WO2009095933A3 - Procédé perfectionné et nouveau pour la préparation de bosentan - Google Patents

Procédé perfectionné et nouveau pour la préparation de bosentan Download PDF

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Publication number
WO2009095933A3
WO2009095933A3 PCT/IN2009/000032 IN2009000032W WO2009095933A3 WO 2009095933 A3 WO2009095933 A3 WO 2009095933A3 IN 2009000032 W IN2009000032 W IN 2009000032W WO 2009095933 A3 WO2009095933 A3 WO 2009095933A3
Authority
WO
WIPO (PCT)
Prior art keywords
bosentan
preparation
improved
novel process
relates
Prior art date
Application number
PCT/IN2009/000032
Other languages
English (en)
Other versions
WO2009095933A2 (fr
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Ghojala Venkat Reddy
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Priority to EP09705099A priority Critical patent/EP2240470A4/fr
Publication of WO2009095933A2 publication Critical patent/WO2009095933A2/fr
Publication of WO2009095933A3 publication Critical patent/WO2009095933A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention porte sur un procédé perfectionné et nouveau pour la préparation du composé bosentan de formule (1). La présente invention porte également sur une forme cristalline de bosentan et sur ses intermédiaires.
PCT/IN2009/000032 2008-01-10 2009-01-09 Procédé perfectionné et nouveau pour la préparation de bosentan WO2009095933A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09705099A EP2240470A4 (fr) 2008-01-10 2009-01-09 Procédé perfectionné et nouveau pour la préparation de bosentan

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN103/CHE/2008 2008-01-10
IN103CH2008 2008-01-10
IN2334CH2008 2008-09-24
IN2334/CHE/2008 2008-09-24

Publications (2)

Publication Number Publication Date
WO2009095933A2 WO2009095933A2 (fr) 2009-08-06
WO2009095933A3 true WO2009095933A3 (fr) 2011-06-30

Family

ID=40913375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000032 WO2009095933A2 (fr) 2008-01-10 2009-01-09 Procédé perfectionné et nouveau pour la préparation de bosentan

Country Status (2)

Country Link
EP (1) EP2240470A4 (fr)
WO (1) WO2009095933A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ600010A (en) 2007-10-24 2013-11-29 Generics Uk Ltd Novel crystalline forms of bosentan, processes for their preparation and uses thereof
WO2009093127A2 (fr) * 2008-01-24 2009-07-30 Actavis Group Ptc Ehf Forme cristallisée stable et sensiblement pure de bosentan
CN101939301B (zh) 2008-02-08 2016-07-06 基因里克斯(英国)有限公司 用于制备波生坦的方法
WO2010015623A1 (fr) * 2008-08-05 2010-02-11 Farmaprojects, S. A. Procédé pour la fabrication d'antagonistes des récepteurs de l'endothéline
WO2010032261A1 (fr) * 2008-08-12 2010-03-25 Cadila Healthcare Limited Procédé pour la préparation de bosentan
AU2009321375A1 (en) * 2008-11-03 2010-06-03 Generics [Uk] Limited HPLC method for the analysis of bosentan and related substances and use of these substances as reference standards and markers
IT1393136B1 (it) * 2009-03-11 2012-04-11 Sifa Vitor S R L Procedimento per la preparazione del bosentan
WO2010118992A1 (fr) 2009-04-13 2010-10-21 Sandoz Ag Procédé de préparation d'un antagoniste du récepteur endothélial (bosentan)
WO2011021216A2 (fr) * 2009-08-10 2011-02-24 Msn Laboratories Limited Procédé amélioré pour la préparation de 4-(1,1-diméthyléthyl)-n-[6-(2-hydroxyéthoxy)-5-(2-méthoxyphénoxy) [2,2'-bipyrimidin]-4-yl] benzènesulfonamide
WO2011024056A2 (fr) 2009-08-27 2011-03-03 Aurobindo Pharma Limited Procédé perfectionné pour la préparation de bosentan
CA2781541A1 (fr) * 2009-11-12 2011-05-19 Ranbaxy Laboratories Limited Formes cristallines du sel de bosentan et leurs procedes de preparation
EP2603497B1 (fr) 2010-08-11 2018-08-08 Megafine Pharma (P) Ltd. Un procédé nouveau pour la préparation de la bosentan.
PL2621909T3 (pl) * 2010-10-01 2019-05-31 Zach System Spa Sposób wytwarzania monohydratu Bosentanu i jego związków pośrednich
US20130245259A1 (en) 2012-03-16 2013-09-19 Natco Pharma Limited Process for the preparation of bosentan monohydrate
WO2013186706A1 (fr) * 2012-06-12 2013-12-19 Cadila Pharmaceuticals Ltd Procédé pour la préparation de bosentan
TR202018841A2 (tr) * 2020-11-23 2021-01-21 Yilmaz Usta Duygu Uzun zi̇nci̇rli̇ mono ve di̇gli̇seri̇t karişimlari i̇le hazirlanan bosentan monohi̇drat yüklü kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stemleri̇n (snedds) formülasyonu

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292740A (en) * 1991-06-13 1994-03-08 Hoffmann-La Roche Inc. Sulfonamides
EP0601386A1 (fr) * 1992-12-10 1994-06-15 F. Hoffmann-La Roche Ag Sulfonamides
WO2001081335A1 (fr) * 2000-04-20 2001-11-01 Actelion Pharmaceuticals Ltd Pyrimidine-sulfonamides agissant comme antagonistes de l'endotheline

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292740A (en) * 1991-06-13 1994-03-08 Hoffmann-La Roche Inc. Sulfonamides
EP0601386A1 (fr) * 1992-12-10 1994-06-15 F. Hoffmann-La Roche Ag Sulfonamides
WO2001081335A1 (fr) * 2000-04-20 2001-11-01 Actelion Pharmaceuticals Ltd Pyrimidine-sulfonamides agissant comme antagonistes de l'endotheline

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOLLI, M.,H. ET AL.: "The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists", BIOORG. MED. CHEM. LETT., vol. 13, 2003, pages 955 - 959, XP002587197 *
See also references of EP2240470A2 *

Also Published As

Publication number Publication date
EP2240470A4 (fr) 2012-05-23
EP2240470A2 (fr) 2010-10-20
WO2009095933A2 (fr) 2009-08-06

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