WO2009134104A3 - 다공성 실리콘을 이용한 면역단백질 탐지용 바이오센서 및 그의 제조방법 - Google Patents

다공성 실리콘을 이용한 면역단백질 탐지용 바이오센서 및 그의 제조방법 Download PDF

Info

Publication number
WO2009134104A3
WO2009134104A3 PCT/KR2009/002320 KR2009002320W WO2009134104A3 WO 2009134104 A3 WO2009134104 A3 WO 2009134104A3 KR 2009002320 W KR2009002320 W KR 2009002320W WO 2009134104 A3 WO2009134104 A3 WO 2009134104A3
Authority
WO
WIPO (PCT)
Prior art keywords
porous silicon
biosensor
detection
immunoproteins
present
Prior art date
Application number
PCT/KR2009/002320
Other languages
English (en)
French (fr)
Other versions
WO2009134104A2 (ko
WO2009134104A4 (ko
Inventor
손홍래
장승현
고영대
박재현
양진석
Original Assignee
조선대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020080041342A external-priority patent/KR101068810B1/ko
Priority claimed from KR1020080041764A external-priority patent/KR101018825B1/ko
Application filed by 조선대학교산학협력단 filed Critical 조선대학교산학협력단
Publication of WO2009134104A2 publication Critical patent/WO2009134104A2/ko
Publication of WO2009134104A3 publication Critical patent/WO2009134104A3/ko
Publication of WO2009134104A4 publication Critical patent/WO2009134104A4/ko

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 다공성 실리콘을 이용한 면역단백질 탐지용 바이오센서 및 그의 제조방법에 관한 것이다. 본 발명의 면역단백질 탐지용 바이오센서는 전기화학적으로 식각된 다공성 실리콘의 표면을 열적 산화하고 그 표면에 아민 유도체를 유도한 후, 상기 아민 유도체 말단에 바이오물질을 인식할 수 있는 감지인식체를 고착시켜 제조된 다공성 실리콘에, 광원을 입사하고, 상기 입사한 광원의 광학적 반사를 이용하여 구현되는 것이다. 본 발명의 면역단백질 탐지용 바이오센서는 다공성 실리콘을 표면 안정화하는 동시에 면역단백질 탐지에 적합하도록 2∼50㎚ 크기를 가지는 메조포러스의 다공성 실리콘을 이용함으로써, 면역성 질환, 만성 감염증, 흡수장애 증후군의 원인이 되는 항체 IgG, 프로테인-A, 아비딘 및 스트렙토아비딘 탐지에 유용하다.
PCT/KR2009/002320 2008-05-02 2009-04-30 다공성 실리콘을 이용한 면역단백질 탐지용 바이오센서 및 그의 제조방법 WO2009134104A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2008-0041342 2008-05-02
KR1020080041342A KR101068810B1 (ko) 2008-05-02 2008-05-02 다공성 실리콘 스마트 입자를 이용한 면역단백질 탐지용바이오센서 및 그의 제조방법
KR10-2008-0041764 2008-05-06
KR1020080041764A KR101018825B1 (ko) 2008-05-06 2008-05-06 다공성 실리콘을 이용한 면역단백질 탐지용 바이오센서 및그의 제조방법

Publications (3)

Publication Number Publication Date
WO2009134104A2 WO2009134104A2 (ko) 2009-11-05
WO2009134104A3 true WO2009134104A3 (ko) 2010-02-11
WO2009134104A4 WO2009134104A4 (ko) 2010-04-15

Family

ID=41255579

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/002320 WO2009134104A2 (ko) 2008-05-02 2009-04-30 다공성 실리콘을 이용한 면역단백질 탐지용 바이오센서 및 그의 제조방법

Country Status (1)

Country Link
WO (1) WO2009134104A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108387424B (zh) * 2018-02-27 2021-08-03 杭州汇健科技有限公司 一种用于生物样本预处理的多孔硅材料的制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100278267B1 (ko) * 1998-06-29 2001-02-01 김영환 캐패시터의제조방법
KR100787468B1 (ko) * 2006-08-21 2007-12-26 손홍래 다층 다공성 실리콘을 이용한 화학신경제 탐지용 센서 및그 제조방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100278267B1 (ko) * 1998-06-29 2001-02-01 김영환 캐패시터의제조방법
KR100787468B1 (ko) * 2006-08-21 2007-12-26 손홍래 다층 다공성 실리콘을 이용한 화학신경제 탐지용 센서 및그 제조방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAUDIA PACHOLSKI ET AL.: "Biosensing using porous silicon double-layer interferometers: Reflective interferometric fourier transform spectroscopy", J. AM. CHEM SOC., vol. 127, 2005, pages 11636 - 11645 *
KOH, YOUNG DAE ET AL.: "Detection of avidin based on rugate-structured porous silicon interferometer", KOREAN CHEM. SOC., vol. 28, no. 11, 2007, pages 2083 - 2088 *

Also Published As

Publication number Publication date
WO2009134104A2 (ko) 2009-11-05
WO2009134104A4 (ko) 2010-04-15

Similar Documents

Publication Publication Date Title
WO2006127167A3 (en) Proteolipid membrane & lipid membrane biosensor
WO2009028484A1 (ja) 半導体装置製造用の接着シート、及びそれを用いた半導体装置の製造方法
WO2011115933A3 (en) Optical-fiber-compatible acoustic sensor
ATE470144T1 (de) Oberflächenplasmonverstärkter fluoreszenzsensor und verfahren zur fluoreszenzdetektion
DE602006006200D1 (de) Antikörper gegen 25-hydroxyvitamin d
WO2009058902A3 (en) Methods and devices for analyte detection
HK1172229A1 (zh) 用於測定分析物濃度的光學傳感器
WO2010117599A3 (en) Optoelectronic methods and devices for detection of analytes
WO2007040559A3 (en) Electrochemiluminescent assay
EA201070226A1 (ru) Способ изготовления стеклопакетного блока и окно, содержащее такой стеклопакетный блок
TW200743788A (en) Method and apparatus for measuring the brightness of a luminous element
WO2006108033A3 (en) Recombinant antigens for the detection of coxiella burnetii
DE502006007729D1 (de) Scanverfahren und -vorrichtung
TW200643637A (en) Mask blanks
WO2009134104A3 (ko) 다공성 실리콘을 이용한 면역단백질 탐지용 바이오센서 및 그의 제조방법
ATE275728T1 (de) Verfahren und biosensor zum nachweis von antigenen
EP2023139A4 (en) IMMUNOASSAY METHOD AND CHIP
EA200600387A1 (ru) Устройство и способ для детектирования очень малых количеств частиц
TW200739165A (en) Lens module of camera and its fabricating method
WO2009019043A3 (de) Untersuchung molekularer wechselwirkungen an und/oder in dünnen schichten
WO2011060528A8 (en) Heteropeptides useful for reducing nonspecific adsorption
WO2006110460A3 (en) Integrated optical device for luminescence sensing
WO2008143109A1 (ja) 抗原検出用センサーチップとその作製方法および抗原検出用センサー
WO2008076367A3 (en) Polymer-protein substrates for immunosorbent fluorescence assays
WO2009005651A3 (en) Complement-mediated thrombophilic assay

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09739010

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09739010

Country of ref document: EP

Kind code of ref document: A2