WO2010000580A2 - Use of rooibos or rooibos extracts with prebiotics for skin and hair - Google Patents
Use of rooibos or rooibos extracts with prebiotics for skin and hair Download PDFInfo
- Publication number
- WO2010000580A2 WO2010000580A2 PCT/EP2009/057118 EP2009057118W WO2010000580A2 WO 2010000580 A2 WO2010000580 A2 WO 2010000580A2 EP 2009057118 W EP2009057118 W EP 2009057118W WO 2010000580 A2 WO2010000580 A2 WO 2010000580A2
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- WIPO (PCT)
- Prior art keywords
- skin
- accordance
- rooibos
- hair
- composition
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-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the present invention relates to the use of rooibos or rooibos extract in combination with at least one prebiotic for improving skin or hair health by preventing, alleviating or treating skin or hair disorders or damages such as is effected by inflammatory reactions, environmental factors, ageing or cancer. It can also be used to improve UV protection or skin glow or reduce skin wrinkles or skin inflammation. It also relates to the compositions containing rooibos or rooibos extracts and at least one prebiotic.
- the most prominent epithelial tissue in living beings is the skin, which represents the largest organ in the organism.
- the system of skin integument which comprises the epidermis, dermis and the stratum corneum, correlates with those of internal organs and concurrently interacts with the surroundings. Being the interface between the environment and organism itself, the skin is heavily influenced by external factors and also variable parameters of the organism's inner system.
- the skin's regulative mechanisms need, therefore, always be active to induce systemic changes necessary to maintain normal pathological events concerning skin integument morphology and activities.
- the cutaneous barrier is exposed daily to chemicals, xenobiotic and particles composing urban pollution.
- atmospheric pollutants likely to exert noxious effects on the skin and the hair, three main categories can be distinguished. They are essentially gas, heavy metals, and particles which are the residues of combustion on which are adsorbed many organic compounds. The gases contribute more particularly to the formation of an environment "pro-oxidant" to which the most external surface tissues are directly exposed.
- the oxidation and the degradation of the lipids of the stratum corneum can deteriorate the function barrier of the stratum corneum.
- the disturbance of the external lipids and the architecture of proteins are factors starting in many dermatoses (psoriasis, atopic dermatitis, irritating dermatitis).
- a significant oxidative attack on the level of the surface layers of the stratum can initiate subjacent localised inflammatory processes.
- This deterioration of the cutaneous barrier can be in particular translated for a subject by feelings of cutaneous discomfort, phenomena sensory and/or the demonstration of undesirable cutaneous signs, even painful such as irritations.
- the above mentioned signs of discomfort can be moreover associated with undesirable cutaneous signs, such as rednesses, irritations, scabs, erythemas inflammatory, oedemas and/or buttons.
- EP 0 761 214 discloses singlet oxygen quenchers comprising aniline derivatives and difurfuryl amine derivatives, which are reported to reduce the oxidative stress to the skin.
- an object of the present invention is to provide J
- compositions that may be used over a long period of time by humans or pets, and susceptible to be provided in the form of a nutritional supplement, a food or petfood composition or a beverage.
- the present inventors were surprised to see that they could achieve this object by using Rooibos or Rooibos extract, in particular in combination with prebiotics.
- Rooibos, Oriental bush is a wild South African plant that grows in a specific area of the south-western part of South Africa, and that is commonly used by local populations to prepare infusion in the same manner as tea. It is a member of the legume family of plants which scientific name is Aspalathus linearis. Rooibos tea is often called South African red tea or simply red tea or bush tea. Rooibos tea has been popular in South Africa for generations, but is recently consumed increasingly in countries all over the world.
- the present invention relates to an orally administrable composition
- an orally administrable composition comprising Aspalathus linearis or an extract thereof in combination with at least one prebiotic.
- composition comprising Aspalathus linearis or an extract thereof in combination with at least one prebiotic.
- a product for the preparation of a product to improve skin or hair health, treat, alleviate and/or prevent skin or hair disorders.
- the skin disorders or damages that can be treated, alleviated or prevented according to the present invention can for example be selected from the group consisting of skin inflammation, such as UV or chemical-induced skin inflammation, reactive or dry skin, psoriasis, vitiligo, acne, ageing, UV protection, photo ageing, wrinkles. It also provides beneficial effects on skin glow or skin moisture, hydration of the skin.
- the hair (or coat) disorders or damages that can be treated or prevented are hair and coat gloss, hair density, color, oilness, ameliorating hair fiber diameter, sebum production, glossiness and preventing hair and coat loss.
- the composition according to the present invention is administered to a human or to an animal, for ameliorating antioxidant status or barrier function of the skin.
- suitable extracts of Aspalathus linearis may be prepared by any means that are known in the art, e.g., by steam extraction, solvent extraction, distillation, pressing or grinding.
- the extract is obtainable, in particular obtained, by extraction with a solvent from Aspalathus linearis plant material, in particular by a water extraction or an alcohol/water extraction, for example by a ethanol/water extraction.
- the Aspalathus linearis extracts may also be obtainable, and are in particularly obtained by a method comprising the steps of: i) mixing and milling Aspalathus linearis material in milk or a milk protein-containing liquid medium, ii) optionally separating insoluble material to obtain an aqueous suspension iii) optionally pasteurising the resulting suspension iv) optionally add synthetic or natural bioactive components during the processing v) and further optionally drying the suspension to obtain a powder.
- This process has the advantage of being natural and cost effective enabling improved delivery of multi-nutrients in the form of a combination of stabilized water- and fat-soluble compounds in their natural compositions, free of organic solvent residues.
- an extract of Aspalathus linearis is used in the present invention it is preferred if at least 50wt.-%, preferably at least 70 wt.-% more preferably at least 95 wt.-% of the extract are water soluble. This has the advantage that the extract can easily be admixed with other water based foodstuffs before consumption.
- One typical example of an extract of Aspalathus linearis that can be used in the framework of the present invention is rooibos tea.
- Suitable extracts of Aspalathus linearis for the purpose of the present invention are also extracts that are commercially available, such as for example Rooibos from Afriplex or Rooibos from Rooibos Ltd.
- the product also contain at least one prebiotic.
- prebiotic means food substances that promote the growth of probiotics in the intestines. They are not broken down in the stomach and/or upper intestine or absorbed in the Gl tract of the person ingesting them, but they are fermented by the gastrointestinal microflora and/or by probiotics.
- Prebiotics are known to produce a synergistic effect with probiotics, thus the combination of probiotics, prebiotics and Aspalathus linearis or an extract thereof will also be very effective in treating or preventing inflammatory disorders.
- the prebiotics that may be used in accordance with the present inventions are not particularly limited and include all food substances that promote the growth of probiotics in the intestines.
- oligosaccharides optionally containing fructose, galactose, mannose; dietary fibers, in particular soluble fibers, soy fibers; inulin; or mixtures thereof.
- the prebiotic is preferably in an amount of 0.3 to 10 % dry weight of the composition.
- prebiotics include certain oligosaccharides, such as fructooligosaccharides (FOS) and galactooligosaccharides (GOS).
- FOS fructooligosaccharides
- GOS galactooligosaccharides
- a combination of prebiotics may be used, such as 90% GOS with 10% short chain fructooligosaccharides such as the product sold under the trade mark Raftilose® or 10% inulin such as the product sold under the trade mark Raftiline®.
- Preferred prebiotics are fructo-oligosaccharides (FOS), galacto-oligosacchahdes (IOS), isomalto-oligosacchahdes, xylo-oligosaccharides, oligosaccharides of soy, glycosylsucrose (GS), lactosucrose (LS), lactulose (LA), palatinose-oligosaccharides (PAO), malto-oligosacchahdes (MOS), gums and/or hydrolysates thereof, pectins and/or hydrolysates thereof.
- FOS fructo-oligosaccharides
- IOS galacto-oligosacchahdes
- IOS isomalto-oligosacchahdes
- xylo-oligosaccharides oligosaccharides of soy
- glycosylsucrose GS
- lactosucrose LS
- LA lactosucrose
- LA lac
- a particularly preferred prebiotic is a mixture of galacto-oligosacchahde(s), N- acetylated oligosacchahde(s) and sialylated oligosaccharide(s) in which the N- acetylated oligosaccharide(s) comprise 0.5 to 4.0% of the oligosaccharide mixture, the galacto-oligosacchahde(s) comprise 92.0 to 98.5% of the oligosaccharide mixture and the sialylated oligosaccharide(s) comprise 1.0 to 4.0% of the oligosaccharide mixture.
- This mixture is hereinafter referred to as "CMOS-GOS”.
- a composition for use according to the invention contains from 2.5 to 15.0 wt% CMOS- GOS on a dry matter basis with the proviso that the composition comprises at least 0.02 wt% of an N-acetylated oligosaccharide, at least 2.0 wt% of a galacto- oligosaccharide and at least 0.04 wt% of a sialylated oligosaccharide.
- the product comprising a composition comprising Aspalathus linearis or an extract thereof and a prebiotic according to the present invention may be for example a food product, a drink, a food supplement, a nutraceutical, a pet food product or a medicament.
- the product may also further comprise a protein source, a carbohydrate source, a lipid source, a mineral source and/or a vitamin source.
- a protein source a carbohydrate source
- a lipid source a mineral source and/or a vitamin source.
- proteins, carbohydrates, lipids, minerals and/or vitamins may have several advantages. These compounds generally contribute to the taste and mouthfeel of the final product. They also provide the body with nutrients that it may need urgently when it is affected by skin/hair disorders. They also allow formulating the product of the present invention as a complete nutritional formula, so that no additional nutrition is needed. This might be in particularly helpful for consumers that do not ingest sufficient amounts of food or that have trouble swallowing and that hence wish to ingest only small amounts of food.
- the products used in the present invention are preferably intended for enteral application. While the products are primarily intended to be used by humans, they may also be applied to animals, in particular companion animals, pets or livestock.
- Particularly preferred products are products selected from the group consisting of teas, iced teas, a foamed beverage, a confectionery product, a culinary product, a nutritional complete formula, a dairy product, a chilled or shelf stable beverage, a product for lactating mothers, a liquid drink, a soup, a dietary supplement, a meal replacement, a nutritional bar, a milk or a fermented milk product, a yoghurt, a milk based powder, an enteral nutrition product, an infant formula, an infant nutritional product, a puree, a cereal product or a fermented cereal based product, an ice-cream, candy, sweets, biscuits, cakes, a chocolate, a cappuccino, a coffee, a culinary product such as mayonnaise, tomato puree or salad dressings, a pet food, a pet beverage, a tablet, a capsule, a pill, a solution, a suspension, a syrup, a powder, a gel, a dried oral supplement or a we
- Aspalathus linearis or an extract thereof and prebiotic in the product will depend on several factors, such as the nature of the extract, the condition of the plant, the age, condition and size of the person or animal to be treated, the frequency, the product will be applied and/or the specific kind of skin/hair disorder or damage to be treated or prevented.
- the effectiveness of the composition according to the present invention is generally dose dependant and follows a dose response curve. If generally mild skin/hair disorders or damages are to be prevented and the product will be used frequently, very small amounts of the composition will be sufficient to achieve the desired effect. If a severe skin disorder is to be treated, larger amounts of the composition will be more appropriate, although also small amounts will produce an effect.
- the product contains Aspalathus linearis or an extract thereof in an amount in the range of about 0,1 g/l to 10 g/l, preferably in the range of 0,5 g/l to 3 g/l product. If the total amount of product cannot be measured in litres it is preferred if the product contains Aspalathus linearis or an extract thereof in an amount in the range of about 0,1 g/kg to 10 g/kg, preferably in the range of 0,5 g/kg to 3 g/kg product.
- the product contains Aspalathus linearis or an extract thereof in a daily dose of 0,01 g-100g, preferably 0,25 g-10g.
- the fibre content is between 2 and 40 g/l of the composition as consumed, more preferably between 4 and 10 g/l.
- the product may also comprises at least one kind of food grade micro-organism, in particular probiotics.
- Food grade are all substances that are approved for human or animal consumption.
- Probiotic means microbial cell preparations or components of microbial cells with a beneficial effect on the health or well-being of the host.
- the probiotics may be selected from the group consisting of group consisting of Bifidobacterium, Lactobacillus, Streptococcus and Saccharomyces or mixtures thereof, in particular selected from the group consisting of Bifidobacterium longum, Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus johnsonii, Lactobacillus plantarum, Lactobacillus salivahus, Streptococcus faecium, Saccharomyces boulardii and Lactobacillus reuteri or mixtures thereof, preferably selected from the group consisting of Lactobacillus johnsonii NCC 533 (CNCM 1-1225), Bifidobacterium longum NCC 490 (CNCM 1-2170), Bifidobacterium longum NCC 2705 (CNCM 1-2618) , Bifidobacterium lactis B
- probiotics in a composition comprising Aspalathus linearis or an extract thereof may have several important effects. Consequently, the combination of probiotics with Aspalathus linearis or an extract thereof can be expected to have a further positive effect on the treatment and prevention of skin/hair disorders or damages.
- the product prepared for the use of the present invention may also contain at least one phytonutrient.
- phytonutrient describes those plant compounds which have health- protecting qualities. For example antioxidant, immune boosting or other health promoting properties of active compounds in plants are typical effects of phytonutrients.
- Phytonuthents include but are not limited to terpenes, carotenoids, limonoids, polyphenols, and phytosterols.
- the carotenoids may be selected from the group consisting of carotenes and xanthophylls such as lycopene, carotene, phytofluene, phytoene, canthaxanthin, beta-cryptoxanthin, capsanthin, lutein, zeaxanthin, or those in the form of fatty acid esters, or mixtures thereof.
- the polyphenols are preferably selected from the group consisting of flavones such as apigenin, luteolin or diosmetin, flavonols such as quercetin, myricetin, kaempferol, flavanones, anthocyanidins or isoflavones such as genistein, daidzein, or phenolic acids such as caffeic, ferulic acid or mixtures thereof.
- Preferred phytonutrients for the present invention are beta-carotene, lutein, and/or catechin.
- the phytonutrients may be also provided in the form of a plant or plant extract.
- Rooibos is added to the other ingredients as Rooibos extract powder.
- "Rooibos" refers to Rooibos extract.
- This Rooibos sweetening powder is obtained by the following preparation process, comprising the steps of, in order: (i) mixing 100g Rooibos dried leaves and stems with 1 litre boiling water,
- Powdered beverage composition comprising cereals, fruit powder and/or bits, and/or chocolate ingredients are prepared that incorporate an extract of Rooibos plant. They are formulated as follows (quantities are given in % of total weight of the composition):
- Example 2 Confectionery and chocolate compositions can also be prepared, that incorporate Rooibos. Examples of such food compositions are as follows (quantities are given in % of total weight of the final composition).
- a cereal beverage composition is prepared that incorporates a sweetening ingredient from Rooibos plant.
- the said food composition comprises (quantities are given in % of total weight of the composition):
Abstract
The present invention relates to the use of rooibos or rooibos extract in combination with at least one prebiotic for improving skin or hair health by preventing, alleviating or treating skin or hair disorders or damages such as is effected by inflammatory reactions, environmental factors, ageing or cancer. It can also be used to improve UV protection or skin glow or reduce skin wrinkles or skin inflammation. It also relates to the compositions containing rooibos or rooibos extracts and at least one prebiotic.
Description
Use of Rooibos or Rooibos extracts with prebiotics for skin and hair
The present invention relates to the use of rooibos or rooibos extract in combination with at least one prebiotic for improving skin or hair health by preventing, alleviating or treating skin or hair disorders or damages such as is effected by inflammatory reactions, environmental factors, ageing or cancer. It can also be used to improve UV protection or skin glow or reduce skin wrinkles or skin inflammation. It also relates to the compositions containing rooibos or rooibos extracts and at least one prebiotic.
Background of the Invention
The most prominent epithelial tissue in living beings is the skin, which represents the largest organ in the organism. The system of skin integument, which comprises the epidermis, dermis and the stratum corneum, correlates with those of internal organs and concurrently interacts with the surroundings. Being the interface between the environment and organism itself, the skin is heavily influenced by external factors and also variable parameters of the organism's inner system. The skin's regulative mechanisms need, therefore, always be active to induce systemic changes necessary to maintain normal pathological events concerning skin integument morphology and activities.
A great deal of processes assuring the adequate consumption of increased affluence of energetic and plastic substances according to the skin's needs become guarantors of morphological and functional stability of skin structures. So, the state of integuments determines the realization of metabolic processes necessary for skin cell viability and activity leading to the presence of healthy skin peculiarities such as barrier function, elasticity, turgor properties, humidity or pigmentation, for example.
During the lifetime of a living being different signs, characteristic of ageing, appear on the skin or hair, with the principal clinical signs being the appearance of fine lines and deep wrinkles which increase or are accentuated with age, loss of hair, reduced hair density, glossiness, color, oilness, fiber diameter, for example.
These signs of ageing are even promoted by exposure of the skin and hair to exogenous influences, such as e.g. UV-radiation, pollutants, free radicals or chemical substances.
Moreover, the cutaneous barrier is exposed daily to chemicals, xenobiotic and particles composing urban pollution. Among these atmospheric pollutants likely to exert noxious effects on the skin and the hair, three main categories can be distinguished. They are essentially gas, heavy metals, and particles which are the residues of combustion on which are adsorbed many organic compounds. The gases contribute more particularly to the formation of an environment "pro-oxidant" to which the most external surface tissues are directly exposed.
The oxidation and the degradation of the lipids of the stratum corneum can deteriorate the function barrier of the stratum corneum. The disturbance of the external lipids and the architecture of proteins are factors starting in many dermatoses (psoriasis, atopic dermatitis, irritating dermatitis). In addition, a significant oxidative attack on the level of the surface layers of the stratum can initiate subjacent localised inflammatory processes. This deterioration of the cutaneous barrier can be in particular translated for a subject by feelings of cutaneous discomfort, phenomena sensory and/or the demonstration of undesirable cutaneous signs, even painful such as irritations. The above mentioned signs of discomfort can be moreover associated with undesirable cutaneous signs, such as rednesses, irritations, scabs, erythemas inflammatory, oedemas and/or buttons.
In the art several means have been proposed to prevent destructive effects of environment or ageing on skin epithelial cells. For example, means to prevent skin deterioration or ageing is to provide compounds scavenging free radicals. In this respect EP 0 761 214 discloses singlet oxygen quenchers comprising aniline derivatives and difurfuryl amine derivatives, which are reported to reduce the oxidative stress to the skin.
Although there is a great diversity of active compounds for ameliorating skin and hair or coat health, there still exists a need in the art to provide new active compounds, naturally occurring. In particular, an object of the present invention is to provide
J
compositions that may be used over a long period of time by humans or pets, and susceptible to be provided in the form of a nutritional supplement, a food or petfood composition or a beverage.
Summary of the invention
The present inventors were surprised to see that they could achieve this object by using Rooibos or Rooibos extract, in particular in combination with prebiotics.
Rooibos, Afrikaans for "red bush"; is a wild South African plant that grows in a specific area of the south-western part of South Africa, and that is commonly used by local populations to prepare infusion in the same manner as tea. It is a member of the legume family of plants which scientific name is Aspalathus linearis. Rooibos tea is often called South African red tea or simply red tea or bush tea. Rooibos tea has been popular in South Africa for generations, but is recently consumed increasingly in countries all over the world.
Thus, the present invention relates to an orally administrable composition comprising Aspalathus linearis or an extract thereof in combination with at least one prebiotic.
It also relates to an orally administrable composition comprising Aspalathus linearis or an extract thereof in combination with at least one prebiotic. for the preparation of a product to improve skin or hair health, treat, alleviate and/or prevent skin or hair disorders.
The skin disorders or damages that can be treated, alleviated or prevented according to the present invention can for example be selected from the group consisting of skin inflammation, such as UV or chemical-induced skin inflammation, reactive or dry skin, psoriasis, vitiligo, acne, ageing, UV protection, photo ageing, wrinkles. It also provides beneficial effects on skin glow or skin moisture, hydration of the skin.
The hair (or coat) disorders or damages that can be treated or prevented are hair and coat gloss, hair density, color, oilness, ameliorating hair fiber diameter, sebum production, glossiness and preventing hair and coat loss.
Also, the composition according to the present invention is administered to a human or to an animal, for ameliorating antioxidant status or barrier function of the skin.
Detailed Description of the Invention
In a particular preferred embodiment of the present invention, suitable extracts of Aspalathus linearis may be prepared by any means that are known in the art, e.g., by steam extraction, solvent extraction, distillation, pressing or grinding.
It is however preferred if the extract is obtainable, in particular obtained, by extraction with a solvent from Aspalathus linearis plant material, in particular by a water extraction or an alcohol/water extraction, for example by a ethanol/water extraction.
The use of water as extraction medium has the advantage that the obtained product can be directly incorporated into final products without having to eliminate the extraction medium first.
The traditional process to prepare infusible leaves out of Rooibos plants was as follows: plants are harvested by cutting their stems and leaves which are then put in a heap. The temperature inside the heap rapidly raises up to 400C, which causes fermentation of the leaves. After about one day, the leaf and stem pieces are dried in the sun and sieved, ready for infusion. This process is progressively replaced by batch rotary fermentation of moistened leaves and stems, after which a sun-drying step is still preferred. The infusion is then prepared in large quantities which are filtered and concentrated. Preferably after further purification, the ingredient is then ready to be added to any food preparation.
The Aspalathus linearis extracts may also be obtainable, and are in particularly obtained by a method comprising the steps of: i) mixing and milling Aspalathus linearis material in milk or a milk protein-containing liquid medium, ii) optionally separating insoluble material to obtain an aqueous suspension iii) optionally pasteurising the resulting suspension iv) optionally add synthetic or natural bioactive
components during the processing v) and further optionally drying the suspension to obtain a powder.
This process has the advantage of being natural and cost effective enabling improved delivery of multi-nutrients in the form of a combination of stabilized water- and fat-soluble compounds in their natural compositions, free of organic solvent residues.
If an extract of Aspalathus linearis is used in the present invention it is preferred if at least 50wt.-%, preferably at least 70 wt.-% more preferably at least 95 wt.-% of the extract are water soluble. This has the advantage that the extract can easily be admixed with other water based foodstuffs before consumption.
One typical example of an extract of Aspalathus linearis that can be used in the framework of the present invention is rooibos tea.
Suitable extracts of Aspalathus linearis for the purpose of the present invention are also extracts that are commercially available, such as for example Rooibos from Afriplex or Rooibos from Rooibos Ltd.
The product also contain at least one prebiotic. "Prebiotic" means food substances that promote the growth of probiotics in the intestines. They are not broken down in the stomach and/or upper intestine or absorbed in the Gl tract of the person ingesting them, but they are fermented by the gastrointestinal microflora and/or by probiotics.
Prebiotics are known to produce a synergistic effect with probiotics, thus the combination of probiotics, prebiotics and Aspalathus linearis or an extract thereof will also be very effective in treating or preventing inflammatory disorders.
The prebiotics that may be used in accordance with the present inventions are not particularly limited and include all food substances that promote the growth of probiotics in the intestines.
Preferably, they may be selected from the group consisting of oligosaccharides,
optionally containing fructose, galactose, mannose; dietary fibers, in particular soluble fibers, soy fibers; inulin; or mixtures thereof. The prebiotic is preferably in an amount of 0.3 to 10 % dry weight of the composition.
Further examples of prebiotics include certain oligosaccharides, such as fructooligosaccharides (FOS) and galactooligosaccharides (GOS). A combination of prebiotics may be used, such as 90% GOS with 10% short chain fructooligosaccharides such as the product sold under the trade mark Raftilose® or 10% inulin such as the product sold under the trade mark Raftiline®.
Preferred prebiotics are fructo-oligosaccharides (FOS), galacto-oligosacchahdes (IOS), isomalto-oligosacchahdes, xylo-oligosaccharides, oligosaccharides of soy, glycosylsucrose (GS), lactosucrose (LS), lactulose (LA), palatinose-oligosaccharides (PAO), malto-oligosacchahdes (MOS), gums and/or hydrolysates thereof, pectins and/or hydrolysates thereof.
A particularly preferred prebiotic is a mixture of galacto-oligosacchahde(s), N- acetylated oligosacchahde(s) and sialylated oligosaccharide(s) in which the N- acetylated oligosaccharide(s) comprise 0.5 to 4.0% of the oligosaccharide mixture, the galacto-oligosacchahde(s) comprise 92.0 to 98.5% of the oligosaccharide mixture and the sialylated oligosaccharide(s) comprise 1.0 to 4.0% of the oligosaccharide mixture. This mixture is hereinafter referred to as "CMOS-GOS". Preferably, a composition for use according to the invention contains from 2.5 to 15.0 wt% CMOS- GOS on a dry matter basis with the proviso that the composition comprises at least 0.02 wt% of an N-acetylated oligosaccharide, at least 2.0 wt% of a galacto- oligosaccharide and at least 0.04 wt% of a sialylated oligosaccharide.
The product comprising a composition comprising Aspalathus linearis or an extract thereof and a prebiotic according to the present invention may be for example a food product, a drink, a food supplement, a nutraceutical, a pet food product or a medicament.
The product may also further comprise a protein source, a carbohydrate source, a lipid source, a mineral source and/or a vitamin source. The presence of proteins,
carbohydrates, lipids, minerals and/or vitamins may have several advantages. These compounds generally contribute to the taste and mouthfeel of the final product. They also provide the body with nutrients that it may need urgently when it is affected by skin/hair disorders. They also allow formulating the product of the present invention as a complete nutritional formula, so that no additional nutrition is needed. This might be in particularly helpful for consumers that do not ingest sufficient amounts of food or that have trouble swallowing and that hence wish to ingest only small amounts of food.
Consequently, the products used in the present invention are preferably intended for enteral application. While the products are primarily intended to be used by humans, they may also be applied to animals, in particular companion animals, pets or livestock.
Particularly preferred products are products selected from the group consisting of teas, iced teas, a foamed beverage, a confectionery product, a culinary product, a nutritional complete formula, a dairy product, a chilled or shelf stable beverage, a product for lactating mothers, a liquid drink, a soup, a dietary supplement, a meal replacement, a nutritional bar, a milk or a fermented milk product, a yoghurt, a milk based powder, an enteral nutrition product, an infant formula, an infant nutritional product, a puree, a cereal product or a fermented cereal based product, an ice-cream, candy, sweets, biscuits, cakes, a chocolate, a cappuccino, a coffee, a culinary product such as mayonnaise, tomato puree or salad dressings, a pet food, a pet beverage, a tablet, a capsule, a pill, a solution, a suspension, a syrup, a powder, a gel, a dried oral supplement or a wet oral supplement.
The amounts of Aspalathus linearis or an extract thereof and prebiotic in the product will depend on several factors, such as the nature of the extract, the condition of the plant, the age, condition and size of the person or animal to be treated, the frequency, the product will be applied and/or the specific kind of skin/hair disorder or damage to be treated or prevented.
The present inventors have found that the effectiveness of the composition according to the present invention is generally dose dependant and follows a dose response
curve. If generally mild skin/hair disorders or damages are to be prevented and the product will be used frequently, very small amounts of the composition will be sufficient to achieve the desired effect. If a severe skin disorder is to be treated, larger amounts of the composition will be more appropriate, although also small amounts will produce an effect.
Generally, it is preferred if the product contains Aspalathus linearis or an extract thereof in an amount in the range of about 0,1 g/l to 10 g/l, preferably in the range of 0,5 g/l to 3 g/l product. If the total amount of product cannot be measured in litres it is preferred if the product contains Aspalathus linearis or an extract thereof in an amount in the range of about 0,1 g/kg to 10 g/kg, preferably in the range of 0,5 g/kg to 3 g/kg product.
Preferably the product contains Aspalathus linearis or an extract thereof in a daily dose of 0,01 g-100g, preferably 0,25 g-10g.
Preferably, if the prebiotic is in the form of dietary fiber, the fibre content is between 2 and 40 g/l of the composition as consumed, more preferably between 4 and 10 g/l.
The product may also comprises at least one kind of food grade micro-organism, in particular probiotics.
"Food grade" are all substances that are approved for human or animal consumption.
"Probiotic" means microbial cell preparations or components of microbial cells with a beneficial effect on the health or well-being of the host.
For the purpose of the present invention, the probiotics may be selected from the group consisting of group consisting of Bifidobacterium, Lactobacillus, Streptococcus and Saccharomyces or mixtures thereof, in particular selected from the group consisting of Bifidobacterium longum, Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus johnsonii, Lactobacillus plantarum, Lactobacillus salivahus, Streptococcus faecium, Saccharomyces boulardii and Lactobacillus reuteri or mixtures thereof, preferably selected from the group
consisting of Lactobacillus johnsonii NCC 533 (CNCM 1-1225), Bifidobacterium longum NCC 490 (CNCM 1-2170), Bifidobacterium longum NCC 2705 (CNCM 1-2618) , Bifidobacterium lactis Bb12, Bifidobacterium lactis NCC2818 (CNCM I-3446), Lactobacillus paracasei NCC 2461 (CNCM 1-2116), Lactobacillus rhamnosus GG, Lactobacillus rhamnosus NCC4007 (CGMCC 1.3724) Enterococcus faecium SF 68 (NCIMB 10415), and mixtures thereof.
The presence of probiotics in a composition comprising Aspalathus linearis or an extract thereof may have several important effects. Consequently, the combination of probiotics with Aspalathus linearis or an extract thereof can be expected to have a further positive effect on the treatment and prevention of skin/hair disorders or damages.
Finally, the product prepared for the use of the present invention may also contain at least one phytonutrient.
The term "phytonutrient" describes those plant compounds which have health- protecting qualities. For example antioxidant, immune boosting or other health promoting properties of active compounds in plants are typical effects of phytonutrients. Phytonuthents include but are not limited to terpenes, carotenoids, limonoids, polyphenols, and phytosterols.
The carotenoids may be selected from the group consisting of carotenes and xanthophylls such as lycopene, carotene, phytofluene, phytoene, canthaxanthin, beta-cryptoxanthin, capsanthin, lutein, zeaxanthin, or those in the form of fatty acid esters, or mixtures thereof.
The polyphenols are preferably selected from the group consisting of flavones such as apigenin, luteolin or diosmetin, flavonols such as quercetin, myricetin, kaempferol, flavanones, anthocyanidins or isoflavones such as genistein, daidzein, or phenolic acids such as caffeic, ferulic acid or mixtures thereof.
Preferred phytonutrients for the present invention are beta-carotene, lutein, and/or catechin. The phytonutrients may be also provided in the form of a plant or plant extract.
It is clear to those of skill in the art that they can freely combine all features described herein without departing from the scope of the present invention as disclosed.
Further advantages and features of the present invention are apparent from the following examples.
For examples 1 and 2 below, Rooibos is added to the other ingredients as Rooibos extract powder. In all example compositions, "Rooibos" refers to Rooibos extract.
This Rooibos sweetening powder is obtained by the following preparation process, comprising the steps of, in order: (i) mixing 100g Rooibos dried leaves and stems with 1 litre boiling water,
(ii) infusing the mix for about 5 minutes, and then
(iii) discarding solids from the infusion so as to obtain a liquid beverage containing about 10 g/l of Rooibos dry matter, (iv) removing water so as to obtain a dry extract powder.
Example 1 :
Powdered beverage composition comprising cereals, fruit powder and/or bits, and/or chocolate ingredients are prepared that incorporate an extract of Rooibos plant. They are formulated as follows (quantities are given in % of total weight of the composition):
- Rooibos dry matter between 0 and 80 %
- Cocoa between 5 and 40 % - Maltodextrine between 0 and 80 %
- Flavours, vitamins and Lecithin 1-5 %
- Sugar between 0 and 80%
Example 2:
Confectionery and chocolate compositions can also be prepared, that incorporate Rooibos. Examples of such food compositions are as follows (quantities are given in % of total weight of the final composition).
For chewing gum:
- gum base from 20 to 35%
- gum acacia solution from 5 to 15%
- sorbitol from 40 to 50% - mannitol from 10 to 20%
- Rooibos from 10 to 35%
- Flavour from 0.001 to 1 %
- Artificial sweeteners from 0 to 2%
For a low-sugar chocolate:
- Cocoa mass from 35 to 45%
- Cocoa butter from 10 to 20%
- erythritol from 40 to 53% - Rooibos from 0.02 to 10%
- Lecithin from 0.1 to 1 %
- Vanillin from 0.01 to 0.03%
Example 3
A cereal beverage composition is prepared that incorporates a sweetening ingredient from Rooibos plant. The said food composition comprises (quantities are given in % of total weight of the composition):
- Cereal beverage (eg. Ecco® or OrzoroCaro® 6% to 99%
- Others (aromas, nutriments) 0.5% to 10%
- Rooibos 0.04% to 0.8%
Claims
1. An orally ingestible composition comprising Aspalathus linearis or an extract thereof and at least one prebiotic.
2. A composition in accordance with claim 1 characterized in that the prebiotic is selected from the group consisting of oligosaccharides, optionally containing fructose, galactose, mannose; dietary fibers, in particular soluble fibers, soy fibers; inulin; or mixtures thereof.
3. A composition in accordance with claim 1 characterized in that the prebiotic is fructo-oligosaccharides (FOS), galacto-oligosacchahdes (IOS), isomalto- oligosaccharides, xylo-oligosacchahdes, oligosaccharides of soy, glycosylsucrose (GS), lactosucrose (LS), lactulose (LA), palatinose-oligosacchahdes (PAO), malto- oligosaccharides (MOS), gums and/or hydrolysates thereof, pectins and/or hydrolysates thereof.
4. A composition in accordance with one of the preceding claims, wherein the extract is obtainable by extraction with a solvent from Aspalathus linearis plant material, in particular by a water extraction or an alcohol/water extraction, for example by a ethanol/water extraction.
5. A composition in accordance with one of the preceding claims, wherein at least 50wt.-%, preferably at least 70 wt.-% more preferably at least 95 wt.-% of the extract are water soluble.
6. A composition in accordance with one of the preceding claims, wherein the extract is a commercially available extract, preferably Rooibos from Afhplex or Rooibos from Rooibos Ltd.
7. A composition in accordance with one of the preceding claims, which further comprises a protein source, a carbohydrate source, a lipid source, a mineral source and/or a vitamin source and is for oral, enteral and/or parenteral application.
8. A composition in accordance with one of the preceding claims, which comprises at least one kind of food grade micro-organisms, in particular probiotics selected from the group consisting of group consisting of Bifidobacterium, Lactobacillus, Streptococcus and Saccharomyces or mixtures thereof.
9. Use of a composition according to claim 1 , for the preparation of an orally administrable product for improving skin or hair health by preventing, alleviating or treating skin or hair disorders or damages such as is effected by inflammatory reactions, environmental factors, ageing or cancer.
10. Use in accordance with claim 9, wherein the skin disorder or damage is selected from the group consisting of skin inflammation, reactive or dry skin, psoriasis, vitiligo, acne, ageing, UV protection, photo ageing, wrinkles, skin glow or skin hydration or moisture of the skin.
11. Use in accordance with claim 9, wherein the hair or coat disorder or damage is selected from the group consisting of hair and coat gloss, hair density, color, oilness, ameliorating hair fiber diameter, sebum production, glossiness and preventing hair and coat loss.
12. Use in accordance with one of the preceding claims, wherein the product is a food product, a drink, a food supplement, a nutraceutical, a pet food product or a medicament.
13. Use in accordance with one of the preceding claims, wherein the product contains Aspalathus linearis or an extract thereof in an amount in the range of about 0,1 g/l to 10 g/l, preferably in the range of 0,5 g/l to 3 g/l.
14. Use in accordance with one of the preceding claims, wherein the product contains Aspalathus linearis or an extract thereof in a daily dose of 0,01 g-100g, preferably 0,25 g-1 Og.
15. Use in accordance with one of the preceding claims, wherein the product further contains at least one phytonutrient, preferably selected from the group consisting of lutein and catechin.
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| EP08157873 | 2008-06-09 | ||
| EP08157873.4 | 2008-06-09 |
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| PCT/EP2009/057118 WO2010000580A2 (en) | 2008-06-09 | 2009-06-09 | Use of rooibos or rooibos extracts with prebiotics for skin and hair |
| PCT/EP2009/057117 WO2010000579A2 (en) | 2008-06-09 | 2009-06-09 | Use of rooibos or rooibos extracts for skin and hair |
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| PCT/EP2009/057117 WO2010000579A2 (en) | 2008-06-09 | 2009-06-09 | Use of rooibos or rooibos extracts for skin and hair |
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| JP2013530177A (en) * | 2010-06-18 | 2013-07-25 | ネステク ソシエテ アノニム | L. John Sonny La1, B. Longum NCC2705 and immune disorders |
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| GB2562302A (en) * | 2017-05-12 | 2018-11-14 | Univ Pretoria | Aspalathus linearis extracts for melanin stimulation |
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| WO2005041854A2 (en) * | 2003-11-03 | 2005-05-12 | Cortex Technology Aps | Composition for the cosmetic treatment of age-related dermatological symptoms |
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| JP2742866B2 (en) * | 1993-08-02 | 1998-04-22 | 株式会社日本ルイボスティー本社 | Rooibos Concentrate Extract |
| JPH08133983A (en) * | 1994-11-02 | 1996-05-28 | Asugen Seiyaku Kk | Extract of aspalathus linealis and its use |
| JPH08256707A (en) * | 1995-03-20 | 1996-10-08 | Ichiro Otake | Jelly food of rooibos tea |
| JP3467576B2 (en) * | 1996-05-01 | 2003-11-17 | 株式会社孔葉堂 | SOD-like action antioxidant beverage |
| DE29717497U1 (en) * | 1997-10-01 | 1999-02-04 | Braun Michaela Dipl Ing | Cosmetic tea extract |
| US20070036742A1 (en) * | 2005-08-09 | 2007-02-15 | Access Business Group International Llc | Methods and compositions for modulating hair growth or regrowth |
| EP1923066A1 (en) * | 2006-11-08 | 2008-05-21 | Cognis IP Management GmbH | Composition comprising rooibos tea and conjugated linoleic acid (CLA) |
| KR100844076B1 (en) * | 2007-08-02 | 2008-07-15 | 리뉴얼라이프(주) | Process for making chunggukjang powder containing dietary fiber and chunggukjang powder thereof |
| JP2009073775A (en) * | 2007-09-21 | 2009-04-09 | Orbis Inc | Composition for oral administration |
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| WO2005041854A2 (en) * | 2003-11-03 | 2005-05-12 | Cortex Technology Aps | Composition for the cosmetic treatment of age-related dermatological symptoms |
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| DATABASE WPI Week 199516 Thomson Scientific, London, GB; AN 1995-117841 XP002542579 & JP 07 039353 A (RUIBOSUTI JAPAN KK) 10 February 1995 (1995-02-10) * |
| DATABASE WPI Week 199631 Thomson Scientific, London, GB; AN 1996-306481 XP002500594 & JP 08 133983 A (ASUGEN SEIYAKU KK) 28 May 1996 (1996-05-28) * |
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| JP2013530177A (en) * | 2010-06-18 | 2013-07-25 | ネステク ソシエテ アノニム | L. John Sonny La1, B. Longum NCC2705 and immune disorders |
| US9937212B2 (en) | 2010-06-18 | 2018-04-10 | Nestec S.A. | L. johnsonii LA1, B. longum NCC2705 and immune disorders |
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| WO2010000580A3 (en) | 2010-06-24 |
| WO2010000579A2 (en) | 2010-01-07 |
| WO2010000579A3 (en) | 2010-06-24 |
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