolian medicine preparation of ulcerative colitis Download PDFInfo
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Abstract
The invention discloses a kind of externally used Mongolian medicine preparation for treating ulcerative colitis, it is made up of 8 herbal medicines such as Radix picrorrhizae, fringed pink, cape jasmine, Ji Leze, Radix Rhapontici seu Radix Echinopsis flower, pseudo-ginseng, madder, Marsh Felwort and bear gall compatibility, has heat-clearing, detoxifies, kills glutinous, only intestines shouting pain, callus and other effects.There is significant curative effect to treatment ulcerative colitis, colon inflammatory polyp etc..
Description
Technical field
The present invention relates to Mongolian medicinal preparation field, especially, is related to a kind of Mongolian medicinal preparation for treating ulcerative colitis.
Background technology
Ulcerative colitis (ulcerative colitis, UC) is called chronic nonspecific colitis (knot of referred to as bursting),
This disease usually protracted course of disease, recurrent exerbation, it is difficult to eradicate, be universally acknowledged refractory disease, by the World Health Organization
It is classified as one of difficult disease.
Its treatment method includes：
1. medical treatment
(1) lying up includes the supplement of balance of fluid and electrolyte, especially potassium, Diagnostic value person with whole body supportive treatment
It should correct.Simultaneously it is noted that the supplement of protein, improves nutrition of whole body situation, should give Totol parenteral nutrition branch if necessary
Hold, there is anaemia person to give blood transfusion, intestines and stomach should try one's best when taking in and avoid milk and dairy products.
(2) 1. salicylazosulfapyridine Salicylic Acid Formulations are primary treatment medicines to drug therapy, such as Etiasa, mesalazine
Deng.2. corticosteroid common medicine is prednisone or dexamethasone, but is not regarded as that long-term hormone maintains to prevent from recurring at present.
Hydrogenation cortisone or dexamethasone drip-feed can be also used in acute attack stage, and is added on physiology salt with hydrogenation cortisone every night
Make retention enema in water, be affirmative in the value of acute attack stage application hormone therapy, but whether should persistently make in chronic phase
Then still disagreed with hormone, because it has certain side effect, therefore majority does not advocate long-term use.3. immunodepressant is exedens
Value in colitis still belongs to suspicious.The work of control disease is had no in disease progression according to the report imuran such as Rosenberg
With, and it helps to reduce the use of corticosteroid in chronic cases.4. treatment by Chinese herbs diarrhea-type ulcerative colitis
Traditional Chinese medical herbal treatment can be used, effect is more satisfactory.Simultaneously it should be noted that diet and habits and customs.
2. surgical intervention
There is 20%~30% final operative treatment of Severe Ulcerative Colitis patient
(1) surgical indication needs the indication of emergency operation to have：1. a large amount of, unmanageable bleeding；2. toxic megacolon companion
Close on or clearly perforate, or toxic megacolon treats nonresponder through a few houres rather than a couple of days；3. fulminant acute ulcer
Property colitis it is invalid to Patients Treated with Steroid, that is, through 4~5 days treatment without improver；4. it is led to obstruction due to narrow；5. cherish
Doubt or confirm there is colon cancer；6. Complicated recurrent exerbation deteriorates, Chronic persistent symptom, malnutritive, empty
It is weak, it is impossible to work, it is impossible to participate in normal social activities and sexual life；7. disease deteriorates after steroid hormone dosage is reduced,
So that some months even can not stop hormone therapy in several years；8. children suffer from chronic colitis and influence it and grow；It is 9. tight
Such as arthritis is showed outside the colon of weight, the operation such as pyoderma gangraenosum or courage liver disease may be effective to its.
(2) the current ulcerative colitis of surgical selection has four kinds of operations alternative.1. Colon and rectum is cut off entirely, ileal stoma
Art；2. colon cuts off, returns anastomosis of rectum entirely；3. controlling ileostomy；4. Colon and rectum is cut off entirely, ileum bag anal anastomosis
Art.
The effective long-term method prevented or treated is there is no at present, and in the operation of existing four class, Colon and rectum cuts off, returned entirely
Bowel bag anal anastomosis be can yet be regarded as relatively reasonable, alternative mode.
Buddhist nun as breathe out therapy be Mongolian medicine often use external therapy, medicine is directly acted on diseased region, have curative effect reliably and
It is inexpensive, the advantage such as simplicity.
The content of the invention
The invention provides a kind of externally used Mongolian medicine preparation for treating ulcerative colitis, it includes the medicine of following parts by weight
Prescription：
Radix picrorrhizae 5, fringed pink 5, cape jasmine 5, Ji Leze 5, Radix Rhapontici seu Radix Echinopsis spend 5, pseudo-ginseng 5, madder 5, Marsh Felwort 5, bear gall powder 2.
Present invention also offers a kind of preparation method of the externally used Mongolian medicine preparation of the treatment ulcerative colitis, it is will
Radix picrorrhizae, fringed pink, cape jasmine, Ji Leze, Radix Rhapontici seu Radix Echinopsis flower, pseudo-ginseng, madder, Marsh Felwort fine lapping are pulvis, and medicinal powder is tuned into boiling water
Scattered paste shape, equitemperature add bear gall powder, bowel lavage after stirring when being down to appropriateness.Usage：According to diseased region and range size, selection
The enema tube of the appropriate good medicine of grinding and suitable length.
In we using removing heat from blood, detoxicating functions Radix picrorrhizae as monarch drug in a prescription.Be aided with removing heat from blood, balance voxel effect fringed pink,
Cape jasmine；Heat-clearing, the Marsh Felwort of effect of curing the wound, Radix Rhapontici seu Radix Echinopsis flower；Heat-clearing, removing toxic substances, the Ji Leze of effect of subsiding a swelling, pseudo-ginseng, madder；It is subject to again
There is the hemostasis of lock arteries and veins, calm down association's day, the bear gall of only corruption, myogenic and other effects, this prescription has removing heat from blood, removing toxic substances, stops blooding, cures the wound, only
Rotten, myogenic and other effects.
This bowel lavage external medicine preparation is by Radix picrorrhizae, fringed pink, cape jasmine, Ji Leze, Radix Rhapontici seu Radix Echinopsis flower, pseudo-ginseng, madder, Marsh Felwort etc.
8 herbal medicines and bear gall compatibility composition, there is heat-clearing, detoxify, kill glutinous, only intestines shouting pain, callus and other effects.Radix picrorrhizae bitter, it is cold in nature,
Imitate light, light, rough, mainly have heat-clearing, detoxify, extravasated blood of dispelling, clear disturb heat, callus and other effects.Radix picrorrhizae glycosides containing Veronica, Radix picrorrhizae are bitter
The compositions such as glycosides, there is the effects such as anti-inflammatory, cholagogic, antiulcer, regulation immunologic function.Fringed pink, bitter is cold in nature, and effect is light, light, mainly
There are removing heat from blood, only shouting pain, removing toxic substances and other effects.The water extract of fringed pink and low polar extract can suppress human body B cell and be immunized
The secretion of globulin, have to Escherichia coli, salmonella paratyphi, staphylococcus aureus, hay bacillus and proteus
Inhibitory action, there is anti-chlamydia activity, excited intestinal tube, analgesic and other effects.Cape jasmine bitter, cool in nature, effect is blunt, rough, and main ask the visitor in
The effect of blood-head, wherein cape jasmine, contain gardenoside, have analgesic, anti-inflammatory, suppress bacterium, repair the pharmacological actions such as soft tissue injury.
Cape jasmine infusion can suppress various dermatophytes in vitro；Decocting liquid can then kill Leptospira and blood fluke in vitro, and
There is anti-echovirus.Ji Leze, bitter is cool in nature, effect it is soft, light, mainly have town association day, heat-clearing, removing toxic substances, detumescence, only
Blood, except Xieri Wusu Symptom and other effects.Ji Leze contains gentiamarin, and inflammation early stage is oozed out with certain inhibitory action, bark of ash alkali
First has antianaphylaxis shock and anti-group of vertical amine, antioxidation.Radix Rhapontici seu Radix Echinopsis is spent, and bitter is cool in nature, and effect is rough, thin, blunt, soft, mainly has
Kill glutinous, only intestines shouting pain, heat-clearing, removing toxic substances and other effects.Radix Rhapontici seu Radix Echinopsis flower contains the compositions such as flavones, volatile oil, phytosterol, terpene, monose,
With analgesia, certain removing free radical etc..Pseudo-ginseng, it is sweet, bitter, it is cool in nature, effect it is blunt, light, soft, rough, mainly have heat-clearing, removing toxic substances,
Convergence, hemostasis, analgesic, detumescence, callus and other effects.Pseudo-ginseng is traumatology key medicine, there is the title of " hemostasis god's medicine ", and its main component has three
Seven total saposins, dencichine, flavones, volatile oil, amino acid, carbohydrate and various trace elements etc., there is stronger anastalsis, its
Hemostasis active ingredient is dencichine, is a kind of special amino acid, water-soluble, can substantially shorten the clotting time of mouse, and make
Platelet counts dramatically increase, while have platelet aggregation-against, hematopoiesis and other effects.Madder, bitter is cool in nature, effect it is rough, blunt, soft,
It is dry, mainly have get mildewed in warm conditions clearly, blood-head and hemostasis, antidiarrheal, only intestines shouting pain and other effects.Madder mainly containing quinones, hexamethylene peptides, terpene,
Polysaccharide etc., with anti-inflammation, anticancer, anti-oxidant, antipyretic-antalgic and the crude extract of madder with function of increasing leukocyte,
Antipyretic-antalgic, hemostasis and other effects.Marsh Felwort, bitter is cold in nature, and effect is blunt, rough, light, dry, mainly has suppression association day, heat-clearing, cures the wound, is good for
Stomach and other effects.Marsh Felwort is to EHEC, shigella dysenteriae, staphylococcus albus, resistant Staphylococcus aureus, golden yellow Portugal
Gram-positive bacteria and Gram-negative bacteria representated by grape coccus, Pseudomonas aeruginosa etc. all have preferable bacteriostatic activity.Using
Mtt assay research each composition of Marsh Felwort is thin to HeLa Cells, Humanmachine tumour A375.S2 cells, human breast carcinoma MCF.7
Born of the same parents, human hepatoma HepG2 cell and human gastric cancer SGC790l cytoactives, there is different degrees of inhibitory action.Bear gall, bitter, property
It is cool, have the hemostasis of lock arteries and veins, calm down association's day, only improving eyesight, rotten, myogenic, cure mainly spitting blood, have blood in stool, spit blood, uterine hemorrhage, liver heat, association's day disease
Deng.Main urso containing mating type (UDCA), chenodeoxycholic acid (CDCA), cholic acid (CA), deoxycholic aicd (DCA), ox sulphur
Urso (TUD.CA), Taurochenodeoxycholic Acid (TCDCA) and cholesterol, bilins, amino acids, protein,
Peptide, aliphatic acid, trace element etc., there is antipyretic-antalgic, anti-inflammatory, antibacterial, antiviral, promotion circulation, tranquilizing to relieve muscle spasm and other effects.
The modern study of this pharmaceutical preparation is very identical with traditional effect.
This pharmaceutical preparation have good effect, have no toxic side effect, (21 days are 1 course for the treatment of to short treating period, and the general state of an illness has substantially good
Turn), the advantage such as inexpensive.This prescription treats colitis, can avoid " first pass effect of hepar ", avoid lesions of liver and kidney and medicine has
Effect composition directly acts on colonic pathological change position mucous membrane, and blood vessel of the active ingredient through intestinal wall rich surrounding, lymphatic vessel follow into body
Ring, so as to play the effect locally or systemically treated.Colon administration feature：
1. by mucosal absorption, fast, markedly fast is absorbed.
2. avoid first pass effect of hepar, it is therefore prevented that the destruction of hydrochloric acid in gastric juice and various enzymes to medicine.
3. avoid stimulation of the medicine to stomach lining.
4. improve the bioavilability of medicine.
5. avoiding oral medicine is not easy received shortcoming because of poor taste.Therefore act on direct and curative effect is fast.
Embodiment：
Embodiment 1
It is each 5g to take the 8 taste medicines such as Radix picrorrhizae, fringed pink, cape jasmine, Ji Leze, Radix Rhapontici seu Radix Echinopsis flower, pseudo-ginseng, madder, Marsh Felwort, fine lapping
For pulvis.Anaesthetic powder is tuned into scattered paste shape with boiling water, equitemperature adds 2g bear gall powders, bowel lavage after stirring when being down to appropriateness.Usage：
According to diseased region and range size, the good medicine of appropriate grinding and the enema tube of suitable length are selected.
Embodiment 2
Patient's defecation or intestinal lavage are allowed before implementing bowel lavage, make patient's left lateral position, left leg stretches, right leg flexing, uses enema tube
Slowly insert in rectum, the data provided according to colonoscopy, slowly inject decoction during away from focus edge 2-3cm, each injection rate, 8
Year, following children were advisable with 5g medicines addition 80-100ml warm waters, and be grown up is advisable with 10g medicines addition 100-200ml warm waters.Medicine
39-41 DEG C of liquid temperature degree is advisable, and is solved after enjoining patient's 20-30 minutes after injection decoction.Treat ulcerative colitis, colon inflammatory
Polyp etc..
From 1 day to 2014 August of September in 2002 30 days, 268 patients, wherein patients of ulcerative colitis 123 were treated altogether
Example (effective 114), the polypous colitis disease 145 (effective 133) of topical ulcers merging, 1 times/day of enema treatment,
Treatment is had blood in stool after 21 days, the symptom such as suffer from abdominal pain, suffer from diarrhoea is clearly better as SS (Effect of follow-up visit by telephone), total effective rate 92.5%；According to
Incomplete statistics, colonoscopy reviewing patient has 197 after treating a course for the treatment of, polyp disappears, ulcer heals substantially 141, accounts for
71.6%.
Claims (2)
1. a kind of externally used Mongolian medicine preparation for treating ulcerative colitis, its bulk drug composition are：Radix picrorrhizae 5, fringed pink 5, cape jasmine 5,
Ji Leze 5, Radix Rhapontici seu Radix Echinopsis spend 5, pseudo-ginseng 5, madder 5, Marsh Felwort 5, bear gall powder 2.
2. a kind of preparation method of the externally used Mongolian medicine preparation for the treatment of ulcerative colitis according to claim 1, its
To be pulvis by Radix picrorrhizae, fringed pink, cape jasmine, Ji Leze, Radix Rhapontici seu Radix Echinopsis flower, pseudo-ginseng, madder, Marsh Felwort fine lapping, by medicinal powder boiling water
Scattered paste shape is tuned into, equitemperature adds bear gall powder when being down to appropriateness, stirred.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698151A (en) * | 2012-05-07 | 2012-10-03 | 邓泽潭 | Traditional Chinese medicine for treating ulcerative colitis |
| CN105250821A (en) * | 2015-11-27 | 2016-01-20 | 辽宁中医药大学 | Traditional Chinese medicine compound preparation for treating ulcerative colitis and preparation method thereof |
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- 2016-03-30 CN CN201610192533.3A patent/CN105748700B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698151A (en) * | 2012-05-07 | 2012-10-03 | 邓泽潭 | Traditional Chinese medicine for treating ulcerative colitis |
| CN105250821A (en) * | 2015-11-27 | 2016-01-20 | 辽宁中医药大学 | Traditional Chinese medicine compound preparation for treating ulcerative colitis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 吉勒泽;国家中医药管理局编委会编著;《中华本草蒙药卷》;上海科学技术出版社;20040930;第175-176页 * |
| 蒙医尼如哈疗法治疗溃疡性结肠炎的方药证治规律研究;布图雅;《中国民族医药杂志》;20100731(第1期);第39-40页 * |
| 蒙医肠疗-尼如哈治疗溃疡性结肠炎辩证论治规律探析;布图雅;《亚太传统医药》;20130430;第9卷(第4期);第7-9页 * |
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