WO2006027602A1 - Melangeur/reacteur a liquides et procede correspondant - Google Patents
Melangeur/reacteur a liquides et procede correspondant Download PDFInfo
- Publication number
- WO2006027602A1 WO2006027602A1 PCT/GB2005/003484 GB2005003484W WO2006027602A1 WO 2006027602 A1 WO2006027602 A1 WO 2006027602A1 GB 2005003484 W GB2005003484 W GB 2005003484W WO 2006027602 A1 WO2006027602 A1 WO 2006027602A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- droplet
- excitation
- substrate
- eigenfrequencies
- frequencies
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
- B01F31/86—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with vibration of the receptacle or part of it
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0454—Numerical frequency values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00925—Irradiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00925—Irradiation
- B01J2219/0093—Electric or magnetic energy
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Definitions
- the present invention relates to a device and method for mixing or reacting liquids within a small volume, such as a droplet, by generating an oscillating perturbation which propagates within the droplet.
- the present invention further provides a method of mixing or reacting two or more components within a droplet, the method comprising the steps of: positioning the droplet upon a substrate; and generating one or more excitation frequencies and resonating the droplet at the one or more excitation frequencies via an excitation means, wherein the one or more excitation frequencies comprise one or more eigenfrequencies of the droplet.
- the major interest in exciting surface eigenmodes is the internal flow it induces.
- the trajectories of fluid particles are given by the gradient of the velocity potential grad ⁇ since the amplitude of oscillation is small.
- Mixing can be optimised by the present invention by using several eigenfrequencies at the same time, and furthermore by controlling singularities and surrounding streamlines which appear as a function of the eigenfrequencies, which can be manipulated to create a compartmentalised mixer or reactor.
- the present invention therefore provides a cheap, simple and efficient mixing device and method on a microscopic or macroscopic scale which is fully applicable to commercial applications such as stand alone mixers, chemical reactors, mixing in micro or macro arrays, microfluidic systems, and inkjet technology.
- the device and method of the present invention can operate within a wide range of temperatures, and are preferably configured to accommodate droplet volumes ranging between nl (nanolitres) and ml (millilitres).
- Figure 1 shows a liquid mixer or reactor device according to the present invention
- Figures 3a-d illustrate the compartmentalisation of a droplet when it is resonated at four different eigenfrequencies according to the present invention
- Figure 4 shows an example of the present invention as a continuous mixer/reactor; and Figure 5 shows a microfluidic device, where the device of the present invention is integrated into the mixing stage of the device.
- the concept underlying the present invention is based on the eigenmodes of vibration of a droplet sitting on a substrate, the droplet having a free surface which contacts the surrounding medium.
- the droplet must be provided with a free surface which contacts the surrounding medium (this is preferably gaseous, but can comprise a non-miscibie liquid).
- the substrate can be an open or a closed container, but in the case of a closed container, the container cannot solely enclose the droplet or volume being mixed/reacted, but must also enclose a surrounding medium.
- the substrate 2 can be permanently attached to the excitation device 3, or may be temporarily fixed, via screws, clips, double-sided tape or glue, for example, (not shown) to the excitation device 3.
- the excitation device 3 which generates an oscillating perturbation on the droplet's surface, can be, for example, a laser (radiative pressure, temperature gradient), a piezoelectric device, an acoustic wave or a vibrating membrane.
- the excitation device 3 generates periodical (square, sinusoidal or triangular) or non- periodical signals of variable amplitudes and frequencies, thereby causing the substrate and liquid droplet to oscillate.
- These droplet oscillations result in the creation of internal flows inside the droplet, which mainly depend on the excitation frequencies. These flows can be controlled and hence exploited for a mixing process or in order to provide a compartmentalised reactor.
- the device and method of the invention are non-invasive, cheap to manufacture and can be employed in a controlled atmosphere.
- the invention can be employed to greatly reduce the mixing time and increase the efficiency when mixing small amounts of liquid within a droplet, and this efficiency can be improved further by exciting the droplet with a square signal or with a sum of frequencies.
- exciting the droplet with, for example, a sinusoidal signal, the droplet can be compartmentalised into several areas determined by internal flows induced in the droplet, and can thereby act as a liquid reactor.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0420155.4 | 2004-09-10 | ||
GBGB0420155.4A GB0420155D0 (en) | 2004-09-10 | 2004-09-10 | Liquid mixing/reactor device and method |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006027602A1 true WO2006027602A1 (fr) | 2006-03-16 |
Family
ID=33186831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2005/003484 WO2006027602A1 (fr) | 2004-09-10 | 2005-09-09 | Melangeur/reacteur a liquides et procede correspondant |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB0420155D0 (fr) |
WO (1) | WO2006027602A1 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2013604A1 (fr) * | 2006-05-02 | 2009-01-14 | Monash University | Concentration et dispersion de petites particules dans de petits volumes de fluide au moyen d'énergie acoustique |
WO2009144209A1 (fr) * | 2008-05-27 | 2009-12-03 | Alifax Holding Spa | Dispositif de mélange et procédé de mélange y relatif |
WO2013192351A1 (fr) * | 2012-06-20 | 2013-12-27 | Bio-Rad Laboratories, Inc. | Gouttelettes stabilisées pour le calibrage et l'essai |
FR3011488A1 (fr) * | 2013-10-07 | 2015-04-10 | Aelorve | Dispositif pour melanger un volume de liquide |
CN113316717A (zh) * | 2019-01-10 | 2021-08-27 | 因塔公司 | 用于通过声波分析流体的传感装置 |
WO2021197790A1 (fr) * | 2020-04-03 | 2021-10-07 | Universite Paris-Saclay | Procede pour generer un ecoulement dans une microgoutte et dispositif pour la mise en œuvre du procede |
US11298701B2 (en) | 2018-11-26 | 2022-04-12 | King Instrumentation Technologies | Microtiter plate mixing control system |
CN114682163A (zh) * | 2022-03-24 | 2022-07-01 | 安徽大学 | 用于生物相容性液滴的输送装置、制造方法及其输送方法 |
US20230120357A1 (en) * | 2020-05-22 | 2023-04-20 | Politecnico Di Milano | Device, method and composition for transfection of cells with nucleic acids |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164357A1 (de) * | 2001-12-28 | 2003-07-10 | Advalytix Ag | Titrationsverfahren |
US20040066118A1 (en) * | 2001-02-28 | 2004-04-08 | Guido Pieper | Micro-reactor |
US20040115097A1 (en) * | 2001-04-09 | 2004-06-17 | Achim Wixforth | Mixing deivce and mixing method for mixing small amounts of liquid |
-
2004
- 2004-09-10 GB GBGB0420155.4A patent/GB0420155D0/en not_active Ceased
-
2005
- 2005-09-09 WO PCT/GB2005/003484 patent/WO2006027602A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040066118A1 (en) * | 2001-02-28 | 2004-04-08 | Guido Pieper | Micro-reactor |
US20040115097A1 (en) * | 2001-04-09 | 2004-06-17 | Achim Wixforth | Mixing deivce and mixing method for mixing small amounts of liquid |
DE10164357A1 (de) * | 2001-12-28 | 2003-07-10 | Advalytix Ag | Titrationsverfahren |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8998483B2 (en) | 2006-05-02 | 2015-04-07 | Royal Melbourne Institute Technology | Concentration and dispersion of small particles in small fluid volumes using acoustic energy |
EP2013604A4 (fr) * | 2006-05-02 | 2013-10-16 | Melbourne Inst Tech | Concentration et dispersion de petites particules dans de petits volumes de fluide au moyen d'énergie acoustique |
EP2013604A1 (fr) * | 2006-05-02 | 2009-01-14 | Monash University | Concentration et dispersion de petites particules dans de petits volumes de fluide au moyen d'énergie acoustique |
WO2009144209A1 (fr) * | 2008-05-27 | 2009-12-03 | Alifax Holding Spa | Dispositif de mélange et procédé de mélange y relatif |
US10240187B2 (en) | 2012-06-20 | 2019-03-26 | Bio-Rad Laboratories, Inc. | Stabilized droplets for calibration and testing |
US9527049B2 (en) | 2012-06-20 | 2016-12-27 | Bio-Rad Laboratories, Inc. | Stabilized droplets for calibration and testing |
WO2013192351A1 (fr) * | 2012-06-20 | 2013-12-27 | Bio-Rad Laboratories, Inc. | Gouttelettes stabilisées pour le calibrage et l'essai |
FR3011488A1 (fr) * | 2013-10-07 | 2015-04-10 | Aelorve | Dispositif pour melanger un volume de liquide |
WO2015052403A1 (fr) | 2013-10-07 | 2015-04-16 | Aelorve | Dispositif et procédé pour mélanger un volume de liquide |
US11298701B2 (en) | 2018-11-26 | 2022-04-12 | King Instrumentation Technologies | Microtiter plate mixing control system |
CN113316717A (zh) * | 2019-01-10 | 2021-08-27 | 因塔公司 | 用于通过声波分析流体的传感装置 |
WO2021197790A1 (fr) * | 2020-04-03 | 2021-10-07 | Universite Paris-Saclay | Procede pour generer un ecoulement dans une microgoutte et dispositif pour la mise en œuvre du procede |
FR3108898A1 (fr) * | 2020-04-03 | 2021-10-08 | Universite Paris-Saclay | Procede pour generer un ecoulement dans une microgoutte et dispositif pour la mise en œuvre du procede |
US20230120357A1 (en) * | 2020-05-22 | 2023-04-20 | Politecnico Di Milano | Device, method and composition for transfection of cells with nucleic acids |
CN114682163A (zh) * | 2022-03-24 | 2022-07-01 | 安徽大学 | 用于生物相容性液滴的输送装置、制造方法及其输送方法 |
CN114682163B (zh) * | 2022-03-24 | 2023-12-29 | 安徽大学 | 用于生物相容性液滴的输送装置、制造方法及其输送方法 |
Also Published As
Publication number | Publication date |
---|---|
GB0420155D0 (en) | 2004-10-13 |
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