WO2009144344A3 - Compuesto para el etiquetado de biomoleculas basado en vinilsulfona. preparación y usos - Google Patents

Compuesto para el etiquetado de biomoleculas basado en vinilsulfona. preparación y usos Download PDF

Info

Publication number
WO2009144344A3
WO2009144344A3 PCT/ES2009/000309 ES2009000309W WO2009144344A3 WO 2009144344 A3 WO2009144344 A3 WO 2009144344A3 ES 2009000309 W ES2009000309 W ES 2009000309W WO 2009144344 A3 WO2009144344 A3 WO 2009144344A3
Authority
WO
WIPO (PCT)
Prior art keywords
vinylsulphone
compound
preparation
labelling
biomolecules based
Prior art date
Application number
PCT/ES2009/000309
Other languages
English (en)
French (fr)
Other versions
WO2009144344A2 (es
Inventor
Francisco SANTOYO GONZÁLEZ
Fernando HERNÁNDEZ MATEO
Javier LÓPEZ JARAMILLO
Julia Morales Sanfrutos
Mariano ORTEGA MUÑOZ
Original Assignee
Universidad De Granada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad De Granada filed Critical Universidad De Granada
Publication of WO2009144344A2 publication Critical patent/WO2009144344A2/es
Publication of WO2009144344A3 publication Critical patent/WO2009144344A3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6809—Determination of free amino acids involving fluorescent derivatizing reagents reacting non-specifically with all amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Compuesto para el etiquetado de biomoléculas basado en vinilsulfona. Preparación y usos que comprenden una molécula etiqueta y un grupo vinilsulfona. Además, se refiere al uso de los compuestos como agentes de etiquetado, al procedimiento de obtención de los mismos y sus usos en el marcaje de biomoléculas, y más concretamente de proteínas.
PCT/ES2009/000309 2008-05-20 2009-05-20 Compuesto para el etiquetado de biomoleculas basado en vinilsulfona. preparación y usos WO2009144344A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200801474A ES2331783B1 (es) 2008-05-20 2008-05-20 Compuesto para el etiquetado de biomoleculas basado en vinilsulfona, preparacion y usos.
ESP200801474 2008-05-20

Publications (2)

Publication Number Publication Date
WO2009144344A2 WO2009144344A2 (es) 2009-12-03
WO2009144344A3 true WO2009144344A3 (es) 2010-02-18

Family

ID=41377651

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2009/000309 WO2009144344A2 (es) 2008-05-20 2009-05-20 Compuesto para el etiquetado de biomoleculas basado en vinilsulfona. preparación y usos

Country Status (2)

Country Link
ES (1) ES2331783B1 (es)
WO (1) WO2009144344A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2970965A1 (fr) * 2011-01-31 2012-08-03 Centre Nat Rech Scient Composes anti-angiogeniques, compositions pharmaceutiques les comprenant, et leur utilisation
CN105820095B (zh) * 2016-04-24 2018-04-06 大连理工大学 乙烯基砜衍生物的制备方法
CN111269160B (zh) * 2020-03-05 2021-07-09 浙江大学 含巯基荧光化合物或其硫酯衍生物及制备和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070888A1 (en) * 2000-03-22 2001-09-27 Ciba Specialty Chemicals Holding Inc. Fibre reactive naphthylazonaphthyl triazinyl dyes
EP1207186A1 (de) * 2000-11-15 2002-05-22 Ciba SC Holding AG Reaktivfarbstoffe, Verfahren zu deren Herstellung und deren Verwendung
ES2269448T3 (es) * 2000-08-19 2007-04-01 DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG Tinturas azoicas reactivas, su preparacion y su uso.
EP1887046A2 (en) * 2006-08-09 2008-02-13 Everlight USA, Inc. Reactive dyes containing an alkylthio-s-triazinyl reactive group
US20080114166A1 (en) * 2004-12-31 2008-05-15 Dystar Textilfarben Gmbh & Co. Deutschland Kg Reactive Triphendioxazine Dyes, Methods for the Production Thereof, and Use Thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070888A1 (en) * 2000-03-22 2001-09-27 Ciba Specialty Chemicals Holding Inc. Fibre reactive naphthylazonaphthyl triazinyl dyes
ES2269448T3 (es) * 2000-08-19 2007-04-01 DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG Tinturas azoicas reactivas, su preparacion y su uso.
EP1207186A1 (de) * 2000-11-15 2002-05-22 Ciba SC Holding AG Reaktivfarbstoffe, Verfahren zu deren Herstellung und deren Verwendung
US20080114166A1 (en) * 2004-12-31 2008-05-15 Dystar Textilfarben Gmbh & Co. Deutschland Kg Reactive Triphendioxazine Dyes, Methods for the Production Thereof, and Use Thereof
EP1887046A2 (en) * 2006-08-09 2008-02-13 Everlight USA, Inc. Reactive dyes containing an alkylthio-s-triazinyl reactive group

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI, L. ET AL.: "Vinyl Sulfone Bifunctional Derivatives of DOTA Allow Sulfhydryl- or Amino-Directed Coupling to Antibodies. Conjugates Retain Immunoreactivity and Have Similar Biodistributions", BIOCONJUGATE CHEMISTRY, vol. 13, 2002, pages 110 - 115 *

Also Published As

Publication number Publication date
WO2009144344A2 (es) 2009-12-03
ES2331783B1 (es) 2010-10-27
ES2331783A1 (es) 2010-01-14

Similar Documents

Publication Publication Date Title
IL204621A0 (en) Bicyclic - ?? - amino acid derivatives, compositions comprising the same and uses thereof
EP1858975B8 (en) Modified novolak resin for use as tackifier
EP3284772B8 (en) Thioethers, methods for their preparation, and compositions including such thioethers
WO2009156462A3 (en) Organic compounds
WO2009070243A3 (en) Wise binding antibodies and epitopes
ZA201104706B (en) Substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
IL200994A (en) Compounds of Imidazole, Pyrazole, Triazole, Pyridinone, Benzyl and Bipinyl, Their Processes and Uses
WO2007114945A3 (en) Compositions and methods for enhancing the antioxidant status of animals
WO2006039250A3 (en) Chemokine-binding heterocyclic compound salts, and methods of use thereof
EP1988090A4 (en) IMIDAZOLE-5-CARBOXYLIC ACID DERIVATIVES, METHOD OF MANUFACTURE AND USE THEREOF
WO2008032227A3 (en) Topical formulations of tellurium-containing compounds
BRPI0816331A2 (pt) Composto, uso de um composto, composição farmacêutica, e, processo para preparar um composto.
BRPI0923291A2 (pt) processo para a destilação de uma mistura aquosa de polimetilol, composição, e, uso de um polimetilol.
AU2008246443A8 (en) 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine-beta-hydroxylase
BRPI0812321A2 (pt) Sais de ácido etilenodiamina dissuccínico, composição contendo os ditos sais, uso e método de preparação destes.
EP2213708A4 (en) Aqueous resin composition for coating purposes and aqueous coating material
FI20090127A (fi) Polymeerikoostumus, joka soveltuu pastöroitavien säilytysastioiden valmistamiseen
WO2009127718A3 (en) Novel microbiocides
WO2010047592A3 (en) Preservation mixture and use thereof
EP2281038B8 (en) Protein formulation
WO2010120058A3 (ko) 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
BRPI0912163A2 (pt) Composto químico, processo para a produção de um composto, compsição química, e, uso de um composto químico.
WO2008073863A3 (en) Preparation and utility of substituted allylamines
EP2088140A4 (en) DIHYDRAZIDE COMPOUNDS, MANUFACTURE AND APPLICATIONS THEREOF
BRPI0916305A2 (pt) processo para preparar concentrado de proteínas do leite, composição e uso de uma composição.

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09753998

Country of ref document: EP

Kind code of ref document: A2