WO2010005195A3 - 아데포버 디피복실의 결정형 ｌ의 제조방법 - Google Patents

아데포버 디피복실의 결정형 ｌ의 제조방법 Download PDF

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Publication number
WO2010005195A3
WO2010005195A3 PCT/KR2009/003472 KR2009003472W WO2010005195A3 WO 2010005195 A3 WO2010005195 A3 WO 2010005195A3 KR 2009003472 W KR2009003472 W KR 2009003472W WO 2010005195 A3 WO2010005195 A3 WO 2010005195A3
Authority
WO
WIPO (PCT)
Prior art keywords
adefovir dipivoxil
crystal form
preparing crystal
preparing
dipivoxil
Prior art date
Application number
PCT/KR2009/003472
Other languages
English (en)
French (fr)
Other versions
WO2010005195A2 (ko
Inventor
이기화
우병영
홍덕기
전재일
Original Assignee
(주)아모레퍼시픽
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020080065440A external-priority patent/KR20090101039A/ko
Application filed by (주)아모레퍼시픽 filed Critical (주)아모레퍼시픽
Publication of WO2010005195A2 publication Critical patent/WO2010005195A2/ko
Publication of WO2010005195A3 publication Critical patent/WO2010005195A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

아데포버 디피복실(adefovir dipivoxil)의 결정형 L의 제조방법으로서, 아데포버 디피복실의 이소프로필알코올 또는 아세트산에틸 용액에 항용매를 첨가하고 교반하여 결정을 생성시키는 방법에 개시되며, 이러한 제조방법에 따르면, 기존에 알려진 방법 보다 훨씬 온화한 조건에서 목적하는 아데포버 디피복실의 결정형 L을 균일하고 적절한 크기로 용이하게 얻을 수 있다.
PCT/KR2009/003472 2008-07-07 2009-06-26 아데포버 디피복실의 결정형 ｌ의 제조방법 WO2010005195A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0065440 2008-07-07
KR1020080065440A KR20090101039A (ko) 2008-03-21 2008-07-07 아데포버 디피복실의 결정형 ｌ의 제조방법

Publications (2)

Publication Number Publication Date
WO2010005195A2 WO2010005195A2 (ko) 2010-01-14
WO2010005195A3 true WO2010005195A3 (ko) 2010-04-01

Family

ID=41507863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/003472 WO2010005195A2 (ko) 2008-07-07 2009-06-26 아데포버 디피복실의 결정형 ｌ의 제조방법

Country Status (1)

Country Link
WO (1) WO2010005195A2 (ko)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004774A2 (en) * 1997-07-25 1999-02-04 Gilead Sciences, Inc. Nucleotide analog compositions
US20060025384A1 (en) * 2002-11-12 2006-02-02 Guocheng Wang New crystal form of adefovir dipivoxil and its composition
CN1903863A (zh) * 2006-07-28 2007-01-31 齐鲁制药有限公司 一种阿德福韦酯结晶的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004774A2 (en) * 1997-07-25 1999-02-04 Gilead Sciences, Inc. Nucleotide analog compositions
US20060025384A1 (en) * 2002-11-12 2006-02-02 Guocheng Wang New crystal form of adefovir dipivoxil and its composition
CN1903863A (zh) * 2006-07-28 2007-01-31 齐鲁制药有限公司 一种阿德福韦酯结晶的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GUANGYANG HOU ET AL.: "Solubilities of Adefovir Dipivoxil in Different Binary Solvents at 298.15 K", J. CHEM. ENG. DATA, vol. 53, April 2008 (2008-04-01), pages 1021 - 1023 *

Also Published As

Publication number Publication date
WO2010005195A2 (ko) 2010-01-14

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