WO2008075205A3 - Procédé amélioré de préparation de la voriconazole - Google Patents
Procédé amélioré de préparation de la voriconazole Download PDFInfo
- Publication number
- WO2008075205A3 WO2008075205A3 PCT/IB2007/004408 IB2007004408W WO2008075205A3 WO 2008075205 A3 WO2008075205 A3 WO 2008075205A3 IB 2007004408 W IB2007004408 W IB 2007004408W WO 2008075205 A3 WO2008075205 A3 WO 2008075205A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- voriconazole
- preparation
- improved process
- relates
- present
- Prior art date
Links
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 title abstract 2
- 229960004740 voriconazole Drugs 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07870444A EP2048950A2 (fr) | 2006-07-13 | 2007-07-12 | Procédé amélioré de préparation de la voriconazole |
CA002658111A CA2658111A1 (fr) | 2006-07-13 | 2007-07-12 | Procede ameliore de preparation de la voriconazole |
US12/373,587 US20100056784A1 (en) | 2006-07-13 | 2007-07-12 | Process for the preparation of voriconazole |
IL196474A IL196474A0 (en) | 2006-07-13 | 2009-01-13 | Improved process for the preparation of voriconazole |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80727506P | 2006-07-13 | 2006-07-13 | |
US60/807,275 | 2006-07-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008075205A2 WO2008075205A2 (fr) | 2008-06-26 |
WO2008075205A3 true WO2008075205A3 (fr) | 2011-06-16 |
Family
ID=39536802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/004408 WO2008075205A2 (fr) | 2006-07-13 | 2007-07-12 | Procédé amélioré de préparation de la voriconazole |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100056784A1 (fr) |
EP (1) | EP2048950A2 (fr) |
AR (1) | AR061889A1 (fr) |
CA (1) | CA2658111A1 (fr) |
IL (1) | IL196474A0 (fr) |
WO (1) | WO2008075205A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8288394B2 (en) | 2009-12-30 | 2012-10-16 | Medichem, S.A. | 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivative for pharmaceutical use, and the use of a 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivative with substantially undefined crystal shape for preparing said 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivative |
WO2011110198A1 (fr) | 2010-03-10 | 2011-09-15 | Synthron B.V. | Procédé de préparation de voriconazole |
WO2012094381A2 (fr) | 2011-01-05 | 2012-07-12 | Hospira, Inc. | Séchage par atomisation de la vancomycine |
CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
CN106432198B (zh) * | 2016-09-08 | 2022-10-21 | 浙江华海药业股份有限公司 | 一种制备伏立康唑拆分中间体的方法 |
CN108276310A (zh) * | 2017-01-06 | 2018-07-13 | 常州齐晖药业有限公司 | 一种伏立康唑拆分剂(r)-10-樟脑磺酸的回收方法 |
CN109212048B (zh) * | 2017-07-07 | 2023-04-21 | 常州齐晖药业有限公司 | 一种伏立康唑中杂质含量的检测方法 |
CN110308212B (zh) * | 2018-03-27 | 2022-03-18 | 成都倍特药业股份有限公司 | 一种伏立康唑有关物质检测方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5567817A (en) * | 1990-02-02 | 1996-10-22 | Pfizer Inc. | Triazole antifungal agents |
US6586594B1 (en) * | 1995-08-05 | 2003-07-01 | Pfizer, Inc. | Preparation of triazoles by organometallic addition to ketones and intermediates therefor |
CN1473825A (zh) * | 2002-08-07 | 2004-02-11 | 张文祥 | 制备伏立康唑的方法 |
WO2006065726A2 (fr) * | 2004-12-14 | 2006-06-22 | Dr. Reddy's Laboratories Ltd. | Procede de preparation de voriconazole |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8819308D0 (en) | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
GB9713149D0 (en) | 1997-06-21 | 1997-08-27 | Pfizer Ltd | Pharmaceutical formulations |
-
2007
- 2007-07-11 AR ARP070103085A patent/AR061889A1/es unknown
- 2007-07-12 US US12/373,587 patent/US20100056784A1/en not_active Abandoned
- 2007-07-12 WO PCT/IB2007/004408 patent/WO2008075205A2/fr active Application Filing
- 2007-07-12 EP EP07870444A patent/EP2048950A2/fr not_active Withdrawn
- 2007-07-12 CA CA002658111A patent/CA2658111A1/fr not_active Abandoned
-
2009
- 2009-01-13 IL IL196474A patent/IL196474A0/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5567817A (en) * | 1990-02-02 | 1996-10-22 | Pfizer Inc. | Triazole antifungal agents |
US5773443A (en) * | 1990-02-02 | 1998-06-30 | Pfizer Inc. | Triazole antifungal agents |
US6586594B1 (en) * | 1995-08-05 | 2003-07-01 | Pfizer, Inc. | Preparation of triazoles by organometallic addition to ketones and intermediates therefor |
CN1473825A (zh) * | 2002-08-07 | 2004-02-11 | 张文祥 | 制备伏立康唑的方法 |
WO2006065726A2 (fr) * | 2004-12-14 | 2006-06-22 | Dr. Reddy's Laboratories Ltd. | Procede de preparation de voriconazole |
Non-Patent Citations (1)
Title |
---|
DICKINSON R P ET AL: "Novel Antifungal 2-Aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Derivatives with High activity Against Aspergillus fumigatus", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 6, no. 16, 20 August 1996 (1996-08-20), pages 2031 - 2036, XP002577258, ISSN: 0960-894X * |
Also Published As
Publication number | Publication date |
---|---|
WO2008075205A2 (fr) | 2008-06-26 |
CA2658111A1 (fr) | 2008-06-26 |
US20100056784A1 (en) | 2010-03-04 |
AR061889A1 (es) | 2008-10-01 |
EP2048950A2 (fr) | 2009-04-22 |
IL196474A0 (en) | 2009-12-24 |
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