KR20070022018A - Delivery of functional ingredients - Google Patents

Abstract

The present invention includes primary compositions containing all essential nutrients of fruit or plant materials, with increased stability, bioavailability and miscibility; And a method of forming the same. This also relates to oral compositions containing the primary composition in foodstuffs, food supplements, cosmetic preparations or pharmaceutical preparations.

Description

Delivering functional materials {DELIVERY OF FUNCTIONAL INGREDIENTS}

The present invention includes primary compositions containing all essential nutrients of fruit or plant materials, with increased stability, bioavailability and miscibility; And a method of forming the same. It also relates to oral compositions containing the primary composition in foodstuffs, food supplements, cosmetic preparations or pharmaceutical preparations.

Pigments and bioactive compounds extracted from fruit or plant materials are widely used as functional materials in the food industry. Among them, the wolfberry (Rice babarum; Lycium barbarum )) is one of the most valuable functional materials in China due to its visual acuity, benefits for the immune system, and anti-aging properties, especially associated with multiple bioactive compounds present in the fruit. It is traditionally consumed through hot water extraction.

Many other materials are also recognized by the consumer for their beneficial properties, but their application in foods is difficult or has insufficient bioavailability. In practice, fruits are usually rich in reducing sugars, making drying and handling of their powders very difficult.

Many extraction techniques are already known. For example, WO03020053 describes a method for extracting carotenoids from carotenoid-containing plant materials. This includes:

(i) Plant materials were mixed with water to achieve Brix of 10 DEG or less.

(ii) milling the mixture from step (i) and separating the solids from the liquid to obtain two phases of pulp and serum.

(iii) Extracting the pulp to obtain a carotenoid-containing plant oleoresin resin. This water extraction technique is natural, but not as efficient as the use of solvents.

 For example, US 6648564 describes a method for forming, isolating and purifying xanthophyll crystals by saponification of a xanthophyll diester-containing plant extract in a composition of propylene glycol and an aqueous alkali to form xanthophyll crystals. do. The substantially pure xanthophyll crystals obtained as above are suitable for human consumption and can be used as nutritional supplements and food additives. However, solvent extraction techniques are more difficult to handle, and the use of solvents can impair the natural image and / or nutritional function of the product.

In addition, conventional extraction techniques usually extract only a few compounds of plant or fruit materials, leaving other bioactive compounds as residue. For example, polysaccharides, polyphenols and other non lipophilic compounds are not extracted with lipophilic components such as carotenoids, lipophilic vitamins and other lipids.

For example, US 6409996 B1 obtains an extract by treating a flavonoid containing raw material with an aqueous extraction medium to obtain an extract and separating the flavonoid from the extract by absorption and / or adsorption to obtain a composition containing one or more flavonoids. Describes the method. The extraction method also provides only extracts containing mainly a portion of the bioactive active ingredient of the raw material.

It is therefore an object of the present invention to provide formulations for the extraction and delivery of multi-nutrients from fruit or plant materials with improved bioavailability and improved stability, miscibility, and dispersibility in aqueous systems of bioactive compounds. Is the purpose. It is also an object of the present invention to provide a primary composition which can be used directly, easily concentrated or dried to a powder for application in food, nutritional supplements, cosmetic or pharmaceutical preparations.

Summary of the invention

Accordingly, a first object of the present invention is to provide a miscible primary composition containing at least the essential lipophilic and hydrophilic bioactive components of complete fruits, plants and / or plant materials, excluding insoluble fibers, in milk or milk protein-containing carriers. It is.

Advantageously, the primary composition has a profile close to the essential active ingredient of the complete fruit and has good stability, miscibility and dispersibility in the aqueous system. In addition, the primary composition has improved nutritional value in the form of better bioavailability and stability. It has a pleasant taste and color. It is used daily for food or other nutritional nutritional use, can be used directly for several applications, or it can be concentrated or dried into powder.

Thus, a further object of the primary compositions is as additives in foodstuffs such as nutritional compositions, food supplements, pet foods, cosmetic preparations or pharmaceutical preparations for oral administration. Primary compositions are also additives in products for external application such as cosmetics or pharmaceutical products.

The invention also relates to a method of forming the primary composition. The method of preparing a primary composition for delivering the essential lipophilic and hydrophilic bioactive components of complete fruits, vegetables and / or plant materials includes the following steps:

i) mixing and grinding fruits, vegetables and / or plant materials in milk or milk protein-containing liquid media,

ii) separating insoluble fibers to give an aqueous suspension

iii) optionally pasteurization of the suspension obtained

iv) optionally adding synthetic or natural bioactive components (eg carotenoids) during the process

v) additionally, optionally drying the suspension to obtain a powder.

The method has a major advantage that is natural and cost effective, which enables improved delivery of multi-nutrients in the form of a mixture of stabilized water soluble and fat soluble compounds, free of organic solvent residues.

In a further aspect, the present invention provides a method using the methods described above to increase the bioavailability, stability, and dispersibility or miscibility of a bioactive compound of fruit, plant, and / or plant material. In particular, by using milk or milk proteins, soy milk or milk-like proteins from plants to extract and deliver multi-nutrients of functional ingredients of fruits, vegetables and / or plant materials.

Another object of the present invention is to provide the use of a primary composition as described above to deliver multi-nutrients of functional ingredients of fruits, vegetables and / or plant materials with improved bioavailability, miscibility and stability. To provide.

It is also desirable to provide the use of a primary composition as described above for the improvement of skin health, in particular for the preparation of oral, cosmetic or pharmaceutical compositions for the purpose of photoprotection of the skin, or for protecting the skin tissue from aging. Another purpose.

It is also an additional object to provide the use of a primary composition as described above for the manufacture of oral, external or pharmaceutical compositions for the purpose of eye health (eg age-related macular degeneration).

The invention also provides the use of a primary composition as described above for the manufacture of a food or pharmaceutical composition, for the purpose of stimulating the immune system.

Finally, the present invention also provides the use of the primary composition described above for the preparation of a food or pharmaceutical composition for the purpose of treating diabetes (eg having a hypoglycemic effect).

The present invention now allows consumers to utilize the improved compositions obtained from natural products. The present invention provides primary compositions that retain important bioactive components of fruit or plant materials or mixtures thereof. The profile of its bioactive components is close to what occurs naturally in fruit or plant materials. The primary composition provides the bioactive component of the fruit or plant material, in particular in a highly bioavailable, stable and miscible form.

The features of the present invention can be best understood with reference to the following description with further objects and advantages.

Detailed Description of the Invention

In the following description, the term bioactive compound is understood to mean a molecule or component that exhibits biologically active or health effects upon oral ingestion or cosmetic application.

According to a first object, a miscible primary composition containing at least the essential lipophilic and hydrophilic active ingredients of fruit, vegetable and / or plant materials, excluding insoluble fibers, in milk or milk protein-containing carriers is relevant.

In a preferred embodiment, the fruits, vegetables and / or plant materials may be in the form of vegetables, leaves, flowers, fruits, seeds and other parts of plants, or mixtures thereof.

In a preferred embodiment, the berry or any other flavonoid-, polyphenol-, or carotenoid-rich fruit or vegetable or seed is selected. For example, berries such as honey, blueberries, cranberries, audi, blackberries, gooseberries, white currants, black currants, red currants, raspberries, sea buckthorn, strawberries, arbutus berry or grapes and others Fruits such as apples, melons, kiwis, cherries, red dates, prunes, peaches, persimmons, citrus fruits such as mandarins, oranges, tangerines, grapefruits can be used. Flowers such as chamomile, chrysanthemum, tangerine, honeysuckle, jasmine and safflower may be used. Vegetables such as tomatoes, spinach, celery, carrots, peas, kale, parsley, watercress, cabbage, broccoli, lettuce, sprouts cabbage, collard plants, turnip plants, fennel, onions. In addition, seeds such as corn, black rice, cocoa, coffee and materials such as tea, thyme and sweet red pepper may also be used.

Fruits, vegetables or plant materials may be used in fresh form, in the form of concentrated or dried materials, for example air dried or freeze dried materials.

Essential bioactive components of fruit, vegetable or plant materials may include, for example, lipids, alkaloids, proteins, carbohydrates, carotenoids, polyphenolic compounds such as flavonoids and vitamins or minerals. In particular, bioactive compounds include flavonoids such as flavones (eg apigenin, luteolin or diosmethin), flavonols (eg quercetin, myricetin, camphorol), flavanones (eg naringenin , Hesperidin), catechins (e.g. epicatechin, gallocatechin), anthocyanidins (e.g. pelarginidine, malvidin, cyanidin) or isoflavones (e.g., genistin, dizaine ( daidzein)); Carotenoids such as carotene and xanthophylls (eg, in the form of lycopene, carotene, phytopluin, phytoin, canthaxanthin, astaxanthin, beta-kryptoxanthin, capxanthine, lutein, zeaxanthin or fatty acid esters; carbohydrates Eg arabinogalactan protein (eg, calcium barbarum polysaccharide); vitamins (eg, vitamins C, B, E ...); minerals (eg, selenium, calcium, magnesium, potassium) Can be.

The primary composition contains, in milk or milk protein-containing carrier, at least essential bioactive ingredients of complete fruit, vegetable and / or plant material, except insoluble fiber. The milk carrier may be in the form of skim milk or crude milk from a zoo or botanical garden (eg, soy milk, juice or coconut milk, etc.). In a more preferred embodiment, cow's milk or soy milk is used, depending on the fruit or primary ingredient desired. The milk-containing carrier may be any edible liquid containing milk protein such as, for example, casein or whey protein. Plant oils may optionally be added to the liquid medium.

The fruit, vegetable or plant material described above is mixed and ground in the milk or milk protein-containing liquid medium in a ratio of about 1: 1 to 1: 1000, preferably 1: 5 to 1:50, respectively. The mixing and grinding step can be carried out at a temperature of 1 to 95 ° C, preferably about 20 to 80 ° C and more preferably 40 to 80 ° C. Thereafter, insoluble fiber was removed to give an aqueous suspension. This can be done in any conventional way. The resulting primary composition can be further sterilized and / or dried to a powder by techniques known in the art. The obtained primary composition may also be in liquid or gel form.

Thus, the present invention provides a primary composition having a similar profile of important nutrients, such as complete fruit, which has good stability, miscibility, and bioavailability. The composition can be very dispersible in an aqueous system, if the powder form is chosen. In this case, the powder is dispersible in cold or hot water.

The composition may additionally contain one or more emulsifiers, stabilizers, antioxidants and other additives. Emulsifiers that are affinity in food can be used, such as phospholipids such as lecithin, polyoxyethylene sorbitan mono- or tristearate, monolaurate, monopalmitate, mono- or trioleate, mono- or diglycerides. . In addition, any type of stabilizer known in foods, cosmetics or drugs can be used. Any type of antioxidant known in food, cosmetics or drugs can be used. Known seasonings, colorants and any other additives in food, cosmetics or drugs can be used as additives. The emulsifiers, stabilizers, antioxidants and additives are added depending on the end use of the primary composition.

The composition may also contain synthetic or natural bioactive materials such as amino acids, fatty acids, vitamins, minerals, carotenoids, polyphenols, and the like, which may be added to the composition by dry or wet mixing prior to sterilization and / or drying. .

According to a further aspect, the present invention relates to an oral composition containing the above-described primary composition in a food supplement, pet food, cosmetic preparation or pharmaceutical preparation.

In a preferred embodiment, the food composition for human consumption is supplemented by said primary composition. The composition may be a nutritional complete formula, dairy product, frozen or room temperature beverage, mineral or purified water, liquid beverage, soup, food supplement, meal substitute, nutritional bar, fructose, milk or fermentation. Dairy products, yogurt, milk based powder, enteric nutrition products, baby food, baby nutrition products, cereal products or fermented cereal based products, ice cream, chocolate, coffee, cooking products such as mayonnaise, tomato puree or salad dressing Or pet food.

In such cases, the primary composition, preferably in the form of a powder, is preferably used to ingest a daily intake of the bioactive nutrients as described above, which depends primarily on the fruit, vegetable or plant used, the desired effect and the target tissue. It may be dispersed in the above-mentioned food or beverage. The amount of primary composition or food composition that an individual must consume to achieve a beneficial effect will also depend on its size, type, and age.

Nutritional supplements for oral administration may be in the form of a capsule, gelatin capsule, soft capsule, tablet, sugar-coated tablet, pill, paste or spice, gum, or drinkable solution or suspension, in a primary composition dose of about 0.1 to 100%, It can be syrup or gel, which can be ingested by water or any other known method. The supplement may include sweeteners, stabilizers, antioxidants, seasonings or coloring agents. Adjuvants for cosmetic purposes may further contain a compound active against the skin. Its manufacturing method is generally known.

In another embodiment, the pharmaceutical composition may be administered for prophylactic and / or therapeutic treatment. In therapeutic applications, the composition is administered to a patient already suffering from the disease in an amount sufficient to treat or at least partially arrest the symptoms of the disease and its complications. An amount sufficient to achieve this is defined as "therapeutically effective amount". The amount effective above will depend on the weight and general state of the severity of the disease. In prophylactic applications, the compositions according to the invention are administered to patients susceptible to certain diseases, or else at risk of disease. This amount is defined as "prophylactically effective amount". Even for this use, the exact amount will depend on the patient's state of health and weight.

The compounds of the present invention are preferably administered with a pharmaceutically acceptable carrier, the nature of the carrier being different depending on the method of administration, for example, intestinal, oral and external (including eye) routes. The desired formulation can be prepared using a variety of excipients, including, for example, pharmaceutical grade mannitol, lactose, starch, magnesium stearate, sodium saccharin, cellulose, magnesium carbonate. The composition may be a tablet, capsule, pill, solution, suspension, syrup, dry oral adjuvant, wet oral adjuvant.

Those skilled in the art will understand that, in view of the route of administration, suitable ingredients and herbal forms for targeting the active ingredient to tissues of interest, such as, for example, skin, colon, stomach, eye, kidney or liver, are to be selected based on their knowledge. .

The present invention also relates to a cosmetic composition containing the primary composition described above. It may be formulated, for example, in lotions, shampoos, creams, sunscreens, after-sun creams, anti-aging creams and / or ointments. The composition, which can be used for external use, further contains fats or oils that can be used in cosmetics, as mentioned, for example, in CTFA work, Cosmetic Ingredients Handbook, Washington. It is also possible to add other cosmetically active materials. The composition may further contain a structuring agent and an emulsifier. Other excipients, colorants, flavors or opacifiers may also be added to the composition. It will be appreciated that the cosmetic product contains a mixture of various materials known to those skilled in the art so that the substrate quickly penetrates into the skin and prevents its degradation during storage.

It will be appreciated that the inventive concept can also be applied to adjuvant therapies to assist with the agents currently used. Since the compounds of the present invention can be easily administered with food ingredients, special clinical foods containing large amounts of such substances can be applied. It will be apparent to one skilled in the art, upon reading the specification and appended claims, that various alternatives to the specific embodiments mentioned herein may be considered.

The administration of a food, nutritional supplement, cosmetic or pharmaceutical composition as mentioned above to pets or humans may result in improved skin health, in particular the protection of skin tissue from aging or the protection of skin, for example collagenase inhibition. And enhancing collagen synthesis results in inhibition of damage to the skin and / or mucous membranes. Indeed, the use of the primary compositions described above makes it possible, for example, to improve the bioavailability of the bioactive compounds in the body and to delay the aging of the skin. It may also be useful for the prevention of dry or sensitive skin, or for improving skin density or firmness.

The primary compositions described above may also be used for the preparation of oral, external or pharmaceutical compositions for reducing the risk of vision, especially cataracts or age-related macular degeneration. It may also be used, for example, for the prevention or treatment of cardiovascular diseases or disorders or cancer and for the stimulation of the immune system, and for the reduction of blood glucose levels.

The following examples do not limit the invention, and illustrate it in more detail. All percentages are stated by weight unless otherwise indicated.

Example  One: From the east  Primary composition preparation

Dried copper fruit (40 g) and crude oil (300 g) were introduced into a 1 liter container. The mixture was left for 10 minutes and treated with Polytron (KINEMATICA, Dispersion and Mixing Technology with PT3000) for 15 minutes at 26000 rpm under nitrogen atmosphere. During the Polytron treatment, the temperature of the mixture was maintained at 80-85 ° C. by water bath, then cooled at room temperature. The resulting mixture was then centrifuged at 2000 G for 10 minutes. Solid residue was removed. The liquid phase (306 g of orange-yellow milk) was lyophilized. The dried product was finally triturated to yield 54 g of orange-yellow powder, which showed improved stability and good water-dispersion properties of zeaxanthin compared to phosphorus fruit powder.

Example  2: Preparation of Primary Composition from Tomato

Fresh tomato fruit (93 g), skim milk powder (10 g) and tap water (30 g) were introduced into a 250 ml container. The mixture was homogenized (Polytron) for 10 minutes at 26000 rpm under nitrogen atmosphere. The mixture was cooled in an ice cold bath to keep the temperature below 30 ° C. The mixture was then centrifuged at 2000 G for 10 minutes. The solid residue was removed and the liquid phase (96 g of red-pink milk) was lyophilized. The dried product was finally triturated to give a red-pink powder (17.5 g).

Example  3: dairy products containing the primary composition according to the invention

The primary composition prepared in Example 1 was used for preparing fermented yoghurt-like dairy products. To do this, 1 L of dairy product containing 2.8% fat and supplemented with 2% skim milk powder and 6% sucrose was prepared, sterilized and the temperature was lowered to 42 ° C. The non-thickening strain of Streptococcus thermophilus and the pre-culture of the non-viscous strain of Lactobacillus bulgaricus contain 10% reduced milk powder and 0.1% commercial yeast extract. Was reactivated in sterile MSK medium. The sterilized dairy product was then inoculated with 1% of the reactivated preculture, respectively, and the dairy product was fermented at 32 ° C. until the pH reached a value of 4.5. To fermented milk, a yoghurt-like product, the same primary composition (1%) as in Example 1 was added and stored at 4 ° C.

Example  4: pet food

The feed mixture consists of corn, corn gluten, chicken and fish, salts, vitamins and minerals. Subsequently, the wet feed discharged from the pre-container was introduced into an extruder-cooker and gelatinized. The gelatinized matrix exiting the extruder was passed through a die and extruded. The extrudate exiting the die head was cut into pieces suitable for feeding the dog, dried at about 110 ° C. for about 20 minutes, and cooled to form pellets. The resulting water activity of the pellets was about 0.6.

The pellet was coated by spraying a coating substrate containing Uji fat and the primary composition prepared in Example 1.

Example  5: cosmetics for oral administration

The composition in the form of a hard capsule has the following formulation:

compound Mg per capsule Primary Composition of Example 1 500 Excipients for the Core Microcrystalline cellulose 70 Encompress TM 60 Magnesium stearate 3 Anhydrous colloidal silica One Coating Sword-rack 5 Talc 61 Sucrose 250 Polyvidone 6 Titanium dioxide 0.3 coloring agent 5

The composition may be administered to an individual in an amount of 2-3 capsules per day.

Example  6: Indong  From formulation Zeaxanthin Bioavailability

Two different phosphorus preparations were prepared as follows:

Treatment A

2 kg of dried phosphorus fruit were rinsed with tap water, mixed with Polytron (dispersion and mixing technology by KINEMATICA, PT120 / 4M) and added to 12 L of milk (reconstituted with 1 kg of skim milk powder) at 30 ° C. The temperature of the mixture was raised to 80 ° C. and maintained for 15 minutes under a nitrogen atmosphere. The temperature of the mixture was maintained at 80-85 ° C. by water bath during the Polytron treatment and then cooled to room temperature. The resulting mixture was then centrifuged at 2000 G for 10 minutes. Solid residue was removed. After addition of 1.3 kg maltodextrin (IT06), the liquid phase was lyophilized. The dried product was finally milled to yield 3 kg of orange-yellow powder.

Treatment B

0.5 kg of dry phosphorus was ground into powder with 0.5 kg of dry ice using a Kenwood and Buhler grinder. The powder mixture was placed under vacuum in an oven at ambient temperature for 1 hour. The resulting powder was introduced into 0.8 L of water (83 ° C.) in a doubled-jacket reactor equipped with a stirrer. After the temperature was raised to 80 ° C. again, the resulting suspension was heat treated under nitrogen for about 7 minutes. The suspension was lyophilized to give sterile phosphorus powder.

Treatment C

Optisharp 5% CWS / S-TG is a reddish, granular powder containing synthetic zeaxanthin finely dispersed in a corn starch-coated matrix of modified food starch from DSM.

Clinical trials were conducted with the three formulations, and 12 received each formulation (all controlled with zeaxanthin, which is within 15 mg of), within three weeks with a sufficient amount of oil and carbohydrates in the meal.

As measured in the microparticle fraction of blood samples taken over 10 hours after ingestion, it was observed that the uptake of zeaxanthin from the phosphorus obtained by Treatment A was significantly better than that found for Treatment B (Table 2). In the treatment C, similar absorption of zeaxanthin was observed.

process Not controlled for Cmax nmol / l baseline (0 h) AUC nmol / l * h baseline regulated A 1.72 (0.46) 9.73 (2.45) B 0.69 (0.21) 3.14 (1.09) C 1.86 (0.39) 8.34 (1.69)

Table 2: Bioavailability of Zeaxanthin and Formulated Synthetic Zeaxanthin from Phosphorous Preparations.

Example  7: From the east  Preparation of Primary Composition

3 kg of dried phosphorus fruit were rinsed with tap water, mixed with Polytron (dispersion and mixing technology by KINEMATICA, PT120 / 4M) and added to 18 L of milk (reconstituted with 0.85 kg of skim milk powder) at 30 ° C. The temperature of the mixture was raised to 30 ° C. and treatment with Polytron was continued for 30 minutes under a nitrogen atmosphere. The resulting mixture was then centrifuged at 2000 G for 10 minutes. The solid was removed. After addition of 2 kg of maltodextrin (IT06), the liquid phase was sterilized and then lyophilized. The dried product was finally milled to yield 4.4 kg of orange-red powder, which had improved stability and good water-dispersibility of zeaxanthin compared to the phosphor fruit powder.

Claims (19)

A miscible primary composition containing at least the essential lipophilic and hydrophilic bioactive ingredients of complete fruit, vegetable and / or plant materials, excluding insoluble fibers, in milk or milk protein-containing carriers. The primary composition of claim 1, wherein the fruit, vegetable and / or plant material is in the form or mixture of vegetables, leaves, flowers, fruits, seeds and other parts of the plant. The fruit, vegetable or plant material of claim 1, wherein the fruit, vegetable or plant material is a berry such as wolfberry, blueberry, cranberry, white currant, red currant, black currant, audi, blackberry, gooseberry, raspberry, sea buckthorn. Tree, strawberry, arbutus berry or grape, or any other flavonoid, polyphenol or carotenoid-rich fruit, vegetable, seed, flower or plant material such as apples, melons, kiwis, cherries, red dates dates, prunes, peaches, persimmons, citrus fruits such as mandarin, oranges, tangerine, grapefruit, and chamomile, chrysanthemums, tangerines, honeysuckle, jasmine and safflower, and tomatoes, spinach, celery, Carrots, peas, kale, parsley, watercress, cabbage, broccoli, lettuce, sprouts cabbage, collard plants, turnip plants, fennel, onions, tea, corn, cocoa, coffee, thyme or sweet pepper (sweet red peppe) r) phosphorus primary composition. The primary composition of claim 1, wherein the essential lipophilic and hydrophilic bioactive components are lipids, alkaloids, proteins, carbohydrates, carotenoids, polyphenolic compounds such as flavonoids, vitamins or minerals. The method according to claim 4, wherein the flavonoids are flavones such as apigenin, luteolin or diosmetin, flavonols such as quercetin, mycetin, camphorol, flavanones such as naringenin and hesperidin, catechins such as epicatechin, gallocatechin, anthocyanidins Primary compositions such as pelargonidine, malvidin, cyanidin or isoflavones such as genistin, diaidzein. 5. The carotenoid of claim 4, wherein the carotenoid is in the form of carotene and xanthophylls such as lycopene, carotene, phytofluin, phytoin, canthaxanthin, astaxanthin, beta-cryptoxanthin, capxanthine, lutein, zeaxanthin or fatty acid esters. Primary composition. The primary composition of claim 1, wherein the milk is of animal or plant origin. The primary composition according to claim 1, which is in the form of a powder, gel or liquid. A process for the preparation of a composition according to claim 1 comprising the following steps: i) mixing and grinding fruits, vegetables and / or plant materials in milk or milk protein-containing liquid media ii) separating insoluble fibers to obtain an aqueous suspension iii) optionally sterilizing the resulting suspension iv) optionally adding synthetic or natural bioactive components during the process v) additionally, optionally drying the suspension to obtain a powder. Dispersibility or miscibility, stability in an aqueous system of bioactive compounds of fruits, vegetables and / or plant materials using the primary composition according to any one of claims 1 to 8 or the method according to claim 9. And a method of increasing bioavailability. The method according to claim 9 or 10, wherein the natural bioactive component is an amino acid, fatty acid, vitamin, mineral, carotenoid, polyphenol, or the like. Foodstuffs for oral administration such as oral compositions containing the primary composition according to any one of claims 1 to 8 in a nutritional composition, food supplement, pet food, cosmetic preparation or pharmaceutical preparation. 13. The nutritional complete formula of claim 12, dairy products, frozen or room temperature stable drinks, mineral or purified water, liquid drinks, soups, food supplements, meal substitutes, nutritional bars, fructose , Milk or fermented dairy products, yogurt, milk based powders, enteric nutrition products, baby foods, infant nutrition products, cereal products or fermented cereal based products, ice cream, chocolate, coffee, cooking products such as mayonnaise, tomatoes Oral compositions that are puree or salad dressings or pet foods. An oral cosmetic or pharmaceutical composition containing the primary composition according to any one of claims 1 to 8 which is a tablet, capsule, pill, solution, suspension, syrup, dry oral adjuvant, wet oral adjuvant. Use of a primary composition according to any one of claims 1 to 8 for the multi-nutrient delivery of functional materials of fruit and plant materials, with improved bioavailability, miscibility and stability. The primary composition according to any one of claims 1 to 8, for the preparation of oral, cosmetic or pharmaceutical compositions for improving skin health, in particular for protecting the light of the skin or protecting skin tissue from aging. Use of Use of a primary composition according to any one of claims 1 to 8 for the manufacture of oral, external or pharmaceutical compositions for the purpose of eye health. Use of a primary composition according to any one of claims 1 to 8 for the preparation of oral, external or pharmaceutical compositions for the purpose of stimulating the immune system. Use of a primary composition according to any one of claims 1 to 8 for the manufacture of oral, external or pharmaceutical compositions for the prevention or treatment of cardiovascular diseases or disorders or cancer or diabetes.