WO2009116081A3 - Procédé amélioré de préparation daprépitant - Google Patents

Procédé amélioré de préparation daprépitant Download PDF

Info

Publication number
WO2009116081A3
WO2009116081A3 PCT/IN2009/000134 IN2009000134W WO2009116081A3 WO 2009116081 A3 WO2009116081 A3 WO 2009116081A3 IN 2009000134 W IN2009000134 W IN 2009000134W WO 2009116081 A3 WO2009116081 A3 WO 2009116081A3
Authority
WO
WIPO (PCT)
Prior art keywords
aprepitant
preparation
improved process
intermediates
compound
Prior art date
Application number
PCT/IN2009/000134
Other languages
English (en)
Other versions
WO2009116081A2 (fr
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Mummadi Venkatesh
Mummadi Venkazesh
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2009116081A2 publication Critical patent/WO2009116081A2/fr
Publication of WO2009116081A3 publication Critical patent/WO2009116081A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé amélioré de préparation d'un composé daprépitant de formule I ainsi que de nouveaux polymorphes de ses intermédiaires.
PCT/IN2009/000134 2008-03-03 2009-03-02 Procédé amélioré de préparation daprépitant WO2009116081A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN526CH2008 2008-03-03
IN526/CHE/2008 2008-03-03

Publications (2)

Publication Number Publication Date
WO2009116081A2 WO2009116081A2 (fr) 2009-09-24
WO2009116081A3 true WO2009116081A3 (fr) 2011-01-06

Family

ID=41091341

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000134 WO2009116081A2 (fr) 2008-03-03 2009-03-02 Procédé amélioré de préparation daprépitant

Country Status (1)

Country Link
WO (1) WO2009116081A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011147279A1 (fr) * 2010-05-24 2011-12-01 成都地奥制药集团有限公司 Procédé de préparation de 5-[[2(r)-[1(r)-[3,5-bis(trifluorométhyl)phényl]éthoxy]-3(s)-4-fluorophényl-4-morpholinyl]méthyl]-1,2-dihydro-3h-1,2,4-triazole-3-one
WO2013124823A1 (fr) * 2012-02-23 2013-08-29 Piramal Enterprises Limited Procédé perfectionné pour la préparation d'aprépitant
CZ304770B6 (cs) * 2012-03-13 2014-10-08 Zentiva, K.S. Způsob výroby 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluormethyl)fenyl)ethoxy)-3-(4-fluorfenyl)morfolino)methyl)-1H-1,2,4-triazol-5(4H)-onu (Aprepitantu) v polymorfní formě II
CN111943904B (zh) * 2019-05-15 2023-05-05 南京正大天晴制药有限公司 一种神经激肽1受体拮抗剂关键中间体的精制方法
CN110746371B (zh) * 2019-11-20 2022-07-15 山东鲁抗医药股份有限公司 制备阿瑞匹坦的中间体及其制备方法与应用
CN112939885A (zh) * 2021-02-05 2021-06-11 海南鑫开源医药科技有限公司 一种阿瑞吡坦关键中间体的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096742A (en) * 1997-07-02 2000-08-01 Merck & Co., Inc. Polymorphic form of a tachykinin receptor antagonist
US6395898B1 (en) * 2000-06-09 2002-05-28 Merck & Co. Inc. Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
US20040214746A1 (en) * 2001-12-10 2004-10-28 Bosch H. William Pharmaceutical composition of a tachykinin receptor antagonist
WO2007039883A2 (fr) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited Procede permettant de preparer de l'aprepitant
WO2008026216A2 (fr) * 2006-08-28 2008-03-06 Hetero Drugs Limited Procédé de purification d'aprépitant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096742A (en) * 1997-07-02 2000-08-01 Merck & Co., Inc. Polymorphic form of a tachykinin receptor antagonist
US6395898B1 (en) * 2000-06-09 2002-05-28 Merck & Co. Inc. Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
US20040214746A1 (en) * 2001-12-10 2004-10-28 Bosch H. William Pharmaceutical composition of a tachykinin receptor antagonist
WO2007039883A2 (fr) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited Procede permettant de preparer de l'aprepitant
WO2008026216A2 (fr) * 2006-08-28 2008-03-06 Hetero Drugs Limited Procédé de purification d'aprépitant

Also Published As

Publication number Publication date
WO2009116081A2 (fr) 2009-09-24

Similar Documents

Publication Publication Date Title
IN2012DN02751A (fr)
WO2010122578A3 (fr) Procédé de préparation de la sitagliptine et de ses intermédiaires
WO2009079008A8 (fr) Benzopyranes et analogues utilisés comme inhibiteurs de la rho kinase
CL2009000503A1 (es) Proceso de preparacion de compuestos derivados de acido 2-amino-5-cianobenzoico-3-sustituidos o 1h-pirazol-5-carboxamida.
WO2010048477A3 (fr) Procede ameliore de preparation de produits couples a partir de 4-amino-3-cyanoquinoleines utilisant des intermediaires stabilises
WO2013121436A3 (fr) Procédé de préparation de rivaroxaban et de ses intermédiaires
WO2009095933A3 (fr) Procédé perfectionné et nouveau pour la préparation de bosentan
WO2009157019A3 (fr) Préparation d'ezetimdie au moyen de nouveaux intermédiaires allyle
WO2009053446A3 (fr) Nouveaux intermédiaires de prégabaline et procédé de préparation desdits intermédiaires et de prégabaline
WO2011024192A3 (fr) Nouveaux polymorphes du raltegravir
WO2010004578A3 (fr) Nouveaux procédés améliorés de préparation de la palipéridone
WO2011157390A3 (fr) Procédé de préparation de composés 3-(1-amino-2-methylpentane-3-yl)phényle substitué
WO2013014665A8 (fr) Composés intermédiaires et procédé pour la préparation de lurasidone et de sels de celle-ci
WO2011004402A3 (fr) Procédé amélioré de préparation d'ambrisentan et nouveaux intermédiaires associés
WO2009116081A3 (fr) Procédé amélioré de préparation daprépitant
WO2008053334A3 (fr) Procédé amélioré de préparation de rosuvastatine calcique
WO2008075205A3 (fr) Procédé amélioré de préparation de la voriconazole
EA201200820A1 (ru) Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов
UA106988C2 (uk) Спосіб одержання 1-бензил-3-гідроксиметил-1h-індазолу і його похідних та необхідні проміжні сполуки магнію
WO2013076743A3 (fr) Procédé de purification de polyaminocarboxylates
WO2009062659A3 (fr) Polymorphes d'erdostéine énantiopure
WO2009060297A3 (fr) Procédé perfectionné pour la préparation de la palipéridone et de ses intermédiaires
WO2013072938A3 (fr) Procédé amélioré pour la préparation de roflumilast
WO2010059916A3 (fr) Préparation de docétaxel
WO2008096373A3 (fr) Procédé de synthèse de polymorphes de natéglinide extrêmement pure

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09722737

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09722737

Country of ref document: EP

Kind code of ref document: A2