WO2009144209A1 - Dispositif de mélange et procédé de mélange y relatif - Google Patents

Dispositif de mélange et procédé de mélange y relatif Download PDF

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Publication number
WO2009144209A1
WO2009144209A1 PCT/EP2009/056346 EP2009056346W WO2009144209A1 WO 2009144209 A1 WO2009144209 A1 WO 2009144209A1 EP 2009056346 W EP2009056346 W EP 2009056346W WO 2009144209 A1 WO2009144209 A1 WO 2009144209A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
mixing
semi
frequency
mixing chamber
Prior art date
Application number
PCT/EP2009/056346
Other languages
English (en)
Inventor
Paolo Galiano
Giovanni Di Cola
Francesco Frappa
Original Assignee
Alifax Holding Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alifax Holding Spa filed Critical Alifax Holding Spa
Publication of WO2009144209A1 publication Critical patent/WO2009144209A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/86—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with vibration of the receptacle or part of it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/89—Methodical aspects; Controlling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2208—Controlling using ultrasonic waves during the operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08—Cleaning containers, e.g. tanks
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D11/00—Control of flow ratio
    • G05D11/02—Controlling ratio of two or more flows of fluid or fluent material
    • G05D11/13—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means
    • G05D11/135—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by sensing at least one property of the mixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N2011/0046—In situ measurement during mixing process
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements

Definitions

  • the present invention concerns a mixing device and the relative mixing method used, preferably but not only, in the biomedical field of laboratory analysis for mixing, in a substantially automatic manner, liquid or semi-liquid masses.
  • the present invention is applied for mixing liquid or semi-liquid masses relating to antigen/antibody reagents in corresponding immunological reactions for carrying out analyses on biological samples, or for mixing with chemical reagents.
  • mixing devices for mixing liquid or semi-liquid masses, formed by a biological sample to be analyzed and one or more reagents, in order to effect predetermined measurements, such as for example photometric measurements of absorbance and/or transmittance of the liquid or semi-liquid mass, at the end of or during the chemical and/or physical reaction that involves the reagents of the mass itself.
  • predetermined measurements such as for example photometric measurements of absorbance and/or transmittance of the liquid or semi-liquid mass
  • a first known mixing device is based on stirring due to the effect of magnetic elements.
  • This mixing device comprises a mixing container, preferably cylindrical, into which both the desired reagents and also some magnetic elements are introduced, the latter being inert to the reaction, and with the function of stirrers/mixers.
  • the magnetic elements are moved inside the mixing container due to the effect of a magnetic field applied externally to the mixing container. The rotation of the magnetic elements allows to mix the liquid or semi- liquid mass in the mixing container simultaneously with the reaction of the reagents.
  • a second known mixing device comprises mechanical stirrers disposed in the mixing container.
  • the mechanical stirrers comprise for example rotating blades kept in rotation by associated drive means at a speed of rotation that can be selectively modified by an operator.
  • Another disadvantage of said known devices is that, during mixing, air bubbles can form that disturb the subsequent photometric measurements of the mixture.
  • One purpose of the present invention is to achieve a mixing device which allows to mix a liquid or semi-liquid mass according to the real chemical/physical properties of the mass without physical contact between the liquid to be mixed and the mechanical parts used for the mixing movement.
  • Another purpose of the present invention is to achieve a mixing method that allows to mix a liquid or semi-liquid mass according to the real chemical/physical properties of the liquid or semi-liquid mass and that, during mixing, prevents the transfer of excess mechanical energy to the liquid or semi- liquid mass.
  • the Applicant has devised, tested and embodied the present invention to overcome the shortcomings of the state of the art and to obtain these and other purposes and advantages.
  • a mixing device is used to mix a predetermined liquid or semi-liquid mass, formed by a biological sample to be analyzed and one or more reagents, subjected to chemical and/or physical reactions, and whose mass can be modified by means of the integration of predetermined quantities of reagents and/or solvents/solutes.
  • Said mixing device typically comprises a mixing chamber, suitable to contain the liquid or semi-liquid mass to be mixed.
  • the mixing device also comprises mixing means associated with the mixing chamber and suitable to be selectively activated at a predetermined or predeterminable intensity in order to mix the liquid or semi-liquid mass in the mixing chamber.
  • the mixing device also comprises detection means associated with the mixing chamber.
  • the detection means are suitable to detect physical and/or chemical properties of the liquid or semi- liquid mass contained in the mixing chamber, such as the mass and/or viscosity and/or concentration.
  • the detection allows to activate the mixing means in relation to an intensity coherent with the actual physical and/or chemical properties of the liquid or semi-liquid mass mixed.
  • it is possible to dynamically adapt the intensity of the mixing according both to chemical reactions, which can modify said physical and/or chemical properties over time, and also according to possible increases in mass due to the gradual addition of reagents to the liquid or semi-liquid mass. This also prevents the transfer to the liquid or semi-liquid mass of excess mechanical energy, allowing not to modify the ideal conditions of possible chemical reactions and allowing to effect precise measurements.
  • the detection means are suitable to carry out an indirect detection of the physical and/or chemical properties of the liquid or semi-liquid mass contained in the mixing chamber.
  • the mixing means comprise an actuator of the piezoelectric type suitable to convert an electric signal entering the actuator, having a predetermined or predeterminable and modifiable frequency, into vibratory mechanical energy applied to the mixing chamber.
  • the intensity and/or frequency of vibration of the mechanical energy generated by the actuator are correlated to the frequency of the electric signal entering the piezoelectric actuator.
  • the detection means comprise a piezoelectric transducer suitable to detect and convert the vibratory mechanical energy transmitted through the mixing chamber and the liquid or semi-liquid mass contained therein into a corresponding output electric signal, having a frequency variable and correlated to that of the vibratory mechanical energy transmitted.
  • the detection means are suitable to make a direct detection of the physical and/or chemical properties of the liquid or semi-liquid mass contained in the mixing chamber.
  • the mixing device comprises a processing and control unit connected both to the mixing means and also to the detection means.
  • the processing and control unit is suitable to selectively activate the mixing means, adjusting the intensity of their application according to the data detected in the mixing chamber by the transducer means.
  • the present invention also concerns a mixing method for mixing in a mixing chamber a liquid or semi- liquid mass. The method provides a step in which the liquid or semi-liquid mass is mixed by means of mixing means associated with the mixing chamber.
  • the method also comprises a step in which, by means of detection means associated with the mixing chamber, one or more physical and/or chemical properties of the liquid or semi-liquid mass contained in the mixing chamber are detected, so as to activate the mixing means in relation to an intensity coherent with the actual physical and/or chemical properties of the liquid or semi-liquid mass mixed.
  • - fig. 1 is a block diagram of a mixing device according to the present invention. DETAILED DESCRIPTION OF A PREFERENTIAL FORM OF
  • a mixing device 10 is used for mixing a liquid or semi-liquid mass in micro volumes, formed by a biological sample to be analyzed and one or more reagents.
  • the device 10 can be used, in this case, in immunological reactions of the antigen/antibody type or in reactions of the globular type.
  • the mixing device 10 comprises a mixing chamber 20, a piezoelectric actuator 22, a piezoelectric detector 24, a processing and control unit 30 and a phase locked loop unit 36.
  • the mixing chamber 20 is suitable to contain the liquid or semi-liquid mass to be mixed.
  • the mixing chamber 20 can also be used to carry out one or more measurements, for example photometric, to detect the reaction kinetics of both an immunological and also globular type in said liquid or semi-liquid mass.
  • the piezoelectric actuator 22 is coupled with a first wall 21 of the mixing chamber 20 and can be selectively activated to convert a periodic input electric signal 19, with a predetermined or predeterminable frequency, into a vibratory mechanical stress 23 entering the mixing chamber 20, with a frequency correlated, for example dependent in linear manner, to said frequency of the input electric signal 19.
  • the input vibratory mechanical stress 23 is applied to the first wall 21, outside the mixing chamber 20, to allow to mix the liquid or semi-liquid mass contained therein without having a mechanical or physical contact with the liquid or semi-liquid mass to be mixed.
  • the piezoelectric detector 24 is coupled with a second wall 26 of the mixing chamber 20, opposite the first wall 21.
  • the piezoelectric detector 24 is suitable to detect the vibratory mechanical stress 25 exiting from the mixing chamber 20 and to convert it into a corresponding output electric signal 51, analog and bipolar, having a frequency correlated, for example linearly dependent, to the frequency of the output vibratory mechanical stress 25.
  • the processing and control unit 30 is directly connected, by means of one or more data lines, to the phase locked loop unit 36, comprising an oscillator device of the PLL/VCO type (Phase Locked Loop/Voltage Controlled Oscillator).
  • the processing and control unit 30 can for example comprise a microprocessor or microcontroller having adequate calculation and processing capacities to command the phase locked loop unit 36 by means of a first and a second data line 32, 34 and to control it by means of a control line 37 and to process, directly or indirectly, the output electric signal 51.
  • the output electric signal 51 is conditioned and converted from its analog format to a digital signal 60 by means of an analog/digital converter 53 (ADC converter) connected to an inlet of the processing and control unit 30.
  • ADC converter analog/digital converter
  • the processing and control unit 30, the phase locked loop unit 36 and the analog/digital converter 53 can be incorporated into a single microprocessor or microcontroller having adequate hardware resources.
  • the phase locked loop unit 36 is suitable to generate, based on the commands received from the processing and control unit 30, a low power electric signal 39, typically a square wave, having a desired frequency substantially coinciding with the frequency of the input electric signal 19.
  • the mixing device 10 also comprises a high power generator 38, and a first low-pass filter 40 located between the high power generator 38 and the piezoelectric actuator 22.
  • the high power generator 38 for example a stage amplifier of a known type, is connected to the phase locked loop unit 36 and is suitable to generate a high power electric signal 139 obtained by raising the tension of the low power electric signal 39 to adequate values for the tension of the input electric signal 19 of the piezoelectric actuator 22.
  • the first low-pass filter 40 is suitable both to transform the high power electric signal 139 into a bipolar sinusoidal electric signal coinciding with the electric signal 19 entering the piezoelectric actuator 22, and also to eliminate unwanted harmonic components, typically at higher frequencies, introduced by the high power generator 38.
  • the mixing device 10 also comprises a precision rectifier 52 and a second low-pass filter, suitable to convert the output electric signal 51 generated by the piezoelectric detector 24 into the digital signal 60.
  • the device 10 also comprises a current sensor 44 connected both to the piezoelectric actuator 22 and also to the processing and control unit 30.
  • the current sensor 44 is suitable to detect the frequency, or rather the current generated at outlet from the piezoelectric actuator 22 and indicative of the intensity and/or frequency of the input mechanical stress 23 generated by the piezoelectric actuator 22.
  • the device 10 also comprises a feed unit 14 to feed with electric energy the electric/electronic components of the device.
  • the feed line is indicated by lines of dashes directed toward the components fed.
  • the mixing device 10 as described heretofore functions as follows.
  • the processing and control unit 30 activates, indirectly, the piezoelectric actuator 22, allowing to generate the input mechanical stress 23 at an initial frequency near to the frequency of mechanical resonance of the mixing chamber 20, found for example mathematically according to the density of the material of which the chamber 20 is made.
  • the processing and control unit 30 supplies a sample frequency to the phase locked loop unit 36, by means of the first data line 32 and, through the second data line 34, the entire division of the frequency generated by the phase locked loop unit 36.
  • the frequency thus generated is acquired by the processing and control unit 30 by means of the control line 37, allowing to adjust the low power electric signal 39 with adequate precision to the desired frequency.
  • the low power electric signal 39 is first converted into a high power electric signal 139 by the high power generator 38, and then filtered and converted into the bipolar and sinusoidal input electric signal 19 by means of the first low-pass filter 40.
  • the input electric signal 19 is then applied to the piezoelectric actuator 22 which, connected to the first wall 21, converts it into the input vibratory mechanical stress 23, with initial frequency, applied to the mixing chamber 20.
  • the input vibratory mechanical stress 23 is therefore transmitted through the mixing chamber 20 generating a vibratory mechanical stress of both the chamber 20 and also the liquid or semi-liquid mass contained therein. This allows to mix the liquid or semi-liquid mass and produces the output vibratory mechanical stress 25, which is different from the input stress 23, according to the specific liquid or semi-liquid mass and/or its specific concentration.
  • the output vibratory mechanical stress 25 is detected by the piezoelectric actuator 24 and converted into the output electric signal 51, analog and bipolar, which is transformed into unipolar and is filtered by means of the precision rectifier and the second low- pass filter 50 and then transformed into the digital signal 60 by the analog/digital converter 53.
  • the processing and control unit 30 detects the actual initial frequency and/or intensity of the input mechanical stress 23 generated by the piezoelectric actuator 22 and compares it with the intensity and frequency of the output mechanical stress 25 following its passage through the mixing chamber 20, as detected by the transducer 24.
  • the processing and control unit 30 subsequently generates incremental variations at constant intervals, for example at pitches of 1 KHz, of the frequency of the low power electric signal 39 and then of the corresponding input mechanical stress 23, until a predetermined final frequency value is reached, memorizing for which specific frequency value we obtain the maximum intensity of the output mechanical stress 25 as detected by the transducer 24.
  • Said specific frequency value substantially corresponds to a resonance frequency, that is, to an optimum mechanical resonance condition of the mixing chamber 20 and the liquid or semi-liquid mass contained therein, according to its mass and/or concentration.
  • the vibratory agitation produced by the piezoelectric actuator 22 supplies optimum and efficient mixing conditions, adapted in a dynamic manner to the actual mixing conditions.
  • the processing and control unit 30 subsequently activates the piezoelectric actuator 22 with an input electric signal 19 having the same frequency as the resonance frequency, for a time needed to mix the liquid or semi-liquid mass.
  • the processing and control unit 30 possibly modifies the frequency so as to adapt to a possible change in the resonance frequency of the mixing chamber 20 and the liquid or semi-liquid mass, according to a change in its physical and/or chemical properties.
  • the mixing device 10 allows to mix the liquid or semi-liquid mass in the mixing chamber 20 without the aid of mobile mechanical parts inside the reaction chamber; this mixing is generated by the piezoelectric actuator 22 outside the mixing chamber 20, and therefore obtains a no contact mixing.
  • the mixing device 10 according to the present invention also allows to optimize the reactions of the antigen antibody type. Furthermore, thanks to the effective mixing, the mixing chamber 20 allows to analyze accurately the speed of aggregation measured photometrically, or to discriminate the speeds of aggregation indicating the samples affected by a prozone effect.
  • the cleaning can also be carried out by evaporation of the liquid or semi- liquid mass, produced by activating the piezoelectric actuator 22 at high frequencies.
  • Another advantage of the mixing device 10 according to the present invention is that it is possible to verify the state of fullness of the mixing chamber 20, allowing to verify that the liquid or semi-liquid mass to be mixed is actually present inside the mixing chamber 20 before beginning the mixing or before adding reagents to the liquid or semi-liquid mass.
  • Another advantage of the present invention is that it can be used as a homogenizer for biological liquids, such as for example feces, blood or bronchial expectorations.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Mechanical Engineering (AREA)
  • Preparation Of Clay, And Manufacture Of Mixtures Containing Clay Or Cement (AREA)

Abstract

L'invention porte sur un dispositif de mélange et sur un procédé qui permet de mélanger une masse liquide ou semi-liquide formée d'un échantillon biologique à analyser et d'un ou plusieurs réactifs, lequel dispositif comprend une chambre de mélange (20) pouvant contenir la masse liquide ou semi-liquide et des moyens de mélange (22) associés à la chambre de mélange (20), qui sont destinés à mélanger la masse liquide ou semi-liquide dans la chambre de mélange (20). Le dispositif de mélange comprend également des moyens de détection (24) associés à la chambre de mélange (20), qui sont aptes à détecter une ou plusieurs propriétés physiques et/ou chimiques de la masse liquide ou semi-liquide contenue dans la chambre de mélange (20) afin d'activer les moyens de mélange (22) avec une intensité conforme aux propriétés physiques et/ou chimiques de la masse liquide ou semi-liquide.
PCT/EP2009/056346 2008-05-27 2009-05-26 Dispositif de mélange et procédé de mélange y relatif WO2009144209A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000126A ITUD20080126A1 (it) 2008-05-27 2008-05-27 Dispositivo di miscelazione e relativo procedimento di miscelazione
ITUD2008A000126 2008-05-27

Publications (1)

Publication Number Publication Date
WO2009144209A1 true WO2009144209A1 (fr) 2009-12-03

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PCT/EP2009/056346 WO2009144209A1 (fr) 2008-05-27 2009-05-26 Dispositif de mélange et procédé de mélange y relatif

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IT (1) ITUD20080126A1 (fr)
WO (1) WO2009144209A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017529540A (ja) * 2014-09-26 2017-10-05 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 位相変調定常波混合装置及び方法
EP4188604A4 (fr) * 2020-08-03 2024-01-31 Siemens Healthcare Diagnostics, Inc. Dispositifs de lyse comprenant un élément piézoélectrique et procédés

Citations (13)

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Publication number Priority date Publication date Assignee Title
US3191913A (en) * 1961-05-22 1965-06-29 Hal C Mettler Ultrasonic unit
GB2040453A (en) * 1978-12-18 1980-08-28 Evans T E Monitoring Mixing of Substances
GB2122396A (en) * 1982-06-11 1984-01-11 Exxon Research Engineering Co Monitoring system, for example for a pump or fluid mixer/agitator
JPS59199025A (ja) * 1983-04-27 1984-11-12 Toshiba Corp 超音波乳化装置
US4907611A (en) * 1986-12-22 1990-03-13 S & C Co., Ltd. Ultrasonic washing apparatus
US20020009015A1 (en) * 1998-10-28 2002-01-24 Laugharn James A. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
EP1260819A1 (fr) * 2000-02-23 2002-11-27 Hitachi, Ltd. Analyseur automatique
DE202004008470U1 (de) * 2004-05-27 2004-09-02 Martin-Luther-Universität Halle-Wittenberg Vorrichtung zum Durchmischen von Flüssigkeiten und/oder Feststoffen
WO2006027602A1 (fr) * 2004-09-10 2006-03-16 Cambridge University Technical Services Ltd Melangeur/reacteur a liquides et procede correspondant
DE102006001623A1 (de) * 2006-01-11 2007-07-12 Sartorius Ag Behälter und Verfahren zum Mischen von Medien
US20070251300A1 (en) * 2004-05-26 2007-11-01 Bo Danielsson Device for Controlling and Regulating the Physical-Biochemical Condition of a Liquid Mixture
US20080056960A1 (en) * 1998-10-28 2008-03-06 Laugharn James A Jr Methods and systems for modulating acoustic energy delivery
EP1946828A1 (fr) * 2006-11-29 2008-07-23 Kabushiki Kaisha Toshiba Dispositif d'analyse microchimique, dispositif de micro-mélange et système d'analyse microchimique correspondant

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3191913A (en) * 1961-05-22 1965-06-29 Hal C Mettler Ultrasonic unit
GB2040453A (en) * 1978-12-18 1980-08-28 Evans T E Monitoring Mixing of Substances
GB2122396A (en) * 1982-06-11 1984-01-11 Exxon Research Engineering Co Monitoring system, for example for a pump or fluid mixer/agitator
JPS59199025A (ja) * 1983-04-27 1984-11-12 Toshiba Corp 超音波乳化装置
US4907611A (en) * 1986-12-22 1990-03-13 S & C Co., Ltd. Ultrasonic washing apparatus
US20080056960A1 (en) * 1998-10-28 2008-03-06 Laugharn James A Jr Methods and systems for modulating acoustic energy delivery
US20020009015A1 (en) * 1998-10-28 2002-01-24 Laugharn James A. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
EP1260819A1 (fr) * 2000-02-23 2002-11-27 Hitachi, Ltd. Analyseur automatique
US20070251300A1 (en) * 2004-05-26 2007-11-01 Bo Danielsson Device for Controlling and Regulating the Physical-Biochemical Condition of a Liquid Mixture
DE202004008470U1 (de) * 2004-05-27 2004-09-02 Martin-Luther-Universität Halle-Wittenberg Vorrichtung zum Durchmischen von Flüssigkeiten und/oder Feststoffen
WO2006027602A1 (fr) * 2004-09-10 2006-03-16 Cambridge University Technical Services Ltd Melangeur/reacteur a liquides et procede correspondant
DE102006001623A1 (de) * 2006-01-11 2007-07-12 Sartorius Ag Behälter und Verfahren zum Mischen von Medien
EP1946828A1 (fr) * 2006-11-29 2008-07-23 Kabushiki Kaisha Toshiba Dispositif d'analyse microchimique, dispositif de micro-mélange et système d'analyse microchimique correspondant

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017529540A (ja) * 2014-09-26 2017-10-05 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 位相変調定常波混合装置及び方法
US10737228B2 (en) 2014-09-26 2020-08-11 Siemens Healthcare Diagnostics Inc Phase-modulated standing wave mixing apparatus and methods
EP4188604A4 (fr) * 2020-08-03 2024-01-31 Siemens Healthcare Diagnostics, Inc. Dispositifs de lyse comprenant un élément piézoélectrique et procédés
US12031890B2 (en) 2020-08-03 2024-07-09 Siemens Healthcare Diagnostics Inc. Lysis devices having a piezo element and methods

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